Jinze Xu

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats
    Jinze Xu
    Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e10572. 2010
  2. pmc Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
  3. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
  4. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
  5. pmc Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
  6. pmc The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
    Jinze Xu
    Department of Aging and Geriatrics Research, Division of Biology of Aging, Genomics, Metabolism and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Mech Ageing Dev 131:487-93. 2010
  7. pmc Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity
    Debapriya Dutta
    Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA
    Autophagy 9:328-44. 2013
  8. pmc Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals
    Anna Maria Joseph
    Department of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, FL 32611, USA
    Exp Gerontol 48:858-68. 2013
  9. pmc Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity
    Debapriya Dutta
    Department of Aging and Geriatric Research, Institute on Aging, and University of Florida, Gainesville, FL 32610, USA Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    Free Radic Biol Med 74:252-62. 2014
  10. pmc Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging
    Wei Hua Lee
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Antioxid Redox Signal 16:339-50. 2012

Collaborators

Detail Information

Publications11

  1. pmc Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats
    Jinze Xu
    Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e10572. 2010
    ..Selected antioxidants and specific combinations of nutritional compounds could target many biochemical pathways that affect both oxidative stress and mitochondrial function and, thereby, preserve or enhance physical performance...
  2. pmc Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
    ..In conclusion, advanced age is associated with disruption of muscle iron metabolism which is further perturbed by disuse and persists over a longer time period...
  3. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
    ..These results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle...
  4. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  5. pmc Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
    ..Overall, our data suggest that age-dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage,thereby enhancing the susceptibility to apoptosis...
  6. pmc The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
    Jinze Xu
    Department of Aging and Geriatrics Research, Division of Biology of Aging, Genomics, Metabolism and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Mech Ageing Dev 131:487-93. 2010
    ..A substantial research effort now focuses on developing and testing safe pharmacologic interventions to combat iron dyshomeostasis in aging, acute injuries and in iron overload disorders...
  7. pmc Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity
    Debapriya Dutta
    Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA
    Autophagy 9:328-44. 2013
    ..We conclude that autophagy induction by rapamycin could be utilized as a potential therapeutic strategy against oxidative stress-mediated damage in cardiomyocytes...
  8. pmc Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals
    Anna Maria Joseph
    Department of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, FL 32611, USA
    Exp Gerontol 48:858-68. 2013
    ....
  9. pmc Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity
    Debapriya Dutta
    Department of Aging and Geriatric Research, Institute on Aging, and University of Florida, Gainesville, FL 32610, USA Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    Free Radic Biol Med 74:252-62. 2014
    ..We propose that a combinatorial approach of low-dose CR and resveratrol has the potential to be used therapeutically to induce autophagy and provides protection against doxorubicin-mediated toxicity...
  10. pmc Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging
    Wei Hua Lee
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Antioxid Redox Signal 16:339-50. 2012
    ....
  11. pmc Impaired iron status in aging research
    Jinze Xu
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Int J Mol Sci 13:2368-86. 2012
    ..This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models...