I Tien Yeh

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Molecular profiling of endometrial malignancies
    Norasate Samarnthai
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Obstet Gynecol Int 2010:162363. 2010
  2. pmc Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
    Huai Chin Chiang
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78245, USA
    Exp Hematol Oncol 1:31. 2012
  3. pmc Clinical array-based karyotyping of breast cancer with equivocal HER2 status resolves gene copy number and reveals chromosome 17 complexity
    Shelly Gunn
    Combimatrix Molecular Diagnostics, 310 Goddard, Irvine, California 92618, USA
    BMC Cancer 10:396. 2010
  4. ncbi request reprint Postmenopausal hormone replacement therapy: endometrial and breast effects
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Adv Anat Pathol 14:17-24. 2007
  5. doi request reprint Malignancy arising in seminal vesicles in the transgenic adenocarcinoma of mouse prostate (TRAMP) model
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Prostate 69:755-60. 2009
  6. doi request reprint Application of immunohistochemistry to breast lesions
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Pathol Lab Med 132:349-58. 2008
  7. ncbi request reprint Pathologic review of atypical hyperplasia identified by image-guided breast needle core biopsy. Correlation with excision specimen
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center, San Antonio 78229, USA
    Arch Pathol Lab Med 127:49-54. 2003
  8. doi request reprint Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mod Pathol 22:1169-75. 2009
  9. pmc Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells
    Dimple Chakravarty
    Department of Obstetrics and Gynecology and CTRC at The UT Health Science Center, San Antonio, Texas 78229 3900, USA
    Cancer Res 70:4092-101. 2010
  10. pmc Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
    Shu Lin
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Biol Cell 23:1569-81. 2012

Detail Information

Publications43

  1. pmc Molecular profiling of endometrial malignancies
    Norasate Samarnthai
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Obstet Gynecol Int 2010:162363. 2010
    ..These molecular changes can help in the diagnosis of endometrial neoplasms, as well as form the basis of molecular targeted therapy...
  2. pmc Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
    Huai Chin Chiang
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78245, USA
    Exp Hematol Oncol 1:31. 2012
    ....
  3. pmc Clinical array-based karyotyping of breast cancer with equivocal HER2 status resolves gene copy number and reveals chromosome 17 complexity
    Shelly Gunn
    Combimatrix Molecular Diagnostics, 310 Goddard, Irvine, California 92618, USA
    BMC Cancer 10:396. 2010
    ..The recent validation of array-based, molecular karyotyping for clinical oncology testing provides an alternative method for determination of HER2 gene copy number status in cases remaining unresolved by traditional methods...
  4. ncbi request reprint Postmenopausal hormone replacement therapy: endometrial and breast effects
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Adv Anat Pathol 14:17-24. 2007
    ..This review explores the evidence of the effects of HRT on the endometrium and the breast, with emphasis on the pathologic changes...
  5. doi request reprint Malignancy arising in seminal vesicles in the transgenic adenocarcinoma of mouse prostate (TRAMP) model
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Prostate 69:755-60. 2009
    ..More recently, epithelial-stromal (ES) tumors resembling phyllodes tumors have been described in the seminal vesicles of TRAMP mice. We report malignancy arising in these ES tumors of the seminal vesicles in TRAMP mice...
  6. doi request reprint Application of immunohistochemistry to breast lesions
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Pathol Lab Med 132:349-58. 2008
    ..Immunohistochemistry has an expanding role in mammary pathology that has been facilitated by a growing list of available antibodies and a better understanding of biology...
  7. ncbi request reprint Pathologic review of atypical hyperplasia identified by image-guided breast needle core biopsy. Correlation with excision specimen
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center, San Antonio 78229, USA
    Arch Pathol Lab Med 127:49-54. 2003
    ..Current recommendations involve excisional biopsy to rule out ductal carcinoma in situ and/or invasive carcinoma, which have been reported in more than 50% of cases in some series...
  8. doi request reprint Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mod Pathol 22:1169-75. 2009
    ..We conclude that array comparative genomic hybridization is an accurate and objective DNA-based alternative for clinical evaluation of HER2 gene copy number, and that polysomy 17 is a rare event in breast cancer...
  9. pmc Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells
    Dimple Chakravarty
    Department of Obstetrics and Gynecology and CTRC at The UT Health Science Center, San Antonio, Texas 78229 3900, USA
    Cancer Res 70:4092-101. 2010
    ....
  10. pmc Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
    Shu Lin
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Biol Cell 23:1569-81. 2012
    ....
  11. ncbi request reprint HER-2/neu expression as a predictor of response to neoadjuvant docetaxel in patients with operable breast carcinoma
    Peter A Learn
    Department of Surgery, University of Texas Health Science Center San Antonio, San Antonio, Texas 78284, USA
    Cancer 103:2252-60. 2005
    ..Taxanes have demonstrated excellent activity in breast carcinoma; however, tumor-specific factors that predict clinical response have not been characterized thoroughly...
  12. pmc Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract
    Addanki P Kumar
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Clin Cancer Res 13:2784-94. 2007
    ..In this study, we used the transgenic adenocarcinoma of mouse prostate (TRAMP) model to examine the ability of Nexrutine to protect TRAMP mice from developing prostate cancer...
  13. pmc Isolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrow
    Keya De Mukhopadhyay
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 6:e20473. 2011
    ....
  14. pmc Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway
    Chunxue Lu
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Vaccine 30:475-85. 2012
    ..These observations have provided important information on how to develop subunit vaccines for inducing protective immunity against urogenital infection with Chlamydia trachomatis organisms...
  15. pmc Blockade of transforming growth factor-beta (TGFβ) signaling inhibits osteoblastic tumorigenesis by a novel human prostate cancer cell line
    Sweta Mishra
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Prostate 71:1441-54. 2011
    ..We investigated the role of TGFβ signaling in prostate cancer-induced bone metastasis using a novel human prostate cancer cell line, PacMetUT1...
  16. ncbi request reprint Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management
    Rita Ghosh
    Department of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Anticancer Res 30:857-65. 2010
    ..009) and prevented the development of metastatic lesions. Nexrutine treatment also significantly (p=0.005) inhibited invasion of androgen-independent prostate cancer cells...
  17. pmc Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models
    Abhik Bandyopadhyay
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 5:e10365. 2010
    ..TGFbeta is a potent inducer of EMT and has been shown to promote tumor progression in various breast cancer cell and animal models...
  18. ncbi request reprint Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer
    Abhik Bandyopadhyay
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Prostate 63:81-90. 2005
    ..In this study, we have investigated the efficacy and the potential mechanism of a TGFbeta antagonist, a recombinant soluble betaglycan (sBG), as a prostate cancer therapeutic agent after systemic administration in a xenograft model...
  19. pmc Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum
    Bo Peng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    BMC Infect Dis 11:347. 2011
    ..Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their roles in chlamydial infection have not been evaluated...
  20. pmc Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential
    Qiaoxiang Dong
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78299, USA
    Aging (Albany NY) 8:2754-2776. 2016
    ..Whole transcriptome analysis showed elevated immune and inflammatory responses in old basal stem cells and stromal cells, which may be the underlying cause for increased CD49fhi basal-like cells in aged glands...
  21. ncbi request reprint Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas
    Cheryl B Hill
    Department of Pathology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Am J Clin Pathol 123:36-44. 2005
    ..The lack of a basal MEC layer in these cases suggests a spectrum of progression from in situ to invasive disease and might help explain distant metastases from previously reported "intraductal papillary carcinoma."..
  22. doi request reprint "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition
    Sophia Yohe
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Int J Surg Pathol 16:137-42. 2008
    ..Increased sampling of a large tumor will likely yield more correct diagnoses...
  23. pmc Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer
    Prajjal K Singha
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Cancer Res 70:6377-83. 2010
    ..Together, these results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter...
  24. ncbi request reprint Analysis of sentinel lymph node mapping with immediate pathologic review in patients receiving preoperative chemotherapy for breast carcinoma
    Alexander R Miller
    Division of Surgery, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Ann Surg Oncol 9:243-7. 2002
    ..In an effort to learn whether patients who have received preoperative chemotherapy can undergo accurate SLNM, we evaluated our experience with this technique...
  25. ncbi request reprint Measuring HER-2 in breast cancer. Immunohistochemistry, FISH, or ELISA?
    I Tien Yeh
    Dept of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Clin Pathol 117:S26-35. 2002
    ..ELISA is useful in the follow-up care of patients with breast cancer. An algorithm for using all 3 methods is presented...
  26. ncbi request reprint Tattoo pigment in sentinel lymph nodes: a mimicker of metastatic malignant melanoma
    Shylashree Chikkamuniyappa
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA
    Dermatol Online J 11:14. 2005
    ..Histological confirmation of an enlarged pigmented node is essential before radical surgery is performed...
  27. ncbi request reprint Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling
    Erik V Verona
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Cancer Res 67:5737-46. 2007
    ..Thus, our study provides evidence for TGFbeta as a supporting agent in tumor progression through the induction of a perpetual wound healing process in the tumor microenvironment...
  28. pmc Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model
    Manonmani Ganapathy
    Department of Urology, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 15:1601-11. 2009
    ....
  29. pmc Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome
    Malini Harigopal
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Pathol 176:1639-47. 2010
    ..This assay method may provide a new companion diagnostic approach for targeted therapies...
  30. pmc Detection of KSHV in transbronchial biopsies in patients with Kaposi sarcoma
    Michael W Si
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Appl Immunohistochem Mol Morphol 13:61-5. 2005
    ..In conclusion, in transbronchial biopsies of the lung suspicious for KS, PCR is the most sensitive technique available for clinical diagnosis of KS. Immunohistochemistry analysis might be helpful in difficult pulmonary KS cases...
  31. pmc Loss of NADPH quinone oxidoreductase in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant 2alpha in hormone-stimulated noble rats: potential role in prostatic intraepithelial neoplasia development
    Rita Ghosh
    Department of Urology, University of Texas Health Science Center, San Antonio, TX, USA
    Transl Oncol 2:65-72. 2009
    ....
  32. ncbi request reprint Positive margins following surgical resection of breast carcinoma: analysis of pathologic correlates
    Alexander R Miller
    Division of Surgical Oncology, Cancer Therapy and Research Center, San Antonio, Texas 78229 3900, USA
    J Surg Oncol 86:134-40. 2004
    ....
  33. pmc Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1
    Feng Chun Ye
    Tumor Virology Program, Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 81:3980-91. 2007
    ..This study also illustrates a distinct mechanism by which a tumor virus modulates vasculature to promote tumorigenesis and exemplifies the convergence of oncogenesis and angiogenesis pathways in tumor development...
  34. doi request reprint A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors
    I Tien Yeh
    Cancer Therapy and Research Center, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Hum Genet 124:279-85. 2008
    ..This may imply the existence of a tissue-specific gene dosage requirement for its tumorigenesis...
  35. doi request reprint Effect of CH-35, a novel anti-tumor colchicine analogue, on breast cancer cells overexpressing the βIII isotype of tubulin
    Lee Chuan C Yeh
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA
    Invest New Drugs 34:129-37. 2016
    ..Although the βIII-over-expressing cells developed into very fast-growing tumors, CH-35 was more effective against this tumor than was Taxol. Our results suggest that CH-35 is a promising candidate for future drug development. ..
  36. pmc Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands
    Danhan Wang
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229 and L Z Sun
    Cancer Prev Res (Phila) 7:445-55. 2014
    ..Thus, our study for the first time shows that pubertal BPA exposure altered MaSC gene expression and function such that they induced early neoplastic transformation...
  37. doi request reprint Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection
    Lili Chen
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 184:2602-10. 2010
    ....
  38. pmc Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia
    Pooja Shivshankar
    Department of Microbiology and Immunology Department of Medicine, Division of Cardiology Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Aging Cell 10:798-806. 2011
    ..This study is the first to suggest a second negative consequence for the senescence-associated secretory phenotype...
  39. pmc Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection
    Wen Cheng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:515-22. 2008
    ....
  40. ncbi request reprint Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica
    Jeannie Chan
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Cancer Lett 184:73-80. 2002
    ..These results support the contention that a mutationally activated N-ras gene contributes to the vertical growth phase, which is specific to the progression of malignant melanoma in humans...
  41. ncbi request reprint The betaII isotype of tubulin is present in the cell nuclei of a variety of cancers
    I Tien Yeh
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Cell Motil Cytoskeleton 57:96-106. 2004
    ..Our results have implications for the diagnosis, biology, and chemotherapy of cancer...
  42. pmc p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy
    Peggy L Porter
    Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Natl Cancer Inst 98:1723-31. 2006
    ..We studied these markers in a clinical trial setting with patients with breast cancer treated by a uniform drug regimen so that treatment was not associated with variability in outcome...
  43. ncbi request reprint Staining of sentinel node reticulum cells with cytokeratin antibody AE3
    I Tien Yeh
    Arch Pathol Lab Med 126:248-9. 2002