Paul A Voziyan

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation
    Paul A Voziyan
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 277:3397-403. 2002
  2. ncbi request reprint Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria
    Jon I Scheinman
    Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Blvd, Room G 019 Miller Bldg, Kansas City, KS 66160 7330, USA
    Urol Res 33:368-71. 2005
  3. doi request reprint Propagation of protein glycation damage involves modification of tryptophan residues via reactive oxygen species: inhibition by pyridoxamine
    Sergei V Chetyrkin
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Free Radic Biol Med 44:1276-85. 2008
  4. ncbi request reprint Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy
    Vadim K Pedchenko
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Diabetes 54:2952-60. 2005
  5. ncbi request reprint Pyridoxamine: the many virtues of a maillard reaction inhibitor
    Paul A Voziyan
    Division of Nephrology, Vanderbilt University Medical Center, S 3223 MCN, 1161 21st Avenue South, Nashville, TN 37232 2372, USA
    Ann N Y Acad Sci 1043:807-16. 2005
  6. ncbi request reprint Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria
    Sergei V Chetyrkin
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Kidney Int 67:53-60. 2005
  7. ncbi request reprint Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions
    Paul A Voziyan
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Biol Chem 278:46616-24. 2003
  8. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
  9. ncbi request reprint Pyridoxamine protects proteins from functional damage by 3-deoxyglucosone: mechanism of action of pyridoxamine
    Sergei V Chetyrkin
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biochemistry 47:997-1006. 2008
  10. ncbi request reprint Designing a high throughput refolding array using a combination of the GroEL chaperonin and osmolytes
    Paul A Voziyan
    Department of Medicine Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Struct Funct Genomics 6:183-8. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation
    Paul A Voziyan
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 277:3397-403. 2002
    ....
  2. ncbi request reprint Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria
    Jon I Scheinman
    Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Blvd, Room G 019 Miller Bldg, Kansas City, KS 66160 7330, USA
    Urol Res 33:368-71. 2005
    ..These results, coupled with favorable toxicity profiles of PM in humans, show promise for the therapeutic use of PM in primary hyperoxaluria and other kidney stone diseases...
  3. doi request reprint Propagation of protein glycation damage involves modification of tryptophan residues via reactive oxygen species: inhibition by pyridoxamine
    Sergei V Chetyrkin
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Free Radic Biol Med 44:1276-85. 2008
    ....
  4. ncbi request reprint Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy
    Vadim K Pedchenko
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Diabetes 54:2952-60. 2005
    ..This mechanism may contribute to the development of diabetic nephropathy...
  5. ncbi request reprint Pyridoxamine: the many virtues of a maillard reaction inhibitor
    Paul A Voziyan
    Division of Nephrology, Vanderbilt University Medical Center, S 3223 MCN, 1161 21st Avenue South, Nashville, TN 37232 2372, USA
    Ann N Y Acad Sci 1043:807-16. 2005
    ..These multiple activities position PM as a promising drug candidate for treatment of multifactorial chronic conditions in which oxidative reactions and/or carbonyl compounds confer pathogenicity...
  6. ncbi request reprint Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria
    Sergei V Chetyrkin
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Kidney Int 67:53-60. 2005
    ..In previous in vitro studies, we demonstrated that pyridoxamine can trap reactive carbonyl compounds, including intermediates of oxalate biosynthesis...
  7. ncbi request reprint Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions
    Paul A Voziyan
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Biol Chem 278:46616-24. 2003
    ....
  8. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
    ....
  9. ncbi request reprint Pyridoxamine protects proteins from functional damage by 3-deoxyglucosone: mechanism of action of pyridoxamine
    Sergei V Chetyrkin
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biochemistry 47:997-1006. 2008
    ..Our data emphasize the potential importance of the contribution by 3-DG, along with other more reactive RCS, to this pathogenic mechanism...
  10. ncbi request reprint Designing a high throughput refolding array using a combination of the GroEL chaperonin and osmolytes
    Paul A Voziyan
    Department of Medicine Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Struct Funct Genomics 6:183-8. 2005
    ..The method allows for isolation of folded monomeric or oligomeric proteins in quantities sufficient for X-ray crystallography or NMR structural determinations...