Elisia D Tichy
Affiliation: University of Cincinnati
- Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksElisia D Tichy
Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
Stem Cells Dev 19:1699-711. 2010..The data suggest that preferential use of HRR rather than NHEJ may lend ES cells an additional layer of genomic protection and that the limited levels of DNA Ligase IV may account for the low level of NHEJ activity...
- The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levelsElisia D Tichy
Department of Molecular Genetics, University of Cincinnati, College of Medicine, Cincinnati OH 45267, USA
Stem Cell Res 9:124-34. 2012..Finally, we show that only a small proportion of the abundant Rad51 protein population is activated under basal conditions in ES cells and recruited to DNA DSBs and/or stalled replication forks...
- Mismatch and base excision repair proficiency in murine embryonic stem cellsElisia D Tichy
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
DNA Repair (Amst) 10:445-51. 2011..The data are consistent with the suggestion that ES cells have multiple mechanisms, including highly active MMR and BER that preserve genetic integrity and minimize the accumulation of mutations...
- Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cellsElisia D Tichy
Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
Exp Biol Med (Maywood) 236:987-96. 2011..This review focuses on the mechanisms employed by murine ESCs, human ESCs and, where data are available, IPSCs to preserve genetic integrity...
- The human DEK oncogene regulates DNA damage response signaling and repairGina M Kavanaugh
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Nucleic Acids Res 39:7465-76. 2011..Taken together, the data demonstrate new molecular links between DEK and DNA damage response signaling pathways, and suggest that DEK contributes to DNA repair...
- Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatmentElisia D Tichy
Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Stem Cell Res 10:428-41. 2013..We coined the term charontosis after Charon, the ferryman of the dead in Greek mythology, to refer to the PCD signaling events induced by ETO in mESCs...
- DNA repair in murine embryonic stem cells and differentiated cellsElisia D Tichy
Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, OH 45267, USA
Exp Cell Res 314:1929-36. 2008..This minireview focuses on repair mechanisms ES cells may use to help preserve genomic integrity and compares available data regarding these mechanisms with those utilized by differentiated cells...
- Preservation of genomic integrity in mouse embryonic stem cellsPeter J Stambrook
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio, 45267 0524, USA
Adv Exp Med Biol 695:59-75. 2010..When mouse ES cells are induced to differentiate, the predominant repair pathway switches from homology-mediated repair to nonhomologous end joining that is characteristic of somatic cells...