Thanos Tzounopoulos

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitus
    Thanos Tzounopoulos
    Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA
    Am J Audiol 17:S170-5. 2008
  2. pmc Learning to encode timing: mechanisms of plasticity in the auditory brainstem
    Thanos Tzounopoulos
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuron 62:463-9. 2009
  3. pmc Mechanisms underlying input-specific expression of endocannabinoid-mediated synaptic plasticity in the dorsal cochlear nucleus
    Yanjun Zhao
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
    Hear Res 279:67-73. 2011
  4. pmc Combined LTP and LTD of modulatory inputs controls neuronal processing of primary sensory inputs
    Brent Doiron
    Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 31:10579-92. 2011
  5. pmc Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis
    Tamara Perez-Rosello
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 33:9259-72. 2013
  6. pmc Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
    Shuang Li
    Department of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 110:9980-5. 2013
  7. pmc Physiological activation of cholinergic inputs controls associative synaptic plasticity via modulation of endocannabinoid signaling
    Yanjun Zhao
    Departments of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 31:3158-68. 2011
  8. pmc Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem
    Yanjun Zhao
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurophysiol 101:2434-46. 2009
  9. pmc Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons
    Ricardo M Leão
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurophysiol 107:3008-19. 2012
  10. pmc AMPA receptor inhibition by synaptically released zinc
    Bopanna I Kalappa
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 112:15749-54. 2015

Collaborators

Detail Information

Publications17

  1. pmc Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitus
    Thanos Tzounopoulos
    Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA
    Am J Audiol 17:S170-5. 2008
    ..A candidate site for the expression of this so-called synaptic plasticity is a region of the brainstem called the dorsal cochlear nucleus (DCN), a site of integration of acoustic and multimodal, sensory inputs...
  2. pmc Learning to encode timing: mechanisms of plasticity in the auditory brainstem
    Thanos Tzounopoulos
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuron 62:463-9. 2009
    ..However, recent groundbreaking results from animal models and human studies have revealed remarkable evidence for cellular and behavioral mechanisms for learning and memory in the auditory brainstem...
  3. pmc Mechanisms underlying input-specific expression of endocannabinoid-mediated synaptic plasticity in the dorsal cochlear nucleus
    Yanjun Zhao
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
    Hear Res 279:67-73. 2011
    ..However, pairing of parallel fiber activity with auditory nerve activity elicits plasticity in parallel fiber inputs, thus suggesting a role for synaptic plasticity in multisensory integration...
  4. pmc Combined LTP and LTD of modulatory inputs controls neuronal processing of primary sensory inputs
    Brent Doiron
    Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 31:10579-92. 2011
    ..Our data reveal a novel mechanism mediating adaptive and concomitant homeostatic regulation of distinct features of neuronal processing of sensory inputs...
  5. pmc Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis
    Tamara Perez-Rosello
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 33:9259-72. 2013
    ..We reveal a previously unknown action of synaptic Zn(2+): synaptic Zn(2+) inhibits glutamate release by promoting 2-AG synthesis...
  6. pmc Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
    Shuang Li
    Department of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 110:9980-5. 2013
    ..Moreover, our findings point to previously unknown biological targets for designing therapeutic drugs that may prevent the development of tinnitus in humans...
  7. pmc Physiological activation of cholinergic inputs controls associative synaptic plasticity via modulation of endocannabinoid signaling
    Yanjun Zhao
    Departments of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 31:3158-68. 2011
    ..Based on the extensive distribution of cholinergic and endocannabinoid signaling, we suggest that their interaction may provide a general mechanism for dynamic, context-dependent modulation of associative synaptic plasticity...
  8. pmc Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem
    Yanjun Zhao
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurophysiol 101:2434-46. 2009
    ..We propose that EC signaling is a major modulator of the balance of excitation and inhibition in auditory circuits...
  9. pmc Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons
    Ricardo M Leão
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurophysiol 107:3008-19. 2012
    ..Our results provide a biophysical mechanism for generating neural heterogeneity, which may play a role in the encoding of sensory information...
  10. pmc AMPA receptor inhibition by synaptically released zinc
    Bopanna I Kalappa
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 112:15749-54. 2015
    ..Our results establish zinc as an activity-dependent, endogenous modulator of AMPARs that tunes fast excitatory neurotransmission and plasticity in glutamatergic synapses. ..
  11. pmc Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission
    Tamara Perez-Rosello
    Department of Otolaryngology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    Neurobiol Dis 81:14-9. 2015
    ..In this context, tonic zinc provides a powerful break of spontaneous firing that may protect against pathological run-up of spontaneous activity in the DCN. ..
  12. pmc Coactivation of pre- and postsynaptic signaling mechanisms determines cell-specific spike-timing-dependent plasticity
    Thanos Tzounopoulos
    Department of Cell Biology and Anatomy, Rosalind Franklin University, Chicago Medical School, North Chicago, IL 60064, USA
    Neuron 54:291-301. 2007
    ..Hence, pre- and postsynaptic sites of expression determine both the sign and timing requirements of long-term plasticity in interneurons...
  13. pmc Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition
    Jason W Middleton
    Department of Otolaryngology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:7601-6. 2011
    ..These findings indicate that auditory circuits in mice with behavioral evidence of tinnitus respond to stimuli in a more robust and spatially distributed manner because of a decrease in GABAergic inhibition...
  14. pmc Cell-Specific Cholinergic Modulation of Excitability of Layer 5B Principal Neurons in Mouse Auditory Cortex
    Ankur Joshi
    Department of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
    J Neurosci 36:8487-99. 2016
    ..We propose that ACh-mediated persistent firing in corticocollicular neurons may represent a critical mechanism required for learning-induced plasticity in AC...
  15. pmc Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc
    Charles T Anderson
    Departments of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 112:E2705-14. 2015
    ..These results demonstrate a physiological role for endogenous synaptic as well as tonic zinc in inhibiting extrasynaptic NMDARs and thereby fine tuning neuronal excitability and signaling. ..
  16. doi request reprint Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators
    Manoj Kumar
    Department of Otolaryngology, School of Medicine M K, T T Department of Chemistry N R, R L, P W Department of Neurobiology E A, T T and Pittsburgh Institute for Neurodegenerative Diseases, School of Medicine E A, University of Pittsburgh, Pittsburgh, Pennsylvania
    Mol Pharmacol 89:667-77. 2016
    ..We suggest that RL648_81 is a promising clinical candidate for treating or preventing neurologic disorders associated with neuronal hyperexcitability. ..
  17. pmc Imaging the neural correlates of tinnitus: a comparison between animal models and human studies
    Jason W Middleton
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh PA, USA
    Front Syst Neurosci 6:35. 2012
    ..We propose that the comparison between animal model and human studies will aid in the design of appropriate experimental paradigms aimed at elucidating the cellular and circuit mechanisms underlying tinnitus...