KENNETH S contact ZARET

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Pioneer transcription factors, chromatin dynamics, and cell fate control
    Kenneth S Zaret
    Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 9 131 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104 5157, USA Electronic address
    Curr Opin Genet Dev 37:76-81. 2016
  2. pmc Chromatin Scanning by Dynamic Binding of Pioneer Factors
    Kenneth S Zaret
    Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104 5157, USA Electronic address
    Mol Cell 62:665-7. 2016
  3. doi From Endoderm to Liver Bud: Paradigms of Cell Type Specification and Tissue Morphogenesis
    Kenneth S Zaret
    Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Electronic address
    Curr Top Dev Biol 117:647-69. 2016
  4. pmc Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?
    Kenneth S Zaret
    Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 29:132-4. 2014
  5. pmc Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
    Palle Serup
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820, Denmark
    Dis Model Mech 5:956-66. 2012
  6. pmc Pioneer transcription factors: establishing competence for gene expression
    Kenneth S Zaret
    Epigenetics Program, Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genes Dev 25:2227-41. 2011
  7. doi Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010

Research Grants

  1. Kenneth S Zaret; Fiscal Year: 2016
  2. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2005
  3. Novel Epigenetic Marks in Mitosis
    KENNETH S contact ZARET; Fiscal Year: 2010

Collaborators

  • Jason S Carroll
  • Palle Serup
  • Ashley Davis
  • Anne Grapin-Botton
  • Janny M L Peterslund
  • Angela Hines
  • Mark A Magnuson
  • Nina Engberg
  • Carsten Gustavsen
  • Ewa Wandzioch
  • Christine Bruun
  • Dorthe R Petersen
  • Nandita Mullapudi
  • Leah A Potter
  • Robert Lin
  • Tino Klein
  • Raymond J Macdonald

Detail Information

Publications7

  1. pmc Pioneer transcription factors, chromatin dynamics, and cell fate control
    Kenneth S Zaret
    Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 9 131 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104 5157, USA Electronic address
    Curr Opin Genet Dev 37:76-81. 2016
    ..Understanding how pioneer factors initiate chromatin dynamics and how such can be blocked at heterochromatic sites provides insights into controlling cell fate transitions at will. ..
  2. pmc Chromatin Scanning by Dynamic Binding of Pioneer Factors
    Kenneth S Zaret
    Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104 5157, USA Electronic address
    Mol Cell 62:665-7. 2016
    ..Taken together, the distinguishing feature of pioneer factors remains nucleosomal access rather than an exceptional residence time in chromatin. ..
  3. doi From Endoderm to Liver Bud: Paradigms of Cell Type Specification and Tissue Morphogenesis
    Kenneth S Zaret
    Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Electronic address
    Curr Top Dev Biol 117:647-69. 2016
    ....
  4. pmc Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?
    Kenneth S Zaret
    Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 29:132-4. 2014
    ..Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment. ..
  5. pmc Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
    Palle Serup
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820, Denmark
    Dis Model Mech 5:956-66. 2012
    ....
  6. pmc Pioneer transcription factors: establishing competence for gene expression
    Kenneth S Zaret
    Epigenetics Program, Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genes Dev 25:2227-41. 2011
    ..Passive and active roles for the pioneer factor FoxA occur in embryonic development, steroid hormone induction, and human cancers. Herein we review the field and describe how pioneer factors may enable cellular reprogramming...
  7. doi Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010
    ..The results indicate that the "pioneer" features of FoxA factors involve various chromatin-binding parameters seen in linker histones and that distinguish the factors with respect to their regulatory and mechanistic functions...

Research Grants3

  1. Kenneth S Zaret; Fiscal Year: 2016
    ..Understanding how multipotent cells are specified to different tissue types is fundamental to organogenesis, tissue regeneration, and stem cell biology, and therefore human health and disease. ..
  2. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2005
    ..abstract_text> ..
  3. Novel Epigenetic Marks in Mitosis
    KENNETH S contact ZARET; Fiscal Year: 2010
    ..We will investigate whether FoxA or PARP occupancy, or polyADP ribosylation may induce special structural configurations at epigenetic marks in mitotic chromatin. ..