Nora Vazquez-Laslop

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Protein accounting in the cellular economy
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA Electronic address
    Cell 157:529-31. 2014
  2. pmc Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, 60607, USA
    J Bacteriol 188:3494-7. 2006
  3. doi request reprint Molecular mechanism of drug-dependent ribosome stalling
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, M C 870, Chicago, IL 60607, USA
    Mol Cell 30:190-202. 2008
  4. pmc The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL, USA
    EMBO J 29:3108-17. 2010
  5. pmc Role of antibiotic ligand in nascent peptide-dependent ribosome stalling
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 108:10496-501. 2011
  6. pmc Regulation of gene expression by macrolide-induced ribosomal frameshifting
    Pulkit Gupta
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell 52:629-42. 2013
  7. doi request reprint Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center
    Haripriya Ramu
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA
    Mol Cell 41:321-30. 2011
  8. doi request reprint Programmed drug-dependent ribosome stalling
    Haripriya Ramu
    Center for Pharmaceutical Biotechnology, University of Illinois, 900 S Ashland Ave, Chicago, IL 60607, USA
    Mol Microbiol 71:811-24. 2009
  9. doi request reprint Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible
    Pulkit Gupta
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Nat Commun 4:1984. 2013
  10. doi request reprint Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel
    Krishna Kannan
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Cell 151:508-20. 2012

Collaborators

  • Alexander S Mankin
  • Bo Liu
  • Tõnu Margus
  • Stephen Douthwaite
  • Maido Remm
  • Wei Han
  • Tanel Tenson
  • Matthew S Sachs
  • Charles Yanofsky
  • Dorota Klepacki
  • Pulkit Gupta
  • Shanmugapriya Sothiselvam
  • Haripriya Ramu
  • Krishna Kannan
  • Cedric Orelle
  • Sezen Meydan
  • James Marks
  • Mashal M Almutairi
  • Klaus Schulten
  • Allyson K Martínez
  • Ronald Micura
  • Subbulakshmi Karthikeyan
  • Jonathan D Dinman
  • Joseph Briggs
  • Yousuf Khan
  • Paul Thomas
  • John E Jones
  • Amira Kefi
  • Emily J Roncase
  • Lukas Rigger
  • Vrinda Gupta
  • Sandro Neuner
  • Hyunwoo Lee
  • Douglas A Hansen
  • Simon Rose
  • Sung Ryeol Park
  • David H Sherman
  • Lewis M Brown
  • Gemma Catherine Atkinson
  • Arnab Sengupta
  • Emily Gordon
  • Luis R Cruz-Vera
  • Age Brauer
  • Nitin Shirole
  • Blanca Martinez-Garriga
  • Michael J Benedik
  • Karen J Shaw
  • Teresa Szal
  • Qing Dai
  • JOSEPH PICCIRILLI
  • Katya A Klyachko
  • Alex A Neyfakh

Detail Information

Publications19

  1. pmc Protein accounting in the cellular economy
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA Electronic address
    Cell 157:529-31. 2014
    ..gain insights into key aspects of translation regulation and fundamental principles of cellular strategies to adjust protein synthesis according to the functional needs. ..
  2. pmc Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, 60607, USA
    J Bacteriol 188:3494-7. 2006
    ..Thus, persistence is linked not only to toxicity caused by expression of HipA or dedicated toxins but also to expression of other unrelated proteins...
  3. doi request reprint Molecular mechanism of drug-dependent ribosome stalling
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, M C 870, Chicago, IL 60607, USA
    Mol Cell 30:190-202. 2008
    ..The cladinose-containing macrolide antibiotic in the tunnel positions the nascent peptide for interaction with the tunnel sensory elements...
  4. pmc The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL, USA
    EMBO J 29:3108-17. 2010
    ..Structural and biochemical evidence suggest that m(2)A2503 may act in concert with the previously identified nascent-peptide sensor, A2062, in the ribosome exit tunnel to relay the stalling signal to the peptidyl transferase centre...
  5. pmc Role of antibiotic ligand in nascent peptide-dependent ribosome stalling
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 108:10496-501. 2011
    ..A similar mechanism could be used by the ribosome to sense a variety of cellular metabolites...
  6. pmc Regulation of gene expression by macrolide-induced ribosomal frameshifting
    Pulkit Gupta
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell 52:629-42. 2013
    ..Conceptually similar mechanisms may control other cellular genes. The identified property of ketolides to reduce the fidelity of reading frame maintenance may have medical implications...
  7. doi request reprint Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center
    Haripriya Ramu
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA
    Mol Cell 41:321-30. 2011
    ..The extent of the conferred A-site selectivity is modulated by the C-terminal segment of the nascent peptide, where the third-from-last residue plays a critical role...
  8. doi request reprint Programmed drug-dependent ribosome stalling
    Haripriya Ramu
    Center for Pharmaceutical Biotechnology, University of Illinois, 900 S Ashland Ave, Chicago, IL 60607, USA
    Mol Microbiol 71:811-24. 2009
    ..In this review, we summarize our current understanding of the molecular mechanisms of drug- and nascent peptide-dependent ribosome stalling...
  9. doi request reprint Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible
    Pulkit Gupta
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Nat Commun 4:1984. 2013
    ..Our findings provide a plausible explanation why erm genes have evolved to be inducible and underscore the importance of nascent peptide recognition by the ribosome for generating a balanced cellular proteome...
  10. doi request reprint Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel
    Krishna Kannan
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Cell 151:508-20. 2012
    ..Our findings reveal that small-molecule effectors can accentuate the discriminatory properties of the ribosomal exit tunnel and that macrolide antibiotics reshape the cellular proteome rather than block global protein synthesis...
  11. doi request reprint Nascent peptide assists the ribosome in recognizing chemically distinct small molecules
    Pulkit Gupta
    Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Nat Chem Biol 12:153-8. 2016
    ..Thus, the ribosomal response to chemical signals can be modulated by minute changes in the nascent peptide, suggesting that protein sequences could have been optimized for rendering translation sensitive to environmental cues. ..
  12. pmc Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan
    Allyson K Martínez
    Department of Biology, Texas A and M University, College Station, TX 77843, USA, Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL 35899, USA, Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60607, USA, Quantitative Proteomics Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA and Department of Biology, Stanford University, Stanford, CA 94305, USA
    Nucleic Acids Res 42:1245-56. 2014
    ..These findings suggest that interactions between TnaC residue I19 and 23S rRNA nucleotide A2058 contribute to the creation of a regulatory L-Trp binding site within the translating ribosome. ..
  13. pmc Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center
    James Marks
    Center for Biomolecular Sciences, University of Illinois, Chicago, IL 60607
    Proc Natl Acad Sci U S A 113:12150-12155. 2016
    ..In addition, our findings expose the functional interplay between the nascent chain and the peptidyl transferase center...
  14. pmc Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size
    Shanmugapriya Sothiselvam
    Center for Biomolecular Sciences, University of Illinois, Chicago, IL 60607, USA
    Cell Rep 16:1789-99. 2016
    ..Our findings emphasize the existence of functional interactions between the nascent protein and the catalytic site of the ribosomal peptidyl transferase center. ..
  15. pmc Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition
    Cedric Orelle
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA and Trius Therapeutics, Inc, San Diego, CA 92121, USA
    Nucleic Acids Res 41:e144. 2013
    ..The utility of the technique is demonstrated by identifying a switch in target specificity of some synthetic inhibitors of threonyl-tRNA synthetase. ..
  16. pmc Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release
    Hyunwoo Lee
    Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60607, USA
    Antimicrob Agents Chemother 47:1267-74. 2003
    ..with increased susceptibility (two- to fivefold decrease in the MIC) to erythromycin. The same technique can be used to identify prospective targets for potentiators of many other antibacterial agents...
  17. pmc Macrolide antibiotics allosterically predispose the ribosome for translation arrest
    Shanmugapriya Sothiselvam
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607
    Proc Natl Acad Sci U S A 111:9804-9. 2014
    ..Our findings offer a new view on the role of small cofactors in the mechanism of translation arrest and reveal an allosteric link between the tunnel and the catalytic center of the ribosome. ..
  18. pmc Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene
    Sezen Meydan
    Center for Biomolecular Sciences m c 870, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell 65:207-219. 2017
    ..Similar mRNA elements are not only found in the copA genes of other bacteria but are also present in ATP7B, the human homolog of copA, and direct ribosomal frameshifting in vivo...
  19. pmc Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides
    Mashal M Almutairi
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607
    Proc Natl Acad Sci U S A 112:12956-61. 2015
    ..Taken together, these findings emphasized the need for surveillance of pikR1/pikR2-based bacterial resistance and the preemptive development of drugs that can remain effective against the ketolide-specific resistance mechanism. ..