Kyle M Walsh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, Program in Pediatric Malignancies, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Carcinogenesis 37:576-82. 2016
  2. pmc A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California
    Cancer Res 75:4884-94. 2015
  3. pmc Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans
    Kyle M Walsh
    Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Cente, San Francisco, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:251-60. 2013
  4. pmc Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis
    Kyle M Walsh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 15:1041-7. 2013
  5. pmc Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies
    Kyle M Walsh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Genet Epidemiol 37:222-8. 2013
  6. pmc Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients
    Linlu Zhao
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA
    BMC Pregnancy Childbirth 12:61. 2012
  7. pmc Whole-exome sequencing of a pedigree segregating asthma
    Andrew T Dewan
    Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    BMC Med Genet 13:95. 2012
  8. pmc Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
    Kyle M Walsh
    1 Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA 2 Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 46:731-5. 2014
  9. pmc Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans
    Kyle M Walsh
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Oncotarget 3:1428-38. 2012
  10. pmc Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
    Terri Rice
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94107, USA
    Neuro Oncol 15:535-41. 2013

Collaborators

Detail Information

Publications24

  1. pmc Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, Program in Pediatric Malignancies, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Carcinogenesis 37:576-82. 2016
    ..19; 95%CI = 1.01-1.40; P = 0.043). These results indicate that genetic predisposition to longer LTL is a newly identified risk factor for neuroblastoma and potentially for other cancers of childhood...
  2. pmc A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California
    Cancer Res 75:4884-94. 2015
    ..Taken together, our findings demonstrate that coding polymorphisms of large effect can underlie GWAS "hits" and that inherited polymorphisms may undergo directional selection during clonal expansion of tumors...
  3. pmc Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans
    Kyle M Walsh
    Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Cente, San Francisco, CA, USA
    Cancer Epidemiol Biomarkers Prev 22:251-60. 2013
    ..1-p21.31, and 15q25.1. We investigated whether these regions contain lung cancer susceptibly loci in African-Americans and refined previous association signals by using the reduced linkage disequilibrium observed in African-Americans...
  4. pmc Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis
    Kyle M Walsh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 15:1041-7. 2013
    ..We examined associations of these 7 established glioma risk loci with age at diagnosis among patients with glioma...
  5. pmc Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies
    Kyle M Walsh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Genet Epidemiol 37:222-8. 2013
    ..These results highlight that the deficiencies of the candidate-gene approach lay in selecting both appropriate genes and relevant SNPs within these genes...
  6. pmc Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients
    Linlu Zhao
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA
    BMC Pregnancy Childbirth 12:61. 2012
    ..This genome-wide association study (GWAS) aims to identify maternal single nucleotide polymorphisms (SNPs) and copy-number variants (CNVs) involved in the etiology of PE...
  7. pmc Whole-exome sequencing of a pedigree segregating asthma
    Andrew T Dewan
    Department of Chronic Disease Epidemiology, Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    BMC Med Genet 13:95. 2012
    ..Some of this "missing heritability" may be accounted for by family-specific coding variants found to be segregating with asthma...
  8. pmc Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
    Kyle M Walsh
    1 Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA 2 Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 46:731-5. 2014
    ..No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. ..
  9. pmc Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans
    Kyle M Walsh
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Oncotarget 3:1428-38. 2012
    ..These findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans...
  10. pmc Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
    Terri Rice
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94107, USA
    Neuro Oncol 15:535-41. 2013
    ..Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this variant increases susceptibility to IDH-mutated gliomas, but not to IDH-wild-type gliomas...
  11. pmc Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia
    Juhi Ojha
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
    Cancer Epidemiol Biomarkers Prev 25:1043-9. 2016
    ..Shorter mean telomere length in leukemic cells has been associated with more aggressive disease. Germline polymorphisms in telomere maintenance genes affect telomere length and may contribute to CLL susceptibility...
  12. pmc Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia
    Adam J de Smith
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
    Oncotarget 7:72733-72745. 2016
    ..Future work is required to investigate whether tumor microheterogeneity impacts clinical outcome and to elucidate the functional consequences of epigenetic dysregulation in HD-ALL, potentially leading to novel therapeutic approaches...
  13. pmc Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA
    Adam J de Smith
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0143343. 2015
    ....
  14. pmc Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Oncotarget 6:42468-77. 2015
    ..33) and CTC1 (O.R.=1.14; 95% C.I.=1.02-1.28). Future work is needed to characterize the role of the CST complex in gliomagenesis and further elucidate the complex balance between ageing, telomere length, and molecular carcinogenesis. ..
  15. pmc Understanding inherited genetic risk of adult glioma - a review
    Terri Rice
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158 T R, A M M, K M W, S S F, J W, J K W, M R W Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 D H L, R B J Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 D H L Department of Epidemiology and Biostatistics, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158 A M M, J W Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 J E E P Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158 K M W, J W, J K W, M R W Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue
    Neurooncol Pract 3:10-16. 2016
    ..This review also provides an information sheet for primary adult glioma patients and their families...
  16. pmc Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates
    Semira Gonseth
    a Department of Epidemiology and Biostatistics, Laboratory for Molecular Epidemiology, University of California, San Francisco, CA, USA
    Epigenetics . 2016
    ..New methods are required for adequate and routine inclusion of genotypic influence on DNA methylation in epigenome-wide association studies to control for potential confounding...
  17. pmc CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas
    Gerald F Reis
    From the Departments of Neurology, Pediatrics, and Neurosurgery, Stanford University School of Medicine, Stanford HV Department of Anatomic Pathology, University of California San Francisco Medical School GFR, MP, AP Division of Neuroepidemiology HMH, TR, JKW, MRW, KMW, Departments of Neurological Surgery REM, AMM, JJP, AP and Epidemiology and Biostatistics AMM and Institute for Human Genetics, University of California San Francisco JKW, MRW, KMW, San Francisco, California
    J Neuropathol Exp Neurol 74:442-52. 2015
    ..These findings suggest that CDKN2A testing may provide further clinical aid in lower-grade glioma substratification beyond IDH mutation and 1p19q codeletion status, particularly in IDH/TP53 mutated astrocytomas. ..
  18. doi request reprint Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents
    Alyson A Endicott
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, California
    Pediatr Blood Cancer . 2016
    ..Birthweight is one measure of perinatal growth that has been investigated as an osteosarcoma risk factor. Whether birthweight affects clinical features of osteosarcoma remains unexplored...
  19. pmc Telomere maintenance and the etiology of adult glioma
    Kyle M Walsh
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California K M W, J K W, A M M, M R W Institute for Human Genetics, University of California San Francisco, San Francisco, California J K W, M R W Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota D H L, R B J Department of Neurology, Mayo Clinic, Rochester, Minnesota D H L Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California J L W, A M M Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota J E E P
    Neuro Oncol 17:1445-52. 2015
    ..Specifically, several inherited and acquired variants underlying gliomagenesis affect telomere pathways and are also associated with increased telomere length. ..
  20. pmc In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
    Stephen Starko Francis
    Department of Epidemiology, University of California, Berkeley, CA, United States
    Blood . 2016
    ..10 CI= 0.69-7.13). This is the first study to suggest that congenital CMV infection is a risk factor for childhood ALL and is more prominent in Hispanic children. Further investigation of CMV as an etiologic agent for ALL is warranted...
  21. doi request reprint Epidemiology
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco and UCSF Helen Diller Family Cancer Center, San Francisco, CA, USA
    Handb Clin Neurol 134:3-18. 2016
    ..Future studies will need to be large enough so that environmental and constitutive genetic risk factors can be examined within molecularly defined, etiologically homogeneous subgroups...
  22. pmc Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia
    Kyle M Walsh
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, 94143 Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, 94143
    Am J Hematol 89:721-5. 2014
    ....
  23. pmc Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS)
    Paige M Bracci
    Departmentsof Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94158, USA
    J Thorac Oncol 7:1352-60. 2012
    ..Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined...
  24. pmc Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
    Robert J A Bell
    Department of Neurological Surgery, University of California, San Francisco, CA Department of Biostatistics and Epidemiology, University of California, San Francisco, CA
    Science 348:1036-9. 2015
    ..GABP thus directly links TERT promoter mutations to aberrant expression in multiple cancers. ..