Chun Yuan

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
  2. pmc Characteristics of carotid atherosclerotic plaques of chronic lipid apheresis patients as assessed by in vivo high-resolution CMR--a comparative analysis
    Jochen M Grimm
    Institute for Clinical Radiology, Ludwig Maximilians University Hospital Munich, Pettenkoferstrasse 8a, Munich, Germany
    J Cardiovasc Magn Reson 14:80. 2012
  3. pmc Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core
    Kiyofumi Yamada
    Department of Radiology, University of Washington, Seattle, WA 98109 4325, USA
    J Cardiovasc Magn Reson 14:81. 2012
  4. pmc High-field atherosclerotic plaque magnetic resonance imaging
    Chun Yuan
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Neuroimaging Clin N Am 22:271-84, xi. 2012
  5. pmc Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study
    Hunter R Underhill
    Department of Radiology University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 10:31. 2008
  6. pmc High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 11:41. 2009
  7. pmc The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 12:37. 2010
  8. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011
  9. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
  10. pmc Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3D fluid-structure interaction study
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PR China
    Biomed Eng Online 9:86. 2010

Research Grants

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
    ..Long-term patient follow up was used to gather data and investigate if the correlations identified above were reproducible...
  2. pmc Characteristics of carotid atherosclerotic plaques of chronic lipid apheresis patients as assessed by in vivo high-resolution CMR--a comparative analysis
    Jochen M Grimm
    Institute for Clinical Radiology, Ludwig Maximilians University Hospital Munich, Pettenkoferstrasse 8a, Munich, Germany
    J Cardiovasc Magn Reson 14:80. 2012
    ..The purpose of this study was to evaluate the influence of chronic lipid apheresis (LA) on the composition of atherosclerotic carotid plaques...
  3. pmc Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core
    Kiyofumi Yamada
    Department of Radiology, University of Washington, Seattle, WA 98109 4325, USA
    J Cardiovasc Magn Reson 14:81. 2012
    ..The aim of this study was to evaluate the quantitative relationships between high intensity signals (HIS) in the plaque on TOF-MRA and IPH or LRNC volumes as measured by multicontrast weighted CMR...
  4. pmc High-field atherosclerotic plaque magnetic resonance imaging
    Chun Yuan
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Neuroimaging Clin N Am 22:271-84, xi. 2012
    ..This article summarizes the technological requirements required for high-field plaque MR imaging and its application in detecting plaque components...
  5. pmc Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study
    Hunter R Underhill
    Department of Radiology University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 10:31. 2008
    ....
  6. pmc High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 11:41. 2009
    ..The purpose of this study was to evaluate a multi-sequence, black-blood MR protocol using parallel imaging and a dedicated 4-channel surface coil for vessel wall imaging of the carotid arteries at 3 T...
  7. pmc The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 12:37. 2010
    ..This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR)...
  8. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011
    ..It has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS). However, mechanisms governing advanced plaque progression are not well understood...
  9. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
    ..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature...
  10. pmc Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3D fluid-structure interaction study
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PR China
    Biomed Eng Online 9:86. 2010
    ....
  11. ncbi request reprint In vitro and in situ magnetic resonance imaging signal features of atherosclerotic plaque-associated lipids
    C Yuan
    Department of Radiology, University of Washington, Seattle 98195 7115, USA
    Arterioscler Thromb Vasc Biol 17:1496-503. 1997
    ..These studies raise the possibility that with further advances in technology, MRI may become a useful tool for determining the lipid content and composition of human atherosclerotic plaques in vivo...
  12. ncbi request reprint Closed contour edge detection of blood vessel lumen and outer wall boundaries in black-blood MR images
    C Yuan
    Department of Radiology, University of Washington, Seattle 98195, USA
    Magn Reson Imaging 17:257-66. 1999
    ..Our algorithm has proven to be sensitive to various contrast situations and is reasonably accurate and highly reproducible...
  13. ncbi request reprint In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques
    C Yuan
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Circulation 104:2051-6. 2001
    ..The purpose of this study was to evaluate differential contrast-weighted images, specifically a multispectral MR technique, to improve the accuracy of identifying the lipid-rich necrotic core and acute intraplaque hemorrhage in vivo...
  14. ncbi request reprint Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions
    C Yuan
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    Radiology 221:285-99. 2001
    ..The purpose of this report is to review the current state of carotid plaque MR imaging and the use of carotid MR to evaluate plaque morphology and composition...
  15. ncbi request reprint Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke
    Chun Yuan
    Department of Radiology, University of Washington, Seattle 98195, USA
    Circulation 105:181-5. 2002
    ..The aim of this study was to determine whether MRI identification of fibrous cap thinning or rupture is associated with a history of recent transient ischemic attack (TIA) or stroke...
  16. ncbi request reprint Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization
    Chun Yuan
    University of Washington, School of Medicine, Seattle, Washington 98195 7115, USA
    J Magn Reson Imaging 15:62-7. 2002
    ..Although high-resolution magnetic resonance imaging (MRI) has been used to identify plaque constituents in advanced atherosclerosis, some constituents, such as neovascularized tissue, defy detection...
  17. ncbi request reprint Carotid atherosclerotic wall imaging by MRI
    Chun Yuan
    Department of Radiology, Box 357115, University of Washington, Seattle, WA 91895, USA
    Neuroimaging Clin N Am 12:391-401, vi. 2002
    ..This article focuses on the current state-of-the-art in MR carotid atherosclerotic plaque imaging to evaluate plaque morphology and composition...
  18. ncbi request reprint MRI of atherosclerosis
    Chun Yuan
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 19:710-9. 2004
    ..In this review, the current state of the art is summarized for the three primary vessel targets: the carotid artery, the aorta, and the coronary arteries...
  19. ncbi request reprint MRI of atherosclerosis in clinical trials
    Chun Yuan
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    NMR Biomed 19:636-54. 2006
    ..Also, the results of validation studies for measuring lesion size, composition and inflammation will be summarized. Finally, the status of several clinical trials involving MRI of atherosclerosis will be reviewed...
  20. pmc MRI of carotid atherosclerosis
    Chun Yuan
    Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle 98019, USA
    J Nucl Cardiol 15:266-75. 2008
  21. pmc MRI plaque imaging and its role in population-based studies
    Chun Yuan
    Department of Radiology, University of Washington School of Medicine, Seattle, USA
    BMC Med 8:78. 2010
    ..The findings from this article call for attention to more in vivo imaging to understand the nature of high-risk atherosclerosis, especially in prospective studies in diabetic patients...
  22. pmc Cardiovascular magnetic resonance in carotid atherosclerotic disease
    Li Dong
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:53. 2009
    ..This review summarizes the current state of knowledge regarding carotid vessel wall CMR and its potential clinical application for management of carotid atherosclerotic disease...
  23. pmc In vivo semi-automatic segmentation of multicontrast cardiovascular magnetic resonance for prospective cohort studies on plaque tissue composition: initial experience
    Taku Yoneyama
    Department of Radiology, University of Washington, 850 Republican St, Seattle, WA, 98109, USA
    Int J Cardiovasc Imaging 32:73-81. 2016
    ..Such automatic classification tools may be beneficial in large-scale multicenter studies by reducing image analysis time and avoiding bias between human reviewers...
  24. doi request reprint Subclinical carotid atherosclerosis: short-term natural history of lipid-rich necrotic core--a multicenter study with MR imaging
    Jie Sun
    Departments of Radiology and Surgery, University of Washington, Box 358050, 850 Republican St, Brotman Room 124, Seattle, WA 98109, USA
    Radiology 268:61-8. 2013
    ..To use magnetic resonance (MR) imaging to examine the short-term (6 months) natural history of the lipid-rich necrotic core (LRNC) in carotid artery plaques by examining the placebo group of a multicenter clinical trial...
  25. pmc Magnetic [corrected] resonance imaging [corrected] features of the disruption-prone and the disrupted carotid plaque
    Baocheng Chu
    Vascular Imaging Laboratory, University of Washington, Seattle, Washington 98109, USA
    JACC Cardiovasc Imaging 2:883-96. 2009
    ..This pictorial essay illustrates the capability of CMR for identifying features of disruption-prone and disrupted atherosclerotic carotid plaques...
  26. ncbi request reprint Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 24:203-10. 2006
    ....
  27. pmc Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths
    Hunter R Underhill
    Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Seattle, WA 98109, USA
    Radiology 248:550-60. 2008
    ..To prospectively compare the interpretation and quantification of carotid vessel wall morphology and plaque composition at 1.5-T with those at 3.0-T magnetic resonance (MR) imaging...
  28. pmc Hemorrhage and large lipid-rich necrotic cores are independently associated with thin or ruptured fibrous caps: an in vivo 3T MRI study
    Hideki Ota
    Department of Radiology, University of Washington, Seattle, WA, USA
    Arterioscler Thromb Vasc Biol 29:1696-701. 2009
    ..We investigated these associations in carotid arteries with mild to severe stenosis by in vivo 3T MRI...
  29. ncbi request reprint Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study
    Baocheng Chu
    Department of Radiology, University of Washington, USA
    Stroke 35:1079-84. 2004
    ..The aim of this study was to develop criteria for the identification of the stages of intraplaque hemorrhage using high-resolution MRI...
  30. pmc Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, WA, USA
    Atherosclerosis 194:e34-42. 2007
    ..Findings from this study suggest that increased normalized wall index and the use of statin therapy are associated with reduced rates of plaque progression amongst individuals with advanced, asymptomatic carotid atherosclerosis...
  31. doi request reprint Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Am Heart J 155:584.e1-8. 2008
    ..Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition...
  32. ncbi request reprint Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 7:799-808. 2005
    ..The percent lipid-rich/necrotic core (%LR/NC) and calcification (%Ca) were measured as a proportion of the vessel wall. For %LR/NC and %Ca, only those subjects that exhibited LR/NC or Ca components were used in the analysis...
  33. pmc Signal features of the atherosclerotic plaque at 3.0 Tesla versus 1.5 Tesla: impact on automatic classification
    William S Kerwin
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    J Magn Reson Imaging 28:987-95. 2008
    ..To investigate the impact of different field strengths on determining plaque composition with an automatic classifier...
  34. doi request reprint Scan-rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    J Magn Reson Imaging 31:168-76. 2010
    ..To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol...
  35. pmc MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    JACC Cardiovasc Imaging 4:977-86. 2011
    ..The purpose of this study was to test the lipid depletion hypothesis and to establish the time course of change in carotid plaque morphology and composition during lipid therapy using high-resolution magnetic resonance imaging (MRI)...
  36. pmc The added value of longitudinal black-blood cardiovascular magnetic resonance angiography in the cross sectional identification of carotid atherosclerotic ulceration
    Wei Yu
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:31. 2009
    ..This study evaluates the efficacy of adding longitudinal black-blood (BB) cardiovascular magnetic resonance (CMR) angiography to cross-sectional CMR images in the identification of carotid atherosclerotic ulceration...
  37. doi request reprint Correlation of coronary plaque phenotype and carotid atherosclerotic plaque composition
    Qian Zhao
    Department of Radiology, The Military General Hospital of Beijing of PLA, China
    Am J Med Sci 342:480-5. 2011
    ..The authors aim to investigate the correlation between coronary plaque phenotype and carotid plaque composition...
  38. ncbi request reprint Images in cardiovascular medicine. Detection of carotid atherosclerotic plaque ulceration, calcification, and thrombosis by multicontrast weighted magnetic resonance imaging
    Baocheng Chu
    Department of Radiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Circulation 112:e3-4. 2005
  39. ncbi request reprint In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology
    Jianming Cai
    Department of Radiology, University of Washington, Seattle, WA, USA
    Circulation 112:3437-44. 2005
    ..The goal of this study was to assess whether CEMRI can be used to accurately measure the dimensions of the intact FC and LR-NC...
  40. ncbi request reprint The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Radiology 244:64-77. 2007
    ..The use of MR imaging in animal models and in human disease in various vascular beds, particularly the carotid arteries, is presented...
  41. doi request reprint Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 Tesla
    Xihai Zhao
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Stroke 42:347-53. 2011
    ..To determine associations between stenosis, measures of plaque burden, and compositional features of carotid atherosclerosis, including high-risk features of intraplaque hemorrhage (IPH) and surface disruption...
  42. pmc Adventitial perfusion and intraplaque hemorrhage: a dynamic contrast-enhanced MRI study in the carotid artery
    Jie Sun
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Stroke 44:1031-6. 2013
    ..The purpose of this investigation was to use dynamic contrast-enhanced MRI to test in vivo in a clinical population whether adventitial perfusion, indicative of vasa vasorum microstructure, is associated with IPH...
  43. doi request reprint Minimization of MR contrast weightings for the comprehensive evaluation of carotid atherosclerotic disease
    Xihai Zhao
    Department of Radiology, University of Washington, Seattle, WA, USA
    Invest Radiol 45:36-41. 2010
    ..In this study, we sought to determine whether contrast weightings beyond T1W (pre- and postcontrast) are necessary for comprehensive, quantitative, carotid plaque interpretation...
  44. pmc Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences
    Hideki Ota
    Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Room 124, Seattle, WA 98109, USA
    Radiology 254:551-63. 2010
    ..To compare the diagnostic performances of three T1-weighted 3.0-T magnetic resonance (MR) sequences at carotid intraplaque hemorrhage (IPH) imaging, with histo logic analysis as the reference standard...
  45. pmc Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging
    Li Dong
    Department of Radiology, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 260:224-31. 2011
    ..To investigate whether short-term, intensive lipid therapy leads to changes in microvascular characteristics, as measured by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging...
  46. ncbi request reprint Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, USA
    Circulation 111:2768-75. 2005
    ..We have shown that MRI can accurately identify carotid intraplaque hemorrhage and precisely measure plaque volume. We tested the hypothesis that hemorrhage into carotid atheroma stimulates plaque progression...
  47. ncbi request reprint Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, WA, USA
    Stroke 37:818-23. 2006
    ..We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events...
  48. pmc Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study
    William S Kerwin
    Department of Radiology, Division of Cardiology, and Department of Surgery, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 241:459-68. 2006
    ..To prospectively evaluate if there is an association between plaque enhancement at magnetic resonance (MR) imaging and proinflammatory cardiovascular risk factors and plaque content...
  49. ncbi request reprint Magnetic resonance imaging of carotid atherosclerosis: plaque analysis
    William Kerwin
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Top Magn Reson Imaging 18:371-8. 2007
    ..The purpose of this investigation was to assess the performance of CASCADE compared with manual outlining...
  50. doi request reprint Sex differences in patients with asymptomatic carotid atherosclerotic plaque: in vivo 3.0-T magnetic resonance study
    Hideki Ota
    Department of Radiology, Michigan State University, East Lansing, MI 48824 1313, USA
    Stroke 41:1630-5. 2010
    ..We hypothesize that MRI carotid plaque features will demonstrate sex differences indicative of higher-risk plaque in men...
  51. doi request reprint Extended graphical model for analysis of dynamic contrast-enhanced MRI
    Huijun Chen
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    Magn Reson Med 66:868-78. 2011
    ..4-99.8% less bias in estimates of K(trans). Thus, the extended graphical model may allow kinetic modeling of DCE-MRI results with shortened data acquisition periods, without sacrificing accuracy in estimates of K(trans) and v(p)...
  52. doi request reprint Longer duration of statin therapy is associated with decreased carotid plaque vascularity by magnetic resonance imaging
    Kevin D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA Electronic address
    Atherosclerosis 245:74-81. 2016
    ....
  53. pmc Summary of clinical and laboratory data of study subjects with and without DCE-MRI plaque measurements in the AIM-HIGH clinical trial
    Kevin D O'Brien
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA
    Data Brief 6:476-81. 2016
    ..The data provided herein are directly related to the article "Longer Duration of Statin Therapy is Associated with Decreased Carotid Plaque Vascularity by Magnetic Resonance Imaging" [2]. ..
  54. pmc Semi-automatic carotid intraplaque hemorrhage detection and quantification on Magnetization-Prepared Rapid Acquisition Gradient-Echo (MP-RAGE) with optimized threshold selection
    Jin Liu
    University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 18:41. 2016
    ..We sought to develop a semi-automatic method with an optimized threshold for carotid IPH detection and quantification on MP-RAGE images using matched histology as the gold standard...
  55. pmc Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study
    Jie Sun
    Department of Radiology, University of Washington, 850 Republican St Brotman 127, Seattle, WA, 98109, USA
    Int J Cardiovasc Imaging 31:95-103. 2015
    ....
  56. ncbi request reprint Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRI
    Binh An P Phan
    Department of Medicine, University of Washington, Seattle, Washington 98103 8771, USA
    J Magn Reson Imaging 23:481-5. 2006
    ..To investigate whether gadolinium (Gd)-based contrast enhancement (CE) affects high-resolution magnetic resonance imaging (MRI) measurements of carotid arterial wall volume...
  57. ncbi request reprint Automated in vivo segmentation of carotid plaque MRI with Morphology-Enhanced probability maps
    Fei Liu
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Magn Reson Med 55:659-68. 2006
    ..71, 0.76, 0.33, and 0.78, respectively. These results show that in vivo automatic segmentation of carotid MRI is feasible and comparable to or possibly more accurate than manual review for quantifying plaque composition...
  58. ncbi request reprint Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition Study
    Xue Qiao Zhao
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Am Heart J 154:239-46. 2007
    ..In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI)...
  59. pmc Comparison between 2D and 3D high-resolution black-blood techniques for carotid artery wall imaging in clinically significant atherosclerosis
    Niranjan Balu
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 27:918-24. 2008
    ..To compare two- (2D) and three-dimensional (3D) black-blood imaging methods for morphological measurements of the carotid artery wall and atherosclerotic plaque...
  60. pmc Improvements in carotid plaque imaging using a new eight-element phased array coil at 3T
    Niranjan Balu
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 30:1209-14. 2009
    ..To design and compare an eight-channel phased array (PA) coil for carotid imaging to an established four-channel PA design at 3T...
  61. doi request reprint Improved carotid intraplaque hemorrhage imaging using a slab-selective phase-sensitive inversion-recovery (SPI) sequence
    Jinnan Wang
    Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, Seattle, WA 98109, USA
    Magn Reson Med 64:1332-40. 2010
    ..It has demonstrated its capability for improved in vivo intraplaque hemorrhage identification and blood suppression in atherosclerosis patients...
  62. doi request reprint Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI
    Huijun Chen
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Magn Reson Med 64:567-73. 2010
    ..This suggests that transfer constant and partial plasma volume could be helpful to differentiate different plaque components and that dynamic contrast-enhanced MRI has the potential to assess inflammatory burden in specific regions...
  63. pmc Efficient flow suppressed MRI improves interscan reproducibility of carotid atherosclerosis plaque burden measurements
    Li Dong
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    J Magn Reson Imaging 32:452-8. 2010
    ..To determine if better flow suppression can meaningfully improve the reproducibility of measurements associated with carotid atherosclerotic disease, particularly for lumen and wall areas...
  64. pmc Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI
    Niranjan Balu
    Department of Radiology, University of Washington, Seattle, Washington 98019, USA
    Magn Reson Med 65:627-37. 2011
    ..3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque...
  65. pmc High resolution FDG-microPET of carotid atherosclerosis: plaque components underlying enhanced FDG uptake
    Jin Liu
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Int J Cardiovasc Imaging 32:145-52. 2016
    ..Loose extracellular matrix and areas containing neovasculature also produced FDG signal. This study points to the potential ability of FDG-PET to detect the cellular components of the vulnerable plaque...
  66. pmc Ipsilateral plaques display higher T1 signals than contralateral plaques in recently symptomatic patients with bilateral carotid intraplaque hemorrhage
    Xianling Wang
    Department of Radiology, University of Washington, Seattle, WA, USA Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
    Atherosclerosis 257:78-85. 2017
    ..We hypothesized that there are differences in the characteristics of IPH+ plaques associated with recent symptoms, compared to IPH+ plaques not associated with recent symptoms...
  67. ncbi request reprint Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studies
    Baocheng Chu
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 21:809-17. 2005
    ..To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers...
  68. pmc Contrast-enhanced MRI of carotid atherosclerosis: dependence on contrast agent
    William S Kerwin
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 30:35-40. 2009
    ..To investigate the dependence of contrast-enhanced magnetic resonance imaging (MRI) of carotid artery atherosclerotic plaque on the use of gadobenate dimeglumine versus gadodiamide...
  69. ncbi request reprint Simultaneous outer volume and blood suppression by quadruple inversion-recovery
    Vasily L Yarnykh
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Magn Reson Med 55:1083-92. 2006
    ..The method was tested for black-blood imaging of the aorta and carotid arteries, and the results demonstrated its ability to eliminate motion and flow artifacts, reduce scan time, and improve spatial resolution...
  70. ncbi request reprint Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque
    William Kerwin
    Department of Radiology, University of Washington, Seattle 98195, USA
    Circulation 107:851-6. 2003
    ..The aim of the present investigation was to determine whether the amount of neovasculature present in advanced carotid plaques can be noninvasively measured by dynamic, contrast-enhanced MRI...
  71. ncbi request reprint In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques
    Lee M Mitsumori
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 17:410-20. 2003
    ..To evaluate the in vivo accuracy of a multisequence MRI technique for prospectively identifying one feature of the vulnerable plaque-an unstable fibrous cap-in human carotid atherosclerosis...
  72. pmc Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging
    Tobias Saam
    Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Seattle, WA 98109, USA
    Radiology 240:464-72. 2006
    ..To retrospectively determine if in vivo magnetic resonance (MR) imaging can simultaneously depict differences between symptomatic and asymptomatic carotid atherosclerotic plaque...
  73. doi request reprint MRI of carotid atherosclerosis: clinical implications and future directions
    Hunter R Underhill
    Department of Radiology, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA
    Nat Rev Cardiol 7:165-73. 2010
    ....
  74. doi request reprint Prevalence of compositional features in subclinical carotid atherosclerosis determined by high-resolution magnetic resonance imaging in chinese patients with coronary artery disease
    Xihai Zhao
    Department of Radiology, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA
    Stroke 41:1157-62. 2010
    ..This study sought to determine the prevalence of compositional features in subclinical carotid atherosclerosis by MRI in CAD patients...
  75. pmc Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence
    Jinnan Wang
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 31:1256-63. 2010
    ....
  76. doi request reprint Current techniques for MR imaging of atherosclerosis
    Niranjan Balu
    Department of Radiology, University of Washington, Seattle, WA, USA
    Top Magn Reson Imaging 20:203-15. 2009
    ..In addition, the application of these techniques to coronary, aortic, and peripheral vascular beds is reviewed...
  77. ncbi request reprint Reproducibility of carotid atherosclerotic lesion type characterization using high resolution multicontrast weighted cardiovascular magnetic resonance
    Baocheng Chu
    Department of Radiology, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 8:793-9. 2006
    ..Cardiovascular magnetic resonance (CMR) can characterize carotid atherosclerosis. The purpose of this study is to evaluate reader agreement of carotid atherosclerotic lesion types by CMR...
  78. pmc Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts
    Anna V Naumova
    Department of Radiology, University of Washington, Seattle, WA, USA
    NMR Biomed 25:1187-95. 2012
    ..These data support the use of ferritin to track the survival, growth and migration of stem cells transplanted into the injured heart...
  79. pmc Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study
    Jie Sun
    Department of Radiology, University of Washington, Seattle, WA, USA
    JACC Cardiovasc Imaging 5:798-804. 2012
    ..This study sought to determine the immediate and long-term effects of intraplaque hemorrhage (IPH) on plaque progression in the carotid artery...
  80. ncbi request reprint Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence
    Jinnan Wang
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Magn Reson Med 58:973-81. 2007
    ....
  81. ncbi request reprint Accuracy and uniqueness of three in vivo measurements of atherosclerotic carotid plaque morphology with black blood MRI
    Ying Luo
    Department of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA
    Magn Reson Med 50:75-82. 2003
    ..3). Black blood MRI technique is a potentially powerful clinical tool to characterize the severity of atherosclerotic plaque. It can provide accurate measurements on different aspects of the plaque, from plaque burden to lumen narrowing...
  82. ncbi request reprint Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging
    Binh An P Phan
    Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
    Int J Cardiovasc Imaging 23:337-42. 2007
    ..81 +/- 19 mm(3), P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI...
  83. ncbi request reprint Serial MRI of carotid plaque burden: influence of subject repositioning on measurement precision
    Niranjan Balu
    Department of Bioengineering, Vascular Imaging Laboratory, University of Washington, Seattle, Washington 98109, USA
    Magn Reson Med 57:592-9. 2007
    ..Orientation variability was the single most important factor that affected reproducibility, which suggests that methods are needed to obtain consistent orientation of the artery relative to the image plane...
  84. doi request reprint Direct quantitative comparison between cross-relaxation imaging and diffusion tensor imaging of the human brain at 3.0 T
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Neuroimage 47:1568-78. 2009
    ..Our findings suggest that whole-brain CRI provides distinct quantitative information compared to DTI, and CRI parameters may prove constructive as biomarkers in neurological diseases...
  85. pmc Atherosclerotic plaque progression in carotid arteries: monitoring with high-spatial-resolution MR imaging--multicenter trial
    Loic Boussel
    Department of Radiology, University of California, San Francisco, San Francisco, Calif, USA
    Radiology 252:789-96. 2009
    ..To estimate the annualized rate of progression of vessel-wall volume in the carotid arteries in 160 patients by using magnetic resonance (MR) imaging and to establish the fraction of studies that have acceptable image quality...
  86. doi request reprint Geometric and compositional appearance of atheroma in an angiographically normal carotid artery in patients with atherosclerosis
    L Dong
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    AJNR Am J Neuroradiol 31:311-6. 2010
    ..Arterial remodeling may enable atherosclerotic disease without luminal stenosis. We sought to assess the prevalence and characteristics of atherosclerosis in angiographically normal carotid arteries...
  87. ncbi request reprint Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imaging
    Baocheng Chu
    Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Stroke 35:2444-8. 2004
    ....
  88. ncbi request reprint Images in cardiovascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaque
    Baocheng Chu
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Circulation 113:e660-1. 2006
  89. ncbi request reprint Detecting objects in image sequences using rule-based control in an active contour model
    Han Chao
    Department of Radiology, AA 010 Health Sciences Bldg, University of Washington, Box 357115, Seattle, WA 98195 7115, USA
    IEEE Trans Biomed Eng 50:705-10. 2003
    ..Evolution of contour segments is controlled by separate processes based on whether the segment is judged to be inside, outside, or near the boundary of the object, leading to robust boundary detection...
  90. pmc Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis
    H R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    AJNR Am J Neuroradiol 31:487-93. 2010
    ..In this prospective observational study, we sought to determine the characteristics of the carotid lesion that predict the development of new surface disruption...
  91. ncbi request reprint Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imaging
    Chun Yuan
    Division of Cardiology, University of Washington, Box 358771, 1914 North 34th Street, Suite 105, Seattle, WA 98103, USA
    Curr Atheroscler Rep 4:351-7. 2002
    ..MRI allows direct visualization of the diseased vessel wall and is capable of characterizing the morphology of individual atherosclerotic carotid plaques...
  92. ncbi request reprint T1-insensitive flow suppression using quadruple inversion-recovery
    Vasily L Yarnykh
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Magn Reson Med 48:899-905. 2002
    ..The clinical application of QIR was demonstrated in high-resolution, contrast-enhanced, black-blood imaging of atherosclerotic plzzaque...
  93. ncbi request reprint Multislice double inversion-recovery black-blood imaging with simultaneous slice reinversion
    Vasily L Yarnykh
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 17:478-83. 2003
    ..To develop a technique for time-efficient multislice double inversion-recovery (DIR) black-blood imaging and to test its applicability and limitations for high-resolution imaging of carotid arteries...
  94. ncbi request reprint Cross-relaxation imaging reveals detailed anatomy of white matter fiber tracts in the human brain
    Vasily L Yarnykh
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neuroimage 23:409-24. 2004
    ..Cross-relaxation imaging can be used in various clinical studies focused on brain development and white matter diseases...
  95. ncbi request reprint Multicontrast black-blood MRI of carotid arteries: comparison between 1.5 and 3 tesla magnetic field strengths
    Vasily L Yarnykh
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 23:691-8. 2006
    ..To compare black-blood multicontrast carotid imaging at 3T and 1.5T and assess compatibility between morphological measurements of carotid arteries at 1.5T and 3T...
  96. doi request reprint A combined solenoid-surface RF coil for high-resolution whole-brain rat imaging on a 3.0 Tesla clinical MR scanner
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    Magn Reson Med 64:883-92. 2010
    ..Improvement in signal-to-noise ratio afforded by the rat brain coil may broaden experiments that utilize clinical MR scanners for in vivo image acquisition...
  97. doi request reprint Carotid MRI: a tool for monitoring individual response to cardiovascular therapy?
    Hunter R Underhill
    Department of Medicine, Division of Medical Genetics, University of Washington, 1705 NE Pacific Street, K253, Box 357720, Seattle, WA 98195, USA
    Expert Rev Cardiovasc Ther 9:63-80. 2011
    ..In accordance, carotid MRI is poised to emerge as a powerful clinical tool for individualized management of carotid atherosclerotic disease to prevent stroke...
  98. ncbi request reprint Black blood magnetic resonance angiography with Dy-DTPA polymer: effect on arterial intraluminal signal intensity, lumen diameter, and wall thickness
    W B Eubank
    Department of Radiology, University of Washington School of Medicine, Seattle 98195 7115, USA
    J Magn Reson Imaging 8:1051-9. 1998
    ..Postcontrast MRA with NC 100283, a macromolecular Dy-DTPA contrast agent, provides more accurate assessment of aortic lumen diameter than precontrast MRA, using conventional angiography as the standard reference...
  99. ncbi request reprint Analysis of the measurement precision of arterial lumen and wall areas using high-resolution MRI
    X Kang
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Magn Reson Med 44:968-72. 2000
    ..2%, 9.2%, and 9.7% for T(1), proton density, and T(2)-weighted images, respectively, and the error of wall area measurement was 10. 8%, 10.9%, and 12.0%. The precision of area measurement correlates strongly with image quality...
  100. ncbi request reprint A multi-scale method for automatic correction of intensity non-uniformity in MR images
    C Han
    Department of Radiology, University of Washington, Seattle, Washington 98195 7115, USA
    J Magn Reson Imaging 13:428-36. 2001
    ..The multi-scale method does not rely on any data other than the image generated by the MR scanner. The experiment showed promising results based on one-dimensional simulation and images of phantom and human images...
  101. ncbi request reprint Comparison of carotid vessel wall area measurements using three different contrast-weighted black blood MR imaging techniques
    S Zhang
    Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College 100037, Beijing, China
    Magn Reson Imaging 19:795-802. 2001
    ..At each matched location, it is recommended that the image with the highest IQ be used for area measurement...

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