Chia Yen Wu
Affiliation: University of Delaware
- Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase AChia Yen Wu
Department of Biological Sciences, University of Delaware, Newark, DE, USA
Biochim Biophys Acta 1814:1134-9. 2011..Mutagenesis of this subset of PKA-phosphorylated sites in SMN affects association of SMN with Gemin2 and Gemin8. This result indicates that phosphorylation of SMN by PKA may play a role in regulation of the in vivo function of SMN...
- Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independentChia Yen Wu
Nemours Biomedical Research, Alfred I, duPont Hospital for Children, Wilmington, DE, USA
BMC Cell Biol 10:40. 2009..Here, we examine the potential mechanism of camptothecin sensitivity in SMA fibroblasts...
- Efficient differentiation of mouse embryonic stem cells into motor neuronsChia Yen Wu
Nemours Biomedical Research, Alfred I duPont Hospital for Children, USA
J Vis Exp . 2012..Our two-step differentiation protocol provides an efficient way to differentiate mES cells into spinal motor neurons...
- Proteomic assessment of a cell model of spinal muscular atrophyChia Yen Wu
Department of Biological Science, University of Delaware, Newark, DE, USA
BMC Neurosci 12:25. 2011..Proteomic and western blot analyses were used to probe protein expression alterations in this cell-culture model of SMA that could be relevant to the disease...