Stephen W Tuttle
Affiliation: University of Pennsylvania
- Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxiaStephen W Tuttle
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
J Biol Chem 282:36790-6. 2007..Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia...
- Role of vicinal protein thiols in radiation and cytotoxic responsesJohn E Biaglow
Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Radiat Res 165:307-17. 2006..We conclude that radiation sensitivity and cell survival are dependent on vicinal thiol and GSH. In the former and latter cases, the protein thiols are also important...
- Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cellsPrashanthi Javvadi
Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 70:1941-50. 2010..These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy...
- pO(2)-dependent NO production determines OPPC activity in macrophagesMary A Robinson
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Free Radic Biol Med 48:189-95. 2010..These results are the first to investigate the effect of pO(2) on the relationship between NO production and OPPC activity, and to rule out limitations in OPPC activity as a mechanism by which NO production is decreased under hypoxia...
- Radiation response of cells during altered protein thiol redoxJohn E Biaglow
Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
Radiat Res 159:484-94. 2003..The results also show that protein thiol status is a critical factor in cell survival after irradiation...
- 2-Deoxyglucose and radiosensitization: teaching an old DOG new tricks?Amit Maity
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 5:824-6. 2006
- AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer TreatmentNatalie A Daurio
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania
Cancer Res 76:3295-306. 2016..Our results demonstrate novel metabolic perturbations by tamoxifen in tumor cells, which can be exploited to expand the therapeutic potential of tamoxifen treatment beyond ER(+) breast cancer. Cancer Res; 76(11); 3295-306. ©2016 AACR. ..
- The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathwayPrashanthi Javvadi
Department of Radiation Oncology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
Mol Pharmacol 73:1491-501. 2008....