Feng Xie

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Diagnostic ultrasound combined with glycoprotein IIb/IIIa-targeted microbubbles improves microvascular recovery after acute coronary thrombotic occlusions
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Circulation 119:1378-85. 2009
  2. pmc Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution
    Feng Xie
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Ultrasound Med Biol 37:280-8. 2011
  3. doi request reprint Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles
    Feng Xie
    Department of Internal Medicine Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    JACC Cardiovasc Imaging 2:511-8. 2009
  4. ncbi request reprint Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, 68198 1165 USA
    J Ultrasound Med 25:1161-8. 2006
  5. doi request reprint Detection of subendocardial ischemia in the left anterior descending coronary artery territory with real-time myocardial contrast echocardiography during dobutamine stress echocardiography
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    JACC Cardiovasc Imaging 1:271-8. 2008
  6. ncbi request reprint Detection of coronary artery disease with a continuous infusion of definity ultrasound contrast during adenosine stress real time perfusion echocardiography
    Feng Xie
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Echocardiography 24:1044-50. 2007
  7. ncbi request reprint Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Circulation 112:1444-50. 2005
  8. ncbi request reprint Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Liver Transpl 12:592-9. 2006
  9. pmc Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska College of Medicine Creighton University, Children s Hospital and Medical Center, Omaha, Nebraska, USA
    PLoS ONE 7:e51453. 2012
  10. ncbi request reprint Comparison of dobutamine stress echocardiography with and without real-time perfusion imaging for detection of coronary artery disease
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Cardiol 96:506-11. 2005

Collaborators

Detail Information

Publications47

  1. pmc Diagnostic ultrasound combined with glycoprotein IIb/IIIa-targeted microbubbles improves microvascular recovery after acute coronary thrombotic occlusions
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Circulation 119:1378-85. 2009
    ..The high mechanical index (MI) impulses from a diagnostic ultrasound transducer may be a method of recanalizing acutely thrombosed vessels if the impulses are applied only when microbubbles are channeling through the thrombus...
  2. pmc Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution
    Feng Xie
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Ultrasound Med Biol 37:280-8. 2011
    ..This treatment modality is less effective, however, for older aged thrombi...
  3. doi request reprint Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles
    Feng Xie
    Department of Internal Medicine Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    JACC Cardiovasc Imaging 2:511-8. 2009
    ..05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion...
  4. ncbi request reprint Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, 68198 1165 USA
    J Ultrasound Med 25:1161-8. 2006
    ..We sought to determine the added value of simultaneous imaging of intravenously infused microbubbles that are being used to dissolve an intravascular thrombus with therapeutic ultrasound (TUS)...
  5. doi request reprint Detection of subendocardial ischemia in the left anterior descending coronary artery territory with real-time myocardial contrast echocardiography during dobutamine stress echocardiography
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    JACC Cardiovasc Imaging 1:271-8. 2008
    ....
  6. ncbi request reprint Detection of coronary artery disease with a continuous infusion of definity ultrasound contrast during adenosine stress real time perfusion echocardiography
    Feng Xie
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Echocardiography 24:1044-50. 2007
    ..Myocardial perfusion imaging during adenosine stress is an accurate method of detecting physiologically relevant coronary artery disease...
  7. ncbi request reprint Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Circulation 112:1444-50. 2005
    ..Its prognostic value is unknown. We sought to determine the value of MP and wall motion (WM) analysis during dobutamine stress echocardiography in predicting the outcome of patients with known or suspected coronary artery disease...
  8. ncbi request reprint Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Liver Transpl 12:592-9. 2006
    ..003). In conclusion, MPI obtained by RTMCE appears to be a useful tool in predicting mortality in patients with ALD. Further studies are required to verify its independent value...
  9. pmc Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska College of Medicine Creighton University, Children s Hospital and Medical Center, Omaha, Nebraska, USA
    PLoS ONE 7:e51453. 2012
    ..We sought to investigate the therapeutic efficacy of microbubble (MB) enhanced sonothrombolysis for aged CVC associated thrombi in vivo...
  10. ncbi request reprint Comparison of dobutamine stress echocardiography with and without real-time perfusion imaging for detection of coronary artery disease
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Cardiol 96:506-11. 2005
    ..The addition of real-time perfusion imaging after intravenous contrast during dobutamine stress echocardiography has the potential to improve detection of coronary artery disease...
  11. pmc Diagnostic ultrasound induced inertial cavitation to non-invasively restore coronary and microvascular flow in acute myocardial infarction
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 8:e69780. 2013
    ....
  12. ncbi request reprint Safety of dobutamine stress real-time myocardial contrast echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    J Am Coll Cardiol 45:1235-42. 2005
    ....
  13. doi request reprint Patient outcome following 2 different stress imaging approaches: a prospective randomized comparison
    Thomas R Porter
    Department of Cardiology, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Am Coll Cardiol 61:2446-55. 2013
    ..The study sought to prospectively compare patient outcome after stress real-time myocardial contrast echocardiography (RTMCE) versus conventional stress echo (CSE), where contrast is used to optimize wall motion (WM) analysis...
  14. pmc Sonothrombolysis of intra-catheter aged venous thrombi using microbubble enhancement and guided three-dimensional ultrasound pulses
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska, Children s Hospital and Medical Center, Omaha, Nebraska 68196, USA
    J Am Soc Echocardiogr 23:1001-6. 2010
    ..The investigators hypothesized that guided high-mechanical index (MI) impulses from diagnostic three-dimensional (3D) ultrasound during an intravenous microbubble infusion could dissolve these thrombi...
  15. doi request reprint Rapid detection of coronary artery stenoses with real-time perfusion echocardiography during regadenoson stress
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, NE 68198 8865, USA
    Circ Cardiovasc Imaging 4:628-35. 2011
    ..We hypothesized that this technique could be used after a bolus injection of the selective A2A receptor agonist regadenoson to rapidly and safely detect coronary artery stenoses...
  16. ncbi request reprint Targeted vascular delivery of antisense molecules using intravenous microbubbles
    Thomas R Porter
    Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Cardiovasc Revasc Med 7:25-33. 2006
    ..The microbubbles also adhere to sites of damaged vascular endothelium and thus may be a method of systemically targeting delivery of anti-c-myc...
  17. ncbi request reprint Noninvasive diagnosis of coronary artery bypass graft disease by dobutamine stress real-time myocardial contrast perfusion imaging
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Soc Echocardiogr 19:1482-7. 2006
    ..The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease...
  18. ncbi request reprint Noninvasive diagnosis of coronary artery disease in patients with diabetes by dobutamine stress real-time myocardial contrast perfusion imaging
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Diabetes Care 28:1662-7. 2005
    ..Myocardial contrast echocardiography is a new technique that allows evaluation of myocardial perfusion. Its utility in diabetic patients has not been defined...
  19. ncbi request reprint Diagnostic accuracy and prognostic value of dobutamine stress myocardial contrast echocardiography in patients with suspected acute coronary syndromes
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Echocardiography 22:487-95. 2005
    ....
  20. pmc Coronary and microvascular thrombolysis with guided diagnostic ultrasound and microbubbles in acute ST segment elevation myocardial infarction
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Soc Echocardiogr 24:1400-8. 2011
    ..The purpose of this study was to further elucidate the mechanism of improved microvascular flow in normal and hyperlipidemic atherosclerotic pigs...
  21. ncbi request reprint Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis
    Feng Xie
    Internal Medicine Cardiology Department, University of Nebraska Medical Center, Omaha, NE 68196 1165, USA
    Ultrasound Med Biol 31:979-85. 2005
    ..US and microbubbles are capable of recanalizing acute arteriovenous graft thromboses. Higher intensities may be needed in the presence of tissue attenuation...
  22. doi request reprint Effects of transcranial ultrasound and intravenous microbubbles on blood brain barrier permeability in a large animal model
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Ultrasound Med Biol 34:2028-34. 2008
    ..This induced opening of BBB is reversible and may be a safe noninvasive method of achieving drug or gene delivery across the BBB...
  23. ncbi request reprint Incidence of cardiac arrhythmias with therapeutic versus diagnostic ultrasound and intravenous microbubbles
    Scott Chapman
    University of Nebraska Medical Center, Omaha, 68198 1165, USA
    J Ultrasound Med 24:1099-107. 2005
    ..The purpose of this study was to determine the type of arrhythmias induced with therapeutic versus diagnostic transthoracic low-frequency ultrasound (TLFUS) transducers in the presence of intravenous microbubbles...
  24. ncbi request reprint Comparison of low-mechanical index pulse sequence schemes for detecting myocardial perfusion abnormalities during vasodilator stress echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Cardiol 95:565-70. 2005
    ..These data indicate that the different low-mechanical index imaging schemes are equivalent to radionuclide SPECT in accurately detecting diseased coronary artery territories during vasodilator stress...
  25. doi request reprint Ultrasound contrast and real-time perfusion in conjunction with supine bicycle stress echocardiography for comprehensive evaluation of surgically corrected congenital heart disease
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska College of Medicine Creighton University, Children s Hospital and Medical Center, Omaha, NE, USA
    Eur Heart J Cardiovasc Imaging 13:500-9. 2012
    ....
  26. ncbi request reprint Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Coll Cardiol 44:2185-91. 2004
    ..This study sought to compare the accuracy of myocardial contrast echocardiography (MCE) and wall motion analysis (WMA) during submaximal and peak dobutamine stress echocardiography (DSE) for the diagnosis of coronary artery disease (CAD)...
  27. ncbi request reprint The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque
    Daniel R Anderson
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Cardiovasc Res 73:597-606. 2007
    ..To determine whether serum complement C3 mediates adherence of albumin-encapsulated microbubbles to vascular endothelium in the development of atherosclerotic plaques...
  28. ncbi request reprint Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction
    Jeane M Tsutsui
    Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    J Am Coll Cardiol 44:1036-46. 2004
    ....
  29. ncbi request reprint Differences in definity and optison microbubble destruction rates at a similar mechanical index with different real-time perfusion systems
    Carolin Sonne
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Am Soc Echocardiogr 16:1178-85. 2003
    ..1- and 0.2-MI settings. These differences indicate that the same MI setting on different real-time perfusion imaging techniques will produce different microbubble responses...
  30. doi request reprint Myocardial perfusion imaging with contrast ultrasound
    Thomas R Porter
    University of Nebraska Medical Center, Cardiology, 981165 Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    JACC Cardiovasc Imaging 3:176-87. 2010
    ..A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed...
  31. pmc Diagnostic Ultrasound High Mechanical Index Impulses Restore Microvascular Flow in Peripheral Arterial Thromboembolism
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, Nebraska, USA Electronic address
    Ultrasound Med Biol 42:1531-40. 2016
    ..IC inducing pulses from a diagnostic transducer can reverse microvascular obstruction after acute arterial thromboembolism. Nitric oxide may prevent unwanted bio-effects of these IC pulses. ..
  32. doi request reprint Prospective randomized comparison of conventional stress echocardiography and real-time perfusion stress echocardiography in detecting significant coronary artery disease
    Deepak Thomas
    Department of Cardiology, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Soc Echocardiogr 25:1207-14. 2012
    ....
  33. ncbi request reprint Interaction of transthoracic ultrasound and intravenous microbubbles with cardiac mechanoreceptors
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ultrasound Med Biol 33:136-44. 2007
    ..The changes in RSNA induced by TTU and MB in all rabbits were abolished by vagotomy. TTU, in the presence of MB, stimulates mechanoreceptors in the heart reflexively to reduce RSNA...
  34. ncbi request reprint Real-time dobutamine stress myocardial perfusion echocardiography predicts outcome in the elderly
    Jeane M Tsutsui
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Eur Heart J 29:377-85. 2008
    ....
  35. doi request reprint Improvements in cerebral blood flow and recanalization rates with transcranial diagnostic ultrasound and intravenous microbubbles after acute cerebral emboli
    Shunji Gao
    From the Department of Internal Medicine, Division of Cardiology, University of Nebraska Medical Center Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska Philips Research North America, Briarcliff Manor, NY Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska Philips Medical Systems, Bothell, WA and Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska
    Invest Radiol 49:593-600. 2014
    ....
  36. pmc Improved sonothrombolysis from a modified diagnostic transducer delivering impulses containing a longer pulse duration
    Juefei Wu
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Ultrasound Med Biol 40:1545-53. 2014
    ..Slightly prolonging the PD on a diagnostic transducer improves the degree of sonothrombolysis that can be achieved without fibrinolytic agents at a lower mechanical index...
  37. pmc The use of microbubbles to target drug delivery
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Cardiovasc Ultrasound 2:23. 2004
    ..In addition, current studies involving this novel therapeutical application of microbubbles will be discussed...
  38. ncbi request reprint Clinical experience in the detection of coronary artery disease with myocardial contrast echocardiography
    Thomas R Porter
    University of Nebraska Medical Center, Omaha 68198 1165, USA
    Echocardiography 19:399-407. 2002
    ..They also have been shown to detect zones of no reflow following coronary revascularization in patients with acute myocardial infarction. These preliminary data will require validation in larger multicenter clinical studies...
  39. ncbi request reprint Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome
    Farhan Majeed
    University of Nebraska Medical Center, Department of Internal Medicine, 982055 Nebraska Medical Center, Omaha, NE 68198 2055, USA
    Eur J Echocardiogr 8:386-9. 2007
    ..These findings suggest that the acute right ventricular dysfunction was secondary to acute carcinoid crisis and resolution resulted in a significant improvement of both right ventricular systolic function and clinical condition...
  40. ncbi request reprint Microbubble responses to a similar mechanical index with different real-time perfusion imaging techniques
    Thomas R Porter
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha NE 68198 1165, USA
    Ultrasound Med Biol 29:1187-92. 2003
    ..1. Contrast intensity seen with PID was less than with PM. Therefore, differences in contrast enhancement and microbubble destruction rates occur at a similar MI setting when using different real-time pulse sequence schemes...
  41. ncbi request reprint Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles
    Jeane Mike Tsutsui
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198, USA
    Cardiol Clin 22:299-312, vii. 2004
    ..Potential applications, such as induction of angiogenesis, inhibition of neointimal hyperplasia, and in the setting of acute myocardial infarction and ischemic stroke,are discussed briefly...
  42. pmc Utilization of diagnostic ultrasound and intravenous lipid-encapsulated perfluorocarbons in non-invasive targeted cardiovascular therapeutics
    Thomas R Porter
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Nebraska Medical Center, 982265 Nebraska Medical Center, 68198 Omaha, NE USA
    J Ther Ultrasound 4:18. 2016
    ..This article will focus on these newer developments for DUS therapeutic applications. ..
  43. doi request reprint Differences in patient outcomes after conventional versus real time perfusion stress echocardiography in men versus women: a prospective randomised trial
    Zenab Laiq
    Department of Internal Medicine, University of Nebraska Medical Center, 983332 Nebraska Medical Center, Omaha, Nebraska, USA
    Heart 101:559-64. 2015
    ....
  44. doi request reprint Acoustic Behavior of a Reactivated, Commercially Available Ultrasound Contrast Agent
    Songita A Choudhury
    Department of Cellular and Integrative Physiology, Division of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska
    J Am Soc Echocardiogr . 2016
    ..The aim of this study was to determine the size range and acoustic characteristics of Definity nanodroplets (DNDs) compared with Definity microbubbles (DMBs)...
  45. doi request reprint Contrast echocardiography: latest developments and clinical utility
    Thomas R Porter
    Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    Curr Cardiol Rep 17:569. 2015
    ..Newer applications are emerging in the detection of left atrial appendage thrombi and quantification of myocardial blood flow and volume in transplant patients. ..
  46. doi request reprint Emerging cardiovascular imaging techniques to non-invasively detect coronary artery disease
    Thomas R Porter
    University of Nebraska Medical Center, Department of Internal Medicine, Section of Cardiology, 982265 Nebraska, Omaha, NE 68198 2265, USA 1 402 559 8150
    Expert Opin Med Diagn 1:203-11. 2007
    ..This paper will present the advantages and disadvantages of stress techniques, and new developments that will further improve the accuracy of these tests...
  47. ncbi request reprint A method of detecting and quantifying severity of myocardial perfusion defects with intravenous ultrasound contrast and breath holding during stress echocardiography
    Thomas R Porter
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Echocardiography 20:411-22. 2003
    ..Coronary artery territory agreement between perfusion assessed during BH(ini) and BH(reinsp) and quantitative coronary angiography was 76% and 81%, respectively...