Affiliation: University of Michigan
- The effects of intestinal microbial community structure on disease manifestation in IL-10-/- mice infected with Helicobacter hepaticusNabeetha A Nagalingam
Department of Internal Medicine Infectious Diseases Division, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
Microbiome 1:15. 2013..Here, we confirmed that an intestinal microbiota is needed for development of typhlocolitis in Helicobacter hepaticus infected IL-10-/- C57BL/6 mice, and investigated the role of the microbiota in modulating disease...
- Therapeutic manipulation of the microbiota: past, present, and considerations for the futureV B Young
Department of Internal Medicine Infectious Diseases Division, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA Electronic address
Clin Microbiol Infect 22:905-909. 2016..The most successful example of microbiota manipulation for treatment of a disease is in recurrent infection with the bacterial pathogen Clostridium difficile...
- Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosisVincent B Young
Department of Internal Medicine, Division of Infectious Diseases, Ann Arbor, MI, USA
Microbiome 1:9. 2013..Following the development of the microbiome of the pouch would allow characterization of the microbial community that predates the development of overt disease...
- Depression, antidepressant medications, and risk of Clostridium difficile infectionMary A M Rogers
Department of Internal Medicine, University of Michigan, 016 440E NCRC, Ann Arbor, MI 48109 2800, USA
BMC Med 11:121. 2013..Our objective was to evaluate whether depression or the use of anti-depressants altered the risk of developing CDI, using two distinct datasets and study designs...
- The intestinal microbiota in health and diseaseVincent B Young
Division of Infectious Diseases, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, USA
Curr Opin Gastroenterol 28:63-9. 2012..This review discusses some of the recent work that reveals how the gut microbiome helps establish and protect intestinal health and how disturbances in this microbial community can lead to disease states...
- Pathogenesis of renal disease due to enterohemorrhagic Escherichia coli in germ-free miceKathryn A Eaton
Unit for Laboratory Animal Medicine, 018 Animal Research Facility, University of Michigan, Ann Arbor, MI 48109 0614, USA
Infect Immun 76:3054-63. 2008..The disease in mice was Stx2 and bacterial strain dependent. This animal model should be a useful tool for studying the pathogenesis of renal disease secondary to EHEC infection...
- Evolutionary genetics of a new pathogenic Escherichia species: Escherichia albertii and related Shigella boydii strainsKatie E Hyma
Microbial Evolution Laboratory, 165 Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824, USA
J Bacteriol 187:619-28. 2005..coli-like ancestor approximately 28 million years ago and formed a distinct evolutionary branch of enteric pathogens that has radiated into groups with distinct virulence properties...
- Explaining unexplained diarrhea and associating risks and infectionsDonna M Denno
Department of Health Services, University of Washington School of Medicine, Seattle, WA, USA
Anim Health Res Rev 8:69-80. 2007..By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses...