Rebecca A Worthylake

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint RhoA and ROCK promote migration by limiting membrane protrusions
    Rebecca A Worthylake
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center and Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:13578-84. 2003
  2. ncbi request reprint Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function
    Erika S Wittchen
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 280:11675-82. 2005
  3. ncbi request reprint Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration
    Erika S Wittchen
    Department of Cell and Developmental Biology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Curr Opin Hematol 12:14-21. 2005

Detail Information

Publications3

  1. ncbi request reprint RhoA and ROCK promote migration by limiting membrane protrusions
    Rebecca A Worthylake
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center and Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:13578-84. 2003
    ..Together, our results show that RhoA/ROCK signaling promotes migration by restricting integrin activity and membrane protrusions to the leading edge...
  2. ncbi request reprint Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function
    Erika S Wittchen
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 280:11675-82. 2005
    ..Furthermore, these results suggest that Rap1 may be a novel therapeutic target for clinical conditions in which an inappropriate inflammatory response leads to disease...
  3. ncbi request reprint Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration
    Erika S Wittchen
    Department of Cell and Developmental Biology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Curr Opin Hematol 12:14-21. 2005
    ..This review focuses on recent developments in understanding regulation of leukocyte transendothelial migration by small GTPase signaling...