Affiliation: University of Miami
- Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activityR Grace Zhai
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Biol 4:e416. 2006..Our data indicate an NAD-independent requirement of NMNAT for maintaining neuronal integrity that can be exploited to protect neurons from neuronal activity-induced degeneration by overexpression of the protein...
- NAD synthase NMNAT acts as a chaperone to protect against neurodegenerationR Grace Zhai
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Nature 452:887-91. 2008..Our studies provide an entry point for understanding how normal neurons maintain activity, and offer clues for the common mechanisms underlying different neurodegenerative conditions...
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzymeRong Grace Zhai
Department of Molecular and Cellular Pharmacology, Neuroscience Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Cell Mol Life Sci 66:2805-18. 2009..The resultant wealth of biochemical data has built a robust framework upon which design of NMNAT activators, inhibitors or enzyme variants of potential medical interest can be based...
- BMAA neurotoxicity in DrosophilaXianchong Zhou
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA
Amyotroph Lateral Scler 10:61-6. 2009..We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts...
- Activity-independent prespecification of synaptic partners in the visual map of DrosophilaP Robin Hiesinger
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Biol 16:1835-43. 2006..Our data suggest cell-autonomous control of synapse numbers as part of a developmental program of activity-independent steps that lead to a "hard-wired" visual map in the fly brain...
- Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst componentsSunil Q Mehta
Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Neuron 46:219-32. 2005..The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions...
- Hauling t-SNAREs on the microtubule highwayR Grace Zhai
Nat Cell Biol 6:918-9. 2004
- Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoatingPatrik Verstreken
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 40:733-48. 2003..Our data also provide further evidence that kiss-and-run is able to maintain neurotransmitter release when synapses are not extensively challenged...
- Mapping Drosophila mutations with molecularly defined P element insertionsR Grace Zhai
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 100:10860-5. 2003..Our data show that this mapping approach is inexpensive, efficient, and precise, and that it significantly broadens the application of P elements in Drosophila...
- Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesiclesMika Shapira
Rappaport Institute and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Haifa, Israel
Neuron 38:237-52. 2003..These findings suggest that AZs are assembled from unitary amounts of AZ material carried on PTVs...