Junru Wu

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Determine mechanical properties of particulate composite using ultrasound spectroscopy
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 44:e793-800. 2006
  2. ncbi request reprint Tofu as a tissue-mimicking material
    J Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasound Med Biol 27:1297-300. 2001
  3. ncbi request reprint Theoretical study on shear stress generated by microstreaming surrounding contrast agents attached to living cells
    Junru Wu
    Department of Physics, Unversity of Vermont, Burlington, VT 05405 1025, USA
    Ultrasound Med Biol 28:125-9. 2002
  4. ncbi request reprint Reparable sonoporation generated by microstreaming
    Junru Wu
    Department of Physics, University of Vermont, Burlington 05405, USA
    J Acoust Soc Am 111:1460-4. 2002
  5. ncbi request reprint Nonlinear behaviors of contrast agents relevant to diagnostic and therapeutic applications
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasound Med Biol 29:555-62. 2003
  6. ncbi request reprint Application of liposomes to sonoporation
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405 0125, USA
    Ultrasound Med Biol 32:429-37. 2006
  7. ncbi request reprint Shear stress in cells generated by ultrasound
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Prog Biophys Mol Biol 93:363-73. 2007
  8. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
  9. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
  10. doi request reprint Dislodgement and removal of dust-particles from a surface by a technique combining acoustic standing wave and airflow
    Di Chen
    Department of Physics and Materials Science Program, The University of Vermont, Burlington, Vermont 05405, USA
    J Acoust Soc Am 127:45-50. 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Determine mechanical properties of particulate composite using ultrasound spectroscopy
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 44:e793-800. 2006
    ..Acoustic scattering theories are then applied to this model to test their predictive capabilities for the real composite's mechanical properties...
  2. ncbi request reprint Tofu as a tissue-mimicking material
    J Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasound Med Biol 27:1297-300. 2001
    ..It is suggested that tofu may serve as a tissue-mimicking material for some biomedical ultrasound (US) through transmission applications in vitro...
  3. ncbi request reprint Theoretical study on shear stress generated by microstreaming surrounding contrast agents attached to living cells
    Junru Wu
    Department of Physics, Unversity of Vermont, Burlington, VT 05405 1025, USA
    Ultrasound Med Biol 28:125-9. 2002
    ..When that happens, the shear stress caused by microstreaming surrounding the free bubble increases dramatically and may play an important role in lethal sonoporation and fragmentation of cells during the early stage of US exposure...
  4. ncbi request reprint Reparable sonoporation generated by microstreaming
    Junru Wu
    Department of Physics, University of Vermont, Burlington 05405, USA
    J Acoust Soc Am 111:1460-4. 2002
    ..The threshold shear stress was determined to be 12 +/- 4 Pa for exposure time up to 7 min. It was also found that the shorter the exposure time, the greater the threshold...
  5. ncbi request reprint Nonlinear behaviors of contrast agents relevant to diagnostic and therapeutic applications
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasound Med Biol 29:555-62. 2003
    ..5%, repetition period = 0.1067 ms; have also shown that the lower-frequency ultrasound (US) excitation (0.5 MHz) is more effective in disruption of the microbubbles due to acoustic inertial cavitation than the higher frequency US (2 MHz)...
  6. ncbi request reprint Application of liposomes to sonoporation
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405 0125, USA
    Ultrasound Med Biol 32:429-37. 2006
    ..2 MHz (the in situ spatial peak-pressure amplitude = 80 W/cm2) with an efficiency of 13 %. It has been experimentally shown that liposomes may be an alternative stable agent to Optison for delivering macromolecules into cells...
  7. ncbi request reprint Shear stress in cells generated by ultrasound
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Prog Biophys Mol Biol 93:363-73. 2007
    ..Numerical calculations have shown that shear stress associated with microstreaming surrounding encapsulated bubbles may be large enough to generate sonoporation at 0.1 MPa of 1 or 2 MHz ultrasound...
  8. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
    ....
  9. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    ....
  10. doi request reprint Dislodgement and removal of dust-particles from a surface by a technique combining acoustic standing wave and airflow
    Di Chen
    Department of Physics and Materials Science Program, The University of Vermont, Burlington, Vermont 05405, USA
    J Acoust Soc Am 127:45-50. 2010
    ..The removal efficiency deteriorates for particles of less than 2 microm in size...
  11. ncbi request reprint Sonoporation, anti-cancer drug and antibody delivery using ultrasound
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 44:e21-5. 2006
    ..When goat anti-rabbit IgG was delivered, the efficiencies were 78.60+/-3.60% (control baseline was 1.60+/-0.00%) and 57.50+/-4.23% (control baseline was 11.30+/-0.81%) respectively for Jurkat cells and PBMC...
  12. doi request reprint An in vitro feasibility study of controlled drug release from encapsulated nanometer liposomes using high intensity focused ultrasound
    Di Chen
    Department of Physics and The Materials Science Program, The University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 50:744-9. 2010
    ..The controlled drug release from liposomes by HIFU may be proven to be a potential useful modality for clinical applications...
  13. ncbi request reprint Theoretical study in applications of doublet mechanics to detect tissue pathological changes in elastic properties using high frequency ultrasound
    Christopher Layman
    Department of Physics, University of Vermont, Burlington, Vermont 05405, USA
    J Acoust Soc Am 116:1244-53. 2004
    ..Potential experimental applications of this technique to tissue characterization are discussed...
  14. doi request reprint A feasibility study of temperature rise measurement in a tissue phantom as an alternative way for characterization of the therapeutic high intensity focused ultrasonic field
    Di Chen
    Department of Physics and The Materials Science Program, The University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 49:733-42. 2009
    ..When acoustic cavitation occurs, the bubble-assisted enhancement of the initial temperature rise (exposure time t<2s) can still be predicted by the theory...
  15. doi request reprint Interaction between parallel polymer fibers insonificated by ultrasound of low/mild intensity: an analytical theory and experiments
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 52:417-21. 2012
    ..The magnitude of the average approaching velocity of the fiber pair due to the attractive force was found in agreement with that predicted by the theory...
  16. doi request reprint Ultrasound, cavitation bubbles and their interaction with cells
    Junru Wu
    Department of Physics, Materials Science Program, University of Vermont, Burlington, VT 05405, USA
    Adv Drug Deliv Rev 60:1103-16. 2008
    ..The ultrasound thermal and mechanical bioeffects and relevant safety issues for in vivo applications are also discussed...
  17. ncbi request reprint Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension
    James C Iatridis
    Department of Mechanical Engineering, University of Vermont, Burlington, Vermont 05405 0156, USA
    Connect Tissue Res 44:208-17. 2003
    ....
  18. ncbi request reprint Evidence of connective tissue involvement in acupuncture
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington Vermont 05405, USA
    FASEB J 16:872-4. 2002
    ..Winding may allow needle movements to deliver a mechanical signal into the tissue and may be key to acupuncture's therapeutic mechanism...
  19. pmc Myosin conformational states determined by single fluorophore polarization
    D M Warshaw
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 95:8034-9. 1998
    ....
  20. pmc Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    BMC Syst Biol 1:25. 2007
    ..In ten additional non-surgical subjects, we quantified changes in tissue spatial organization over time during needle rotation vs. no rotation using ultrasound and semi-variogram analyses...
  21. doi request reprint Damage Effects on Bacille Calmette-Guérin by Low-Frequency, Low-Intensity Ultrasound: A Pilot Study
    Hang Su
    State Key Laboratory of Ultrasound Engineering in Medicine, Cofounded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Biomedical Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China H S, Z L, Y D, H Z J, H M Z, Y H D, Z B W and Department of Physics, University of Vermont, Burlington, Vermont USA J W
    J Ultrasound Med 35:581-7. 2016
    ....
  22. ncbi request reprint Wave equations, dispersion relations, and van Hove singularities for applications of doublet mechanics to ultrasound propagation in bio- and nanomaterials
    Junru Wu
    Department of Physics, University of Vermont, Burlington, Vermont 05405, USA
    J Acoust Soc Am 115:893-900. 2004
    ..The experimental dispersion data for soft tissue and low-density polyethylene are compared with results predicted by Doublet Mechanics and an attenuation model based on a Kramers-Kronig relation in classical continuum mechanics...
  23. ncbi request reprint Feasibility study of effect of ultrasound on water chestnuts
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405 0125, USA
    Ultrasound Med Biol 32:595-601. 2006
    ..The treated plants started to die within 72 h and the mortality rate of water chestnut plants treated with the ultrasound application was 100%...
  24. ncbi request reprint Inactivation of microorganisms in milk and apple cider treated with ultrasound
    Dennis J D'Amico
    Department of Nutrition and Food Sciences, University of Vermont, Burlington, Vermont 05405, USA
    J Food Prot 69:556-63. 2006
    ..Results indicate that ultrasound technology is a promising processing alternative for the reduction of microorganisms in liquid foods...
  25. pmc Smooth muscle myosin: a high force-generating molecular motor
    P VanBuren
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington 05405, USA
    Biophys J 68:256S-258S; 258S-259S. 1995
    ..This approach should allow us to determine whether an increase in unitary force, duty cycle, or both contribute to smooth muscle myosin's enhanced force-generating capacity compared with skeletal muscle myosin...
  26. doi request reprint A targeting drug-delivery model via interactions among cells and liposomes under ultrasonic excitation
    Xiaoyu Xi
    Institute of Acoustics, Lab of Modern Acoustics, Nanjing University, Nanjing 210093, People s Republic of China
    Phys Med Biol 53:3251-65. 2008
    ..25 MPa. It was found that the possible mechanisms might include the acoustic cavitation, the endocytosis and cell-fusion. Acoustic radiation force might make liposomes collide with cells effectively and facilitate the delivery process...
  27. ncbi request reprint Optical and atomic force microscopic studies on sonoporation
    Joel P Ross
    J Acoust Soc Am 111:1161-4. 2002
  28. ncbi request reprint Application of ultrasound in preparing pathological sections to reduce processing time
    Qian Chen
    Key Laboratory of Modern Acoustics, Ministry of Education and Institute of Acoustics, Nanjing University, Nanjing 210093, People s Republic of China
    Ultrasonics 47:78-81. 2007
    ..It has been proposed that ultrasound inducing non-inertial cavitation enhanced the permeability of cell membrane to liquid. Thus tissue fixation and dehydration were speeded up by application of US...
  29. ncbi request reprint Bioeffects considerations for diagnostic ultrasound contrast agents
    Douglas L Miller
    Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0553, USA
    J Ultrasound Med 27:611-32; quiz 633-6. 2008
    ..Bioeffects of contrast-aided diagnostic ultrasound happen on a microscopic scale, and their importance in the clinical setting remains uncertain...
  30. doi request reprint Comment on "Three-dimensional finite element modeling of guided ultrasound wave propagation in intact and healing long bones," [J. Acoust. Soc. Am. 121(6), 3907-3921 (2007)]
    Xiasheng Guo
    Institute of Acoustics, Key Laboratory of Modern Acoustics Nanjing University, Ministry of Education, Nanjing University, Nanjing 210093, China
    J Acoust Soc Am 123:4047-50. 2008
    ..It is concluded that in order to extract quantitative ultrasonic features, FE simulations should be supplemented by other techniques such as the NME...
  31. pmc Electrical impedance along connective tissue planes associated with acupuncture meridians
    Andrew C Ahn
    Fletcher Allen Health Care, University of Vermont General Clinical Research Center, VT, USA
    BMC Complement Altern Med 5:10. 2005
    ....
  32. ncbi request reprint Transdermal delivery of poly-l-lysine by sonomacroporation
    Ludwig J Weimann
    Ultra Sonic Technologies Inc, Saint Albans, VT, USA
    Ultrasound Med Biol 28:1173-80. 2002
    ..The confocal images also suggest the formation of microm-size pathways in epidermis during US exposure...