Jian Zhang

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain
    G Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cell Death Differ 17:522-33. 2010
  2. ncbi request reprint Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    Dongdong Li
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 173:7135-9. 2004
  3. pmc T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
    Mol Cell Biol 28:2470-80. 2008
  4. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
  5. ncbi request reprint IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism
    Jian Zhang
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 170:3495-503. 2003
  6. pmc CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
    Tamas Bardos
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St, Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R106-13. 2003
  7. doi request reprint Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Clin Exp Metastasis 26:161-9. 2009
  8. pmc Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
    Xiaoyan Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 105:885-95. 2008
  9. pmc Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo
    Zhong Cai
    Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Neoplasia 11:228-36. 2009
  10. doi request reprint CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain
    G Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cell Death Differ 17:522-33. 2010
    ..Therefore, we have identified c-FLIP(L) as a susceptibility factor under the influence of epistatic modifiers for the development of autoimmunity...
  2. ncbi request reprint Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    Dongdong Li
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 173:7135-9. 2004
    ..These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation...
  3. pmc T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
    Mol Cell Biol 28:2470-80. 2008
    ....
  4. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
  5. ncbi request reprint IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism
    Jian Zhang
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 170:3495-503. 2003
    ..Furthermore, IL-4 regulates the T cell thresholds for IL-2 signaling during AICD. These data suggest that IL-4 promotes AICD via an IL-2-dependent mechanism...
  6. pmc CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
    Tamas Bardos
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St, Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R106-13. 2003
    ..Moreover, CD28-deficient mice, which have very few CD4+CD25+ T cells, were highly resistant to PGIA. These findings indicate that the CD4+CD25+ regulatory T cells may not play a critical role in controlling PGIA...
  7. doi request reprint Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Clin Exp Metastasis 26:161-9. 2009
    ..MCP-1 knockdown diminished PC3 tumor growth in bone. We concluded that activation of MCP-1/CCR2 axis promotes PCa growth in bone. This study suggests that MCP-1 may be a target for PCa progression...
  8. pmc Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
    Xiaoyan Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 105:885-95. 2008
    ..Taken together, these results for the first time demonstrate that ATF4 is a critical regulator of proliferation and survival in BMSCs and osteoblasts in vitro and in vivo...
  9. pmc Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo
    Zhong Cai
    Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Neoplasia 11:228-36. 2009
    ..The MCP-1 knockdown significantly diminished A549 cell growth. We conclude that MCP-1 promotes lung cancer-induced osteoclast activity and thus bone resorptive lesions in vivo...
  10. doi request reprint CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro
    Yi Lu
    Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Mol Cancer Res 6:546-54. 2008
    ..CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells...
  11. ncbi request reprint Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption
    Yi Lu
    Department of Medicine, University of Pittsburgh, University Drive, Pittsburgh, PA 15240, USA
    Cancer Res 67:3646-53. 2007
    ..This study may provide novel therapeutic targets for treatment of prostate cancer skeletal metastasis...
  12. pmc Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression
    Shibing Yu
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Endocrinology 149:1960-8. 2008
    ..Collectively, these studies for the first time demonstrate that PTH increases ATF4 expression and activity and that ATF4 is required for PTH induction of Ocn expression in osteoblasts...
  13. ncbi request reprint IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms
    Alison Finnegan
    Section of Rheumatology, Department of Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 169:3345-52. 2002
    ..Taken together, these results suggest that IL-4 regulates the severity of disease in PGIA by controlling IL-12 production, which in turn regulates the magnitude of IFN-gamma expression through a Stat4-dependent pathway...
  14. ncbi request reprint PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Int J Cancer 121:724-33. 2007
    ..We conclude that PTHrP-induced MCP-1 production by HBME and hFOB cells promotes osteoclast differentiation in vitro and such induction may play a critical role in PCa development in the bone microenvironment...
  15. doi request reprint Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation
    Yi Lu
    Department of Medicine, University of Pittsburgh, VA Pittsburgh Healthcare Systems, Room 2E146, University Drive, Pittsburgh, PA 15240, USA
    Mol Cancer Ther 7:3203-11. 2008
    ..These results suggest that fat-1 gene transfer directly into tumor cells could be used as a novel therapeutic approach...
  16. pmc T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 191:632-9. 2013
    ..Furthermore, we show that Akt-2 but not Akt-1 regulates Foxp3 expression downstream of Cbl-b. Therefore, we demonstrate that Cbl-b regulates the fate of iTregs via controlling the threshold for T cell activation. ..
  17. pmc Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth
    Jian Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Natl Cancer Inst 102:522-8. 2010
    ..The multiple roles of CCL2 in the tumor microenvironment make it an attractive therapeutic target in metastatic prostate cancer as well as in other cancers...
  18. ncbi request reprint Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 6063, USA
    J Immunol 179:4473-9. 2007
    ..Together, our data suggest that Cbl-b attenuates CD40-mediated NF-kappaB and JNK activation, thereby suppressing B cell responses...
  19. ncbi request reprint Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination
    Jian Zhang
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 169:2236-40. 2002
    ..Our results demonstrate that CD28 costimulation regulates the threshold for T cell activation, at least in part, by promoting Cbl-b ubiquitination and degradation...
  20. pmc Collagen-induced arthritis is exacerbated in IL-10-deficient mice
    Alison Finnegan
    Department of Medicine, Section of Rheumatology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R18-24. 2003
    ..Since IL-10 levels are elevated in rheumatoid arthritis synovial fluid, these findings may have relevance to rheumatoid arthritis...
  21. pmc Prediction of geometrically feasible three-dimensional structures of pseudoknotted RNA through free energy estimation
    Jian Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    RNA 15:2248-63. 2009
    ..These close-to-native structures can be used as starting points for further refinement to derive accurate three-dimensional structures of RNA molecules, including those with pseudoknots...
  22. pmc E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity
    Hui Guo
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cell Rep 1:472-82. 2012
    ..Hence, our data demonstrate that Cbl-b inhibits T cell activation by suppressing Pten inactivation independently of its ubiquitin ligase activity...
  23. ncbi request reprint Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells
    Ujjal K Singha
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 103:434-46. 2008
    ..Taken together, our studies demonstrate that mTOR signaling affects osteoblast functions by targeting osteoblast proliferation and the early stage of osteoblast differentiation...
  24. ncbi request reprint Activation-induced cell death in T cells and autoimmunity
    Jian Zhang
    Departments of Orthopedic Surgery and Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Mol Immunol 1:186-92. 2004
    ..In this review, we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases...
  25. pmc Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Clin Immunol 143:128-33. 2012
    ..Therefore, we first demonstrate that PD-1 controls peripheral T cell tolerance via an anergy-independent but iTreg-dependent mechanism...
  26. pmc Syk mediates BCR- and CD40-signaling integration during B cell activation
    Haiyan Ying
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, IL 60637, United States
    Immunobiology 216:566-70. 2011
    ..Therefore, our data suggest that CD40 can strengthen BCR-signaling pathway and quantitatively modify BCR signaling during B cell activation...
  27. pmc E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA Committee on Immunology, University of Chicago, Chicago, IL 60637, USA Electronic address
    Cell Rep 6:709-23. 2014
    ..Therefore, our data reveal a function for Cbl-b in the regulation of Th2 and Th9 cell differentiation. ..
  28. ncbi request reprint T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system
    Tamas Bardos
    Section of Molecular Medicine, Departments of Orthopedic Surgery and Biochemistry, Section of Rheumatology, Department of Medicine, and Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Rush University, Chicago, IL 60612
    J Immunol 168:6013-21. 2002
    ..Our results indicate a selective and highly effective cooperation between CD4(+) T cells and B lymphocytes that is required for the restoration of pathological homeostasis and development of autoimmune arthritis in SCID mice...
  29. ncbi request reprint Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock
    Limin Liu
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 116:617-28. 2004
    ..Thus, SNOs regulate innate immune and vascular function, and are cleared actively to ameliorate nitrosative stress. Nitrosylation of cysteine thiols is a critical mechanism of NO function in both health and disease...
  30. pmc Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells
    Lihua Bao
    University of Chicago, Illinois, 60637, USA
    J Clin Invest 119:1264-74. 2009
    ..These findings add to growing evidence that complement-derived signals shape T cell responses, since T cells that recognize sheep Abs bound to podocytes can lead to cellular injury and development of FSGS...
  31. ncbi request reprint Ubiquitin ligases in T cell activation and autoimmunity
    Jian Zhang
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Immunol 111:234-40. 2004
    ..This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and autoimmunity...
  32. ncbi request reprint Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis
    Ying Zhuo
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 286:L182-8. 2004
    ..Moreover, there is in vivo phosphorylation of the PDGF-receptor that binds PDGF-C in response to bleomycin administration. These observations strongly suggest a role for PDGF-C in bleomycin-induced pulmonary fibrosis...
  33. pmc Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic
    Jian Zhang
    Department of Medicine, Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Prog Mol Biol Transl Sci 95:31-53. 2010
    ..In this chapter, targeting CCL2 in prostate cancer will be used as an example to show translation of laboratory findings from cancer molecular biology to the clinic...
  34. ncbi request reprint Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals
    Jian Zhang
    Department of Statistics, University of Chicago, Chicago, Illinois 60637, USA
    Genet Epidemiol 29:128-40. 2005
    ..We apply the method to fine-mapping of a susceptibility locus for bronchial hyperresponsiveness (BHR) in the Hutterites. The results confirm the importance of taking into account the relatedness of individuals in LD mapping...
  35. pmc Discrete state model and accurate estimation of loop entropy of RNA secondary structures
    Jian Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Chem Phys 128:125107. 2008
    ..The discrete model and the program used to calculate loop entropy can be downloaded at http://gila.bioengr.uic.edu/resources/RNA.html...
  36. pmc Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation
    Sunit Singla
    Pulmonary and Critical Care Medicine, Rush University Medical Center, 1750 W, Harrison Street, 297 Jelke, Chicago, IL 60612, USA
    Respir Res 12:46. 2011
    ..Here we further characterized the cyto-protective EC response to LPS and pro-inflammatory dysfunction...
  37. ncbi request reprint Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model
    Jian Zhang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 110:750-5. 2004
    ..However, whether this mechanism operates in the systemic and coronary beds that subserve the antianginal action of GTN is not known. In this study, we address this question in an intact canine model...
  38. ncbi request reprint Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion
    Yi Lu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    Prostate 66:1311-8. 2006
    ..Increased MCP-1 serum levels in patients with various cancers were correlated with advanced stage. Here, we evaluated the role of MCP-1 on prostate cancer (CaP) cell proliferation and invasion...

Research Grants9

  1. DEFECTS IN ACTIVATION-INDUCED T CELL DEATH IN ARTHRITIS
    Jian Zhang; Fiscal Year: 2003
    ....
  2. Cbl-b in T Cell Activation and Autoimmunity
    Jian Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  3. Cbl-b in T Cell Activation and Autoimmunity
    Jian Zhang; Fiscal Year: 2005
    ..abstract_text> ..
  4. Cbl-b in T Cell Activation and Autoimmunity
    Jian Zhang; Fiscal Year: 2006
    ..abstract_text> ..
  5. IL-4 Potentiates T Cell Death in Autoimmune Arthritis
    Jian Zhang; Fiscal Year: 2006
    ..abstract_text> ..
  6. Cbl-b in T Cell Activation and Autoimmunity
    Jian Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  7. Cbl-b in T Cell Activation and Autoimmunity
    Jian Zhang; Fiscal Year: 2010
    ....