S A Tisherman

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 72:295-305. 2007
  2. ncbi request reprint Trauma fluid resuscitation in 2010
    Samuel A Tisherman
    Safar Center for Resuscitation Research, Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    J Trauma 54:S231-4. 2003
  3. ncbi request reprint Therapeutic hypothermia in traumatology
    S A Tisherman
    Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania, USA
    Surg Clin North Am 79:1269-89. 1999
  4. ncbi request reprint Thiopental and phenytoin by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study
    W Behringer
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 49:83-97. 2001
  5. ncbi request reprint Mild hypothermia increases survival from severe pressure-controlled hemorrhagic shock in rats
    S Prueckner
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Trauma 50:253-62. 2001
  6. ncbi request reprint Intraperitoneal, but not enteric, adenosine administration improves survival after volume-controlled hemorrhagic shock in rats
    X Wu
    Safar Center for Resuscitation Research, Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1767-73. 2001
  7. ncbi request reprint Fructose-1,6-bisphosphate and MK-801 by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 min in dogs. An exploratory study
    W Behringer
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 50:205-16. 2001
  8. ncbi request reprint Future directions for resuscitation research. V. Ultra-advanced life support
    S A Tisherman
    Safar Center for Resuscitation Research, University of Pittsburgh, PA 15260, USA
    Resuscitation 34:281-93. 1997
  9. ncbi request reprint Gut damage during hemorrhagic shock: effects on survival of oral or enteral interleukin-6
    X Wu
    Safar Center for Resuscitation Research and the Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15260, USA
    Shock 16:449-53. 2001
  10. ncbi request reprint Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 72:295-305. 2007
    ..We hypothesized that combining potent antioxidants with a hypertonic solution during UHS would preserve the logistical advantage of small volume resuscitation and improve survival...
  2. ncbi request reprint Trauma fluid resuscitation in 2010
    Samuel A Tisherman
    Safar Center for Resuscitation Research, Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    J Trauma 54:S231-4. 2003
  3. ncbi request reprint Therapeutic hypothermia in traumatology
    S A Tisherman
    Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania, USA
    Surg Clin North Am 79:1269-89. 1999
    ..The most futuristic applications will be hypothermic strategies to achieve prolonged suspended animation for delayed resuscitation in traumatic exsanguination cardiac arrest...
  4. ncbi request reprint Thiopental and phenytoin by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study
    W Behringer
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 49:83-97. 2001
    ..Other drugs and drug-combinations should be tested with this model in search for a breakthrough effect...
  5. ncbi request reprint Mild hypothermia increases survival from severe pressure-controlled hemorrhagic shock in rats
    S Prueckner
    Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Trauma 50:253-62. 2001
    ..Extending the duration of hypothermia beyond the acute phases of shock and resuscitation may be needed to ensure improved outcome after prolonged HS...
  6. ncbi request reprint Intraperitoneal, but not enteric, adenosine administration improves survival after volume-controlled hemorrhagic shock in rats
    X Wu
    Safar Center for Resuscitation Research, Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1767-73. 2001
    ..This beneficial effect may not be attributable to effects of adenosine on the inflammatory response...
  7. ncbi request reprint Fructose-1,6-bisphosphate and MK-801 by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 min in dogs. An exploratory study
    W Behringer
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 50:205-16. 2001
    ..v. infusion of the same drug during reperfusion, can provide cerebral preservation during CA 20 min no-flow. Other drugs and drug-combinations should be tested with this model in search for a breakthrough effect...
  8. ncbi request reprint Future directions for resuscitation research. V. Ultra-advanced life support
    S A Tisherman
    Safar Center for Resuscitation Research, University of Pittsburgh, PA 15260, USA
    Resuscitation 34:281-93. 1997
    ..Research and development of UALS techniques needs to be coordinated with cerebral resuscitation research...
  9. ncbi request reprint Gut damage during hemorrhagic shock: effects on survival of oral or enteral interleukin-6
    X Wu
    Safar Center for Resuscitation Research and the Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15260, USA
    Shock 16:449-53. 2001
    ..IL-6, administered into the stomach or directly injected into the small intestine lumen, did not protect the gut from ischemic injury, nor did it improve survival following severe HS in rats...
  10. ncbi request reprint Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005
    ..The goal of this study was to evaluate the independent association between admission hypothermia and mortality after major trauma, with adjustment for clinical confounders...
  11. ncbi request reprint Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs
    Xianren Wu
    Safar Center for Resuscitation Research, Department of Anesthesiology, University of Pittsburgh, PA 15260, USA
    J Trauma 59:291-9; discussion 299-301. 2005
    ....
  12. ncbi request reprint Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs
    Xianren Wu
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 113:1974-82. 2006
    ..Previously, we achieved intact survival of dogs from 2 hours of EPR after rapid hemorrhage. We tested the hypothesis that EPR would achieve good outcome if prolonged hemorrhage preceded cardiac arrest...
  13. ncbi request reprint Winning the cold war: inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group
    Ericka L Fink
    Crit Care Med 35:1199-202. 2007
  14. ncbi request reprint Titrated hypertonic/hyperoncotic solution for hypotensive fluid resuscitation during uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 65:87-95. 2005
    ..v. infusion of HHS, compared to titrated lactated Ringer's solution (LR), for hypotensive fluid resuscitation during uncontrolled HS reduces fluid requirement, does not increase blood loss, and improves survival...
  15. ncbi request reprint Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Resuscitation 75:114-23. 2007
    ..This model should serve as a screening model both for testing new pharmacological adjuncts to improve survival after exsanguination CA, and for elucidating the underlying mechanisms of ischemia/reperfusion injury...
  16. ncbi request reprint Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs
    Xianren Wu
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 28:302-11. 2008
    ....
  17. ncbi request reprint Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh, School of Medicine, Pittsburgh PA 15260, USA
    Life Sci 81:543-52. 2007
    ..sham, and no cognitive deficits were seen in either group vs. sham. Future studies with longer DHCA duration will be necessary to provide targets to assess novel preservation strategies...
  18. ncbi request reprint Comment on article by Ahmed and Cheng-Robles
    Samuel A Tisherman
    J Trauma 63:455. 2007
  19. doi request reprint Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation
    Tomas Drabek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States
    Resuscitation 77:220-8. 2008
    ..1+/-30.3 in D10 groups, respectively (p=0.3). OPC, NDS and HDS were not significantly different between groups. In conclusion, DADLE failed to confer benefit on functional or histological outcome in our model of prolonged rat EPR...
  20. doi request reprint Clinical practice guideline: penetrating zone II neck trauma
    Samuel A Tisherman
    Departments of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 64:1392-405. 2008
  21. ncbi request reprint Hot or cold? In support of cold
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hosp Med 66:78-80. 2005
  22. ncbi request reprint Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs
    Ala Nozari
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 57:1266-75. 2004
    ..This study is designed to better mimic the clinical scenario of an exsanguinating trauma victim, for whom suspended animation may buy time for resuscitative surgery and delayed resuscitation...
  23. ncbi request reprint Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Department of Anesthesiology Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 22:105-17. 2002
    ..The mechanisms involved in this beneficial effect need further clarification...
  24. ncbi request reprint Effects of mild hypothermia on survival and serum cytokines in uncontrolled hemorrhagic shock in rats
    Rainer Kentner
    Safar Center for Resuscitation Research and the Department of Anesthesiology CCM, University of Pittsburgh, Pennsylvania 15260, USA
    Shock 17:521-6. 2002
    ..We conclude that mild hypothermia improves survival time after uncontrolled HS. Uncontrolled HS induces a robust proinflammatory cytokine response. The unexpected increase in TNF-alpha with hypothermia deserves further investigation...
  25. ncbi request reprint Systemic hypothermia, but not regional gut hypothermia, improves survival from prolonged hemorrhagic shock in rats
    Xianren Wu
    Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania 15260, USA
    J Trauma 53:654-62. 2002
    ..We hypothesized that cooling the gut alone could improve survival in a rat HS model and avoid potential deleterious effects of systemic hypothermia...
  26. ncbi request reprint Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats
    Rainer Kentner
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania 15260, USA
    J Trauma 53:968-77. 2002
    ..We hypothesized that the combination of free Tempol with polynitroxylated albumin (PNA)-bound Tempol (which prolongs half-life and decreases toxicity) improves outcome after HS in rats...
  27. ncbi request reprint Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses
    Xianren Wu
    Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA
    Crit Care Med 31:195-202. 2003
    ..To explore the hypothesis that the survival benefit of mild, therapeutic hypothermia during hemorrhagic shock is associated with inhibition of lipid peroxidation and the acute inflammatory response...
  28. ncbi request reprint Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Pittsburgh, PA, USA
    Crit Care Med 31:1523-31. 2003
    ....
  29. pmc Regulatory challenges for the resuscitation outcomes consortium
    Samuel A Tisherman
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 118:1585-92. 2008
  30. ncbi request reprint Hypothermia and injury
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 10:512-9. 2004
    ..Therapeutic hypothermia for traumatic brain injury is discussed...
  31. ncbi request reprint Clinical practice guideline: endpoints of resuscitation
    Samuel A Tisherman
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Trauma 57:898-912. 2004
  32. ncbi request reprint Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs
    Ala Nozari
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:2110-6. 2004
    ..The effect of cooling during CPCR is not known. We hypothesized that mild to moderate hypothermia during CPCR would increase the rate of neurologically intact survival after prolonged cardiac arrest in dogs...
  33. ncbi request reprint Suspended animation for resuscitation from exsanguinating hemorrhage
    Samuel A Tisherman
    Department of Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:S46-50. 2004
    ..As laboratory studies to optimize suspended animation proceed, clinical trials should be initiated. In addition, devices should be developed to facilitate induction of suspended animation, eventually in the field...
  34. ncbi request reprint After spontaneous hypothermia during hemorrhagic shock, continuing mild hypothermia (34 degrees C) improves early but not late survival in rats
    Xianren Wu
    Department of Anesthesiology, University of Pittsburgh, Pennsylvania, 15260, USA
    J Trauma 55:308-16. 2003
    ..We hypothesized that after spontaneous cooling during HS, continuing mild therapeutic hypothermia during resuscitation is beneficial compared with active rewarming...
  35. ncbi request reprint Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Departments of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    Resuscitation 54:89-98. 2002
    ..There were no arrhythmias. We conclude that in large dogs the induction of mild systemic hypothermia with extracorporeal veno-venous blood shunt cooling is simple and four times more rapid than skin surface cooling...
  36. ncbi request reprint Hydrogen sulfide: metabolic mediator or toxic gas?
    Samuel A Tisherman
    Pediatr Crit Care Med 9:129-30. 2008
  37. ncbi request reprint Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial
    Tomas Drabek
    Safar Center for Resuscitation Research, and the Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Crit Care Med 35:532-7. 2007
    ..Development of a rat EPR model would enable study of the molecular mechanisms of neuronal injury and the screening of novel agents for emergency preservation...
  38. pmc No sampling technique was superior for the diagnosis of ventilator-associated pneumonia
    Deanna Blisard
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 9:E4. 2005
  39. ncbi request reprint Management of sepsis
    Gina Howell
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Surg Clin North Am 86:1523-39. 2006
    ..In the future, a better understanding of the pathophysiology of sepsis and clinical studies may further improve outcomes from severe sepsis...