Genomes and Genes
D M Virshup
Affiliation: University of Utah
- Protein phosphatase 2A: a panoply of enzymesD M Virshup
Departments of Pediatrics and Oncological Sciences, 5C334 School of Medicine, University of Utah, Salt Lake City, 84132, USA david
Curr Opin Cell Biol 12:180-5. 2000..During the past year, studies have shown that protein phosphatase 2A influences events ranging from the initiation of DNA replication to vertebrate axis formation to apoptosis...
- Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in XenopusX Li
Department of Oncological Sciences and the Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
EMBO J 20:4122-31. 2001..These results support the hypothesis that PP2A:B56 directly inhibits Wnt signaling and plays a role in development and carcinogenesis...
- Reversible protein phosphorylation regulates circadian rhythmsD M Virshup
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
Cold Spring Harb Symp Quant Biol 72:413-20. 2007..Pharmacological manipulation of rhythms could mitigate stress from jet lag, shift work, and perhaps even seasonal affective disorder...
- Nuclear export of mammalian PERIOD proteinsE L Vielhaber
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
J Biol Chem 276:45921-7. 2001..The presence of a functional NES in mPER1 and mPER2 as well as related sequences in a variety of other PER proteins suggests that nuclear export may be a conserved and important feature of circadian regulators...
- Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2AJ M Seeling
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
Science 283:2089-91. 1999..B56 may direct PP2A to dephosphorylate specific components of the APC-dependent signaling complex and thereby inhibit Wnt signaling...
- An hPer2 phosphorylation site mutation in familial advanced sleep phase syndromeK L Toh
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Science 291:1040-3. 2001..Thus, a variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period...