ELIZABETH SALLY WARD

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice
    E Sally Ward
    Department of Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA Electronic address
    Immunol Lett 160:158-62. 2014
  2. ncbi request reprint Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
    E Sally Ward
    Center for Immunology and Cancer Immunobiology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8576, USA
    Int Immunol 15:187-95. 2003
  3. pmc From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling
    E Sally Ward
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, 75390 8576, USA
    Mol Biol Cell 16:2028-38. 2005
  4. ncbi request reprint Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
  5. doi request reprint Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn
    E Sally Ward
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Adv Immunol 103:77-115. 2009
  6. pmc Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy
    Prashant Prabhat
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:5889-94. 2007
  7. ncbi request reprint Transcytosis and catabolism of antibody
    Victor Ghetie
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas 75390 8576, USA
    Immunol Res 25:97-113. 2002
  8. ncbi request reprint Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    J Mol Biol 332:901-13. 2003
  9. pmc Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
  10. ncbi request reprint Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9093, USA
    J Mol Biol 345:1071-81. 2005

Research Grants

  1. IMPROVING SURFACE PLASMON RESONANCE TECHNOLOGY
    Elizabeth Ward; Fiscal Year: 2002
  2. MOLECULAR ANALYSIS OF T CELL RECOGNITION IN EAE
    Elizabeth Ward; Fiscal Year: 2007
  3. Antibody engineering: targeting Bacillus anthracis
    Elizabeth Ward; Fiscal Year: 2007
  4. Structure-function studies of human FcRn
    Elizabeth Ward; Fiscal Year: 2008

Collaborators

  • V Ghetie
  • Prashant Prabhat
  • Michael K Racke
  • Raimund J Ober
  • Carlos Vaccaro
  • Jinchun Zhou
  • Zhuo Gan
  • Sripad Ram
  • Héctor Pérez Montoyo
  • Wentao Mi
  • Doris Lambracht-Washington
  • Sylvia Wanjie
  • Jason C Huang
  • Cruz Martinez
  • Werner Mueller
  • Martin Hafner
  • Beatrix Pickl-Herk
  • Jerry Chao
  • Su Tang Lo
  • Andrea Jowdry
  • Nancy L Monson
  • Elliot Frohman
  • Elizabeth M Cameron
  • Kevin C O'Connor
  • Roger Bawdon
  • Fernando Mateos
  • Xuming Lai
  • James E Johnson

Detail Information

Publications19

  1. pmc Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice
    E Sally Ward
    Department of Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA Electronic address
    Immunol Lett 160:158-62. 2014
    ..Finally, the cross-species difference between mouse and man for FcRn-IgG interactions needs to be considered when engineering antibodies for improved activities in FcRn-mediated functions. ..
  2. ncbi request reprint Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
    E Sally Ward
    Center for Immunology and Cancer Immunobiology Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8576, USA
    Int Immunol 15:187-95. 2003
    ..Our observations have direct relevance to the understanding and treatment of IgG deficiency, and to the effective application of therapeutic antibodies...
  3. pmc From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling
    E Sally Ward
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, 75390 8576, USA
    Mol Biol Cell 16:2028-38. 2005
    ..The Rab11(+)FcRn(+) vesicle or tubule subsequently fuses with the plasma membrane in an exocytic event. In contrast to Rab11, Rab4 is not involved in exocytosis...
  4. ncbi request reprint Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
    ..The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis...
  5. doi request reprint Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn
    E Sally Ward
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Adv Immunol 103:77-115. 2009
    ..In addition, molecular studies of FcRn-IgG interactions indicate that mice have limitations as preclinical models for FcRn function, primarily due to cross-species differences in FcRn-binding specificity...
  6. pmc Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy
    Prashant Prabhat
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:5889-94. 2007
    ..TCs can also interact with different sorting endosomes before exocytosis. Our data provide insight into the intracellular events that precede exocytic fusion...
  7. ncbi request reprint Transcytosis and catabolism of antibody
    Victor Ghetie
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas 75390 8576, USA
    Immunol Res 25:97-113. 2002
    ..IgG that is taken up by cells in the absence of binding to FcRn undergoes degradation. Thus, FcRn is the "protective" receptor that serves to maintain IgG homeostasis and deliver IgGs across cellular barriers...
  8. ncbi request reprint Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    J Mol Biol 332:901-13. 2003
    ..In turn, understanding human FcRn function has significance for the optimization of the serum half-lives of therapeutic and prophylactic antibodies...
  9. pmc Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
    ..Such retrograde movement may represent a mechanism for FcRn retrieval. Our studies provide insight into the events that lead to IgG exocytosis...
  10. ncbi request reprint Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9093, USA
    J Mol Biol 345:1071-81. 2005
    ..These studies define the molecular basis for the marked difference in binding specificity between human and rodent FcRn, and give insight into how human FcRn recognizes IgGs...
  11. pmc Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments
    Wentao Mi
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    J Immunol 181:7550-61. 2008
    ....
  12. pmc Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
    Héctor Pérez Montoyo
    Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9093, USA
    Proc Natl Acad Sci U S A 106:2788-93. 2009
    ..The primary sites for the maintenance of endogenous IgGs in mice are therefore endothelial and hematopoietic cells...
  13. ncbi request reprint Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
    Carlos Vaccaro
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9093, USA
    Nat Biotechnol 23:1283-8. 2005
    ..Such FcRn blockers (or 'Abdegs,' for antibodies that enhance IgG degradation) may have uses in reducing IgG levels in antibody-mediated diseases and in inducing the rapid clearance of IgG-toxin or IgG-drug complexes...
  14. pmc Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies
    Carlos Vaccaro
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9093, USA
    Proc Natl Acad Sci U S A 103:18709-14. 2006
    ..These studies indicate potential limitations of using mice as preclinical models for the analysis of engineered antibodies. Alternative assays are proposed that serve as indicators of the properties of IgGs in humans...
  15. ncbi request reprint Acquiring maternal immunoglobulin; different receptors, similar functions
    E Sally Ward
    Center for Immunology, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 USA
    Immunity 20:507-8. 2004
    ..This receptor is distinct from its mammalian counterpart and is a phospholipase A(2) receptor homolog. Biophysical analyses indicate that FcRY achieves pH-dependent binding to IgY through a conformational change...
  16. pmc Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery
    Zhuo Gan
    Biomedical Engineering Graduate Program, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Traffic 10:600-14. 2009
    ..Consequently, late endosomes have functional plasticity, consistent with the presence of the Rab5 GTPase in discrete domains on these compartments...
  17. pmc Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS
    Doris Lambracht-Washington
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroimmunol 186:164-76. 2007
    ..Targeting the mechanisms that allow these self-reactive B cells to reside in the CSF of MS patients may prove to be a potent immunotherapeutic strategy...
  18. ncbi request reprint The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis
    Jason C Huang
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    Eur J Immunol 35:299-304. 2005
    ..The importance of the triple glycines for antigen recognition provides an explanation at the molecular level for the recruitment of T cells bearing the DAGGGY motif into the responding repertoire during EAE induction...
  19. pmc High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells
    Sripad Ram
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biophys J 95:6025-43. 2008
    ..Here, using MUM and MUMLA we report for the first time the full 3D trajectories of QD-labeled antibody molecules undergoing endocytosis in live cells from the plasma membrane to the sorting endosome deep inside the cell...

Research Grants4

  1. IMPROVING SURFACE PLASMON RESONANCE TECHNOLOGY
    Elizabeth Ward; Fiscal Year: 2002
    ....
  2. MOLECULAR ANALYSIS OF T CELL RECOGNITION IN EAE
    Elizabeth Ward; Fiscal Year: 2007
    ..affinities, plasticities and cross-reactivities These studies should lead to an improved understanding of the factors that lead to the activation of autoreactive T cells and have general relevance to T cell recognition ..
  3. Antibody engineering: targeting Bacillus anthracis
    Elizabeth Ward; Fiscal Year: 2007
    ..They should also give new insight into understanding the role of antibodies in limiting infection, and this has broader relevance to other pathogens. ..
  4. Structure-function studies of human FcRn
    Elizabeth Ward; Fiscal Year: 2008
    ..This impacts the successful application of therapeutic and prophylactic IgGs, and also has broader relevance to the factors that regulate humoral immunity. ..