Michael W Weiner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Leon Thal's vision for the treatment and prevention of Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Disease, VA Medical Center, University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 4:S150-2. 2008
  2. doi request reprint The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment
    R Scott Mackin
    Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA Department of Psychiatry, University of California, San Francisco, CA Electronic address
    Am J Geriatr Psychiatry 21:906-14. 2013
  3. pmc Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment
    Niklas Mattsson
    1 Department of Veterans Affairs Medical Centre, Centre for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Brain 137:1550-61. 2014
  4. pmc The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 9:e111-94. 2013
  5. pmc Nonlinear time course of brain volume loss in cognitively normal and impaired elders
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases and VA Medical Center, San Francisco, CA, USA
    Neurobiol Aging 33:845-55. 2012
  6. pmc Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI
    Linda L Chao
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America linda chao ucsf edu
    PLoS ONE 8:e65175. 2013
  7. pmc Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease
    Katherine P Rankin
    University of California San Francisco, San Francisco, CA, USA
    J Mol Neurosci 45:594-608. 2011
  8. pmc Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, USA
    Alzheimers Dement 7:514-20. 2011
  9. pmc Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data
    Duygu Tosun
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Alzheimers Dis 26:77-90. 2011
  10. doi request reprint The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement . 2016

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. pmc Leon Thal's vision for the treatment and prevention of Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Disease, VA Medical Center, University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 4:S150-2. 2008
  2. doi request reprint The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment
    R Scott Mackin
    Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA Department of Psychiatry, University of California, San Francisco, CA Electronic address
    Am J Geriatr Psychiatry 21:906-14. 2013
    ..To assess the effect of subsyndromal symptoms of depression (SSD) on ratings of disability for individuals with mild cognitive impairment (MCI)...
  3. pmc Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment
    Niklas Mattsson
    1 Department of Veterans Affairs Medical Centre, Centre for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Brain 137:1550-61. 2014
    ..Amyloid-β pathology has different associations with cerebral blood flow and volume, and may cause more loss of blood flow in early stages, whereas volume loss dominates in late disease stages. ..
  4. pmc The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 9:e111-94. 2013
    ..The ADNI study was extended by a 2-year Grand Opportunities grant in 2009 and a renewal of ADNI (ADNI-2) in October 2010 through to 2016, with enrollment of an additional 550 participants. ..
  5. pmc Nonlinear time course of brain volume loss in cognitively normal and impaired elders
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases and VA Medical Center, San Francisco, CA, USA
    Neurobiol Aging 33:845-55. 2012
    ..The approach has potential uses for early detection of AD and differentiation between stable and progressing MCI...
  6. pmc Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI
    Linda L Chao
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America linda chao ucsf edu
    PLoS ONE 8:e65175. 2013
    ....
  7. pmc Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease
    Katherine P Rankin
    University of California San Francisco, San Francisco, CA, USA
    J Mol Neurosci 45:594-608. 2011
    ..Despite a remarkable overlap between the two patient types, bvFTD patients with underlying CBD pathology show subtle clinical features that may distinguish them from patients with Pick's disease neuropathology...
  8. pmc Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, USA
    Alzheimers Dement 7:514-20. 2011
    ..No studies have considered the effects of amyloid pathology and APOE ɛ4 together on longitudinal volume loss...
  9. pmc Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data
    Duygu Tosun
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Alzheimers Dis 26:77-90. 2011
    ....
  10. doi request reprint The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement . 2016
    ..The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI-3, which began on August 1, 2016, is a 5-year renewal of the current ADNI-2 study...
  11. pmc The transitional association between β-amyloid pathology and regional brain atrophy
    Philip S Insel
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Electronic address
    Alzheimers Dement 11:1171-9. 2015
    ..To determine the relationship between Aβ and atrophy, we compared the performance of the usual dichotomization of cerebrospinal fluid (CSF) Aβ to identify subjects as Aβ+ and Aβ- with a trilinear spline model of CSF Aβ...
  12. pmc Different structural correlates for verbal memory impairment in temporal lobe epilepsy with and without mesial temporal lobe sclerosis
    Susanne G Mueller
    Department of Radiology, Center for Imaging of Neurodegenerative Diseases, University of California, San Francisco, CA 94121, USA
    Hum Brain Mapp 33:489-99. 2012
    ..It was hypothesized that volume loss in different subfields determines memory impairment in TLE-MTS and temporal neocortical thinning in TLE-no...
  13. doi request reprint Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    Neurotoxicology 32:814-22. 2011
    ..5T MR scanner. In this study, we reexamine the relationship between GB/GF exposure and volumetric measurements of gross neuroanatomical structures in a different cohort of GW veterans on a 4T MR scanner...
  14. pmc Different associations of white matter lesions with depression and cognition
    Jun Young Lee
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    BMC Neurol 12:83. 2012
    ....
  15. pmc Changes in brain anatomy during the course of posttraumatic stress disorder
    Valerie A Cardenas
    San Francisco Veterans Affairs Medical Center, San Francisco, CA, CA 94121 United States
    Psychiatry Res 193:93-100. 2011
    ..Lastly, for the sample as a whole, greater rates of brain atrophy were associated with greater rates of decline in verbal memory and delayed facial recognition...
  16. pmc Genome-wide interaction analysis reveals replicated epistatic effects on brain structure
    Derrek P Hibar
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 36:S151-8. 2015
    ..Each additional loading in the interaction effect was associated with approximately 5% greater brain regional brain volume (a protective effect) in both Alzheimer's Disease Neuroimaging Initiative and Queensland Twin Imaging samples. ..
  17. doi request reprint 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement 11:e1-120. 2015
    ....
  18. pmc Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Alzheimers Dement 11:865-84. 2015
    ..The Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for AD clinical trials...
  19. pmc The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:S1-68. 2012
    ..The ADNI study was extended by a 2-year Grand Opportunities grant in 2009 and a renewal of ADNI (ADNI-2) in October 2010 through to 2016, with enrollment of an additional 550 participants...
  20. pmc MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 59:2098-109. 2012
    ....
  21. pmc CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects
    Michael Ewers
    Department of Radiology, University of California, San Francisco, 94143, USA
    Cereb Cortex 22:1993-2004. 2012
    ....
  22. pmc Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA, USA
    Amyotroph Lateral Scler 12:421-9. 2011
    ..In conclusion, longitudinal DTI study captures progression of upper motor fiber degeneration in ALS. DTI can be useful for monitoring ALS progression and efficacy of treatment interventions...
  23. pmc Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases and Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Neurol 258:603-12. 2011
    ..This reduces their value for focus lateralization and suggests a heterogeneous etiology of extrahippocampal spectroscopic metabolic abnormalities in TLE...
  24. pmc MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes
    Yu Zhang
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA 94121, USA
    J Alzheimers Dis 33:431-44. 2013
    ..The findings suggest that DTI in general and radial diffusivity in particular are more powerful measures for the classification of FTLD patients from controls than brain atrophy...
  25. pmc Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures
    Liana G Apostolova
    From the Departments of Neurology L G A, K S H, D A, O K, E T, P M T, Medicine Statistics Core D E, and School of Nursing S S, David Geffen School of Medicine at University of California, Los Angeles Institute for Neuroinformatics P M T, Keck School of Medicine, University of Southern California, Los Angeles Veterans Affairs Greater Los Angeles Healthcare System E T Department of Diagnostic Radiology C R J, Mayo Clinic, Rochester, MN Department of Public Health and Neuroscience W J J, University of California, Berkeley Department of Pathology and Laboratory Medicine L S, J Q T, University of Pennsylvania School of Medicine, Philadelphia Department of Radiology M W W, University of California, San Francisco and Department of Veterans Affairs Medical Center M W W, San Francisco, CA
    Neurology 84:729-37. 2015
    ..The goal of this study was to identify a clinical biomarker signature of brain amyloidosis in the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) mild cognitive impairment (MCI) cohort...
  26. pmc Diffusion weighted imaging-based maximum density path analysis and classification of Alzheimer's disease
    Talia M Nir
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 36:S132-40. 2015
    ..As an MDP is a compact low-dimensional representation of white matter organization, we tested the utility of diffusion tensor imaging measures along these MDPs as features for support vector machine based classification of AD. ..
  27. doi request reprint Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment
    Rachel L Nosheny
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Electronic address
    Neurobiol Aging 36:273-82. 2015
    ..Therefore, we conclude that even when accounting for other covariates, Aβ status, and not age, is a significant predictor of HAR; and that most of the HAR is not accounted for by Aβ status in either NC or MCI. ..
  28. pmc Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis
    Cathy Scanlon
    Center for Imaging of Neurodegenerative Diseases and Department of Radiology, University of California, San Francisco, CA, USA
    J Neurol 260:2320-9. 2013
    ..The microstructural organization in the corpus callosum was related to hippocampal volume in both patients and healthy subjects demonstrating the association of these distal regions...
  29. ncbi request reprint Military risk factors for cognitive decline, dementia and Alzheimer's disease
    Dallas P Veitch
    Center for Imaging of Neurodegenerative Diseases, Veterans Medical Center and Departments of Radiology, Medicine, Psychiatry and Neurology, University of California, San Francisco, San Francisco, CA, USA
    Curr Alzheimer Res 10:907-30. 2013
    ....
  30. pmc The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, VA Medical Center, 4150 Clement Street 114M, San Francisco, CA 94121, USA
    Mil Med 176:896-902. 2011
    ..Veterans with GWI had significantly higher rates of post-traumatic stress disorder, supporting the idea that GWI symptoms are stress related...
  31. pmc Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Department of Veterans Affairs Medical Centre, 4150 Clement Street, Building 13, 114 M, San Francisco, CA 94121, USA
    Brain 134:1077-88. 2011
    ....
  32. pmc Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging
    Wang Zhan
    Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
    Mov Disord 27:90-7. 2012
    ..Our data suggest that microstructural alterations detected with diffusion tensor might serve as a potential biomarker for PD...
  33. pmc Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly
    Priya Rajagopalan
    Laboratory of Neuro Imaging, Department of Neurology, Imaging Genetics Center, UCLA School of Medicine, Los Angeles, CA, USA
    Neuroreport 24:58-62. 2013
    ..Greater brain atrophy may occur in people with central leptin insufficiency, a marker of obesity. Therapeutic manipulation of leptin may be a promising direction for slowing brain decline...
  34. pmc Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
    Radiology 259:844-51. 2011
    ..To determine whether automated temporoparietal brain volumes can be used to accurately predict future memory decline among a multicenter cohort of cognitively healthy elderly individuals...
  35. pmc Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response
    R Scott Mackin
    Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, University of California, San Francisco, CA Department of Psychiatry, University of California, San Francisco, CA Electronic address
    Am J Geriatr Psychiatry 21:794-802. 2013
    ..This study was conducted to evaluate patterns of cortical thickness in LLD and in relation to psychotherapy treatment outcomes...
  36. pmc Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease
    Niklas Mattsson
    1 Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden 2 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA 3 Department of Veterans Affairs Medical Centre, Centre for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Brain 138:772-83. 2015
    ..Reduced cerebrospinal fluid amyloid-β may be more strongly related to early stage Alzheimer's disease, whereas increased positron emission tomography amyloid-β may be more strongly related to disease progression. ..
  37. pmc Connectivity network measures predict volumetric atrophy in mild cognitive impairment
    Talia M Nir
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 36:S113-20. 2015
    ..This study suggests that DWI-based network measures may be a novel predictor of AD progression. ..
  38. pmc Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia
    Simona Sacuiu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Am J Geriatr Psychiatry 24:126-35. 2016
    ..Investigate the association of chronic depressive symptomatology (chrDS) with cortical atrophy rates and conversion to Alzheimer dementia (AD) over 3 years in mild cognitive impairment (MCI)...
  39. pmc MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials
    Xue Hua
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, USA Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 37:26-37. 2016
    ..ApoE4 strongly predicted atrophy rates across brain regions most affected by AD, but the remaining 9 of the top 10 AD risk genes offered no added predictive value in this cohort...
  40. pmc Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology
    Robert Laforce
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA Memory and Aging Center, Department of Neurology, University of California San Francisco, CA, USA
    Neuroimage Clin 4:508-16. 2014
    ..Applying multivariate approaches such as pICA to multimodal imaging data is a promising approach for unraveling the complex relationships between different elements of AD pathophysiology. ..
  41. pmc Neural substrates of socioemotional self-awareness in neurodegenerative disease
    Marc Sollberger
    Memory and Aging Center, University of California San Francisco, California Department of Neurology, University of California San Francisco, California Department of Neurology, University Hospital Basel, Switzerland Memory Clinic, University Center for Medicine of Aging, Felix Platter Hospital Basel, Switzerland
    Brain Behav 4:201-14. 2014
    ..Evidence is accumulating to suggest that self-awareness arises from a combination of modality-specific and large-scale supramodal neural networks...
  42. pmc Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects
    Derrek P Hibar
    Imaging Genetics Center at the Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E 635 Charles Young Drive, Los Angeles, CA, 90095 1769, USA
    Brain Imaging Behav 7:102-15. 2013
    ..The genetic variants we identified provide replicated, genome-wide significant evidence for the FMO gene cluster's involvement in lentiform nucleus volume differences in human populations...
  43. pmc Perioperative cognitive decline in the aging population
    Niccolò Terrando
    Department of Anesthesia and Perioperative Care, San Francisco, CA 94143 0648, USA
    Mayo Clin Proc 86:885-93. 2011
    ..A road map to further elucidate the mechanisms, diagnosis, risk factors, mitigation, and treatment of postoperative cognitive decline in the elderly is provided...
  44. pmc Ventricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline
    Yi Yu Chou
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Neurobiol Aging 31:1386-400. 2010
    ..These statistical maps are highly automated, and offer a promising biomarker of AD for large-scale studies...
  45. pmc Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs San Francisco VA, Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Int J Alzheimers Dis 2011:546871. 2011
    ..Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD...
  46. pmc Seemingly unrelated regression empowers detection of network failure in dementia
    Neda Jahanshad
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA Department of Psychiatry, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 36:S103-12. 2015
    ..In a subsample with no apparent associations using the general linear model, power was boosted with our SUR model-combining genotype, educational level, and clinical diagnosis. ..
  47. pmc Does MRI scan acceleration affect power to track brain change?
    Christopher R K Ching
    Department of Neurology, Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, CA, USA Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, USA
    Neurobiol Aging 36:S167-77. 2015
    ..Scan acceleration may influence brain measures but has minimal effects on tensor-based morphometry-derived atrophy measures, at least over the 6- and 12-month intervals examined here. ..
  48. pmc Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI
    Valerie A Cardenas
    University of California, San Francisco, CA Veterans Affairs Medical Center, San Francisco, CA
    J Neuroimaging 24:435-43. 2014
    ....
  49. pmc Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information
    Philip S Insel
    Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Alzheimers Dement (Amst) 4:76-84. 2016
    ..This study's objective was to evaluate the extent to which inexpensive and easily obtainable information can reduce the number of screen failures by increasing the proportion of Aβ+ participants identified for screening...
  50. pmc Mapping ventricular expansion onto cortical gray matter in older adults
    Sarah K Madsen
    USC Imaging Genetics Center, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA
    Neurobiol Aging 36:S32-41. 2015
    ..Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression. ..
  51. pmc ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Neuroimage Clin 4:461-72. 2014
    ....
  52. doi request reprint Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment
    Philip S Insel
    Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA Electronic address
    Neurobiol Aging 48:172-181. 2016
    ..Composites incorporating both cognitive and functional measures may substantially increase the power of a trial in a preclinical (Aβ+) AD population with subtle evidence of cognitive dysfunction...
  53. pmc Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative
    Michael W Weiner
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA Department of Radiology, University of California, San Francisco, CA, USA Department of Medicine, University of California, San Francisco, CA, USA Department of Psychiatry, University of California, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S226-35. 2014
    ..This study is a first step toward the design and statistical powering of an AD prevention trial using at-risk veterans as subjects, and provides the basis for a larger, more comprehensive study of dementia risk factors in veterans. ..
  54. doi request reprint Military risk factors for Alzheimer's disease
    Michael W Weiner
    San Francisco Veterans Administration Medical Center, San Francisco, CA, USA
    Alzheimers Dement 9:445-51. 2013
    ..Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran. ..
  55. pmc Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
    Manja Lehmann
    UCSF Memory and Ageing Centre, Department of Neurology, Box 1207, San Francisco, CA 94158 1207, USA
    Brain 136:844-58. 2013
    ....
  56. pmc Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years
    R Scott Mackin
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Int J Geriatr Psychiatry 27:355-63. 2012
    ..To evaluate the degree to which longitudinal stability of subsyndromal symptoms of depression (SSD) is associated with conversion to dementia in patients with mild cognitive impairment (MCI)...
  57. pmc Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
    Michael Ewers
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Trends Neurosci 34:430-42. 2011
    ..A dynamic sequence model of changes that occur in neuroimaging markers during the different disease stages is presented and the predictive value of multimodal neuroimaging for AD dementia is considered...
  58. pmc Algebraic connectivity of brain networks shows patterns of segregation leading to reduced network robustness in Alzheimer's disease
    Madelaine Daianu
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, USA
    Comput Diffus MRI (2014) 2014:55-64. 2014
    ..Network components became more disconnected and segregated, and their modularity increased. These measures are sensitive to diagnostic group differences, and may help understand the complex changes in AD...
  59. pmc The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
    Paul M Thompson
    Imaging Genetics Center, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, 2001 N Soto Street, Los Angeles, CA, 90033, USA
    Brain Imaging Behav 8:153-82. 2014
    ..We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. ..
  60. pmc Clinicopathological correlations in corticobasal degeneration
    Suzee E Lee
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 70:327-40. 2011
    ..To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology-proven corticobasal degeneration (CBD) and corticobasal syndrome (CBS) with known histopathology...
  61. doi request reprint Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics
    Yinan Liu
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, California, USA
    Magn Reson Med 68:912-22. 2012
    ..01) than men, regardless of age. The findings imply that CBF and blood transit times are compromised in aging, and these changes together with differences between genders should be taken into account when studying brain perfusion...
  62. doi request reprint Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI
    Susan C Woolley
    Forbes Norris ALS Research Center, Department of Neurology, California Pacific Medical Center, San Francisco, CA 94115, USA
    Amyotroph Lateral Scler 12:52-8. 2011
    ..In conclusion, our findings point towards a biological basis for apathy in the anterior cingulum, consistent with research on apathy in other neurological populations...
  63. pmc Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease
    Michael Ewers
    Department of Radiology, University of California, San Francisco, CA, USA
    Neurology 80:1194-201. 2013
    ..To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD)...
  64. pmc Neural basis of interpersonal traits in neurodegenerative diseases
    Marc Sollberger
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Neuropsychologia 47:2812-27. 2009
    ..In addition, these findings indicate that interpersonal traits are subserved by complex neural networks rather than discrete anatomic areas...
  65. pmc Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging
    Duygu Tosun
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 52:186-97. 2010
    ..Compared to reduced rCBF, regional cortical thinning better explained the variability in dementia severity. In conclusion, structural brain alterations compared to physiological variations are the dominant features of MRI in AD...
  66. pmc Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression
    Omid Kohannim
    Imaging Genetics Center at the Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine Los Angeles, CA, USA
    Front Neurosci 6:115. 2012
    ..8 ± 2.2 SD years). Our approach powerfully complements univariate techniques in detecting influences of genes on the living brain...
  67. doi request reprint Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA, USA
    Alzheimers Dement 7:425-35. 2011
    ..This study was designed to assess changes in brain volume and cognitive abilities in memantine-treated patients with Alzheimer's disease (AD) by using an exploratory, single-arm, delayed-start design...
  68. pmc Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms
    Brigitte A Apfel
    Department of Psychiatry, University of California, San Francisco, California, USA
    Biol Psychiatry 69:541-8. 2011
    ..However, it is not known whether it is a risk factor for the development of PTSD or a consequence of PTSD. We sought to determine the effects of PTSD and depressive symptoms on hippocampal volume...
  69. pmc Smoking and increased Alzheimer's disease risk: a review of potential mechanisms
    Timothy C Durazzo
    Center for Imaging of Neurodegenerative Diseases CIND, San Francisco VA Medical Center, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S122-45. 2014
    ..Cigarette smoking has been linked with both increased and decreased risk for Alzheimer's disease (AD). This is relevant for the US military because the prevalence of smoking in the military is approximately 11% higher than in civilians...
  70. pmc Are hippocampal size differences in posttraumatic stress disorder mediated by sleep pathology?
    Brian S Mohlenhoff
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA Electronic address
    Alzheimers Dement 10:S146-54. 2014
    ..We outline a broad research agenda centered on the hypothesis that sleep changes mediate the relationship between PTSD and hippocampal volume. ..
  71. pmc Locally linear embedding (LLE) for MRI based Alzheimer's disease classification
    Xin Liu
    Center of Imaging of Neurodegenerative Disease, VA Medical Center and the Department of Radiology and Biomedical Imaging University of California, San Francisco, CA, USA Electronic address
    Neuroimage 83:148-57. 2013
    ..The improvement in predicting conversion to AD in MCI could have important implications for health management and for powering therapeutic trials by targeting non-demented subjects who later convert to AD...
  72. pmc Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Hum Brain Mapp 31:1339-47. 2010
    ..2) To determine if measurements of hippocampal subfields provide advantages over total hippocampal volume for differentiation between groups...
  73. pmc Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults
    Valerie A Cardenas
    University of California, San Francisco, Department of Veterans Affairs Medical Center, 4150 Clement Street 114M, San Francisco, CA 94121, USA
    Stroke 43:2865-70. 2012
    ..The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness...
  74. pmc Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking
    Timothy C Durazzo
    San Francisco VA Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
    Alzheimers Dement 8:513-9. 2012
    ....
  75. pmc Neuroimaging predictors of brain amyloidosis in mild cognitive impairment
    Duygu Tosun
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA
    Ann Neurol 74:188-98. 2013
    ..To identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid-free...
  76. pmc Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA
    Epilepsia 51:1436-45. 2010
    ..This study investigated how structural abnormalities in the focus, ipsilateral thalamus and extrafocal cortical structures relate to each other in TLE with mesiotemporal sclerosis (TLE-MTS) and without hippocampal sclerosis (TLE-no)...
  77. pmc The Alzheimer's disease neuroimaging initiative: progress report and future plans
    Michael W Weiner
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, USA
    Alzheimers Dement 6:202-11.e7. 2010
    ..All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD...
  78. pmc In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging
    Marzieh Nezamzadeh
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Eur J Radiol 75:e29-36. 2010
    ..This optimized DSI setting should be useful for detecting alterations along the cingulum bundle in Alzheimer disease and related neurodegenerative disorders...
  79. pmc Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults
    Judy Pa
    Alzheimer Disease Research Center, Dept of Neurology, University of California, San Francisco, California, USA
    J Int Neuropsychol Soc 16:640-50. 2010
    ..Overall, these findings highlight the neuroanatomical correlates of set-shifting and the importance of controlling for component processes when investigating complex cognitive tasks...
  80. pmc Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California 94141, USA
    NMR Biomed 18:51-5. 2005
    ..Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects...
  81. pmc Hippocampal volume and retention in Alzheimer's disease
    Joel H Kramer
    Department of Neurology, University of California at San Francisco, 94143, USA
    J Int Neuropsychol Soc 10:639-43. 2004
    ..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
  82. pmc Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD
    Katherine P Rankin
    University of California San Francisco, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:328-32. 2004
    ..These data support the hypothesis that regulation of agreeableness arises from a balanced, mutually inhibitory circuit involving both hemispheres...
  83. pmc Attention, learning, and memory in posttraumatic stress disorder
    Thomas C Neylan
    Mental Health Service, San Francisco DVA Medical Center, San Francisco, California 94121, USA
    J Trauma Stress 17:41-6. 2004
    ..In this study, reduced hippocampal NAA did not appear to be associated with impaired declarative memory...
  84. pmc Reduced extrahippocampal NAA in mesial temporal lobe epilepsy
    Susanne G Mueller
    Department of Veterans Affairs DVA Medical Center, Magnetic Resonance Spectroscopy Unit, University of California San Francisco, California 94143 0138, USA
    Epilepsia 43:1210-6. 2002
    ..This study was designed to characterize extrahippocampal metabolic abnormalities in mTLE with magnetic resonance spectroscopy in combination with tissue segmentation and volumetry of gray and white matter...
  85. pmc Human brain: reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging
    Geon Ho Jahng
    Department of Radiology, University of California San Francisco, 4150 Clement St, Rm 114M, San Francisco, CA 94121, USA
    Radiology 234:909-16. 2005
    ..5%), and (b) random noise rather than within-subject variability limited reliability and reproducibility. It was concluded that low signal-to-noise ratios substantially limit the reliability and reproducibility of perfusion measurements...
  86. pmc Sensitive and fast T1 mapping based on two inversion recovery images and a reference image
    Geon Ho Jahng
    University of California San Francisco, 4150 Clement Street, 114M San Francisco, California 94121, USA
    Med Phys 32:1524-8. 2005
    ..The proposed method should be useful for clinical studies because the T1 maps can be obtained within a few seconds...
  87. ncbi request reprint 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions
    Kirk C Wilhelmsen
    Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
    Arch Neurol 61:398-406. 2004
    ..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions...
  88. pmc Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report
    Maria Luisa Gorno-Tempini
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 1207, USA
    Neurocase 10:426-36. 2004
    ..This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage...
  89. pmc Achieving sufficient spectral bandwidth for volumetric 1H echo-planar spectroscopic imaging at 4 Tesla
    Andreas Ebel
    Northern California Institute for Research and Education, VA Medical Center San Francisco, San Francisco, CA 94121, USA
    Magn Reson Med 54:697-701. 2005
    ..In this Note, limitations of the iFT method are discussed and an alternative, cyclic spectral unwrapping, is proposed, which is based on prior knowledge of typical in vivo spectral patterns...
  90. pmc Neuroanatomical correlates of behavioural disorders in dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Brain 128:2612-25. 2005
    ..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions...
  91. pmc Cognition and anatomy in three variants of primary progressive aphasia
    Maria Luisa Gorno-Tempini
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Neurol 55:335-46. 2004
    ..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes...
  92. pmc Multisection proton MR spectroscopy for mesial temporal lobe epilepsy
    Aristides A Capizzano
    Department of Veterans Affairs Medical Center, Magnetic Resonance Spectroscopy Unit, University of California, San Francisco, USA
    AJNR Am J Neuroradiol 23:1359-68. 2002
    ..We investigated whether proton MR spectroscopy ((1)H-MRS) depicts metabolic changes beyond the hippocampus in cases of mTLE and whether these changes help lateralize the seizure focus...
  93. pmc Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
    ..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
  94. pmc Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
    Nathan A Johnson
    MR Research Unit, VA Medical Center, 4150 Clement St 114M San Francisco, CA 94107, USA
    Radiology 234:851-9. 2005
    ....
  95. pmc Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit, DVA Medical Center 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Neurobiol Aging 26:665-72. 2005
    ..Reduced glutamate and N-acetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study...
  96. pmc Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performance
    Johannes C Rothlind
    Mental Health Service, DVA Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Int Neuropsychol Soc 11:70-83. 2005
    ....
  97. pmc Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging
    Susanne G Mueller
    Department of Veterans Affairs DVA Medical Center, Magnetic Resonance Spectroscopy Unit, University of California, San Francisco, San Francisco, California 64115, USA
    Epilepsia 45:1580-9. 2004
    ..The aim of this study was to evaluate the usefulness of multislice magnetic resonance spectroscopic imaging (MRSI) in combination with tissue segmentation for the identification of the epileptogenic focus in neocortical epilepsy (NE)...
  98. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  99. pmc Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes
    Yuan Yu Hsu
    Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, San Francisco, California, USA
    Alzheimer Dis Assoc Disord 16:58-64. 2002
    ..In conclusion, the presence of subcortical lacunes in those with AD is associated with more WM lesions and ventriculomegaly but not with cortical atrophy...
  100. pmc Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia
    Chris Zarow
    University of Southern California, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
    Ann Neurol 57:896-903. 2005
    ..Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons...
  101. ncbi request reprint Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes
    Valerie A Cardenas
    University of California, San Francisco and San Francisco VA Medical Center, 4150 Clement St, San Francisco CA 94121, USA
    Psychiatry Res 138:115-30. 2005
    ..Community-dwelling heavy drinkers who are not in alcoholism treatment have dose-related gray matter volume losses, and family history of problem drinking ameliorates some structural consequences of heavy drinking...