Budd A Tucker

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation
    Budd A Tucker
    Department of Ophthalmology, University of Iowa, Iowa City, IA, USA
    Stem Cells Transl Med 2:16-24. 2013
  2. pmc Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice
    Budd A Tucker
    Department of Ophthalmology, Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e18992. 2011
  3. pmc Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration
    Shemin Zeng
    Stephen A Wynn Institute for Vision Research and Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    J Pathol 238:446-56. 2016
  4. doi request reprint The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation
    Budd A Tucker
    Schepens Eye Research Institute, Harvard Medical School, Department of Ophthalmology, Boston, MA 02114, USA
    Biomaterials 31:9-19. 2010
  5. pmc The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa Electronic address
    Am J Pathol 184:3142-53. 2014
  6. pmc cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness
    Luke A Wiley
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Sci Rep 6:30742. 2016
  7. doi request reprint Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration
    Allison E Songstad
    Stephen A Wynn Institute for Vision Research Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
    Invest Ophthalmol Vis Sci 56:8258-67. 2015
  8. pmc Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq
    S Scott Whitmore
    Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA, USA Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA Electronic address
    Exp Eye Res 129:93-106. 2014
  9. doi request reprint Is age-related macular degeneration a microvascular disease?
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of lowa, 52242, lowa City, IA, USA
    Adv Exp Med Biol 801:283-9. 2014
  10. pmc Müller cell activation, proliferation and migration following laser injury
    Mark A Tackenberg
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:1886-96. 2009

Collaborators

Detail Information

Publications25

  1. pmc Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation
    Budd A Tucker
    Department of Ophthalmology, University of Iowa, Iowa City, IA, USA
    Stem Cells Transl Med 2:16-24. 2013
    ..These findings demonstrate the potential utility of these surfaces for the production of clinical-grade retinal neurons for transplantation and induction of retinal regeneration...
  2. pmc Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice
    Budd A Tucker
    Department of Ophthalmology, Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 6:e18992. 2011
    ..As such, adult fibroblast-derived iPSCs provide a viable source for the production of retinal precursors to be used for transplantation and treatment of retinal degenerative disease...
  3. pmc Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration
    Shemin Zeng
    Stephen A Wynn Institute for Vision Research and Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    J Pathol 238:446-56. 2016
    ..Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  4. doi request reprint The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation
    Budd A Tucker
    Schepens Eye Research Institute, Harvard Medical School, Department of Ophthalmology, Boston, MA 02114, USA
    Biomaterials 31:9-19. 2010
    ....
  5. pmc The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa Electronic address
    Am J Pathol 184:3142-53. 2014
    ..05). These findings suggest that increased complement activation in AMD and in high-risk genotypes can lead to loss of endothelial cells in early AMD. Treatments to protect the choriocapillaris in early AMD are needed. ..
  6. pmc cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness
    Luke A Wiley
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Sci Rep 6:30742. 2016
    ..These studies will enable clinical trials to test the safety and efficiency of patient-specific photoreceptor cell replacement in humans...
  7. doi request reprint Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration
    Allison E Songstad
    Stephen A Wynn Institute for Vision Research Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
    Invest Ophthalmol Vis Sci 56:8258-67. 2015
    ..The purpose of this study was to generate stem cell-derived CECs to develop efficient differentiation and transplantation protocols...
  8. pmc Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq
    S Scott Whitmore
    Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, IA, USA Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA Electronic address
    Exp Eye Res 129:93-106. 2014
    ..Datasets such as these can be used to prioritize candidate genes for possible involvement in retinal diseases with regional phenotypes...
  9. doi request reprint Is age-related macular degeneration a microvascular disease?
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of lowa, 52242, lowa City, IA, USA
    Adv Exp Med Biol 801:283-9. 2014
    ..We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies. ..
  10. pmc Müller cell activation, proliferation and migration following laser injury
    Mark A Tackenberg
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:1886-96. 2009
    ..In this study we used a mouse model of retinal laser photocoagulation to examine injury-induced Müller glial reaction, and determine how this reaction was related to injury-induced retinal regeneration and cellular repopulation...
  11. pmc Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease
    Joseph C Giacalone
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Stem Cells Transl Med 5:132-40. 2016
    ..In the present review, we discuss how the iPSC technology is being used to confirm the pathogenesis of novel genetic variants, interrogate the pathophysiology of disease, and accelerate the development of patient-centered treatments...
  12. pmc Mechanical properties of murine and porcine ocular tissues in compression
    Kristan S Worthington
    Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, IA, USA Department of Pharmaceutics and Experimental Therapeutics, The University of Iowa, Iowa City, IA, USA Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA The Stephen A Wynn Institute for Vision Research, University of Iowa, Iowa City, IA, USA
    Exp Eye Res 121:194-9. 2014
    ....
  13. pmc Stem cells as tools for studying the genetics of inherited retinal degenerations
    Luke A Wiley
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242
    Cold Spring Harb Perspect Med 5:a017160. 2015
    ..Furthermore, autologous, patient-specific induced pluripotent stem cells could be a viable source to treat rare Mendelian retinal degenerative diseases such as retinitis pigmentosa, Stargardt disease, and Best disease, to name a few. ..
  14. doi request reprint Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases
    Luke A Wiley
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    Prog Retin Eye Res 44:15-35. 2015
    ..We will focus on the use of iPSCs for interrogation of disease pathophysiology, analysis of drug and gene therapeutics and as a source of autologous cells for cell transplantation and replacement. ..
  15. pmc Structural and biochemical analyses of choroidal thickness in human donor eyes
    Elliott H Sohn
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa
    Invest Ophthalmol Vis Sci 55:1352-60. 2014
    ..In this study we sought to evaluate biochemical differences in human donor eyes between very thin and thick choroids...
  16. pmc Photoreceptor cells with profound structural deficits can support useful vision in mice
    Stewart Thompson
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa
    Invest Ophthalmol Vis Sci 55:1859-66. 2014
    ..The purpose of this study was to determine whether photoreceptor cells that lack a fully formed outer segment could usefully contribute to vision...
  17. pmc Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa
    Budd A Tucker
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 108:E569-76. 2011
    ....
  18. pmc Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study
    Elliott H Sohn
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA
    Sci Rep 5:11791. 2015
    ..These findings suggest that immunologically matched or autologous donor cells should be considered for clinical RPE cell replacement. ..
  19. pmc Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial
    Budd A Tucker
    Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa
    Transl Res 166:740-749.e1. 2015
    ..In this study, we demonstrate how patient-specific iPSCs can be used to confirm pathogenicity of unknown mutations, which can enable positive clinical outcomes...
  20. ncbi request reprint CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism
    Yiqin Zhang
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 27:4499-506. 2007
    ..This suggests a novel therapeutic role for progenitor cells in the treatment of CNS degenerative diseases...
  21. pmc Induction of trabecular meshwork cells from induced pluripotent stem cells
    Qiong J Ding
    The Stephen A Wynn Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
    Invest Ophthalmol Vis Sci 55:7065-72. 2014
    ..Here we demonstrate that mouse iPSCs can be induced to differentiate into TM-like cells suitable for autologous transplantation...
  22. pmc Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy
    Shannon E Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e92928. 2014
    ..Analyses of retinal structure and visual function in CEP290-LCA patients were also performed for comparison with the results in the model...
  23. pmc Loss of CD34 expression in aging human choriocapillaris endothelial cells
    Elliott H Sohn
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America Stephen A Wynn Institute for Vision Research, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 9:e86538. 2014
    ....
  24. pmc Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRα and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model
    Gisela Velez
    Department of Ophthalmology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Stem Cells Int 2012:106486. 2012
    ..Müller cells may play a more active role than previously thought in the development of PVR membranes, particularly when stimulated by an RPE-cell-rich environment. Additional studies of human samples and in animal models are warranted...
  25. ncbi request reprint Peripheral sensory axon growth: from receptor binding to cellular signaling
    Budd A Tucker
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Can J Neurol Sci 35:551-66. 2008
    ....