Melissa A Troester

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Pubertal high fat diet: effects on mammary cancer development
    Yong Zhao
    Breast Cancer and the Environment Research Program, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Breast Cancer Res 15:R100. 2013
  2. pmc Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo
    Jodie M Fleming
    Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Breast Cancer Res 14:R97. 2012
  3. pmc Activation of host wound responses in breast cancer microenvironment
    Melissa A Troester
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 15:7020-8. 2009
  4. pmc Challenges in studying the etiology of breast cancer subtypes
    Melissa A Troester
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Breast Cancer Res 11:104. 2009
  5. pmc Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
    Heather Ann Brauer
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 19:571-85. 2013
  6. pmc Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer
    Sneha Sundaram
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB 7461, 2203 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7461, USA
    Breast Cancer Res Treat 142:489-503. 2013
  7. pmc Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell lines
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 112:1607-13. 2004
  8. pmc Basal-like breast cancer cells induce phenotypic and genomic changes in macrophages
    Delisha A Stewart
    Department of Epidemiology, Campus Box 7435, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cancer Res 10:727-38. 2012
  9. pmc Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
    Erick Roman-Perez
    Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC 27599, USA
    Breast Cancer Res 14:R51. 2012
  10. pmc Gene expression analysis of in vitro cocultures to study interactions between breast epithelium and stroma
    Patricia Casbas-Hernandez
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    J Biomed Biotechnol 2011:520987. 2011

Collaborators

Detail Information

Publications54

  1. pmc Pubertal high fat diet: effects on mammary cancer development
    Yong Zhao
    Breast Cancer and the Environment Research Program, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Breast Cancer Res 15:R100. 2013
    ..To test the effect of HFD initiated during puberty on tumorigenesis, we utilized BALB/c mice, for which HFD neither induces obesity nor metabolic syndrome, allowing dissociation of HFD effects from other conditions associated with HFD...
  2. pmc Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo
    Jodie M Fleming
    Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Breast Cancer Res 14:R97. 2012
    ..We hypothesized that adding primary human macrophages to the murine mammary gland would enhance and provide a novel approach to examine immune-stromal cell interactions during the humanization process...
  3. pmc Activation of host wound responses in breast cancer microenvironment
    Melissa A Troester
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 15:7020-8. 2009
    ..Despite the widespread acknowledgment of commonalities between host responses to wounds and host responses to cancer, the gene expression responses of normal tissue adjacent to cancers have not been well characterized...
  4. pmc Challenges in studying the etiology of breast cancer subtypes
    Melissa A Troester
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Breast Cancer Res 11:104. 2009
    ....
  5. pmc Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
    Heather Ann Brauer
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 19:571-85. 2013
    ..This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabolism...
  6. pmc Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer
    Sneha Sundaram
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB 7461, 2203 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7461, USA
    Breast Cancer Res Treat 142:489-503. 2013
    ..Understanding the effects of obesity on risk and progression is important given that epidemiologic studies imply a portion of BBC could be eliminated by reducing obesity...
  7. pmc Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell lines
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 112:1607-13. 2004
    ..These analyses also showed that toxicant-specific gene expression patterns, similar to general stress responses, vary according to cell type...
  8. pmc Basal-like breast cancer cells induce phenotypic and genomic changes in macrophages
    Delisha A Stewart
    Department of Epidemiology, Campus Box 7435, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cancer Res 10:727-38. 2012
    ....
  9. pmc Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
    Erick Roman-Perez
    Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC 27599, USA
    Breast Cancer Res 14:R51. 2012
    ..We hypothesized that gene expression subtypes of breast cancer microenvironment can be defined and that these microenvironment subtypes have clinical relevance...
  10. pmc Gene expression analysis of in vitro cocultures to study interactions between breast epithelium and stroma
    Patricia Casbas-Hernandez
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7255, USA
    J Biomed Biotechnol 2011:520987. 2011
    ..Coculture systems are manipulable systems that can yield important insights about cell-cell interactions and the cellular phenotypes that occur as tumor and stroma co-evolve...
  11. pmc Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer
    Jason R Pirone
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 21:1735-44. 2012
    ..Characterizing age-related patterns of gene expression in normal breast tissues may provide insights on etiology of distinct breast cancer subtypes that arise from these tissues...
  12. pmc EGFR associated expression profiles vary with breast tumor subtype
    Katherine A Hoadley
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genomics 8:258. 2007
    ..An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors...
  13. pmc Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures
    Cheng Fan
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
    BMC Med Genomics 4:3. 2011
    ..We evaluated whether combining the prognostic powers of standard breast cancer clinical variables with a large set of gene expression signatures could improve on our ability to predict patient outcomes...
  14. pmc Association of Parity and Time since Last Birth with Breast Cancer Prognosis by Intrinsic Subtype
    Xuezheng Sun
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 25:60-7. 2016
    ..Parity and time since last birth influence breast cancer risk and vary by intrinsic tumor subtype, but the independent effects of these factors on prognosis have received limited attention...
  15. pmc Tumor intrinsic subtype is reflected in cancer-adjacent tissue
    Patricia Casbas-Hernandez
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 24:406-14. 2015
    ..Understanding the gene expression of the cancer-adjacent tissue and the stromal response to specific tumor subtypes is important for developing clinical strategies to reduce recurrence risk...
  16. pmc Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis
    J Chuck Harrell
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Campus Box 7295, 450 West Drive, Chapel Hill, NC, 27599, USA
    Clin Exp Metastasis 31:33-45. 2014
    ..We hypothesize that the genetic signatures we have identified highlight patients that should respond most favorably to anti-vascular agents. ..
  17. ncbi request reprint Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
    Daniel S Oh
    Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Oncol 24:1656-64. 2006
    ..Therefore, we developed a gene expression-based outcome predictor for ER+ and/or PR+ (ie, luminal) breast cancer patients using biologic differences among these tumors...
  18. pmc Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation
    Brante P Sampey
    Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e38812. 2012
    ..These data also suggest that modifying the availability or metabolism of saturated fatty acids may limit the inflammation associated with obesity leading to Metabolic Syndrome...
  19. pmc Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography
    Richard L Blackmon
    Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Biophys J 110:1858-68. 2016
    ..In combination with the topical deposition of GNRs, the minimally invasive nature of DS-OCT makes this a promising technology for studying tissue remodeling processes. ..
  20. pmc Weight loss reduces basal-like breast cancer through kinome reprogramming
    Yuanyuan Qin
    CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599 7461 USA
    Cancer Cell Int 16:26. 2016
    ..Reducing adiposity in adulthood can lower incidence of BBC in humans. Thus, this study investigated whether a dietary intervention to reduce adiposity prior to tumor onset would reverse HFD-induced BBC...
  21. pmc Body mass index associated with genome-wide methylation in breast tissue
    Brionna Y Hair
    Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, 2101 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7435, USA
    Breast Cancer Res Treat 151:453-63. 2015
    ..Our results suggest that BMI is associated with genome-wide methylation in non-diseased breast tissue and may influence epigenetic pathways involved in inflammatory and other carcinogenic processes...
  22. pmc Body mass index is associated with gene methylation in estrogen receptor-positive breast tumors
    Brionna Y Hair
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer Epidemiol Biomarkers Prev 24:580-6. 2015
    ..The goal of this study, therefore, was to investigate associations between obesity and gene methylation in breast tumors...
  23. pmc Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography
    Raghav K Chhetri
    Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3255
    Proc Natl Acad Sci U S A 111:E4289-97. 2014
    ..This novel method comprises a broad-based platform for studying heterogeneous nanotopology, as distinct from bulk viscoelasticity, in biological milieu. ..
  24. pmc Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples
    Fathi Elloumi
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Med Genomics 4:54. 2011
    ..This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification...
  25. pmc Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers
    J Terese Camp
    Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, 135 Dauer Ln, Chapel Hill, NC 27599, USA
    Mol Cancer Res 9:3-13. 2011
    ..The phenotypes and gene expression changes invoked by cancer cell interactions with fibroblasts support the microenvironment and cell-cell interactions as intrinsic features of breast cancer subtypes...
  26. pmc Mammographic density and breast cancer risk in White and African American Women
    Hilda Razzaghi
    Department of Epidemiology, Gillings Global School of Public Health, University of North Carolina, 2104 McGavran Greenberg, 135 Dauer Drive, Campus Box 7435, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 135:571-80. 2012
    ..However, exposures such as BMI and hormone therapy may be important modifiers of this association and merit further investigation...
  27. pmc Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
    Xuezheng Sun
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Breast Cancer Res Treat 131:1003-12. 2012
    ..Given the role of macrophages in carcinogenesis, these findings have important implications for breast cancer etiology and progression...
  28. ncbi request reprint Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  29. pmc Breast cancer biologic and etiologic heterogeneity by young age and menopausal status in the Carolina Breast Cancer Study: a case-control study
    Lynn Chollet-Hinton
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 18:79. 2016
    ....
  30. pmc Cafeteria diet-induced obesity causes oxidative damage in white adipose
    Amy R Johnson
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Biochem Biophys Res Commun 473:545-50. 2016
    ..Oxidative stress drives activation of inflammatory kinases that can perturb insulin signaling leading to glucose intolerance and diabetes. ..
  31. pmc Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study
    Ebonee N Butler
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, CB 7435, 2101 McGavran Greenberg Hall, Chapel Hill, NC, 27599 7435, USA
    Cancer Causes Control 27:775-86. 2016
    ..However, the weak magnitude of association and conflicting results have yielded uncertainty and it is unknown whether associations differ by breast cancer subtype...
  32. pmc Race-associated biological differences among Luminal A breast tumors
    Monica D'arcy
    Department of Epidemiology, CB 7435, North Carolina Central University, 135 Dauer Drive, Durham, NC, USA
    Breast Cancer Res Treat 152:437-48. 2015
    ..Some of these differences (CRYBB2 and PSPH) may exist from the earliest stages of tumor development, or may even precede malignancy...
  33. pmc Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status
    Rupninder Sandhu
    UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Carcinogenesis 35:2567-75. 2014
    ..These findings suggest that targeting miR-146a expression may have value for altering the aggressiveness of p53 mutant basal-like tumors. ..
  34. pmc Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype
    Xuezheng Sun
    Department of Epidemiology, CB 7435, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
    Cancer Causes Control 26:1803-11. 2015
    ..Adiposity has been linked with increased breast cancer risk and mortality. It is established that etiologic associations for adiposity vary by tumor subtype, but the influence of adiposity on subtype-specific survival is unknown...
  35. pmc cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer
    Alyssa J Cozzo
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
    Springerplus 5:348. 2016
    ..We next investigated if administering crizotinib in a window prior to tumor development would inhibit or delay BBC tumorigenesis...
  36. pmc Genetic variation in cell cycle regulatory gene AURKA and association with intrinsic breast cancer subtype
    Nicholas J Taylor
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina
    Mol Carcinog 54:1668-77. 2015
    ..We found differential associations by specific subtypes and by race. Replication of these findings in larger AA populations would allow more powerful race-stratified subtype analyses...
  37. pmc Integrated RNA and DNA sequencing improves mutation detection in low purity tumors
    Matthew D Wilkerson
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 42:e107. 2014
    ..g. PIK3CA, ERBB2 and FGFR2). In summary, integrating RNA-seq with DNA-WES increases mutation detection performance, especially for low purity tumors. ..
  38. pmc African American women's perspectives on breast cancer: implications for communicating risk of basal-like breast cancer
    Marlyn Allicock
    University of North Carolina, Department of Nutrition, Schools of Medicine and Public Health, Chapel Hill, NC 27599, USA
    J Health Care Poor Underserved 24:753-67. 2013
    ..These findings will assist in developing health communication tools that encourage prevention...
  39. pmc Longitudinal study of mammary epithelial and fibroblast co-cultures using optical coherence tomography reveals morphological hallmarks of pre-malignancy
    Raghav K Chhetri
    Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e49148. 2012
    ....
  40. ncbi request reprint Cell-type-specific responses to chemotherapeutics in breast cancer
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cancer Res 64:4218-26. 2004
    ..Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics...
  41. pmc The association of diabetes and obesity with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study
    Saira Khan
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, 135 Dauer Drive, Chapel Hill, NC, 27599, USA
    Cancer Causes Control 27:1475-1485. 2016
    ..Here we evaluate the independent association between diabetes and obesity with prostate cancer aggressiveness in White Americans and Black Americans...
  42. pmc Body size across the life course and risk of premenopausal and postmenopausal breast cancer in Black women, the Carolina Breast Cancer Study, 1993-2001
    Whitney R Robinson
    Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, CB 7435, McGavran Greenberg, Chapel Hill, NC, 27599 7435, USA
    Cancer Causes Control 25:1101-17. 2014
    ..However, few studies have evaluated these relationships among Black women or examined anthropometric measures other than near-diagnosis body mass index (BMI)...
  43. pmc Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures
    Amy L Oldenburg
    Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3255, USA
    Opt Lett 38:2923-6. 2013
    ..This has implications toward highly specific contrast in molecular (nanoparticle-based) and functional (cellular activity) imaging using standard PS-OCT hardware. ..
  44. ncbi request reprint Expression of exogenous human telomerase in cultures of endometrial stromal cells does not alter their hormone responsiveness
    Claire S Barbier
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Biol Reprod 73:106-14. 2005
    ....
  45. pmc Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification
    Emma H Allott
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Breast Cancer Res 18:68. 2016
    ....
  46. pmc Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat
    Adam J Filgo
    Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA National Toxicology Program NTP Laboratory, Division of the NTP, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 44:1034-58. 2016
    ....
  47. pmc Inverse-power-law behavior of cellular motility reveals stromal-epithelial cell interactions in 3D co-culture by OCT fluctuation spectroscopy
    Amy L Oldenburg
    Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3255 Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7513 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295
    Optica 2:877-885. 2015
    ..We also show how the hyperspectral data can be visualized using these metrics to observe heterogeneity within organoids. This constitutes a simple and powerful tool for detecting and imaging cellular functional changes with OCT...
  48. pmc Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study
    Lindsay A Williams
    Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, Campus Box 7435, Chapel Hill, NC, 27599, USA
    Cancer Causes Control 27:259-69. 2016
    ..Alcohol is an established breast cancer risk factor, but there is little evidence on whether the association differs between African Americans and whites...
  49. pmc Racial variation in adjuvant chemotherapy initiation among breast cancer patients receiving oncotype DX testing
    Megan C Roberts
    Health Policy Management, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, McGavran Greenberg Hall, CB 7411, Chapel Hill, NC, 27599 7411, USA
    Breast Cancer Res Treat 153:191-200. 2015
    ..As treatment decision-making becomes increasingly targeted with the use of genetic technologies, these results provide evidence that test results may drive treatment in a similar way across racial subgroups...
  50. pmc Temporal trends in the inflammatory cytokine profile of human breastmilk
    Lynn S Chollet-Hinton
    1 Department of Epidemiology, Gillings Global School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Breastfeed Med 9:530-7. 2014
    ..Our results suggest that inflammatory cytokine expression during lactation is dynamic, and expressed milk may provide a noninvasive window into the extensive biological changes that occur in the postpartum breast...
  51. pmc Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites
    Leila Family
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 149:181-90. 2015
    ..SKAT analysis showed no significant combined SNP effects. These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer...
  52. pmc Relationship of mammographic density and gene expression: analysis of normal breast tissue surrounding breast cancer
    Xuezheng Sun
    Authors Affiliations Department of Epidemiology Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Department of Biology, Trinity University, San Antonio, Texas Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Clin Cancer Res 19:4972-82. 2013
    ..To evaluate how mammographic density and breast tissue composition relate to extratumoral microenvironment gene expression, we used data on 121 patients with breast cancer from the population-based Polish Women's Breast Cancer Study...
  53. ncbi request reprint Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:2269-75. 2007
    ..These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships...
  54. pmc Gene expression patterns associated with p53 status in breast cancer
    Melissa A Troester
    Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA
    BMC Cancer 6:276. 2006
    ..The relation between p53 status and subtype can be better studied by combining data from primary tumors with data from isogenic cell line pairs (with and without p53 function)...