P L Vera

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 4:34. 2004
  2. pmc Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
    Irving Nadelhaft
    Veteran s Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Neurosci 3:8. 2002
  3. pmc Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines Veterans Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 5:73. 2005
  4. ncbi request reprint Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat
    Pedro L Vera
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, Bay Pines, Florida, USA
    J Urol 174:338-43. 2005
  5. pmc Anatomical location of macrophage migration inhibitory factor in urogenital tissues, peripheral ganglia and lumbosacral spinal cord of the rat
    Pedro L Vera
    Research and Development 151, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
    BMC Neurosci 4:17. 2003
  6. pmc Central effects of clozapine in regulating micturition in anesthetized rats
    Pedro L Vera
    Bay Pines VA Medical Center, Research and Development Service, Bay Pines, FL 33744, USA
    BMC Pharmacol 2:6. 2002
  7. pmc Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats
    P L Vera
    VA Medical Center Research and Development Service Bay Pines, University of South Florida, FL 33744, USA
    BMC Pharmacol 1:4. 2001
  8. ncbi request reprint Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, University of South Florida, Bay Pines, Florida 33744, USA
    Neurourol Urodyn 20:623-39. 2001
  9. pmc Substance P induces localization of MIF/alpha1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladder
    Pedro L Vera
    The Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, USA
    BMC Urol 6:24. 2006
  10. ncbi request reprint Clozapine inhibits micturition parameters and the external urethral sphincter during cystometry in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, R and D Service 151, Bay Pines, FL 33744, USA
    Brain Res 901:219-29. 2001

Detail Information

Publications29

  1. pmc Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 4:34. 2004
    ..Increased expression of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) has previously been associated with various types of adenocarcinoma...
  2. pmc Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
    Irving Nadelhaft
    Veteran s Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Neurosci 3:8. 2002
    ..25, 2.5, 2.75, 3 and 4 days, sections from the spinal cord and brain were processed immunohistochemically to detect cells, within a single section, which were labeled separately by each virus or were labeled by both viruses...
  3. pmc Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines Veterans Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 5:73. 2005
    ..Additional aims were to examine MIF expression, as well as the location of MIF's receptor, CD74, in human prostatic adenocarcinoma compared to matched benign prostate...
  4. ncbi request reprint Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat
    Pedro L Vera
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, Bay Pines, Florida, USA
    J Urol 174:338-43. 2005
    ..We investigated the forms of MIF that are released. We examined MIF release after subcutaneous substance P (SP) or intravesical capsaicin and studied proteins associated with excreted MIF in ILF...
  5. pmc Anatomical location of macrophage migration inhibitory factor in urogenital tissues, peripheral ganglia and lumbosacral spinal cord of the rat
    Pedro L Vera
    Research and Development 151, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
    BMC Neurosci 4:17. 2003
    ..Therefore, the location of MIF was determined immunohistochemically in the bladder, prostate, major pelvic ganglia, sympathetic chain, the L6-S1 dorsal root ganglia (DRG) and the lumbosacral spinal cord of the rat...
  6. pmc Central effects of clozapine in regulating micturition in anesthetized rats
    Pedro L Vera
    Bay Pines VA Medical Center, Research and Development Service, Bay Pines, FL 33744, USA
    BMC Pharmacol 2:6. 2002
    ..We extended our observations by delivering clozapine centrally in anesthetized rats instrumented with either an intrathecal (L6-S1 spinal segment) or an intracerebroventricular (lateral ventricle) catheter...
  7. pmc Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats
    P L Vera
    VA Medical Center Research and Development Service Bay Pines, University of South Florida, FL 33744, USA
    BMC Pharmacol 1:4. 2001
    ....
  8. ncbi request reprint Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, University of South Florida, Bay Pines, Florida 33744, USA
    Neurourol Urodyn 20:623-39. 2001
    ....
  9. pmc Substance P induces localization of MIF/alpha1-inhibitor-3 complexes to umbrella cells via paracellular transit through the urothelium in the rat bladder
    Pedro L Vera
    The Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, USA
    BMC Urol 6:24. 2006
    ..The location of A1-I3 in the bladder had not been investigated. Therefore, we examined the location of A1-I3 and MIF/A1-I3 complexes in the bladder and changes due to experimental inflammation...
  10. ncbi request reprint Clozapine inhibits micturition parameters and the external urethral sphincter during cystometry in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, R and D Service 151, Bay Pines, FL 33744, USA
    Brain Res 901:219-29. 2001
    ..Clozapine inhibits several urodynamic parameters and inhibits the activity of the external urethral sphincter in anesthetized rats. These effects may help explain the urinary disturbances reported in the clinical literature...
  11. ncbi request reprint Inflammation of the rat prostate evokes release of macrophage migration inhibitory factor in the bladder: evidence for a viscerovisceral reflex
    Pedro L Vera
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, Bay Pines, Florida 33744, USA
    J Urol 172:2440-5. 2004
    ..We examined the effects of prostatic inflammation on micturition frequency, bladder histology and bladder MIF content as a model in which to study viscerovisceral reflexes mediating pelvic visceral inflammation...
  12. ncbi request reprint Anatomical evidence for two spinal 'afferent-interneuron-efferent' reflex pathways involved in micturition in the rat: a 'pelvic nerve' reflex pathway and a 'sacrolumbar intersegmental' reflex pathway
    P L Vera
    Veteran s Administration Medical Center, R and D Service 151, Bay Pines, FL 33744, USA
    Brain Res 883:107-18. 2000
    ....
  13. ncbi request reprint Neurons in the rat brain and spinal cord labeled after pseudorabies virus injected into the external urethral sphincter
    I Nadelhaft
    Veterans Administration Medical Center, Bay Pines, Florida 33504, USA
    J Comp Neurol 375:502-17. 1996
    ..Lett. 143:271-274). In both cases, neurons were labeled in the DGC in the spinal cord. The data therefore suggest that neurons in the DGC may be involved in the integrated control of the bladder and the external urethral sphincter...
  14. pmc Substance P increases cell-surface expression of CD74 (receptor for macrophage migration inhibitory factor): in vivo biotinylation of urothelial cell-surface proteins
    Katherine L Meyer-Siegler
    Research and Development Service, Bay Pines VA Healthcare System, VA Medical Center, Bay Pines, FL 33744, USA
    Mediators Inflamm 2009:535348. 2009
    ..These results document that our previously described MIF-CD74 interaction occurs at the urothelial cell surface...
  15. ncbi request reprint Separate urinary bladder and external urethral sphincter neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
    I Nadelhaft
    Veteran s Administration Medical Center, R and D Service 151, Bay Pines, FL 33744, USA
    Brain Res 903:33-44. 2001
    ..A very small number of double-labeled neurons were found in the pontine micturition center and the locus coeruleus or subcoeruleus...
  16. ncbi request reprint Intraluminal antibodies to macrophage migration inhibitory factor decrease substance P induced inflammatory changes in the rat bladder and prostate
    Katherine L Meyer-Siegler
    Bay Pines Veterans Affairs Medical Center, Research and Development Service, Bay Pines, Florida 33744, USA
    J Urol 172:1504-9. 2004
    ..MIF may act in an amplifying manner to maintain or increase inflammation. Inducing inflammatory changes with SP, while sequestering released luminal MIF with an antibody, tested this hypothesis...
  17. doi request reprint Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice
    Pedro L Vera
    The Bay Pines VA Healthcare System, Bay Pines, Florida, USA
    Neurourol Urodyn 29:1451-7. 2010
    ..Therefore, we examined the effects of a MIF tautomerase inhibitor (ISO-1; also blocks biological activity) on cyclophosphamide (CYP)-induced cystitis in mice...
  18. pmc Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat
    Pedro L Vera
    The Bay Pines VA Healthcare System, Research and Development, Bay Pines, Florida, United States of America
    PLoS ONE 4:e5835. 2009
    ....
  19. pmc Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association
    Pedro L Vera
    Bay Pines VA Healthcare System, Research and Development 151, Bay Pines, Florida, USA
    PLoS ONE 3:e3898. 2008
    ..We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis...
  20. pmc Neural control of substance P induced up-regulation and release of macrophage migration inhibitory factor in the rat bladder
    Pedro L Vera
    Bay Pines Veterans Affairs Healthcare System, Research and Development, Bay Pines, Florida 33744, USA
    J Urol 180:373-8. 2008
    ..We examined the contribution of nerve activity and specific neurotransmitter systems to the mechanism of macrophage migration inhibitory factor release from the bladder during inflammation...
  21. doi request reprint Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation
    Pedro L Vera
    Bay Pines VA Healthcare System, Research and Development 151, 10000 Bay Pines Boulevard, Bay Pines, FL 33744, USA
    Exp Biol Med (Maywood) 233:620-6. 2008
    ..This supports the hypothesis that MIF and CD74 play a significant role in both acute and persistent stages of bladder inflammation...
  22. ncbi request reprint Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat
    Pedro L Vera
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, and Department of Surgery, University of South Florida, Tampa, USA
    J Urol 170:623-7. 2003
    ....
  23. ncbi request reprint Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats
    Katherine L Meyer-Siegler
    Bay Pines VA Medical Center, Research and Development Service 151, and University of South Florida, Department of Surgery, Division of Urology, Tampa, FL, USA
    J Interferon Cytokine Res 24:55-63. 2004
    ..Finally, changes in prostate MIF content after intravesical LPS suggest that MIF may be involved in viscerovisceral interactions associated with chronic pelvic pain syndromes...
  24. pmc Thrombin induces macrophage migration inhibitory factor release and upregulation in urothelium: a possible contribution to bladder inflammation
    Pedro L Vera
    Research and Development, The Bay Pines VA Healthcare System, Bay Pines, Florida, United States of America
    PLoS ONE 5:e15904. 2010
    ..We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF release and MIF mRNA upregulation in urothelial cells...
  25. ncbi request reprint Substance P induced changes in CD74 and CD44 in the rat bladder
    Katherine L Meyer-Siegler
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, Bay Pines, Florida 33744, USA
    J Urol 173:615-20. 2005
    ..To describe the mechanism of MIF action we examined changes in the amount of CD74 (membrane receptor for MIF), CD44 and phospho-(p-ERK)1/2 in the bladder...
  26. ncbi request reprint Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells
    Katherine L Meyer-Siegler
    Research and Development 151, The Bay Pines Veterans Affairs Healthcare System, 10000 Bay Pines Boulevard, Bay Pines, FL 33744, USA
    J Immunol 177:8730-9. 2006
    ..Thus, blocking MIF either at the ligand (MIF) or receptor (CD74) may provide new, targeted specific therapies for androgen-independent prostate cancer...
  27. ncbi request reprint Substance P induced release of macrophage migration inhibitory factor from rat bladder epithelium
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines Veterans Affairs Medical Center, Bay Pines and Department of Surgery, University of South Florida, Tampa, Florida 33744, USA
    J Urol 171:1698-703. 2004
    ..We documented the time course of SP effects on rat bladder inflammation...
  28. ncbi request reprint Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine
    Katherine L Meyer-Siegler
    Research and Development Service, Bay Pines Veterans Affairs Medical Center, Bay Pines, USA
    J Urol 175:1523-8. 2006
    ..We compared urine MIF amounts in patients with UTI to that in patients without UTI, and we examined and identified MIF-protein complexes in urine...
  29. pmc Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation
    Katherine L Meyer-Siegler
    Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL 33744, USA
    Cancer Lett 290:49-57. 2010
    ..These data suggest that increased circulating levels of bioactive MIF are present in bladder cancer patient serum...