J A Widness

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Adaptive responses during anemia and its correction in lambs
    J A Widness
    Department of Pediatrics, College of Medicine, The University of Iowa, Iowa City 52242, USA
    J Appl Physiol (1985) 88:1397-406. 2000
  2. doi request reprint Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates
    John A Widness
    Department of Pediatrics, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA Electronic address
    J Pediatr 167:1001-6. 2015
  3. pmc Change in erythropoietin pharmacokinetics following hematopoietic transplantation
    J A Widness
    Department of Pediatrics, The College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Clin Pharmacol Ther 81:873-9. 2007
  4. pmc Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor
    John A Widness
    Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 115:1299-306. 2005
  5. ncbi request reprint Clinical performance of an in-line point-of-care monitor in neonates
    J A Widness
    Department of Pediatrics, Children s Hospital of Iowa, Iowas City, USA
    Pediatrics 106:497-504. 2000
  6. ncbi request reprint Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phlebotomy-induced anemia and bone marrow ablation
    P Veng-Pedersen
    The College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    Biopharm Drug Dispos 25:149-56. 2004
  7. ncbi request reprint Pharmacokinetic/pharmacodynamic analysis of paradoxal regulation of erythropoietin production in acute anemia
    N H Al-Huniti
    Division of Pharmaceutics, The College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 310:202-8. 2004
  8. ncbi request reprint Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics
    S H Chapel
    College of Pharmacy, Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA
    Exp Hematol 29:425-31. 2001
  9. ncbi request reprint Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pathway
    S Chapel
    The Colleges of Pharmacy, Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 298:820-4. 2001
  10. ncbi request reprint Erythropoietin production rate in phlebotomy-induced acute anemia
    N H Al-Huniti
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Biopharm Drug Dispos 25:389-97. 2004

Research Grants

  1. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007

Detail Information

Publications53

  1. ncbi request reprint Adaptive responses during anemia and its correction in lambs
    J A Widness
    Department of Pediatrics, College of Medicine, The University of Iowa, Iowa City 52242, USA
    J Appl Physiol (1985) 88:1397-406. 2000
    ..We speculate that plasma Epo and blood lactate concentrations may be useful measures of clinically significant anemia in infants and may indicate when an infant might benefit from a RBC transfusion...
  2. doi request reprint Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates
    John A Widness
    Department of Pediatrics, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA Electronic address
    J Pediatr 167:1001-6. 2015
    ....
  3. pmc Change in erythropoietin pharmacokinetics following hematopoietic transplantation
    J A Widness
    Department of Pediatrics, The College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Clin Pharmacol Ther 81:873-9. 2007
    ..The association of EPO elimination with decreased bone marrow activity in patients undergoing transplantation conclusively establishes the bone marrow as a key determinant of EPO elimination in humans...
  4. pmc Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor
    John A Widness
    Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 115:1299-306. 2005
    ..To date, researchers have had only limited success in finding ways to reduce transfusions significantly in this patient population...
  5. ncbi request reprint Clinical performance of an in-line point-of-care monitor in neonates
    J A Widness
    Department of Pediatrics, Children s Hospital of Iowa, Iowas City, USA
    Pediatrics 106:497-504. 2000
    ..To evaluate the bias, precision, and blood loss characteristics of an ex vivo in-line point-of-care testing blood gas and electrolyte monitor designed for use in critically ill newborn infants...
  6. ncbi request reprint Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phlebotomy-induced anemia and bone marrow ablation
    P Veng-Pedersen
    The College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    Biopharm Drug Dispos 25:149-56. 2004
    ..The objective was to study in vivo erythropoietin (Epo) progenitor cell surface receptors (EpoR) in the bone marrow (BM) after phlebotomy and bone marrow ablation...
  7. ncbi request reprint Pharmacokinetic/pharmacodynamic analysis of paradoxal regulation of erythropoietin production in acute anemia
    N H Al-Huniti
    Division of Pharmaceutics, The College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 310:202-8. 2004
    ..The hypothesis was supported by a PK/PD feedback inhibition model that showed good agreement with the data (r = 0.973 +/- 1.57)...
  8. ncbi request reprint Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics
    S H Chapel
    College of Pharmacy, Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA
    Exp Hematol 29:425-31. 2001
    ....
  9. ncbi request reprint Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pathway
    S Chapel
    The Colleges of Pharmacy, Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 298:820-4. 2001
    ..The present study indicates that the bone marrow significantly contributes to the elimination of EPO in vivo...
  10. ncbi request reprint Erythropoietin production rate in phlebotomy-induced acute anemia
    N H Al-Huniti
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Biopharm Drug Dispos 25:389-97. 2004
    ..To estimate the rate of erythropoietin (EPO) production under physiological, conditions and to examine the regulatory mechanism of EPO production in response to acute phlebotomy-induced anemia...
  11. ncbi request reprint A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep
    P Veng-Pedersen
    The Colleges of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 306:532-7. 2003
    ..The larger dominance of the nonhematopoietic EpoR in lamb supports the hypothesis that these receptors are more needed in early life, e.g., providing neuroprotection from perinatal hypoxemic-ischemic episodes...
  12. ncbi request reprint Neonatal laboratory blood sampling: comparison of results from arterial catheters with those from an automated capillary device
    K J Johnson
    University of Iowa Hospitals and Clinics, Department of Pediatrics, W226 GH 200 Hawkins Drive, Iowa City, IA 52242, USA
    Neonatal Netw 19:27-34. 2000
    ..To compare neonatal laboratory results from capillary blood samples drawn using the Tenderfoot automated capillary sampling device with those drawn through arterial catheters...
  13. pmc A 'bottom-up' approach for endo-PK/PD analysis
    S Neelakantan
    College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Biopharm Drug Dispos 27:313-27. 2006
    ..The proposed approach provides a rational informative starting point for developing parametric PK/PD models to resolve the complex endo-PK/PD of recombinant drugs...
  14. ncbi request reprint Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants
    K M Shannon
    Department of Pediatrics, University of California, San Francisco 94143 0724, USA
    Pediatrics 95:1-8. 1995
    ..All patients received oral iron and were managed according to uniform conservative transfusion guidelines...
  15. ncbi request reprint An integrated pharmacodynamic analysis of erythropoietin, reticulocyte, and hemoglobin responses in acute anemia
    P Veng-Pedersen
    University of Iowa, College of Pharmacy, Division of Pharmaceutics, Iowa City, Iowa, 52242, USA
    Pharm Res 19:1630-5. 2002
    ..To determine by pharmacodynamic (PD) analysis physiologically relevant parameters of the cellular kinetics of erythropoiesis in acute anemia...
  16. ncbi request reprint Correction for non-ideal tracer pharmacokinetic disposition by disposition decomposition analysis (DDA)
    P Veng-Pedersen
    The College of Pharmacy, Department of Pharmaceutics, The University of Iowa, Iowa City 52242, USA
    Pharm Res 15:1469-73. 1998
    ..This assumption is often violated. The aim of this work is to present a method enabling the ideal tracer PK, i.e. the PK of the parent compound, to be predicted from the non-ideal tracer...
  17. ncbi request reprint Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants
    Ashima Madan
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Perinatol 25:21-5. 2005
    ....
  18. pmc Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants
    Kevin J Freise
    Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 332:229-37. 2010
    ..5 mU/ml and maximal Hb production rate (E(max)) indicated that a severalfold increase in Hb production rate could be achieved with only a modest increase in plasma EPO concentrations...
  19. pmc Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a tracer interaction methodology
    Mohammed H El-Komy
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, 115 S Grand Ave, Iowa City, IA 52242, USA
    Drug Metab Dispos 39:603-9. 2011
    ..Taken together, these differences favor a more efficacious and prolonged action for CERA...
  20. pmc Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants
    Edward F Bell
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Pediatrics 115:1685-91. 2005
    ..The objective of this study was to determine if restrictive guidelines for red blood cell (RBC) transfusions for preterm infants can reduce the number of transfusions without adverse consequences...
  21. pmc Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions
    Peg C Nopoulos
    University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Arch Pediatr Adolesc Med 165:443-50. 2011
    ..To assess the long-term outcome of brain structure in preterm infants, at an average age of 12 years, who received a red blood cell transfusion for anemia of prematurity...
  22. pmc Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity?
    Ronald G Strauss
    Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Transfus Med Rev 24:125-9. 2010
    ....
  23. pmc Pharmacokinetic differentiation of drug candidates using system analysis and physiological-based modelling. Comparison of C.E.R.A. and erythropoietin
    Peter Veng-Pedersen
    College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharm Pharmacol 60:1321-34. 2008
    ..E.R.A. shows Epo-receptor binding with a lower association constant and a larger dissociation constant...
  24. pmc How fast is too fast? a practice change in umbilical arterial catheter blood sampling using the Iowa Model for Evidence-Based Practice
    Myrna Gordon
    University of Iowa Children s Hospital, University of Iowa Hospitals and Clinics, Iowa, USA
    Adv Neonatal Care 8:198-207. 2008
    ..Using this research as a guide, along with expert opinion, scientific principles, and theories, a new standard of practice was written, and the staff educated...
  25. pmc Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
    Ronald G Strauss
    Department of Pathology and Pediatrics, University of Iowa Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1009, USA
    Transfusion 44:871-6. 2004
    ..We measured the posttransfusion recovery and intravascular survival of allogeneic RBCs stored up to 42 days to further elucidate their efficacy...
  26. ncbi request reprint Microanalysis of non-heme iron in animal tissues
    Charles J Rebouche
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Biochem Biophys Methods 58:239-51. 2004
    ..The new method was more sensitive, required less time, and was less cumbersome than the three published methods to which it was compared...
  27. pmc The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time
    K J Freise
    College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    Int J Lab Hematol 31:496-504. 2009
    ..Diluted samples did not change further over 4 h at room temperature. With a 1 : 5 dilution, analysis of 40 microl of cord blood stored for 3 days at room temperature may provide useful hematologic information with little phlebotomy loss...
  28. ncbi request reprint Cost-effectiveness of a limited-donor blood program for neonatal red cell transfusions
    P Hilsenrath
    Department of Preventive Medicine, College of Medicine, University of Iowa, Iowa City 52242, USA
    Transfusion 39:938-43. 1999
    ..Recently, to limit donor exposures, large volumes of RBCs are reserved for the long-term transfusion support of individual infants...
  29. pmc Modeling time variant distributions of cellular lifespans: increases in circulating reticulocyte lifespans following double phlebotomies in sheep
    Kevin J Freise
    College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharmacokinet Pharmacodyn 35:285-323. 2008
    ....
  30. pmc Pharmacodynamic analysis of time-variant cellular disposition: reticulocyte disposition changes in phlebotomized sheep
    Kevin J Freise
    Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharmacokinet Pharmacodyn 34:519-47. 2007
    ..The determined increase in reticulocyte residence time produced under stress erythropoiesis is similar to the commonly reported 2- to 3-fold increase observed in human patients...
  31. pmc Increased erythropoietin elimination in fetal sheep following chronic phlebotomy
    Kevin J Freise
    College of Pharmacy, The University of Iowa, 115 S Grand Ave, Iowa City, Iowa 52242, USA
    Pharm Res 24:1653-9. 2007
    ..To determine by pharmacokinetic (PK) means the role of erythropoietin-receptor (EPO-R) upregulation in fetuses on the elimination of erythropoietin (EPO)...
  32. ncbi request reprint Erythrocyte iron incorporation but not absorption is increased by intravenous iron administration in erythropoietin-treated premature infants
    John A Widness
    Department of Pediatrics, Barbara Bush Children s Hospital at Maine Medical Center, Portland, ME, USA
    J Nutr 136:1868-73. 2006
    ..We conclude that IV sucrose Fe administered in combination with EPO to very-low-birth weight premature infants significantly increases RBC Fe incorporation and erythropoiesis more than EPO alone, but without increasing iron absorption...
  33. ncbi request reprint Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis
    Nidal H Al-Huniti
    College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharmacokinet Pharmacodyn 32:359-76. 2005
    ....
  34. ncbi request reprint Endogenous and recombinant erythropoietin levels decline in human amniotic fluid and fetal plasma in vitro at 37 degrees C
    Nicole M Schmidt
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    J Perinatol 24:218-22. 2004
    ..To determine the in vitro stability of endogenous and recombinant erythropoietin (EPO) incubated at 37 degrees C in amniotic fluid (AF) and fetal plasma...
  35. ncbi request reprint Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia
    David G Lott
    Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 116:414-22. 2005
    ....
  36. ncbi request reprint Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor
    S M Zeng
    Department of Obstetrics and Gynecology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242-1080, USA
    J Gend Specif Med 4:35-40. 2001
    ..These findings offer new clues to understanding Hct variation in the general population and to elucidating mechanisms of controlling Hct levels...
  37. pmc Evidence of receptor-mediated elimination of erythropoietin by analysis of erythropoietin receptor mRNA expression in bone marrow and erythropoietin clearance during anemia
    Demet Nalbant
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 333:528-32. 2010
    ..Together, these findings provide strong evidence that receptor-mediated Epo clearance is an important route for Epo's elimination...
  38. pmc Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia
    Srividya Neelakantan
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Int 51:25-32. 2009
    ..The purpose of the present preclinical study in sheep was to elucidate the stimulatory effect of EPO on erythroid progenitors and their differentiation into reticulocytes useful in predicting optimal r-HuEPO dosing...
  39. pmc Pharmacodynamic modeling of the effect of changes in the environment on cellular lifespan and cellular response
    Kevin J Freise
    College of Pharmacy, University of Iowa, 115 S Grand Ave, Iowa City, IA, 52242, USA
    J Pharmacokinet Pharmacodyn 35:527-52. 2008
    ..These PD models have potential applications in hematological management of end-stage renal disease, transfusion medicine, and patients undergoing chemotherapy, among other diseases and therapies...
  40. ncbi request reprint Posttransfusion recovery of stored red blood cells in very low birth weight infants using a hemoglobin balance model
    Anne Grete Bechensteen
    Department of Pediatrics, University of Iowa, College of Medicine, Iowa City, Iowa, USA
    Transfusion 44:1019-24. 2004
    ..A Hb balance model was used in very low birth weight (VLBW) infants to predict posttransfusion Hb levels from which we inferred allogeneic RBC recovery after transfusion of RBCs stored for varying periods of time...
  41. pmc The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations
    Ashajyothi M Siddappa
    Division of Neonatology, Hennepin County Medical Center, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minn, USA
    Neonatology 92:73-82. 2007
    ..The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abnormal iron status in the neonatal period...
  42. ncbi request reprint Expanded Möbius syndrome
    D Peleg
    Department of Obstetrics and Gynecology, The University of Iowa, Iowa City, Iowa, USA
    Pediatr Neurol 24:306-9. 2001
    ..Together these finding are compatible with a diagnosis of expanded Möbius syndrome...
  43. ncbi request reprint Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level
    She Min Zeng
    Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
    J Gend Specif Med 6:36-42. 2003
    ..The Bcl-2 family mediates erythropoietin-dependent survival of erythroid progenitor cells and regulates erythropoiesis. We assessed for any association between Bcl-2 family nucleotide variation and hematocrit (HCT) in healthy blood donors...
  44. ncbi request reprint Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products
    Talkad S Raghuveer
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 52:964-72. 2002
    ..Whether iron-containing formula with lactoferrin administered enterally to preterm infants will result in less free radical generation in vivo has yet to be established...
  45. ncbi request reprint Cost analysis of a neonatal point-of-care monitor
    Joseli A Alves-Dunkerson
    Department of Health Management and Policy, College of Medicine, University of Iowa, Iowa City, USA
    Am J Clin Pathol 117:809-18. 2002
    ..Because most cost savings result from offsetting indirect costs (eg, building space and hospital overhead) that are of a longer term nature, short-run cost savings are less likely to be realized...
  46. ncbi request reprint Long-term neurodevelopmental outcome and brain volume after treatment for hydrops fetalis by in utero intravascular transfusion
    Dennis C Harper
    Department of Pediatric, The University of Iowa, College of Medicine, Iowa City, IA 52242 1011, USA
    Am J Obstet Gynecol 195:192-200. 2006
    ....
  47. pmc Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  48. ncbi request reprint Red cell mass responses to daily erythropoietin and iron injections in the ovine fetus
    Lingna Zhang
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093 0802, USA
    Am J Obstet Gynecol 186:315-20. 2002
    ..The present study tested the hypothesis that nonanemic fetuses that were supplemented with daily intra-amniotic iron plus intravascular injections of erythropoietin would experience accelerated erythrocyte production...
  49. ncbi request reprint Increased wave latency in auditory brainstem response to anemia in newborn and adult sheep
    Rafael E Quiñónez
    Medical Sciences Campus, College of Health Related Professions, University of Puerto Rico, San Juan, P R, USA
    Biol Neonate 84:179-86. 2003
    ..We speculate that ABR wave latency prolongation might serve as an indicator of the need for red blood cell transfusion...
  50. ncbi request reprint Renal and placental secretion of erythropoietin during anemia or hypoxia in the ovine fetus
    Lowell E Davis
    Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, OR, USA
    Am J Obstet Gynecol 189:1764-70. 2003
    ..This study tested to what extent in vivo EPO secretion by the fetal kidneys and placenta can be demonstrated under normoxic and hypoxic conditions...
  51. ncbi request reprint Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep
    Robert A Brace
    Department of Reproductive Medicine, University of California, San Diego, CA, USA
    Am J Obstet Gynecol 195:246-54. 2006
    ....
  52. ncbi request reprint Temporal response of plasma erythropoietin to hemorrhage in the ovine fetus
    Sa Jin Kim
    Division of Perinatal Medicine, Department of Reproductive Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0802, USA
    J Soc Gynecol Investig 9:75-9. 2002
    ..The present study in fetal sheep was designed to determine in detail the time course of the hemorrhage-induced changes in plasma EPO levels and explore the relationships among EPO concentration, blood oxygen tension, and hematocrit...
  53. ncbi request reprint Clinical performance of an in-line, ex vivo point-of-care monitor: a multicenter study
    Glenn F Billman
    Department of Pathology, Children s Hospital of San Diego, San Diego, CA 92123, USA
    Clin Chem 48:2030-43. 2002
    ..An objective of attached point-of-care patient monitoring is to provide clinically relevant data without the adverse consequences associated with serial phlebotomy...

Research Grants1

  1. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007
    ..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..