Peter A Watson
Affiliation: University of Colorado Health Sciences Center
- Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercisePeter A Watson
University of Colorado Health Sciences Center, and Denver VA Medical Center, 1055 Clermont Street, Denver CO 80220, USA
Am J Physiol Heart Circ Physiol 293:H246-59. 2007..These data support a model wherein CREB contributes to physiological hypertrophy by enhancing expression of genes important for efficient oxidative capacity and resistance to apoptosis...
- Loss of CREB regulation of vascular smooth muscle cell quiescence in diabetesJane E B Reusch
Associate Professor of Medicine, University of Colorado, Staff Endocrinologist, Denver VA Medical Center, American Federation for Medical Research, Colorado, USA
Rev Endocr Metab Disord 5:209-19. 2004
- Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth musclesPeter A Watson
Denver Research Institute, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, 1055 Clermont Street, Denver, CO 80220, USA
Endocrinology 143:2922-9. 2002..Thus, both in vitro and in vivo loss of CREB content and activity and subsequent accumulation of PDGFRalpha may contribute to SMC activation during diabetes...
- Novel actions of thiazolidinediones on vascular function and exercise capacityJane E B Reusch
Denver Veterans Affairs Medical Center, Denver, Colorado 80220, USA
Am J Med 115:69S-74S. 2003..Preliminary data suggest that TZDs improve measures of cardiac function and exercise capacity, and investigators are assessing the impact of treatment with rosiglitazone on exercise capacity in an ongoing clinical trial...
- Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the ratDavid A Brown
Department of Integrative Physiology, 202D Carlson Gymnasium, Campus Box 354, Boulder, CO 80309 USA
J Physiol 569:913-24. 2005....
- Exercise can prevent and reverse the severity of hypertrophic cardiomyopathyJohn P Konhilas
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
Circ Res 98:540-8. 2006..Remarkably, there were no differences in mortality between exercised NTG and HCM mice. Thus, not only was exercise not harmful but also it was able to prevent and even reverse established cardiac disease phenotypes in this HCM model...