Timothy F Walseth

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc A multifunctional enzyme adds to its repertoire
    Timothy F Walseth
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 102:14941-2. 2005
  2. ncbi request reprint Altered airway responsiveness in CD38-deficient mice
    Deepak A Deshpande
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
    Am J Respir Cell Mol Biol 32:149-56. 2005
  3. ncbi request reprint Cyclic ADP-ribose analogues containing the methylenebisphosphonate linkage: effect of pyrophosphate modifications on Ca2+ release activity
    Libo Xu
    Department of Medicinal and Biological Chemistry, College of Pharmacy, The University of Toledo, Ohio 43606, USA
    J Med Chem 48:4177-81. 2005
  4. ncbi request reprint Methodologic advancements in the study of airway smooth muscle
    Michael I Kotlikoff
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Allergy Clin Immunol 114:S18-31. 2004
  5. ncbi request reprint Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
  6. ncbi request reprint Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads
    Ewa Prochniewicz
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 43:10642-52. 2004
  7. ncbi request reprint Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells
    Bit Na Kang
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Can J Physiol Pharmacol 83:799-804. 2005
  8. ncbi request reprint Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:7827-39. 2007
  9. ncbi request reprint CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle
    Deepak A Deshpande
    Dept of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 288:L773-88. 2005
  10. pmc Calcium signaling in airway smooth muscle
    Joseph A Jude
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Proc Am Thorac Soc 5:15-22. 2008

Collaborators

  • Frances E Lund
  • A H Guse
  • Dawn A Lowe
  • Junichi Nakai
  • Michael Kotlikoff
  • Barry Vl Potter
  • Y Amrani
  • Mathur S Kannan
  • Deepak A Deshpande
  • Thomas A White
  • Reynold A Panettieri
  • Soner Dogan
  • Bit Na Kang
  • Joseph A Jude
  • Santiago Partida-Sanchez
  • Libo Xu
  • Ewa Prochniewicz
  • Omar Tliba
  • Mark E Wylam
  • Werner Dammermann
  • Cornelia C Siebrands
  • Harivadan Bhagat
  • Adriana Sumoza-Toledo
  • Guixiu Shi
  • Betty J Mousseau
  • Ralf Fliegert
  • Andreas Gasser
  • Carlos Milla
  • Alonso G P Guedes
  • K G Tirumurugaan
  • James T Slama
  • David D Thomas
  • Steven M Miller
  • Samira Tliba
  • Michael P Murtaugh

Detail Information

Publications19

  1. pmc A multifunctional enzyme adds to its repertoire
    Timothy F Walseth
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 102:14941-2. 2005
  2. ncbi request reprint Altered airway responsiveness in CD38-deficient mice
    Deepak A Deshpande
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
    Am J Respir Cell Mol Biol 32:149-56. 2005
    ..The results of the present study demonstrate that CD38/cADPR contributes to airway smooth muscle tone and responsiveness through its effects on agonist-induced elevation of intracellular calcium in ASM cells...
  3. ncbi request reprint Cyclic ADP-ribose analogues containing the methylenebisphosphonate linkage: effect of pyrophosphate modifications on Ca2+ release activity
    Libo Xu
    Department of Medicinal and Biological Chemistry, College of Pharmacy, The University of Toledo, Ohio 43606, USA
    J Med Chem 48:4177-81. 2005
    ..The EC(50) for cADPR[CH(2)] was 856 nM and that for 3-deaza-cADPR[CH(2)] was 300 nM, about 15- and 5-fold less potent than cADPR, respectively...
  4. ncbi request reprint Methodologic advancements in the study of airway smooth muscle
    Michael I Kotlikoff
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Allergy Clin Immunol 114:S18-31. 2004
    ....
  5. ncbi request reprint Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM...
  6. ncbi request reprint Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads
    Ewa Prochniewicz
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 43:10642-52. 2004
    ..We propose that the transition on the acto-myosin interface from weak to strong binding is accompanied by transitions in the structural dynamics of actin parallel to transitions in the dynamics of interacting myosin heads...
  7. ncbi request reprint Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells
    Bit Na Kang
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Can J Physiol Pharmacol 83:799-804. 2005
    ..001). These results provide evidence for the feasibility of using adenoviral vectors for gene transfer to down regulate gene expression, and confirm the role of CD38 in calcium homeostatis in ASM cells...
  8. ncbi request reprint Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:7827-39. 2007
    ....
  9. ncbi request reprint CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle
    Deepak A Deshpande
    Dept of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 288:L773-88. 2005
    ....
  10. pmc Calcium signaling in airway smooth muscle
    Joseph A Jude
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Proc Am Thorac Soc 5:15-22. 2008
    ..In this review, we will discuss the specific roles of cyclic ADP-ribose/ryanodine receptor channels and transient receptor potential channels in the regulation of intracellular calcium in airway smooth muscle cells...
  11. ncbi request reprint Estrogen increases CD38 gene expression and leads to differential regulation of adenosine diphosphate (ADP)-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in rat myometrium
    Soner Dogan
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    Biol Reprod 66:596-602. 2002
    ..The differential regulation of CD38 by estradiol-17 beta, resulting in increased cADPR synthesis, would have profound effects on calcium regulation and myometrial contractility...
  12. ncbi request reprint Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
    ..Our study is the first to demonstrate that IFNbeta-dependent activation of CD38 pathway is a novel component by which TNFalpha differentially regulates the expression of inflammatory genes in ASM cells...
  13. ncbi request reprint Bronchial hyperresponsiveness: insights into new signaling molecules
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Pharmacol 4:230-4. 2004
    ..Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness...
  14. ncbi request reprint Medicinal chemistry and pharmacology of cyclic ADP-ribose
    Barry V L Potter
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Mol Med 4:303-11. 2004
    ..This review will focus on the synthesis and properties of analogs that have been shown to have utility in dissecting the role of cADPR in calcium signaling...
  15. ncbi request reprint Changes in CD38 expression and ADP-ribosyl cyclase activity in rat myometrium during pregnancy: influence of sex steroid hormones
    Soner Dogan
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Biol Reprod 71:97-103. 2004
    ..These results indicate that the estrogen:progesterone ratio determines CD38 expression and ADP-ribosyl cyclase activity. These changes in CD38/cADPR pathway may contribute to increased uterine motility and onset of labor...
  16. ncbi request reprint Intracellular calcium signaling through the cADPR pathway is agonist specific in porcine airway smooth muscle
    Thomas A White
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, USA
    FASEB J 17:482-4. 2003
    ..In airway smooth muscle, the CD38/cADPR signaling pathway is involved in [Ca2+]i responses to contractile agonists in an agonist-specific manner...
  17. ncbi request reprint CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    FASEB J 17:452-4. 2003
    ..This study provides the first demonstration of a role for CD38-cADPR signaling in a model of inflammatory airway disease...
  18. ncbi request reprint Nitric oxide inhibits ADP-ribosyl cyclase through a cGMP-independent pathway in airway smooth muscle
    Thomas A White
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1065-71. 2002
    ..These results provide a novel mechanism for differential regulation of CD38 by NO through a cGMP-independent pathway involving S-nitrosylation of thiols...
  19. pmc Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1
    Bit Na Kang
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota 55108, USA
    Am J Physiol Lung Cell Mol Physiol 295:L186-93. 2008
    ..The glucocorticoid effects on decreased CD38 expression and function result from regulation through transcription and transcript stability...