Chia Ling Tu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, CA, USA Electronic address
    J Dermatol Sci 73:142-51. 2014
  2. pmc Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
    Chia Ling Tu
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:2350-9. 2012
  3. ncbi Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
  4. pmc The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 131:1119-28. 2011
  5. ncbi Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
  6. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
  7. ncbi Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
  8. ncbi The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
  9. ncbi The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
  10. pmc Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
    Chia Ling Tu
    Endocrine Unit, Veterans Affair Medical Center and The University of California, San Francisco, CA, USA
    Best Pract Res Clin Endocrinol Metab 27:415-27. 2013

Collaborators

Detail Information

Publications16

  1. pmc Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, CA, USA Electronic address
    J Dermatol Sci 73:142-51. 2014
    ..Filamin A has the ability to interact directly with CaR, Trio, and Rho and mediate CaR-dependent signaling events...
  2. pmc Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
    Chia Ling Tu
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:2350-9. 2012
    ..3%) diet. Deleting CaR perturbs the epidermal Ca(2+) gradient and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role for the CaR in normal epidermal development...
  3. ncbi Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
    ..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling...
  4. pmc The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 131:1119-28. 2011
    ..These results indicate that Rho is a downstream mediator of CaR in the regulation of Ca(2+)(o)-induced E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation...
  5. ncbi Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
    ..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes...
  6. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ....
  7. ncbi Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
    ..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes...
  8. ncbi The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
    ..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models...
  9. ncbi The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
    ..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores...
  10. pmc Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
    Chia Ling Tu
    Endocrine Unit, Veterans Affair Medical Center and The University of California, San Francisco, CA, USA
    Best Pract Res Clin Endocrinol Metab 27:415-27. 2013
    ..The concepts derived from in vitro gene knockdown experiments have been evaluated and confirmed in three mouse models in vivo. ..
  11. ncbi Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 124:187-97. 2005
    ..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R...
  12. pmc Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism
    Christian Santa Maria
    Endocrine Research Unit, University of California, San Francisco, Veterans Affairs Medical Center, San Francisco, CA, USA
    Semin Cell Dev Biol 49:11-23. 2016
    ..Lastly, novel therapeutic regimens that exploit interrelationship between the CaSR and PTH1R are proposed to produce more robust osteoanabolism. ..
  13. pmc Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer
    Daniel D Bikle
    Departments of Medicine and Dermatology, VA Medical Center and University of California, San Francisco San Francisco, CA, USA
    Front Physiol 7:296. 2016
    ..The roles of the β-catenin, hedgehog, and lncRNA pathways in predisposing the epidermis to tumor formation when vitamin D and calcium signaling are disrupted will be discussed. ..
  14. ncbi Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003
    ....
  15. pmc Vitamin D and calcium regulation of epidermal wound healing
    Yuko Oda
    VA Medical Center and University of California San Francisco, 1700 Owens St, San Francisco, CA 94158, USA Electronic address
    J Steroid Biochem Mol Biol . 2015
    ..These data suggest that vitamin D and calcium signaling are necessary components of the epidermal response to wounding, likely by regulating stem cell activation through increased β-catenin transcriptional activity...
  16. pmc Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer
    Daniel D Bikle
    Department of Medicine and Dermatology, 1700 Owens Street, VA Medical Center and University of California, San Francisco, CA 94158, USA Electronic address
    J Steroid Biochem Mol Biol 148:47-51. 2015
    ..This article is part of a Special Issue entitled '17th Vitamin D Workshop'. ..