Rebecca A Worthylake
Affiliation: University of North Carolina
- RhoA and ROCK promote migration by limiting membrane protrusionsRebecca A Worthylake
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center and Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:13578-84. 2003..Together, our results show that RhoA/ROCK signaling promotes migration by restricting integrin activity and membrane protrusions to the leading edge...
- Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier functionErika S Wittchen
Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
J Biol Chem 280:11675-82. 2005..Furthermore, these results suggest that Rap1 may be a novel therapeutic target for clinical conditions in which an inappropriate inflammatory response leads to disease...
- Trading spaces: Rap, Rac, and Rho as architects of transendothelial migrationErika S Wittchen
Department of Cell and Developmental Biology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
Curr Opin Hematol 12:14-21. 2005..This review focuses on recent developments in understanding regulation of leukocyte transendothelial migration by small GTPase signaling...