Nancy R Webb

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation
    Nancy R Webb
    From the Departments of Pharmacology Division of Nutritional Sciences N R W, Physiology M C D B and Internal Medicine J M W, A J, W B, P S, V P N, D A H, A B, D L R, A D, F C D B, and Saha Cardiovascular Research Center N R W, M C D B, J M W, A J, P S, V P N, D A H, A B, D L R, A D, F C D B, and Departments of Statistics and Biostatistics R J C, University of Kentucky, Lexington and Foundation Gastroenterology, Nashua, NH J W
    Arterioscler Thromb Vasc Biol 35:1156-65. 2015
  2. ncbi Secretory phospholipase A2 enzymes in atherogenesis
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Curr Opin Lipidol 16:341-4. 2005
  3. ncbi The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Lipid Res 43:1890-8. 2002
  4. ncbi Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center MN520, 800 Rose St, Lexington, KY 40536 0084, USA
    Arterioscler Thromb Vasc Biol 23:263-8. 2003
  5. ncbi ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 45:272-80. 2004
  6. ncbi Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
  7. pmc Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice
    Maria C de Beer
    From the Graduate Center for Nutritional Science M C D B, J M W, V P N, A J, P S, J C T, D R v d W, L R T, N R W, F C D B, Saha Cardiovascular Research Center M C D B, J M W, V P N, D L R, D A H, A B, A J, P S, J C T, D R v d W, L R T, A D, N R W, F C D B, and the Departments of Physiology M C D B and Internal Medicine J M W, V P N, D L R, D A H, A B, A J, P S, Israel
    Arterioscler Thromb Vasc Biol 34:255-61. 2014
  8. pmc SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL
    Maria C de Beer
    Graduate Center for Nutritional Science, University of Kentucky Medical Center, Lexington, USA
    Arterioscler Thromb Vasc Biol 29:1298-303. 2009
  9. pmc The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo
    Boris Boyanovsky
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 29:532-8. 2009
  10. ncbi Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536
    J Lipid Res 43:1421-8. 2002

Collaborators

Detail Information

Publications45

  1. pmc Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation
    Nancy R Webb
    From the Departments of Pharmacology Division of Nutritional Sciences N R W, Physiology M C D B and Internal Medicine J M W, A J, W B, P S, V P N, D A H, A B, D L R, A D, F C D B, and Saha Cardiovascular Research Center N R W, M C D B, J M W, A J, P S, V P N, D A H, A B, D L R, A D, F C D B, and Departments of Statistics and Biostatistics R J C, University of Kentucky, Lexington and Foundation Gastroenterology, Nashua, NH J W
    Arterioscler Thromb Vasc Biol 35:1156-65. 2015
    ..We investigated whether SAA deficiency in mice affects AAA formation during angiotensin II (Ang II) infusion...
  2. ncbi Secretory phospholipase A2 enzymes in atherogenesis
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Curr Opin Lipidol 16:341-4. 2005
    ..The possibility that secretory phospholipase A2 plays a role in the pathophysiology of atherosclerosis (and is not merely a marker for localized inflammation) has been substantiated by a number of recent in-vitro and in-vivo studies...
  3. ncbi The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Lipid Res 43:1890-8. 2002
    ..This remodeling pathway may represent a process that is important in determining the rate of apoA-I catabolism and HDL-mediated reverse cholesterol transport...
  4. ncbi Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center MN520, 800 Rose St, Lexington, KY 40536 0084, USA
    Arterioscler Thromb Vasc Biol 23:263-8. 2003
    ..In the present study, we show for the first time that elicited peritoneal macrophages from transgenic mice express human group IIA sPLA(2). This study tested whether macrophage-expressed sPLA(2) contributes to atherogenesis...
  5. ncbi ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 45:272-80. 2004
    ..Taken together, these data establish that SR-BI does not play a direct role in the metabolism of apoE(-/-) mouse lipoprotein remnants...
  6. ncbi Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
    ..We conclude that HDL remnants, generated by SR-BI, are converted to larger particles by rapidly reassociating with existing HDL particles in an enzyme-independent manner...
  7. pmc Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice
    Maria C de Beer
    From the Graduate Center for Nutritional Science M C D B, J M W, V P N, A J, P S, J C T, D R v d W, L R T, N R W, F C D B, Saha Cardiovascular Research Center M C D B, J M W, V P N, D L R, D A H, A B, A J, P S, J C T, D R v d W, L R T, A D, N R W, F C D B, and the Departments of Physiology M C D B and Internal Medicine J M W, V P N, D L R, D A H, A B, A J, P S, Israel
    Arterioscler Thromb Vasc Biol 34:255-61. 2014
    ..Our goal was to determine the impact of SAA deficiency on atherosclerosis in hypercholesterolemic mice...
  8. pmc SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL
    Maria C de Beer
    Graduate Center for Nutritional Science, University of Kentucky Medical Center, Lexington, USA
    Arterioscler Thromb Vasc Biol 29:1298-303. 2009
    ..The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL)...
  9. pmc The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo
    Boris Boyanovsky
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 29:532-8. 2009
    ..Consistent with this, gain and loss of function studies demonstrated that GV sPLA(2) promotes atherosclerosis in LDLR(-/-) mice. The current study investigates whether GV sPLA(2) promotes atherosclerotic processes in apoE(-/-) mice...
  10. ncbi Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536
    J Lipid Res 43:1421-8. 2002
    ..However, such uptake was not significantly increased in mice over-expressing SR-BI. We conclude that SR-BI-mediated selective uptake from LDL plays a minor role in LDL metabolism in vivo...
  11. pmc Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice
    Melissa Zack
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Atherosclerosis 214:58-64. 2011
    ..Specific interventions that prevent AAA progression remain to be identified. In this study, we tested the hypothesis that Group X secretory phospholipase A(2) (GX sPLA(2)), an enzyme implicated in inflammatory processes, mediates AAA...
  12. pmc Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages
    Preetha Shridas
    Graduate Center for Nutritional Sciences, Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington 40536 0200, USA
    Arterioscler Thromb Vasc Biol 30:2014-21. 2010
    ....
  13. pmc HDL remodeling during the acute phase response
    Anisa Jahangiri
    Department of Internal Medicine, Division of Endocrinology and Molecular Medicine, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 29:261-7. 2009
    ....
  14. pmc Scavenger receptor SR-BI in macrophage lipid metabolism
    Ailing Ji
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    Atherosclerosis 217:106-12. 2011
    ..To investigate the mechanisms by which macrophage scavenger receptor BI (SR-BI) regulates macrophage cholesterol homeostasis and protects against atherosclerosis...
  15. pmc Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands
    Preetha Shridas
    Graduate Center for Nutritional Sciences, The Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Biol Chem 285:20031-9. 2010
    ..In summary, GX sPLA(2) is expressed in mouse adrenal glands and functions to negatively regulate corticosteroid synthesis, most likely by negatively regulating StAR expression...
  16. ncbi Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans
    Boris B Boyanovsky
    Department of Internal Medicine and Veterans Affairs Medical Center, Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky 40536 0200, USA
    J Biol Chem 280:32746-52. 2005
    ..Our data point to a physiological modification of LDL that has the potential to promote macrophage foam cell formation independent of scavenger receptors...
  17. ncbi Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI
    Bing Sun
    Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 48:2560-70. 2007
    ....
  18. pmc Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI
    Ailing Ji
    Department of Veterans Affairs Medical Center, Lexington, KY, USA
    J Lipid Res 53:446-55. 2012
    ..2 nm-sized particles generated by glyburide treatment were also detected in ABCG1-deficient and SR-BI-deficient hepatocytes. Our data indicate that hepatic nascent HDL formation is highly dependent on ABCA1 but not on ABCG1 or SR-BI...
  19. pmc Impact of serum amyloid A on high density lipoprotein composition and levels
    Maria C de Beer
    Graduate Center for Nutritional Science, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 51:3117-25. 2010
    ..These data need to be transferred to humans with caution due to differences in apoA-I structure and remodeling functions...
  20. pmc Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase
    Joanne M Wroblewski
    Department of Internal Medicine, Endocrinology Division and Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 52:2255-61. 2011
    ..Our findings suggest that a reduction in nascent HDL formation may be partly responsible for reduced HDL-C during inflammation when both EL and SAA are known to be upregulated...
  21. ncbi Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts
    Bing Sun
    Department of Internal Medicine, Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, 40536, USA
    J Lipid Res 47:1700-13. 2006
    ..From these data, we conclude that HDL retroendocytosis in COS-7 and HepG2 cells is similar and that the vast majority of SR-BI-dependent selective uptake occurs at the cell surface in both cell types...
  22. ncbi Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice
    Meredith A Bostrom
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 27:600-6. 2007
    ..However, there is no direct evidence that this enzyme promotes atherogenic processes in vivo...
  23. pmc ATP binding cassette G1-dependent cholesterol efflux during inflammation
    Maria C de Beer
    Departments of Physiology, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 52:345-53. 2011
    ..Our data indicate that inflammatory remodeling of HDL impacts ABCG1-dependent efflux independent of SAA...
  24. pmc Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages
    Preetha Shridas
    University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Immunol 187:482-9. 2011
    ..Thus, GX sPLA(2) amplifies signaling through TLR4 by a mechanism that is dependent on its catalytic activity. Our data indicate this effect is mediated through alterations in plasma membrane free cholesterol and lipid raft content...
  25. pmc Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL
    Boris B Boyanovsky
    Department of Internal Medicine, Endocrinology Division, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 50:641-50. 2009
    ..Taken together, our data point to a novel role for syndecan-4 in mediating the uptake of GV-LDL, a process implicated in atherosclerotic lesion progression...
  26. pmc Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner
    Patricia G Wilson
    Division of Endocrinology and Molecular Medicine, University of Kentucky, Lexington, KY 40536 0200, USA
    Am J Pathol 173:1902-10. 2008
    ..Thus, SAA alters vascular proteoglycans in a pro-atherogenic manner via the stimulation of TGF-beta and may play a causal role in the development of atherosclerosis...
  27. pmc Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice
    Boris B Boyanovsky
    Endocrinology Division, The Department of Internal Medicine, University of Kentucky, Lexington, USA
    Am J Pathol 181:1088-98. 2012
    ..Our findings indicate that GV sPLA(2) modulates pathological responses to Ang II, with different outcomes for AAA and cardiac fibrosis...
  28. pmc Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines
    Boris B Boyanovsky
    Department of Internal Medicine Endocrinology Division, University of Kentucky, Lexington, 40536, USA
    Cytokine 50:50-7. 2010
    ..The aim of the present study was to determine whether GV sPLA(2)-hydrolyzed LDL (GV-LDL) produces pro-atherogenic effects in macrophages independent of cholesterol accumulation...
  29. ncbi Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation
    C Ruth Wooton-Kee
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    Arterioscler Thromb Vasc Biol 24:762-7. 2004
    ..The present study assesses the presence of group V sPLA2 in human and mouse atherosclerotic lesions and its activity toward low-density lipoprotein (LDL) particles...
  30. ncbi High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif
    Erik R M Eckhardt
    Department of Internal Medicine, University of Kentucky, Lexington, 40536 0200, USA
    J Biol Chem 281:4348-53. 2006
    ..These results demonstrated that SR-BII differs from SR-BI in subcellular localization and trafficking and suggest that the two isoforms differ in the manner in which they target ligands intracellularly...
  31. ncbi SR-BI-mediated selective lipid uptake segregates apoA-I and apoA-II catabolism
    Maria C de Beer
    Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipid Res 46:2143-50. 2005
    ..Extensive SR-BI processing generates small apoA-II-depleted particles unable to reassociate with HDL and readily taken up by the liver. This represents a pathway by which apoA-I and apoA-II catabolism are segregated...
  32. pmc Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice
    Myung Hee Kim
    Departments of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536
    J Lipid Res 57:969-79. 2016
    ..These studies enhance our understanding of SAA metabolism and SAA's effects on AP-HDL composition and catabolism. ..
  33. pmc Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models
    Xia Li
    Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, KY 40536 0200, USA
    FASEB J 24:4313-24. 2010
    ..Thus, hydrolytic products generated by GX sPLA(2) negatively regulate adipogenesis, possibly by suppressing LXR activation...
  34. pmc SAA does not induce cytokine production in physiological conditions
    Myung Hee Kim
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Cytokine 61:506-12. 2013
    ..Taken together, our findings suggest that lipid-poor SAA, but not HDL-associated SAA, stimulates G-CSF production and this stimulation is mediated through TLR 2 in J774 cells. However, its physiological role in vivo remains ambiguous...
  35. pmc The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A
    Maria C de Beer
    Saha Cardiovascular Research Center, University of Kentucky Medical Center, Lexington, KY 40536, USA Department of Physiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Lipids 2013:283486. 2013
    ..Our study confirms reports that acute inflammation impairs steps in the RCT pathway and establishes that SAA plays only a minor role in this impairment...
  36. ncbi Lack of a direct role for macrosialin in oxidized LDL metabolism
    Maria C de Beer
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536, USA
    J Lipid Res 44:674-85. 2003
    ..We conclude that although MS expression in macrophages and Kupffer cells is responsive to a proatherogenic inflammatory diet and to oxLDL, MS does not function as an oxLDL receptor on the cell surface...
  37. ncbi HDL cholesterol transport during inflammation
    Deneys R van der Westhuyzen
    Department of Internal Medicine, Cardiovascular Research Center and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Curr Opin Lipidol 18:147-51. 2007
    ....
  38. ncbi High density lipoprotein uptake by scavenger receptor SR-BII
    Erik R M Eckhardt
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 279:14372-81. 2004
    ..We conclude that SR-BII may influence cellular cholesterol trafficking and homeostasis in a manner that is distinct from SR-BI...
  39. pmc Impact of phospholipid transfer protein on nascent high-density lipoprotein formation and remodeling
    Ailing Ji
    From the Department of Internal Medicine A J, J M W, D R v d W, Department of Pharmacology and Nutritional Sciences A J, J M W, N R W, D R v d W, Department of Molecular and Cellular Biochemistry D R v d W, and Saha Cardiovascular Research Center A J, J M W, N R W, D R v d W, University of Kentucky, Lexington and Department of Veterans Affairs Medical Center N R W, D R v d W, Lexington, KY
    Arterioscler Thromb Vasc Biol 34:1910-6. 2014
    ..The effect of PLTP overexpression on apolipoprotein A-I (apoA-I) lipidation by primary mouse hepatocytes was investigated...
  40. ncbi Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis
    Alan Daugherty
    Cardiovascular Research Center, Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    J Lipid Res 46:1812-22. 2005
    ..There will be an emphasis on the role of cytokines in regulating lipid metabolism by macrophages. We will provide an overview of the major findings in cell culture and then put these in the context of in vivo studies...
  41. doi Biology of secretory phospholipase A2
    Boris B Boyanovsky
    Department of Internal Medicine, Division of Endocrinology and Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0200, USA
    Cardiovasc Drugs Ther 23:61-72. 2009
    ..In addition, some sPLA(2)'s are high affinity ligands for cellular receptors...
  42. ncbi Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy
    Nancy R Webb
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Drug Targets 8:1249-63. 2007
    ..Specific emphasis will be placed on recent findings from mouse models of atherosclerosis regarding the pathways of macrophage differentiation into foam cells and their implications for developing macrophage-directed therapeutic targets...
  43. ncbi Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, 2300 RA Leiden, The Netherlands
    J Lipid Res 46:1172-81. 2005
    ....
  44. ncbi Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro
    Veneracion G Cabana
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Lipid Res 45:317-25. 2004
    ..In the absence of both apoA-I and apoE, SAA-HDL is not formed and SAA associates with any available lipoprotein...
  45. ncbi Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant
    Frederick C de Beer
    Arterioscler Thromb Vasc Biol 26:1421-2. 2006