Emily R Troemel

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Genome analysis and polar tube firing dynamics of mosquito-infecting microsporidia
    Emily R Troemel
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States Electronic address
    Fungal Genet Biol 83:41-4. 2015
  2. pmc Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 6:2736-52. 2008
  3. pmc C. elegans detects pathogen-induced translational inhibition to activate immune signaling
    Tiffany L Dunbar
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Host Microbe 11:375-86. 2012
  4. pmc bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans
    Kathleen A Estes
    Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 107:2153-8. 2010
  5. pmc Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus
    Javier E Irazoqui
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000982. 2010
  6. pmc DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans
    Sachiko Miyata
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genetics 178:903-18. 2008
  7. pmc Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans
    Robert J Luallen
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego UCSD, La Jolla, California, United States of America
    PLoS Pathog 12:e1005724. 2016
  8. pmc Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells
    Kathleen A Estes
    Division of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 7:e1002227. 2011
  9. doi request reprint Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells
    Suzannah C Szumowski
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, La Jolla, CA, USA
    Cell Microbiol 18:30-45. 2016
  10. pmc Caenorhabditis elegans as a model for intracellular pathogen infection
    Keir M Balla
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Cell Microbiol 15:1313-22. 2013

Collaborators

Detail Information

Publications22

  1. pmc Genome analysis and polar tube firing dynamics of mosquito-infecting microsporidia
    Emily R Troemel
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States Electronic address
    Fungal Genet Biol 83:41-4. 2015
    ..We also show a video of E. aedis polar tube firing, which is the dramatic mechanism used by microsporidia to deliver the germ cell (sporoplasm) into the host cell to initiate intracellular infection. ..
  2. pmc Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 6:2736-52. 2008
    ..elegans and its natural microsporidian parasites provides a system in which to dissect intracellular intestinal infection in vivo and insight into the diversity of pathogenic mechanisms used by intracellular microbes...
  3. pmc C. elegans detects pathogen-induced translational inhibition to activate immune signaling
    Tiffany L Dunbar
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Host Microbe 11:375-86. 2012
    ..Thus, translational inhibition, a common pathogenic strategy, can trigger activation of an immune surveillance pathway to provide host defense...
  4. pmc bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans
    Kathleen A Estes
    Division of Biological Sciences, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 107:2153-8. 2010
    ..aeruginosa. These data indicate that zip-2 is part of a specialized pathogen response pathway that is induced by virulent strains of P. aeruginosa and provides defense against this pathogen...
  5. pmc Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus
    Javier E Irazoqui
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000982. 2010
    ..aeruginosa nor the S. aureus-triggered response requires canonical TLR signaling, they imply the existence of unidentified mechanisms for pathogen detection in C. elegans, with potentially conserved roles also in mammals...
  6. pmc DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans
    Sachiko Miyata
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genetics 178:903-18. 2008
    ..The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response...
  7. pmc Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans
    Robert J Luallen
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego UCSD, La Jolla, California, United States of America
    PLoS Pathog 12:e1005724. 2016
    ..Altogether, this system provides a powerful whole-animal model to investigate factors responsible for pathogen growth in different tissue niches. ..
  8. pmc Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells
    Kathleen A Estes
    Division of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 7:e1002227. 2011
    ..These results provide insight into parasite manipulation of the host cytoskeleton and non-lytic escape from intestinal cells in vivo...
  9. doi request reprint Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells
    Suzannah C Szumowski
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, La Jolla, CA, USA
    Cell Microbiol 18:30-45. 2016
    ..These findings provide insight into microsporidia interaction with host cells, and provide novel in vivo examples of the manner in which intracellular pathogens co-opt host actin during their life cycle...
  10. pmc Caenorhabditis elegans as a model for intracellular pathogen infection
    Keir M Balla
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Cell Microbiol 15:1313-22. 2013
    ..Together, these two natural pathogens of C. elegans provide powerful systems in which to study microbial pathogenesis and host responses to intracellular infection...
  11. pmc Cell-to-cell spread of microsporidia causes Caenorhabditis elegans organs to form syncytia
    Keir M Balla
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Microbiol 1:16144. 2016
    ..These findings show how microsporidia can maximize the use of host space for growth and that environmental cues in the host can regulate a developmental switch in the pathogen...
  12. pmc The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans
    Suzannah C Szumowski
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, CA 92093
    Proc Natl Acad Sci U S A 111:8215-20. 2014
    ..Altogether, these findings provide an in vivo example of the major mode of exit used by a natural pathogen for disease spread via fecal-oral transmission. ..
  13. pmc Ubiquitin-mediated response to microsporidia and virus infection in C. elegans
    Malina A Bakowski
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 10:e1004200. 2014
    ..parisii and virus may be perturbation of the UPS. Altogether, our results demonstrate an in vivo role for ubiquitin-mediated defense against microsporidian and viral infections in C. elegans. ..
  14. pmc Three-dimensional fluorescent microscopy via simultaneous illumination and detection at multiple planes
    Qian Ma
    Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Sci Rep 6:31445. 2016
    ....
  15. pmc Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host
    Michael R Botts
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093
    G3 (Bethesda) 6:2707-16. 2016
    ..We also found that both MDL-1::GFP and MML-1::GFP are expressed in intestinal cells during infection. These findings provide novel insight into the host transcription factors that regulate microsporidia development. ..
  16. doi request reprint Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
    Aaron W Reinke
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Commun 8:14023. 2017
    ..The unbiased method described here for identifying potential pathogen effectors represents a powerful approach to study a broad range of pathogens...
  17. pmc The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity
    Kirthi C Reddy
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell Rep 14:1581-9. 2016
    ..aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses. ..
  18. pmc Microsporidia-host interactions
    Suzannah C Szumowski
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States
    Curr Opin Microbiol 26:10-6. 2015
    ..Altogether, these and other recent findings are providing much-needed insight into the underlying mechanisms of microsporidia interaction with host animals. ..
  19. pmc A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite
    Keir M Balla
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 11:e1004583. 2015
    ..Thus, our findings show that early-life immunity of C. elegans against microsporidia is a complex trait that enables the host to produce more progeny later in life, likely improving its evolutionary success...
  20. pmc p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e183. 2006
    ..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity...