R C Wester
Affiliation: University of California
- Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects of heat-separation and freezingR C Wester
Department of Dermatology, University of California, San Francisco 94143, USA
Pharm Res 15:82-4. 1998..Skin storage maintenance and confirmation of skin viability is important for both uses, especially for the absorption process where the in vivo situation is simulated...
- In vivo percutaneous absorption of arsenic from water and CCA-treated wood residueRonald C Wester
University of California, San Francisco, Dermatology Department, PO Box 0989, San Francisco, California 94143 0989, USA
Toxicol Sci 79:287-95. 2004..Additionally, the results show that arsenic is poorly absorbed from CCA-treated wood residues (i.e., does not result in urinary arsenic excretion above background levels)...
- Polymers effect on estradiol partition coefficient between powdered human stratum corneum and waterRonald C Wester
Dermatology Department, University of California, San Francisco, California 94143 0989, USA
J Pharm Sci 91:2642-5. 2002..01) in log PC for estradiol concentrations. Thus, a macromolecular chemical has the potential to alter the partitioning of chemical into the outer layers of skin, the first step in percutaneous absorption...
- Human in vivo and in vitro hydroquinone topical bioavailability, metabolism, and dispositionR C Wester
Department of Dermatology, University of California, San Francisco 94143 0989, USA
J Toxicol Environ Health A 54:301-17. 1998..Risk assessment should not only involve the bioavailability of intact topical hydroquinone, but also consider phase I and phase II metabolism in both humans and any animal for which toxicity potential was assessed...
- In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plateXiaoying Hui
Department of Dermatology, University of California San Francisco, Box 0989, 90 Medical Center Way, San Francisco, California 94143, USA
J Pharm Sci 96:2622-31. 2007..AN2690 has superior penetration compared to ciclopirox, and achieves levels within and under the nail plate that suggest it has the potential to be an effective topical treatment for onychomycosis...
- Enhanced human nail drug delivery: nail inner drug content assayed by new unique methodXiaoying Hui
Department of Dermatology, University of California, San Francisco, California 94143, USA
J Pharm Sci 91:189-95. 2002..The assay system has the unique characteristic of being able to assay the inner part of the nail where the disease resides...
- Ciclopirox delivery into the human nail plateXiaoying Hui
Department of Dermatology, University of California San Francisco, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, CA 94143, USA
J Pharm Sci 93:2545-8. 2004..The formulation plays an important role in the enhancement of ciclopirox permeation into and through the human nail plate, and the concentration of ciclopirox in the formulation was not a factor in determining penetration...
- Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolaneXiaoying Hui
Department of Dermatology, University of California San Francisco, Surge pound 110, Box 0989, 90 Medical Center Way, San Francisco, California 94143 0989, USA
J Pharm Sci 92:142-8. 2003..In a subsequent study, [(14)C]-dioxolane did not penetrate the nail well. Therefore, the mechanism of enhancement of econazole penetration is at the formulation/nail interface...
- In vitro percutaneous absorption of benzene in human skinXiaoying Hui
Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Cutan Ocul Toxicol 28:65-70. 2009..6 times. These data place into partial perspective the role of occlusion in benzene flux, but should not be generalized until other volatile substances are studied in the experimental system and further validated with in vivo systems...
- Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urineS D Gilman
Department of Entomology, University of California, Davis 95616, USA
Anal Chem 70:3463-9. 1998..7%, and the day-to-day reproducibility of the AMS measurements is 3.9%. Factors limiting AMS detection limits for these samples and ways in which these can be improved are examined...
- In vivo human transfer of topical bioactive drug between individuals: estradiolRonald C Wester
Department of Dermatology, School of Medicine, University of California San Francisco, 94143, USA
J Invest Dermatol 126:2190-3. 2006..It is important for prescribing physicians and patients to understand that clinically significant transfer of topical bioactive drugs can occur. This may be particularly important for substances which may produce inadvertent effects...
- In vitro human nail penetration and kinetics of panthenolX Hui
University of California San Francisco, San Francisco, CA 94143, USA
Int J Cosmet Sci 29:277-82. 2007..The film acts not only as a reservoir of panthenol, but also acts to increase the hydration of the nail and the thermodynamic activity of panthenol as well, thereby enhancing diffusion...
- Percutaneous absorption of arsenic from environmental mediaYvette W Lowney
Exponent, 4940 Pearl East Circle, Suite 300, Boulder, CO 80301, USA
Toxicol Ind Health 21:1-14. 2005..We conclude that there are likely to be many site- or sample-specific factors that will control the absorption of arsenic, and matrix-specific analyses may be required to understand the degree of percutaneous absorption...
- Dermal absorption of arsenic from soils as measured in the rhesus monkeyYvette W Lowney
Exponent, Boulder, CO, USA
Toxicol Sci 100:381-92. 2007..Our findings suggest that dermal absorption of arsenic from soil is truly negligible, and that EPA's current default assumption of 3% dermal absorption of arsenic from soils results in significant overestimates of exposure...
- Partition coefficients for benzene in human skinGeorgia C Sinclair
Deakin University, P O Box 210, Glen Iris, Victoria 3146, Australia
AIHA J (Fairfax, Va) 63:685-8. 2002..2), benzene : water (109/126), and benzene : blood substitute (55/59) also were determined for the purposes of validating the blood substitute: viable epidermis and blood substitute : dermis partition coefficients...
- PBPK modeling of the percutaneous absorption of perchloroethylene from a soil matrix in rats and humansTorka S Poet
Battelle, Pacific Northwest Division, P O Box 999, Richland, Washington 99352, USA
Toxicol Sci 67:17-31. 2002..In real-world situations, percutaneous absorption of PCE is likely to be minimal...