Genomes and Genes
Kathleen C Torkko
Affiliation: University of Colorado Denver
- Prostate Biopsy Markers of Inflammation are Associated with Risk of Clinical Progression of Benign Prostatic Hyperplasia: Findings from the MTOPS StudyKathleen C Torkko
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado Electronic address
J Urol 194:454-61. 2015..Factors associated with worsening of benign prostatic hyperplasia are not well understood. We measured inflammatory markers from prostate biopsies to study if inflammation is related to clinical progression of benign prostatic hyperplasia...
- VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White menKathleen C Torkko
Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
Clin Cancer Res 14:3223-9. 2008..This study tested the interactions of VDR (CDX2, FokI) and SRD5A2 (V89L, A49T) polymorphisms, and their associations with prostate cancer...
- B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltrationTakashi Miyatake
Department of Pathology, University of Colorado at Denver and Health Sciences Center, 12800 E 19th Ave Aurora, CO 80010, USA
Gynecol Oncol 106:119-27. 2007..B7-H4 expression was evaluated in apoptotic tumor cells...
- ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive diseaseMeenakshi Singh
Department of Pathology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Mod Pathol 21:912-23. 2008..It may help identify women who would most benefit from chemotherapy. Furthermore, if expression of ZEB1 in type II endometrial cancers could be reversed, it might be exploited as therapy for these highly aggressive tumors...
- Detection of B7-H4 and p53 in pancreatic cancer: potential role as a cytological diagnostic adjunctNida S Awadallah
Division of Gastroenterology, Department of Internal Medicine, University of Colorado at Denver and Health Science Center, Aurora, CO 80045, USA
Pancreas 36:200-6. 2008..This study compared p53 expression with B7-H4, a novel cancer biomarker, in pancreatic ductal adenocarcinoma (PDA) resection specimens and in a pilot series of endoscopic ultrasound-guided fine-needle aspirations (EUS-FNAs)...
- Pseudolumen size and perimeter in prostate cancer: correlation with patient outcomeKenneth A Iczkowski
Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Prostate Cancer 2011:693853. 2011..015), space size was smaller (P = .11), perimeters were smaller (P = .04), and perimeter/size ratio was higher (P = .02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome...
- B7-h4 expression in a range of breast pathology: correlation with tumor T-cell infiltrationKimberly C Mugler
Department of Pathology, University of Colorado at Denver and Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80045, USA
Appl Immunohistochem Mol Morphol 15:363-70. 2007..002). The cellular distribution of B7-H4 appears altered in the spectrum of normal to malignant breast. Its overexpression may help cancers avoid immune detection...
- Preoperative prediction of unifocal, unilateral, margin-negative, and small volume prostate cancerKenneth A Iczkowski
Department of Pathology, University of Colorado Health Science Center, Denver, Colorado 80045, USA
Urology 71:1166-71. 2008..Subtotal gland ablation by minimally invasive therapies such as cryotherapy demands preoperative prediction of unifocal, unilateral, margin-negative, and small volume (less than 0.5 mL) cancer...
- Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostateJames R Lambert
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado
Prostate 75:255-65. 2015..Growth differentiation factor-15 (GDF-15) is highly expressed in the prostate and has been associated with inflammation and tumorigenesis...
- Anterior tumors of the prostate: diagnosis and significancePriya N Werahera
University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA
Can J Urol 20:6897-906. 2013..Consequently, tumors originating from the anterior apical region and transition zones may be under-sampled. We examined whether addition of transrectal anterior biopsy (TAB) would improve efficacy of prostate biopsies...
- p16(INK4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasiaPanduka Samarawardana
Department of Pathology, Stony Brook University Medical Center, Stony Brook, New York 11794 8691, USA
Cancer Cytopathol 118:146-56. 2010....
- Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcomeKenneth A Iczkowski
Department of Pathology, University of Colorado, Denver School of Medicine, Aurora, CO 80045, USA
Am J Clin Pathol 136:98-107. 2011..The cribriform pattern has particularly adverse implications for outcome...
- Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancersHamid H Gari
Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA
Oncotarget 7:15757-71. 2016....
- Clinical staging of prostate cancer: a computer-simulated study of transperineal prostate biopsyE David Crawford
Radiation Oncology, Department of Pathology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
BJU Int 96:999-1004. 2005..To identify the precise location of prostate cancer within the gland and thus possibly permit more aggressive therapy of the lesion, while potentially sparing the noncancerous gland from ablative therapy...
- Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumorsKenneth A Iczkowski
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32608, USA
Hum Pathol 39:275-81. 2008..For embryonal carcinoma, OCT3/4 was superior to PLAP and more specific than CD30. D2-40 is recommended to discriminate between seminoma and embryonal carcinoma...
- Human papillomavirus testing and molecular markers of cervical dysplasia and carcinomaDonna Dehn
Department of Pathology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Cancer 111:1-14. 2007....
- B7-H4 overexpression in ovarian tumorsBarbara Tringler
Department of Pathology, University of Colorado Health Sciences Center, B 216, 4200 East Ninth Avenue, Denver, CO 80262, USA
Gynecol Oncol 100:44-52. 2006....
- Cooperative Dynamics of AR and ER Activity in Breast CancerNicholas C D'Amato
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado
Mol Cancer Res 14:1054-1067. 2016..In addition, single-agent efficacy may be possible in tumors resistant to traditional endocrine therapy, as clinical specimens of recurrent disease demonstrate AR expression in tumors with absent or refractory ER...
- Steroid receptor coactivator AIB1 in endometrial carcinoma, hyperplasia and normal endometrium: Correlation with clinicopathologic parameters and biomarkersNicole N Balmer
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Mod Pathol 19:1593-605. 2006..Future studies correlating expression with response to hormonal therapy may be beneficial...
- Association of RNASEL variants with prostate cancer risk in Hispanic Caucasians and African AmericansStacie J Shook
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Clin Cancer Res 13:5959-64. 2007..The RNASEL gene at 1q25 has been identified as a hereditary prostate cancer susceptibility gene, but to date, no study has investigated the role of RNASEL variants in Hispanic Caucasian men with prostate cancer...
- Association between an estrogen receptor alpha gene polymorphism and the risk of prostate cancer in black menJavier Hernandez
Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
J Urol 175:523-7. 2006..Studies suggest that SNPs within ESR1 may be associated with an increased risk of prostate cancer. We evaluated the association of the XbaI and PvuII ESR1 SNPs and prostate cancer risk in 3 different racial/ethnic populations...
- Inflammation as a target for prostate cancer chemoprevention: pathological and laboratory rationaleM Scott Lucia
Department of Pathology and Preventive Medicine and Biometrics, Unibersity of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Urol 171:S30-4; discussion S35. 2004..We review the literature addressing a potential causal role for chronic or recurrent inflammation or infection in the development of prostate cancer...
- Laterally directed biopsies detect more clinically threatening prostate cancer: computer simulated resultsNozomu Kawata
Department Urology, Nihon University School of Medicine, Tokyo, Japan
Prostate 57:118-28. 2003....