Cara J Westmark

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The quest for fragile X biomarkers
    Cara J Westmark
    Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cell Pediatr 1:1. 2014
  2. pmc Soy infant formula and seizures in children with autism: a retrospective study
    Cara J Westmark
    Department of Neurology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 9:e80488. 2014
  3. pmc Soy-based diet exacerbates seizures in mouse models of neurological disease
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 33:797-805. 2013
  4. doi request reprint What's hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders
    C J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Madison, WI 53705, USA
    Mol Psychiatry 18:425-34. 2013
  5. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
  6. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
  7. pmc The regulation of AβPP expression by RNA-binding proteins
    Cara J Westmark
    University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705, USA
    Ageing Res Rev 11:450-9. 2012
  8. pmc Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e26549. 2011
  9. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
  10. pmc Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, USA
    J Vis Exp . 2011

Collaborators

  • Corinna Burger
  • Pamela R Westmark
  • James S Malter
  • Athavi Jeevananthan
  • Kenneth J O'Riordan
  • Jonathan Levenson
  • Suqing Wang
  • Hyun C Shin
  • Syrus R Soltaninassab
  • Emily K Reinke

Detail Information

Publications16

  1. pmc The quest for fragile X biomarkers
    Cara J Westmark
    Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cell Pediatr 1:1. 2014
    ..Multiple recent clinical trials have failed on their primary endpoints indicating that there is a compelling need for validated biomarkers and outcome measures in fragile X...
  2. pmc Soy infant formula and seizures in children with autism: a retrospective study
    Cara J Westmark
    Department of Neurology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 9:e80488. 2014
    ..Given the lack of data on critical confounders and the retrospective nature of the study, a prospective study is required to confirm the association. ..
  3. pmc Soy-based diet exacerbates seizures in mouse models of neurological disease
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 33:797-805. 2013
    ..Thus, the soy isoflavone daidzein recapitulated seizure induction in vivo and altered AβPP expression in vitro. These results have important implications for individuals on soy-based diets as well as for rodent model research...
  4. doi request reprint What's hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders
    C J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Madison, WI 53705, USA
    Mol Psychiatry 18:425-34. 2013
    ....
  5. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
    ..These data suggest that Abeta contributes to seizure incidence and may be an appropriate therapeutic target to lessen seizure pathology in FXS, Alzheimer's disease (AD) and Down syndrome (DS) patients...
  6. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
    ..Our data strongly implicates AbetaPP or a catabolite in seizure susceptibility and suggests that mGluR5 mediates this response...
  7. pmc The regulation of AβPP expression by RNA-binding proteins
    Cara J Westmark
    University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705, USA
    Ageing Res Rev 11:450-9. 2012
    ....
  8. pmc Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e26549. 2011
    ..Evolving therapies directed at reducing Aβ in AD may be applicable to FXS and Aβ may serve as a plasma-based biomarker to facilitate disease diagnosis or assess therapeutic efficacy...
  9. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
    ..Our data indicate that postsynaptic FMRP binds to and regulates the translation of APP mRNA through metabotropic glutamate receptor activation and suggests a possible link between Alzheimer disease and fragile X syndrome...
  10. pmc Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, USA
    J Vis Exp . 2011
    ..The Percoll-sucrose gradient method is quick and gentle as it employs isotonic conditions, has fewer and shorter centrifugation spins and avoids centrifugation steps that pellet SNs and cause mechanical damage...
  11. ncbi request reprint HuR mRNA ligands expressed after seizure
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neuropathol Exp Neurol 64:1037-45. 2005
    ..These results demonstrate a biochemical approach to identify and characterize the diverse repertoire of ligands for HuR and other regulatory mRNA-binding proteins...
  12. ncbi request reprint Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 27:787-96. 2006
    ....
  13. pmc Pin1 and PKMzeta sequentially control dendritic protein synthesis
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Sci Signal 3:ra18. 2010
    ..PKMzeta interacted with and inhibited Pin1 by phosphorylating serine 16. Therefore, glutamate-induced, dendritic protein synthesis is sequentially regulated by Pin1 and PKMzeta signaling...
  14. pmc Seizure susceptibility and mortality in mice that over-express amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin Madison, WI 53705, USA
    Int J Clin Exp Pathol 1:157-68. 2008
    ..9-2.9). Seizures are a major phenotype of AD, FXS, Down syndrome, autism and epilepsy, and these data suggested that developmental over-expression of dendritic APP or Abeta increased seizure susceptibility...
  15. pmc APP Causes Hyperexcitability in Fragile X Mice
    Cara J Westmark
    Department of Neurology, University of Wisconsin Madison, Madison Madison, WI, USA
    Front Mol Neurosci 9:147. 2016
    ..These findings are discussed in relation to novel treatment approaches to restore APP homeostasis in FXS...