David A Williams

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Patient-Reported Outcomes and Fibromyalgia
    David A Williams
    Department of Anesthesiology, University of Michigan Health System, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 385, Lobby M, Ann Arbor, MI 48106, USA Department of Internal Medicine, University of Michigan, 3110 Taubman Center, SPC 5368, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Department of Psychiatry, University of Michigan, F6327 UH South, SPC 5295, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Department of Psychology, University of Michigan, F6327 UH South, SPC 5295, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Electronic address
    Rheum Dis Clin North Am 42:317-32. 2016
  2. ncbi request reprint Cognitive - Behavioral Therapy in Central Sensitivity Syndromes
    David A Williams
    Department of Anesthesiology, University of Michigan Health System, 24 Frank Lloyd Wright Drive, P O Box 385, Lobby M, Ann Arbor, MI 48106, USA
    Curr Rheumatol Rev 12:2-12. 2016
  3. pmc Fatigue in fibromyalgia: a conceptual model informed by patient interviews
    Louise Humphrey
    Mapi Values, Adelphi Mill, Bollington, Macclesfield Cheshire SK10 5JB, UK
    BMC Musculoskelet Disord 11:216. 2010
  4. pmc Understanding fibromyalgia: lessons from the broader pain research community
    David A Williams
    Chronic Pain and Fatigue Research Center, The University of Michigan, Ann Arbor, Michigan 48106, USA
    J Pain 10:777-91. 2009
  5. pmc Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia
    David A Williams
    Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, University of Michigan, Ann Arbor, MI, USA
    Arthritis Res Ther 8:224. 2006
  6. ncbi request reprint Assessor status influences pain recall
    David A Williams
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Pain 8:343-8. 2007
  7. ncbi request reprint Utility of cognitive behavioral therapy as a treatment for insomnia in patients with fibromyalgia
    David A Williams
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Nat Clin Pract Rheumatol 2:190-1. 2006
  8. pmc Advances in the assessment of fibromyalgia
    David A Williams
    Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI 48106, USA
    Rheum Dis Clin North Am 35:339-57. 2009
  9. ncbi request reprint Psychological and behavioural therapies in fibromyalgia and related syndromes
    David A Williams
    University of Michigan, Room 5510D, MSRB 1, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
    Best Pract Res Clin Rheumatol 17:649-65. 2003
  10. pmc Internet-enhanced management of fibromyalgia: a randomized controlled trial
    David A Williams
    Chronic Pain and Fatigue Research Center, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby M, Ann Arbor, MI 48106, USA
    Pain 151:694-702. 2010

Research Grants

Detail Information

Publications85

  1. pmc Patient-Reported Outcomes and Fibromyalgia
    David A Williams
    Department of Anesthesiology, University of Michigan Health System, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 385, Lobby M, Ann Arbor, MI 48106, USA Department of Internal Medicine, University of Michigan, 3110 Taubman Center, SPC 5368, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Department of Psychiatry, University of Michigan, F6327 UH South, SPC 5295, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Department of Psychology, University of Michigan, F6327 UH South, SPC 5295, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA Electronic address
    Rheum Dis Clin North Am 42:317-32. 2016
    ..This paper provides an overview of patient-reported approaches that can be taken to assess FM in the contexts of diagnosis, symptom monitoring, phenotyping/characterization, and for purposes of clinical trials. ..
  2. ncbi request reprint Cognitive - Behavioral Therapy in Central Sensitivity Syndromes
    David A Williams
    Department of Anesthesiology, University of Michigan Health System, 24 Frank Lloyd Wright Drive, P O Box 385, Lobby M, Ann Arbor, MI 48106, USA
    Curr Rheumatol Rev 12:2-12. 2016
    ..This paper provides a description of CBT, some recommendations for integrating CBT into clinical practice, and a brief review of the evidence supporting the use of CBT with various forms of CSS...
  3. pmc Fatigue in fibromyalgia: a conceptual model informed by patient interviews
    Louise Humphrey
    Mapi Values, Adelphi Mill, Bollington, Macclesfield Cheshire SK10 5JB, UK
    BMC Musculoskelet Disord 11:216. 2010
    ..The data obtained informed the development of a conceptual model of fatigue in FM...
  4. pmc Understanding fibromyalgia: lessons from the broader pain research community
    David A Williams
    Chronic Pain and Fatigue Research Center, The University of Michigan, Ann Arbor, Michigan 48106, USA
    J Pain 10:777-91. 2009
    ..Such insights are not likely to be limited in application just to FM and could have relevance to the broader field of pain research as well...
  5. pmc Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia
    David A Williams
    Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, University of Michigan, Ann Arbor, MI, USA
    Arthritis Res Ther 8:224. 2006
    ..This article provides an overview of the nociceptive system as it functions normally, reviews functional brain imaging methods, and integrates the existing literature utilizing fMRI to study central pain mechanisms in fibromyalgia...
  6. ncbi request reprint Assessor status influences pain recall
    David A Williams
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Pain 8:343-8. 2007
    ....
  7. ncbi request reprint Utility of cognitive behavioral therapy as a treatment for insomnia in patients with fibromyalgia
    David A Williams
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Nat Clin Pract Rheumatol 2:190-1. 2006
  8. pmc Advances in the assessment of fibromyalgia
    David A Williams
    Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI 48106, USA
    Rheum Dis Clin North Am 35:339-57. 2009
    ..This article provides an overview of how the art of assessing FM has evolved over time, current methods of assessment, the value of patients' perspectives in assessment, and emerging advancements representing the future of for FM...
  9. ncbi request reprint Psychological and behavioural therapies in fibromyalgia and related syndromes
    David A Williams
    University of Michigan, Room 5510D, MSRB 1, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
    Best Pract Res Clin Rheumatol 17:649-65. 2003
    ..While the benefits are not curative or universally obtained by all patients, the benefits are sufficiently large to encourage future refinement of CBT for this population of patients...
  10. pmc Internet-enhanced management of fibromyalgia: a randomized controlled trial
    David A Williams
    Chronic Pain and Fatigue Research Center, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby M, Ann Arbor, MI 48106, USA
    Pain 151:694-702. 2010
    ..While not everyone is expected to benefit from this approach, this study demonstrated that non-pharmacological interventions can be efficiently integrated into routine clinical practice with positive outcomes...
  11. doi request reprint Web-based behavioral interventions for the management of chronic pain
    David A Williams
    Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, USA
    Curr Rheumatol Rep 13:543-9. 2011
    ....
  12. ncbi request reprint Pain assessment in patients with fibromyalgia syndrome: a consideration of methods for clinical trials
    David A Williams
    Department of Medicine, Division of Rheumatology, University of Michigan, Ann Arbor 48106, USA
    Clin J Pain 20:348-56. 2004
    ..Baseline characteristics, characteristics over time, and compliance were evaluated for each of the methods...
  13. pmc Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia
    Samuel A McLean
    Department of Emergency Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Neuropsychopharmacology 31:2776-82. 2006
    ..Further studies are needed to better understand the nature of the association between CSF CRF and pain symptoms in FM...
  14. ncbi request reprint Comparison of clinical and evoked pain measures in fibromyalgia
    Richard E Harris
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan 48106, USA
    J Pain 7:521-7. 2006
    ..05). Pain sensitivity as assessed by random paradigms was associated with improvements in clinical FM pain. Sophisticated pain testing paradigms might be responsive to change in clinical trials...
  15. pmc Executive function in chronic pain patients and healthy controls: different cortical activation during response inhibition in fibromyalgia
    Jennifer M Glass
    Addiction Research Center, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pain 12:1219-29. 2011
    ..Compensatory cortical plasticity may be required to achieve performance on a par with control groups...
  16. ncbi request reprint Evidence of augmented central pain processing in idiopathic chronic low back pain
    Thorsten Giesecke
    University of Michigan, Ann Arbor, MI 48106, USA
    Arthritis Rheum 50:613-23. 2004
    ..We compared the results of both of these methods as applied to patients with idiopathic CLBP (n = 11), patients with widespread pain (fibromyalgia; n = 16), and healthy control subjects (n = 11)...
  17. doi request reprint Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism
    Michael E Geisser
    Chronic Pain and Fatigue Research Center, Dept of Internal Medicine, Div of Rheumatology, Univ of Michigan, Ann Arbor, MI 48108, USA
    Psychosomatics 49:235-42. 2008
    ..Somatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS)...
  18. ncbi request reprint Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia
    Samuel A McLean
    Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
    Arthritis Rheum 52:3660-9. 2005
    ....
  19. ncbi request reprint Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency
    Richard E Harris
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48106, USA
    J Altern Complement Med 11:663-71. 2005
    ..DESIGN/SETTINGS/SUBJECTS: A single-site, single-blind, randomized trial of 114 participants diagnosed with fibromyalgia for at least 1 year was performed...
  20. ncbi request reprint The association between experimental and clinical pain measures among persons with fibromyalgia and chronic fatigue syndrome
    Michael E Geisser
    Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA
    Eur J Pain 11:202-7. 2007
    ..These findings merit consideration when designing experimental studies of clinical pain associated with FM and CFS...
  21. doi request reprint Contributions of change in clinical status parameters to Patient Global Impression of Change (PGIC) scores among persons with fibromyalgia treated with milnacipran
    Michael E Geisser
    Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI48108, USA
    Pain 149:373-8. 2010
    ..Several domains were associated with PGIC ratings, highlighting the need to assess multiple outcomes in clinical trials of treatments for FM...
  22. ncbi request reprint Characterization and consequences of pain variability in individuals with fibromyalgia
    Richard E Harris
    Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
    Arthritis Rheum 52:3670-4. 2005
    ..We used electronic assessment data derived from a study of patients with fibromyalgia (FM) to examine variability of pain over time and to investigate the implications of pain fluctuation in the context of a clinical trial...
  23. doi request reprint Pain is associated with short leukocyte telomere length in women with fibromyalgia
    Afton L Hassett
    Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48106, USA
    J Pain 13:959-69. 2012
    ..These preliminary data support a relationship between pain and telomere length...
  24. pmc Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms
    Susan L Murphy
    Department of Physical Medicine and Rehabilitation, University of Michigan, 300 North Ingalls, 9th Floor, Ann Arbor, MI 48109 2007, USA
    Arthritis Res Ther 13:R135. 2011
    ....
  25. doi request reprint A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls
    Michael E Geisser
    Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan 48108, USA
    J Pain 9:417-22. 2008
    ..Further research is needed to examine the neural substrates associated with this abnormality and its role in the etiology and maintenance of FM...
  26. doi request reprint Changes in clinical pain in fibromyalgia patients correlate with changes in brain activation in the cingulate cortex in a response inhibition task
    Tobias Schmidt-Wilcke
    Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, USA Department of Neurology, Bergmannsheil, Ruhr Universitat Bochum, Bochum, Germany
    Pain Med 15:1346-58. 2014
    ....
  27. pmc Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty: a prospective, observational cohort study
    Chad M Brummett
    Assistant Professor, Associate Research Scientist, Professor, Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan Medical Student, University of Michigan Medical School, Ann Arbor, Michigan Medical Student, Wayne State University School of Medicine, Detroit, Michigan Professor, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan
    Anesthesiology 119:1434-43. 2013
    ..To test this hypothesis, the authors conducted a prospective, observational cohort study of patients undergoing lower-extremity joint arthroplasty...
  28. pmc No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder
    Michael C Hsu
    Department of Physical Medicine and Rehabilitation, University of Michigan Chronic Pain and Fatigue Research Center, 24 Frank Lloyd Wright Drive, Lobby M, PO Box 385, Ann Arbor, MI 48106, USA
    Pain 143:262-7. 2009
    ..470, p<.001). No other significant clusters were found on ROI-based analysis. Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain...
  29. pmc History of abuse and its relationship to pain experience and depression in women with chronic pelvic pain
    Sawsan As-Sanie
    Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, MI
    Am J Obstet Gynecol 210:317.e1-8. 2014
    ..We sought to determine the relationship among a history of physical or sexual abuse, pain experience, and depressive symptoms among women with chronic pelvic pain (CPP)...
  30. pmc Activity pacing for osteoarthritis symptom management: study design and methodology of a randomized trial testing a tailored clinical approach using accelerometers for veterans and non-veterans
    Susan L Murphy
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA
    BMC Musculoskelet Disord 12:177. 2011
    ..In a pilot study, we found that participants who underwent a tailored activity pacing intervention had reduced fatigue interference with daily activities. We are now conducting a full-scale trial...
  31. ncbi request reprint The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort
    Thorsten Giesecke
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 52:1577-84. 2005
    ..This study evaluated the effect of symptoms of depression and/or clinically diagnosed major depressive disorder (MDD) on pain processing in patients with fibromyalgia (FM)...
  32. pmc Characterizing Pain Flares From the Perspective of Individuals With Symptomatic Knee Osteoarthritis
    Susan L Murphy
    University of Michigan, Ann Arbor
    Arthritis Care Res (Hoboken) 67:1103-11. 2015
    ..Specifically, the nature and impact of pain flares is not well understood. This study characterized pain flares as defined by participants with knee OA. Pain flare occurrence and experience were measured over 7 days...
  33. doi request reprint The role of the central nervous system in osteoarthritis pain and implications for rehabilitation
    Susan L Murphy
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA
    Curr Rheumatol Rep 14:576-82. 2012
    ....
  34. doi request reprint Non-pharmacological treatment of chronic widespread musculoskeletal pain
    Afton L Hassett
    Department of Anesthesiology, University of Michigan Medical School, Chronic Pain and Fatigue Research Center, Domino s Farms, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Best Pract Res Clin Rheumatol 25:299-309. 2011
    ..Lastly, the methods by which exercise and CBT can be combined for a multi-component approach, which is consistent with the current evidence-based guidelines of several American and European medical societies, are addressed...
  35. doi request reprint Presence of Spontaneous Pain and Comorbid Pain Conditions Identifies Vulvodynia Subgroups
    Barbara D Reed
    1Department of Family Medicine, 2Chronic Pain and Fatigue Research Center, and 3Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI
    J Low Genit Tract Dis 20:57-63. 2016
    ..The aims of the study were to define the heterogeneity of vulvodynia by determining data-driven subgroups within the vulvodynia diagnosis using exploratory cluster analysis and to characterize the subgroups identified...
  36. pmc Preliminary validation of the Michigan Body Map
    Chad M Brummett
    Departments of aAnesthesiology and bPhysical Medicine and Rehabilitation, University of Michigan Medical School, MI, USA
    Pain 157:1205-12. 2016
    ..In conclusion, the MBM demonstrated utility, reliability, and construct validity. This new measure can be used to accurately assess the distribution of pain or widespread bodily pain as an element of the fibromyalgia survey score. ..
  37. pmc Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis
    Susan L Murphy
    aDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA bGeriatric Research Education and Clinical Center, VA Ann Arbor Health Care System, GRECC, Ann Arbor, MI, USA Departments of cBiostatistics dCardiology, and eAnesthesiology, University of Michigan, Ann Arbor, MI, USA
    Pain 157:1563-73. 2016
    ..This trial does not support the use of time-based pacing as a singular behavioral strategy for people with knee or hip OA. ..
  38. pmc Characteristics of fibromyalgia independently predict poorer long-term analgesic outcomes following total knee and hip arthroplasty
    Chad M Brummett
    University of Michigan Health System, Ann Arbor
    Arthritis Rheumatol 67:1386-94. 2015
    ....
  39. ncbi request reprint Stress Gym: Feasibility of deploying a web-enhanced behavioral self-management program for stress in a military setting
    Arthur Williams
    School of Nursing and Psychiatry, Medical School, University of Michigan, 400 N Ingalls Building, Ann Arbor, MI 48109, USA
    Mil Med 175:487-93. 2010
    ..These data support Stress Gym as being an online CBT-based self-help intervention that is feasible to deploy, accepted by the intended end users, and demonstrates the intended goal of reducing stress...
  40. ncbi request reprint Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors
    Thorsten Giesecke
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 48:2916-22. 2003
    ..In this study, we attempt to identify patient subsets by incorporating these features as well as the degree of hyperalgesia/tenderness, which is a key neurobiologic feature of this illness...
  41. ncbi request reprint Knee pain and radiographic osteoarthritis interact in the prediction of levels of self-reported disability
    David A Williams
    The University of Michigan, Ann Arbor, MI 48106, USA
    Arthritis Rheum 51:558-61. 2004
    ..To determine predictors of disability depending on whether joint deformity and pain reporting exist independently or concurrently...
  42. pmc Association between pain, radiographic severity, and centrally-mediated symptoms in women with knee osteoarthritis
    Susan L Murphy
    VA Ann Arbor Health Care System and University of Michigan, USA
    Arthritis Care Res (Hoboken) 63:1543-9. 2011
    ..To examine the relationship between pain, radiographic severity, and a common set of co-occurring centrally-mediated symptoms (fatigue, sleep quality, and depression) in women with knee osteoarthritis...
  43. pmc The Association between Symptoms, Pain Coping Strategies, and Physical Activity Among People with Symptomatic Knee and Hip Osteoarthritis
    Susan L Murphy
    Department of Physical Medicine and Rehabilitation, University of Michigan Ann Arbor, MI, USA
    Front Psychol 3:326. 2012
    ..This study provides an initial understanding of how people with OA cope with symptoms as they engage in daily life activities using ecological momentary assessment and objective physical activity measurement...
  44. pmc The PROMIS FatigueFM Profile: a self-report measure of fatigue for use in fibromyalgia
    Anna L Kratz
    Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd, Building NCRC B14, Room G218, Ann Arbor, MI, 48109 2800, USA
    Qual Life Res 25:1803-13. 2016
    ..The purpose of this study was to use fatigue item banks that were developed as part of the Patient-Reported Outcomes Measurement Information System (PROMIS) to devise a self-report measure of fatigue for use in individuals with FM...
  45. ncbi request reprint The allure of a cure
    Michael E Geisser
    The Spine Program, Department of Physical Medicine and Rehabilitation, University of Michigan Health System, Ann Arbor, Michigan 48108, USA
    J Pain 7:797-9; discussion 804-6. 2006
  46. pmc Somatic Awareness and Tender Points in a Community Sample
    Andrew Schrepf
    Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan Electronic address
    J Pain 17:1281-1290. 2016
    ..Our primary finding was that SA is strongly related to the number of tender points in a community sample. Mechanisms linking SA to the spatial distribution of pain sensitivity should be investigated further...
  47. doi request reprint Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations
    Ann M Taylor
    aCentre for Medical Education, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom bDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA cDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA dDepartment of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA eDepartment of Occupational Science and Occupational Therapy, University of Toronto, ON, Canada fInstitute for Work and Health, University of Toronto, ON, Canada gDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA hInstitute for Work and Health, University of Toronto, ON, Canada iDepartment of Neurology, University of Rochester, Rochester, NY, USA jDepomed, Newark, CA, USA kLORAGroup LLC, Royal Oak, MD, USA lDepartment of Health Services Research University of Maryland, Baltimore, MD, USA mPublic Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA nDivision of Infection and Immunity, Cardiff University, Cardiff, Sweden
    Pain 157:1836-50. 2016
    ..We provide recommendations regarding important domains to stimulate research to develop tools that are more robust, address consistency and standardization, and engage patients early in tool development. ..
  48. ncbi request reprint Premature Aging in Fibromyalgia
    Afton L Hassett
    Department of Anesthesiology, University of Michigan Medical School, Chronic Pain and Fatigue Research Center, Domino s Farms, Lobby M, P O Box 385, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Curr Aging Sci 8:178-85. 2015
    ..Herein, we focus on one chronic pain state, fibromyalgia, and provide an overview of the evidence suggesting that individuals with this chronic pain condition show signs of premature aging. ..
  49. pmc Altered resting state connectivity of the insular cortex in individuals with fibromyalgia
    Eric Ichesco
    Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, Michigan Electronic address
    J Pain 15:815-826.e1. 2014
    ..Within the FM group, greater connectivity between the IC and CC was associated with decreased pressure-pain thresholds...
  50. pmc Patient-reported symptoms and discontinuation of adjuvant aromatase inhibitor therapy
    Kelley M Kidwell
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan
    Cancer 120:2403-11. 2014
    ..Although pain-related symptoms may worsen during AI therapy, the authors hypothesized that nonpersistence with AI therapy was associated with symptoms that were present before treatment initiation...
  51. ncbi request reprint Fibromyalgia after motor vehicle collision: evidence and implications
    Samuel A McLean
    Department of Emergency Medicine and The Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Traffic Inj Prev 6:97-104. 2005
    ..Assess currently available evidence regarding the ability of a motor vehicle collision (MVC) to trigger the development of fibromyalgia (FM)...
  52. pmc Development and initial validation of a brief self-report measure of cognitive dysfunction in fibromyalgia
    Anna L Kratz
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan Electronic address
    J Pain 16:527-36. 2015
    ..The MISCI showed excellent internal reliability, low ceiling/floor effects, and good convergent validity with the MASQ (r = -.82)...
  53. pmc The MAPP research network: design, patient characterization and operations
    J Richard Landis
    Department of Urology, Division of Neurourology and Pelvic Reconstructive Surgery, University of Michigan, Ann Arbor, MI, USA
    BMC Urol 14:58. 2014
    ..The evolution, organization, and scientific scope of the MAPP Research Network, and the unique approach of the network's central study and common data elements are described...
  54. pmc Comparison of baseline urological symptoms in men and women in the MAPP research cohort
    J Quentin Clemens
    University of Michigan Medical Center, Ann Arbor, Michigan
    J Urol 193:1554-8. 2015
    ..However, to our knowledge no studies have directly compared the characteristics of these syndromes in men and women...
  55. pmc The importance of psychological assessment in chronic pain
    David A Williams
    University of Michigan, USA
    Curr Opin Urol 23:554-9. 2013
    ..Supported by over 30 years of evidence, the bio-psycho-social model acknowledges that psychosocial factors are inherent in chronic pain and require assessment if meaningful diagnostics and treatments are to occur...
  56. ncbi request reprint Relationship between stress and pain in work-related upper extremity disorders: the hidden role of chronic multisymptom illnesses
    Daniel J Clauw
    Division of Rheumatology, Immunology, and Allergy, Georgetown University Medical Center, Washington, DC, USA
    Am J Ind Med 41:370-82. 2002
    ..In such a scenario, the chronic regional pain and other symptoms that the individual is experiencing would be attributable to the CMI rather than to tissue damage or a biomechanical dysfunction of the upper-extremity...
  57. doi request reprint Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises
    Phillip J Mease
    Seattle Rheumatology Associates, Seattle, Washington 98104, USA
    Arthritis Rheum 59:952-60. 2008
    ....
  58. ncbi request reprint Self-reported symptoms before and after September 11 in patients with fibromyalgia
    David A Williams
    JAMA 289:1637-8. 2003
  59. ncbi request reprint Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome
    Willem J Kop
    Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Arthritis Rheum 52:296-303. 2005
    ....
  60. ncbi request reprint Cognitive behavioral therapy and aerobic exercise for Gulf War veterans' illnesses: a randomized controlled trial
    Sam T Donta
    VA Medical Center, Boston, Mass, USA
    JAMA 289:1396-404. 2003
    ..Gulf War veterans' illnesses (GWVI), multisymptom illnesses characterized by persistent pain, fatigue, and cognitive symptoms, have been reported by many Gulf War veterans. There are currently no effective therapies available to treat GWVI...
  61. ncbi request reprint Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls
    Frank Petzke
    Department of Anesthesiology of the University of Cologne, Germany
    Eur J Pain 9:325-35. 2005
    ..Clinical pain in patients with FM was perceived to be more unpleasant than the evoked pain stimuli. These results are consistent with the concept that chronic pain may reduce the relative unpleasantness of evoked pain sensations...
  62. ncbi request reprint Efficacy of milnacipran in patients with fibromyalgia
    R Michael Gendreau
    Cypress Biosciences, 4350 Executive Drive, San Diego, CA 92121, USA
    J Rheumatol 32:1975-85. 2005
    ..Milnacipran, a nontricyclic compound that inhibits the reuptake of both serotonin and norepinephrine, may provide many of the beneficial effects of TCA with a superior side effect profile...
  63. ncbi request reprint Improving physical functional status in patients with fibromyalgia: a brief cognitive behavioral intervention
    David A Williams
    Department of Psychiatry, Georgetown University Medical Center, Washington, DC 20007, USA
    J Rheumatol 29:1280-6. 2002
    ..Sustained improvement in physical functional status was the primary goal of a brief, 6 session cognitive behavioral therapy (CBT) protocol for fibromyalgia (FM)...
  64. doi request reprint Measuring health in patients with fibromyalgia: content comparison of questionnaires based on the International Classification of Functioning, Disability and Health
    Birgit Prodinger
    Vienna University, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria
    Arthritis Rheum 59:650-8. 2008
    ....
  65. ncbi request reprint Endurance training adaptations modulate the redox-force relationship of rat isolated slow-twitch skeletal muscles
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 30:77-81. 2003
    ..We conclude that endurance training-adapted soleus muscles have a slightly altered redox-force relationship...
  66. ncbi request reprint Intestinal permeability and absorption in dogs with traumatic injury
    Elizabeth M Streeter
    Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
    J Vet Intern Med 16:669-73. 2002
    ..Results of this study support the hypothesis that intestinal permeability and absorption are altered in dogs with traumatic injury...
  67. pmc Development and analytic validation of an enzyme-linked immunosorbent assay for the measurement of canine pancreatic lipase immunoreactivity in serum
    Jorg M Steiner
    Gastrointestinal Laboratory, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4474, USA
    Can J Vet Res 67:175-82. 2003
    ..Evaluation of its clinical usefulness for the diagnosis of exocrine pancreatic disorders in dogs is under way...
  68. ncbi request reprint Hyperbaric oxygen increases the contractile function of regenerating rat slow muscles
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia 3010
    Med Sci Sports Exerc 34:630-6. 2002
    ..Human trials of hyperbaric oxygen (HBO) treatment of sports-related muscle injuries are equivocal. Although most human skeletal muscles are composed of mixed muscle fiber types, it is unclear whether HBO affects fiber types differently...
  69. pmc Hydrogen peroxide increases depolarization-induced contraction of mechanically skinned slow twitch fibres from rat skeletal muscles
    David R Plant
    Department of Physiology, University of Melbourne, Victoria 3010, Australia
    J Physiol 539:883-91. 2002
    ..The increase in depolarization-induced contraction in slow twitch fibres might be mediated by an increased SR Ca(2+) release during contraction and/or an increase in Ca(2+) sensitivity...
  70. ncbi request reprint Effects of leukemia inhibitory factor on rat skeletal muscles are modulated by clenbuterol
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Muscle Nerve 25:194-201. 2002
    ..The hypertrophic effects of exogenous LIF on uninjured skeletal muscles indicate that LIF may have application in the treatment of conditions characterized by muscle wasting...
  71. ncbi request reprint Bile acids diagnostic test believed to contain limitations
    Jorg M Steiner
    J Am Vet Med Assoc 223:429; author reply 429-30. 2003
  72. ncbi request reprint Medicine. Gene therapy--new challenges ahead
    David A Williams
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 302:400-1. 2003
    ..reinforces the need to develop even more specific gene therapy interventions...
  73. ncbi request reprint Development and validation of a radioimmunoassay for the measurement of canine pancreatic lipase immunoreactivity in serum of dogs
    Jorg M Steiner
    Gastrointestinal Laboratory, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4474, USA
    Am J Vet Res 64:1237-41. 2003
    ..To develop and validate a radioimmunoassay (RIA) for measuring canine pancreatic lipase immunoreactivity (cPLI) in serum obtained from dogs...
  74. ncbi request reprint Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
    Christopher Baum
    Department of Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Mol Ther 9:5-13. 2004
    ..Based on these considerations, we propose approaches to risk prediction and prevention...
  75. ncbi request reprint Clinical effects of short-term oral budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease
    Joshua W Tumulty
    The Animal Medical Center, E and M Bobst Hospital, Caspary Research Institute, New York, New York 10021 8314, USA
    J Am Anim Hosp Assoc 40:120-3. 2004
    ..Significant suppression of the HPA axis occurred. No significant differences in SAP activity, urine specific gravity, or owner-subjective assessments were detected...
  76. ncbi request reprint Effects of exchange of dietary medium chain triglycerides for long-chain triglycerides on serum biochemical variables and subjectively assessed well-being of dogs with exocrine pancreatic insufficiency
    Gabriele M Rutz
    Gastrointestinal Laboratory, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, USA
    Am J Vet Res 65:1293-302. 2004
    ....
  77. pmc Development and analytical validation of a radioimmunoassay for the measurement of feline pancreatic lipase immunoreactivity in serum
    Jorg M Steiner
    Gastrointestinal Laboratory, Department of Small Animal Clinical Science, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Can J Vet Res 68:309-14. 2004
    ..Further studies to evaluate the clinical usefulness of this assay are needed and in progress...
  78. ncbi request reprint Sustained strenuous exercise increases intestinal permeability in racing Alaskan sled dogs
    Michael S Davis
    Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    J Vet Intern Med 19:34-9. 2005
    ..We conclude that sustained strenuous exercise is associated with increased intestinal permeability, but the sucrose permeability test as we performed it did not correlate with visible gastric lesions...
  79. ncbi request reprint Tylosin-responsive chronic diarrhea in dogs
    Elias Westermarck
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    J Vet Intern Med 19:177-86. 2005
    ..Additional studies are required to identify the specific cause of TRD...
  80. ncbi request reprint Age-relatedchanges in the ultrasound appearance of the normal feline pancreas
    Martha Moon Larson
    Department of Small Animal Clinical Sciences, VA MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    Vet Radiol Ultrasound 46:238-42. 2005
    ..Based on this study, feline pancreatic size and echogenicity do not change with age. Pancreatic duct diameter increases slightly with age and should not be used as a sole indicator of pancreatitis in the geriatric cat...
  81. ncbi request reprint Gene therapy in the treatment of Fanconi anemia, a progressive bone marrow failure syndrome
    David A Williams
    Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Division of Experimental Hematology, Department of Pediatrics, Cincinnati, OH 45229, USA
    Curr Opin Mol Ther 7:461-6. 2005
    ..However, disease-specific characteristics make application of viral vector technology difficult. Multiple studies are currently underway to develop a gene therapy approach for treating this disease, including phase I trials...
  82. ncbi request reprint Fibromyalgia syndrome
    Philip J Mease
    Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
    J Rheumatol 32:2270-7. 2005
    ..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached...
  83. ncbi request reprint Comparison of various doses of carbon 13-labeled aminopyrine for a carbon 13-labeled aminopyrine demethylation blood test in healthy dogs
    E Michael Moeller
    Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A and M University, College Station, 77843, USA
    Am J Vet Res 67:1110-4. 2006
    ..To determine an optimal dose of carbon 13 ((13)C)-labeled aminopyrine for use in a (13)C-aminopyrine demethylation blood test in healthy dogs...
  84. ncbi request reprint Small pituitary size in children with Fanconi anemia
    Rosa Sherafat-Kazemzadeh
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio
    Pediatr Blood Cancer 49:166-70. 2007
    ..Fanconi anemia (FA) is a genetic disorder associated with multiple congenital anomalies, bone marrow failure, and pituitary hypofunction including hypogonadism, thyroid dysfunction, and growth hormone (GH) deficiency...
  85. ncbi request reprint Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity
    Melanie Craven
    Royal Dick School of Veterinary Studies, University of Edinburgh, UK
    J Vet Intern Med 21:917-23. 2007
    ..Their beneficial actions can be offset by gastrointestinal (GI) toxicosis. Endoscopy has traditionally been employed to detect GI lesions, but alterations in GI permeability precede the development of mucosal damage...

Research Grants1

  1. Locus of Pain Control: Neural Substrates & Modifiability
    David Williams; Fiscal Year: 2007
    ..unreadable] [unreadable]..