Yi Yang

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia
    Yi Yang
    Department of Neurology, University of New Mexico, Albuquerque, NM, USA
    Methods Mol Biol 762:333-45. 2011
  2. pmc Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 112:134-49. 2010
  3. pmc Early inhibition of MMP activity in ischemic rat brain promotes expression of tight junction proteins and angiogenesis during recovery
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Cereb Blood Flow Metab 33:1104-14. 2013
  4. doi request reprint Increased apparent diffusion coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats
    Rohit Sood
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 29:308-16. 2009
  5. pmc Myelin loss associated with neuroinflammation in hypertensive rats
    Fakhreya Y Jalal
    Department of Neurology, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 43:1115-22. 2012
  6. ncbi request reprint Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
  7. pmc Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia
    Xinchun Jin
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Exp Neurol 240:9-16. 2013
  8. pmc Transient increase of fractional anisotropy in reversible vasogenic edema
    Shihoko Kimura-Ohba
    Department of Neurology, University of New Mexico, Albuquerque, USA
    J Cereb Blood Flow Metab 36:1731-1743. 2016
  9. pmc Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery
    Yirong Yang
    College of Pharmacy, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, 87131, USA
    J Neuroinflammation 12:26. 2015
  10. ncbi request reprint Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Neurosurg Focus 22:E4. 2007

Collaborators

Detail Information

Publications20

  1. pmc MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia
    Yi Yang
    Department of Neurology, University of New Mexico, Albuquerque, NM, USA
    Methods Mol Biol 762:333-45. 2011
    ....
  2. pmc Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 112:134-49. 2010
    ..Our data suggest that intranuclear MMP activity cleaves PARP-1 and XRCC1, interfering with oxidative DNA repair. This novel role for MMPs could contribute to neuronal apoptosis in ischemic injuries...
  3. pmc Early inhibition of MMP activity in ischemic rat brain promotes expression of tight junction proteins and angiogenesis during recovery
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Cereb Blood Flow Metab 33:1104-14. 2013
    ..Early MMP inhibition benefits neurovascular remodeling after stroke. ..
  4. doi request reprint Increased apparent diffusion coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats
    Rohit Sood
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 29:308-16. 2009
    ..We propose that increased ADC, which is a marker of vasogenic edema, is related to activity of MMP-2 and MMP-9. MRI provides unique information that can be used to guide tissue studies of WM injury...
  5. pmc Myelin loss associated with neuroinflammation in hypertensive rats
    Fakhreya Y Jalal
    Department of Neurology, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 43:1115-22. 2012
    ..Therefore, we used spontaneously hypertensive stroke-prone rats to study the role of neuroinflammation in white matter damage...
  6. ncbi request reprint Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes. Our results provide direct evidence that MMPs open the BBB by degrading TJPs and that an MMP inhibitor prevents degradation of the TJPs by MMPs...
  7. pmc Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia
    Xinchun Jin
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Exp Neurol 240:9-16. 2013
    ....
  8. pmc Transient increase of fractional anisotropy in reversible vasogenic edema
    Shihoko Kimura-Ohba
    Department of Neurology, University of New Mexico, Albuquerque, USA
    J Cereb Blood Flow Metab 36:1731-1743. 2016
    ..Our results highlight the importance of the fractional anisotropy increase as a marker for the reversibility of brain edema, which can delineate the brain areas for which recovery is possible...
  9. pmc Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery
    Yirong Yang
    College of Pharmacy, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, 87131, USA
    J Neuroinflammation 12:26. 2015
    ..In the present study, we longitudinally investigated neurological outcome, neurovascular remodeling and microglia/macrophage alternative activation after spontaneous and minocycline-induced stroke recovery...
  10. ncbi request reprint Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Neurosurg Focus 22:E4. 2007
    ..Because these inhibitors block MMPs involved in angiogenesis and neurogenesis, they also slow recovery. The challenge is to identify agents that will protect the BBB, blocking vasogenic edema without interfering with recovery...
  11. doi request reprint Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery
    Yirong Yang
    College of Pharmacy, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, NM, 87131, USA
    J Neuroinflammation 12:245. 2015
    ..In the present study, we longitudinally investigated neurological outcome, neurovascular remodeling and microglia/macrophage alternative activation after spontaneous and minocycline-induced stroke recovery...
  12. pmc Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Neuroinflammation 8:108. 2011
    ..TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs undergo apoptosis during ischemia, we hypothesized that TIMP-3 contributes to OL death...
  13. pmc Tissue oxygen is reduced in white matter of spontaneously hypertensive-stroke prone rats: a longitudinal study with electron paramagnetic resonance
    John Weaver
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Cereb Blood Flow Metab 34:890-6. 2014
    ..Our findings suggest that changes in WM pO₂ may contribute to WM damage in SHR/SP rat model, and that EPR oximetry can monitor brain pO₂ in the WM of small animals...
  14. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  15. pmc Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP
    Fakhreya Y Jalal
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Cereb Blood Flow Metab 35:1145-53. 2015
    ..We propose that BBB disruption occurred secondary to hypoxia, which induced an MMP-9-mediated infiltration of leukocytes. Minocycline significantly reduced WM damage, improved behavior, and prolonged life...
  16. pmc Rodent Models of Vascular Cognitive Impairment
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA
    Transl Stroke Res 7:407-14. 2016
    ..This review describes the most commonly used models, and the drugs that have been used to reduce the damage. ..
  17. doi request reprint Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset
    Xinchun Jin
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Neurobiol Dis 48:309-16. 2012
    ..Unlike ischemic neuronal damage, BBB damage appears to develop faster in brain regions with moderately severe ischemia, and MMP-2 contributes to this early ischemic BBB damage...
  18. doi request reprint Multiple roles of metalloproteinases in neurological disorders
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Prog Mol Biol Transl Sci 99:241-63. 2011
    ..Growing literature on the functions of MMPs and ADAMs in the central nervous system is opening up new and exciting areas of research that may lead to novel approaches to treatment of neurological diseases...
  19. pmc Matrix metalloproteinases as therapeutic targets for stroke
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Brain Res 1623:30-8. 2015
    ..This dual role complicates the planning of treatment strategies. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke. ..
  20. pmc Blood-brain barrier breakdown in acute and chronic cerebrovascular disease
    Yi Yang
    Department of Neurology, University of New Mexico, Albuquerque, NM 87107, USA
    Stroke 42:3323-8. 2011
    ..This review will describe the molecular and cellular events associated with BBB disruption and potential therapies directed toward restoring the integrity of the neurovascular unit...