Wolfgang A Tome

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Commissioning and quality assurance of an optically guided three-dimensional ultrasound target localization system for radiotherapy
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison 53792, USA
    Med Phys 29:1781-8. 2002
  2. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
  3. ncbi request reprint Comparison of linac based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-base tumors
    Emilie T Soisson
    Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Radiother Oncol 78:313-21. 2006
  4. ncbi request reprint On the automated definition of mobile target volumes from 4D-CT images for stereotactic body radiotherapy
    Tiezhi Zhang
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 32:3493-502. 2005
  5. ncbi request reprint Pelvic nodal dose escalation with prostate hypofractionation using conformal avoidance defined (H-CAD) intensity modulated radiation therapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Acta Oncol 45:717-27. 2006
  6. doi request reprint Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 85:348-54. 2013
  7. ncbi request reprint Clinical assessment of three-dimensional ultrasound prostate localization for external beam radiotherapy
    Nigel P Orton
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 33:4710-7. 2006
  8. ncbi request reprint Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation
    Wes Hodge
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Acta Oncol 45:890-6. 2006
  9. ncbi request reprint Improvements in dose calculation accuracy for small off-axis targets in high dose per fraction tomotherapy
    Nicholas Hardcastle
    Department of Human Oncology, University of Wisconsin Madison, WI 53792, USA
    Med Phys 39:4788-94. 2012
  10. pmc Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 95:327-31. 2010

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Commissioning and quality assurance of an optically guided three-dimensional ultrasound target localization system for radiotherapy
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison 53792, USA
    Med Phys 29:1781-8. 2002
    ..On average, the magnitude of the shifts could be determined to within 1.0 mm along each axis...
  2. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
    ..Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases...
  3. ncbi request reprint Comparison of linac based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-base tumors
    Emilie T Soisson
    Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Radiother Oncol 78:313-21. 2006
    ..To compare and evaluate helical tomotherapy and linac based fractionated stereotactic radiotherapy (FSRT) techniques in the treatment of skull-base tumors...
  4. ncbi request reprint On the automated definition of mobile target volumes from 4D-CT images for stereotactic body radiotherapy
    Tiezhi Zhang
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 32:3493-502. 2005
    ....
  5. ncbi request reprint Pelvic nodal dose escalation with prostate hypofractionation using conformal avoidance defined (H-CAD) intensity modulated radiation therapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Acta Oncol 45:717-27. 2006
    ..A phase II trial to more thoroughly examine this treatment approach is currently underway...
  6. doi request reprint Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 85:348-54. 2013
    ..To prospectively evaluate the association between hippocampal dose and long-term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors treated with fractionated stereotactic radiotherapy (FSRT)...
  7. ncbi request reprint Clinical assessment of three-dimensional ultrasound prostate localization for external beam radiotherapy
    Nigel P Orton
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 33:4710-7. 2006
    ..Taken together with the results of the US-MVCT comparison, this indicates that the shifts improved patient localization despite differences between users...
  8. ncbi request reprint Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation
    Wes Hodge
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Acta Oncol 45:890-6. 2006
    ..Daily pretreatment MVCT imaging allows for precise daily tumor targeting with the patient in the actual treatment position, and therefore provides for precise image guidance...
  9. ncbi request reprint Improvements in dose calculation accuracy for small off-axis targets in high dose per fraction tomotherapy
    Nicholas Hardcastle
    Department of Human Oncology, University of Wisconsin Madison, WI 53792, USA
    Med Phys 39:4788-94. 2012
    ..This study evaluates a correction method to reduce the underdosing, to be implemented in the current version (v4.1) of the TomoTherapy treatment planning software...
  10. pmc Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 95:327-31. 2010
    ..By quantifying baseline incidence of perihippocampal or hippocampal metastasis, we sought to estimate the risk of developing metastases in the hippocampal avoidance region (the hippocampus plus 5mm margin)...
  11. ncbi request reprint Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect?
    Malika L Siker
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 66:135-41. 2006
    ....
  12. ncbi request reprint Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangements
    Rufus A Scrimger
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Am J Clin Oncol 26:70-8. 2003
    ..This has important implications for dose escalation strategies in the future...
  13. pmc Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 83:e487-93. 2012
    ..To prospectively evaluate the association between hippocampal dose and long-term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors treated with fractionated stereotactic radiotherapy (FSRT)...
  14. ncbi request reprint Modelling simple helically delivered dose distributions
    John D Fenwick
    Department of Human Oncology, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792, USA
    Phys Med Biol 50:1505-17. 2005
    ..The impact on these dose levels of angular variations in gantry speed or output per linear accelerator pulse is also explored...
  15. pmc A technique for stereotactic radiosurgery treatment planning with helical tomotherapy
    Emilie T Soisson
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Med Dosim 36:46-56. 2011
    ....
  16. ncbi request reprint Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation
    Amol Ghia
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 68:971-7. 2007
    ....
  17. ncbi request reprint Intensity-modulated radiation therapy in the management of head and neck cancer
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI, USA
    Curr Opin Oncol 17:231-5. 2005
    ..This review updates recent advances regarding the use of this emerging technology...
  18. doi request reprint On the dosimetric effect and reduction of inverse consistency and transitivity errors in deformable image registration for dose accumulation
    Edward T Bender
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Med Phys 39:272-80. 2012
    ..The purpose of this study was to investigate the dosimetric effect of and propose a postprocessing solution to reduce inverse consistency and transitivity errors...
  19. ncbi request reprint Quality assurance of an image guided intracranial stereotactic positioning system for radiosurgery treatment with helical tomotherapy
    Emilie T Soisson
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Neurooncol 98:277-85. 2010
    ..Results show that the accuracy of the delivery can be verified to within +/-1 voxel dimension. These results are well within conventional SRS tolerances and compare favorably to other linear accelerator based techniques...
  20. doi request reprint Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region
    Gregory M Richards
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Breast Cancer Res Treat 114:307-13. 2009
    ..2 Gy pulses separated by 3-min time intervals is delivered, creating an apparent dose rate of 0.0667 Gy/min. Here we describe our early experience with PRDR...
  21. ncbi request reprint Single institution experience treating 104 vestibular schwannomas with fractionated stereotactic radiation therapy or stereotactic radiosurgery
    Bethany M Anderson
    Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, USA
    J Neurooncol 116:187-93. 2014
    ..0% of SRS patients, 63.2% of HypoFSRT patients, and 44.4% of ConFSRT patients (p = 0.6). Similarly, there were no significant differences in 5-year rates of trigeminal toxicity facial nerve toxicity, vestibular dysfunction, or tinnitus...
  22. ncbi request reprint The impact of dental metal artifacts on head and neck IMRT dose distributions
    Yusung Kim
    Department of Medical Physics, University of Wisconsin Medical School, Madison, 53792, USA
    Radiother Oncol 79:198-202. 2006
    ..To quantify the cold or hot spot induced in IMRT treatment plans due to the presence of metal artifact in CT image data sets stemming from dental work...
  23. ncbi request reprint High dose per fraction dosimetry of small fields with gafchromic EBT2 film
    Nicholas Hardcastle
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Med Phys 38:4081-5. 2011
    ..This is a requirement in stereotactic radiosurgery deliveries, which deliver high doses per fraction to small targets...
  24. pmc Why avoid the hippocampus? A comprehensive review
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 97:370-6. 2010
    ..We also introduce our phase II cooperative group clinical trial (RTOG 0933) designed to prospectively evaluate the postulated neurocognitive benefit of hippocampal subgranular zone sparing and scheduled to open in 2010...
  25. ncbi request reprint Helical tomotherapy: image guidance and adaptive dose guidance
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Front Radiat Ther Oncol 40:162-78. 2007
    ....
  26. pmc Emphasizing conformal avoidance versus target definition for IMRT planning in head-and-neck cancer
    Paul M Harari
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 77:950-8. 2010
    ..To describe a method for streamlining the process of elective nodal volume definition for head-and-neck (H&N) intensity-modulated radiotherapy (IMRT) planning...
  27. ncbi request reprint The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, University Hospital and Clinics, 600 Highland Avenue K4 332, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 61:779-88. 2005
    ..This study provides a detailed analysis regarding the potential impact of daily setup variations on the overall integrity of H&N IMRT...
  28. doi request reprint Dose calculation on kV cone beam CT images: an investigation of the Hu-density conversion stability and dose accuracy using the site-specific calibration
    Yi Rong
    Department of Human Oncology, K4 B100, University of Wisconsin Medical School, Madison, WI 53792, USA
    Med Dosim 35:195-207. 2010
    ..Our phantom study showed that CBCT imaging can be a feasible option for dose computation in adaptive radiotherapy approach if the site-specific calibration is applied...
  29. doi request reprint A comparison of helical tomotherapy to circular collimator-based linear-accelerator radiosurgery for the treatment of brain metastases
    Emilie T Soisson
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, 53792, USA
    Am J Clin Oncol 34:388-94. 2011
    ..To compare stereotactic radiosurgery treatment plans for the treatment of patients with brain metastases generated using Tomotherapy and a circular collimator-based SRS approach...
  30. doi request reprint Quality assurance of ultrasound imaging systems for target localization and online setup corrections
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin, Clinical Science Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 71:S53-6. 2008
    ....
  31. ncbi request reprint The impact of daily shifts on prostate IMRT dose distributions
    Nigel P Orton
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 31:2845-8. 2004
    ..These results indicate that for a symmetric beam arrangement and properly chosenmargins, shifting the patient each day and treating without recalculating the dose is unlikely toaffect local control or the sparing of normal tissues...
  32. ncbi request reprint Wide-field pulsed reduced dose rate radiotherapy (PRDR) for recurrent ependymoma in pediatric and young adult patients
    Pranshu Mohindra
    Department of Human Oncology, University of Wisconsin Hospital and Clinics, Paul P Carbone Cancer Center, Madison, WI, USA
    Anticancer Res 33:2611-8. 2013
    ..PRDR employs a dose rate of 6 cGy/min, as opposed to 400-600 cGy/min for conventional radiation, allowing for enhanced normal tissue repair...
  33. ncbi request reprint Radiation oncology advances: an introduction
    Søren M Bentzen
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, USA
    Cancer Treat Res 139:1-4. 2008
  34. pmc A multi-institution evaluation of deformable image registration algorithms for automatic organ delineation in adaptive head and neck radiotherapy
    Nicholas Hardcastle
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI, USA
    Radiat Oncol 7:90. 2012
    ..This requires regions of interest (ROIs) to be defined using the most recent imaging data. This study investigates the clinical utility of using deformable image registration (DIR) to automatically propagate ROIs...
  35. doi request reprint Fractionated radiotherapy for intracranial meningiomas
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    J Neurooncol 99:349-56. 2010
    ..EBRT planning is highly individualized and requires a detailed understanding of tumor grade, adjacent radiosensitive structures such as the anterior optic apparatus, and radiographic characteristics of the tumor such as hyperostosis...
  36. ncbi request reprint Integral radiation dose to normal structures with conformal external beam radiation
    Hidefumi Aoyama
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 64:962-7. 2006
    ..This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer...
  37. ncbi request reprint Does a local bystander effect necessitate a revision of TCP models that are based on observed clinical data?
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Acta Oncol 45:406-11. 2006
    ..Based on this new set of assumptions the equation for TCP is derived, first for the homogenous case and then for the general case of a heterogeneous ensemble of tumors irradiated in-homogeneously...
  38. ncbi request reprint Quality assurance of an image guided intracranial stereotactic positioning system
    Emilie T Soisson
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Technol Cancer Res Treat 8:39-49. 2009
    ..A system delivery verification test in phantom using film showed spatial agreement between planned and delivered dose distributions to within 1 mm...
  39. ncbi request reprint Dosimetric verification of helical tomotherapy for total scalp irradiation
    Nicholas Hardcastle
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Med Phys 35:5061-8. 2008
    ..It is suggested that to achieve the prescription dose at the surface (< or =2 mm depth) bolus or a custom thermoplastic helmet is used...
  40. ncbi request reprint Clinical implementation of adaptive helical tomotherapy: a unique approach to image-guided intensity modulated radiotherapy
    James S Welsh
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA
    Technol Cancer Res Treat 5:465-79. 2006
    ....
  41. ncbi request reprint Radiation techniques in neuro-oncology
    Deepak Khuntia
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792
    Neurotherapeutics 6:487-99. 2009
    ..Included is a discussion of standard two- and three-dimensional radiation, as well as intensity-modulated radiotherapy, image-guided radiation therapy, stereotactic radiosurgery, and heavy particles...
  42. ncbi request reprint On cold spots in tumor subvolumes
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, CSc, Madison 53792, USA
    Med Phys 29:1590-8. 2002
    ..The effect of cold regions on TCP can be minimized if the EUD associated with the target DVH is constrained to be equal to or larger than the prescription dose...
  43. pmc A comprehensive assessment by tumor site of patient setup using daily MVCT imaging from more than 3,800 helical tomotherapy treatments
    Leah K Schubert
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Int J Radiat Oncol Biol Phys 73:1260-9. 2009
    ..To assess patient setup corrections based on daily megavoltage CT (MVCT) imaging for four anatomic treatment sites treated on tomotherapy...
  44. ncbi request reprint Fractionated stereotactic radiotherapy: a short review
    Wolfgang A Tome
    Department of Human Oncology, Medical School, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    Technol Cancer Res Treat 1:153-72. 2002
    ....
  45. ncbi request reprint Beam modeling for a convolution/superposition-based treatment planning system
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison 53792, USA
    Med Dosim 27:11-9. 2002
    ..The objective of beam modeling is to build a model of the primary fluence that is incident on the patient which can then be used in the calculation of the dose deposited in the patient, by using the convolution superposition method...
  46. ncbi request reprint Pulsed reduced dose-rate radiotherapy: case report : a novel re-treatment strategy in the management of recurrent glioblastoma multiforme
    George M Cannon
    Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, K4 350 CSC, 600 Highland Ave, Madison, WI 53792, USA
    J Neurooncol 83:307-11. 2007
    ..The radiobiologic basis for the use of pulsed reduced dose-rate external beam radiotherapy in the management of recurrent glioma patients is discussed...
  47. ncbi request reprint Linear accelerator radiosurgery for trigeminal neuralgia
    Gregory M Richards
    Department of Human Oncology, University of Wisconsin Medical School, K4 B29 Clinical Sciences Center, Madison, Wisconsin 53792, USA
    Neurosurgery 57:1193-200; discussion 1193-200. 2005
    ..To report the clinical outcomes following treatment of trigeminal neuralgia with linear accelerator-based radiosurgery...
  48. ncbi request reprint A challenge to traditional radiation oncology
    Jack F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:1241-56. 2004
    ....
  49. pmc On the use of hyperpolarized helium MRI for conformal avoidance lung radiotherapy
    C W Hodge
    Department of Human Oncology, University of Wisconsin, Madison, 53792, USA
    Med Dosim 35:297-303. 2010
    ..A prospective clinical study evaluating this imaging technique is being developed...
  50. ncbi request reprint On the incorporation of multi-modality image registration into the radiotherapy treatment planning process
    Hazim A Jaradat
    University of Wisconsin, Department of Human Oncology, 600 Highland Ave, Madison, WI 53792, USA
    Technol Cancer Res Treat 2:1-12. 2003
    ..The desired registration of the physiological image studies to the treatment planning CT is then accomplished by simply composing the appropriate transformation matrices...
  51. ncbi request reprint On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, K4 344 CSC 600 Highland Avenue, Madison, WI 53792, USA
    Phys Med Biol 48:N261-8. 2003
    ....