Affiliation: University of Pittsburgh
- Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitusThanos Tzounopoulos
Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA
Am J Audiol 17:S170-5. 2008..A candidate site for the expression of this so-called synaptic plasticity is a region of the brainstem called the dorsal cochlear nucleus (DCN), a site of integration of acoustic and multimodal, sensory inputs...
- Learning to encode timing: mechanisms of plasticity in the auditory brainstemThanos Tzounopoulos
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuron 62:463-9. 2009..However, recent groundbreaking results from animal models and human studies have revealed remarkable evidence for cellular and behavioral mechanisms for learning and memory in the auditory brainstem...
- Mechanisms underlying input-specific expression of endocannabinoid-mediated synaptic plasticity in the dorsal cochlear nucleusYanjun Zhao
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
Hear Res 279:67-73. 2011..However, pairing of parallel fiber activity with auditory nerve activity elicits plasticity in parallel fiber inputs, thus suggesting a role for synaptic plasticity in multisensory integration...
- Combined LTP and LTD of modulatory inputs controls neuronal processing of primary sensory inputsBrent Doiron
Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 31:10579-92. 2011..Our data reveal a novel mechanism mediating adaptive and concomitant homeostatic regulation of distinct features of neuronal processing of sensory inputs...
- Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesisTamara Perez-Rosello
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 33:9259-72. 2013..We reveal a previously unknown action of synaptic Zn(2+): synaptic Zn(2+) inhibits glutamate release by promoting 2-AG synthesis...
- Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitusShuang Li
Department of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 110:9980-5. 2013..Moreover, our findings point to previously unknown biological targets for designing therapeutic drugs that may prevent the development of tinnitus in humans...
- Physiological activation of cholinergic inputs controls associative synaptic plasticity via modulation of endocannabinoid signalingYanjun Zhao
Departments of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 31:3158-68. 2011..Based on the extensive distribution of cholinergic and endocannabinoid signaling, we suggest that their interaction may provide a general mechanism for dynamic, context-dependent modulation of associative synaptic plasticity...
- Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstemYanjun Zhao
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Neurophysiol 101:2434-46. 2009..We propose that EC signaling is a major modulator of the balance of excitation and inhibition in auditory circuits...
- Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neuronsRicardo M Leão
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Neurophysiol 107:3008-19. 2012..Our results provide a biophysical mechanism for generating neural heterogeneity, which may play a role in the encoding of sensory information...
- AMPA receptor inhibition by synaptically released zincBopanna I Kalappa
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15261
Proc Natl Acad Sci U S A 112:15749-54. 2015..Our results establish zinc as an activity-dependent, endogenous modulator of AMPARs that tunes fast excitatory neurotransmission and plasticity in glutamatergic synapses. ..
- Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmissionTamara Perez-Rosello
Department of Otolaryngology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
Neurobiol Dis 81:14-9. 2015..In this context, tonic zinc provides a powerful break of spontaneous firing that may protect against pathological run-up of spontaneous activity in the DCN. ..
- Coactivation of pre- and postsynaptic signaling mechanisms determines cell-specific spike-timing-dependent plasticityThanos Tzounopoulos
Department of Cell Biology and Anatomy, Rosalind Franklin University, Chicago Medical School, North Chicago, IL 60064, USA
Neuron 54:291-301. 2007..Hence, pre- and postsynaptic sites of expression determine both the sign and timing requirements of long-term plasticity in interneurons...
- Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibitionJason W Middleton
Department of Otolaryngology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 108:7601-6. 2011..These findings indicate that auditory circuits in mice with behavioral evidence of tinnitus respond to stimuli in a more robust and spatially distributed manner because of a decrease in GABAergic inhibition...
- Cell-Specific Cholinergic Modulation of Excitability of Layer 5B Principal Neurons in Mouse Auditory CortexAnkur Joshi
Department of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
J Neurosci 36:8487-99. 2016..We propose that ACh-mediated persistent firing in corticocollicular neurons may represent a critical mechanism required for learning-induced plasticity in AC...
- Modulation of extrasynaptic NMDA receptors by synaptic and tonic zincCharles T Anderson
Departments of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261
Proc Natl Acad Sci U S A 112:E2705-14. 2015..These results demonstrate a physiological role for endogenous synaptic as well as tonic zinc in inhibiting extrasynaptic NMDARs and thereby fine tuning neuronal excitability and signaling. ..
- Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel ActivatorsManoj Kumar
Department of Otolaryngology, School of Medicine M K, T T Department of Chemistry N R, R L, P W Department of Neurobiology E A, T T and Pittsburgh Institute for Neurodegenerative Diseases, School of Medicine E A, University of Pittsburgh, Pittsburgh, Pennsylvania
Mol Pharmacol 89:667-77. 2016..We suggest that RL648_81 is a promising clinical candidate for treating or preventing neurologic disorders associated with neuronal hyperexcitability. ..
- Imaging the neural correlates of tinnitus: a comparison between animal models and human studiesJason W Middleton
Department of Otolaryngology, University of Pittsburgh, Pittsburgh PA, USA
Front Syst Neurosci 6:35. 2012..We propose that the comparison between animal model and human studies will aid in the design of appropriate experimental paradigms aimed at elucidating the cellular and circuit mechanisms underlying tinnitus...