Elisia D Tichy

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks
    Elisia D Tichy
    Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Stem Cells Dev 19:1699-711. 2010
  2. pmc The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati, College of Medicine, Cincinnati OH 45267, USA
    Stem Cell Res 9:124-34. 2012
  3. pmc Mismatch and base excision repair proficiency in murine embryonic stem cells
    Elisia D Tichy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    DNA Repair (Amst) 10:445-51. 2011
  4. pmc Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Exp Biol Med (Maywood) 236:987-96. 2011
  5. pmc The human DEK oncogene regulates DNA damage response signaling and repair
    Gina M Kavanaugh
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nucleic Acids Res 39:7465-76. 2011
  6. pmc Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Stem Cell Res 10:428-41. 2013
  7. pmc DNA repair in murine embryonic stem cells and differentiated cells
    Elisia D Tichy
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    Exp Cell Res 314:1929-36. 2008
  8. doi request reprint Preservation of genomic integrity in mouse embryonic stem cells
    Peter J Stambrook
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio, 45267 0524, USA
    Adv Exp Med Biol 695:59-75. 2010

Collaborators

  • Li Liang
  • Lisa Wiesmuller
  • Boris Gole
  • Rachid Drissi
  • Peter J Stambrook
  • Gina M Kavanaugh
  • Monique A Morrison
  • Susanne I Wells
  • Trisha M Wise-Draper
  • Paul R Andreassen
  • George F Babcock
  • John J Bissler
  • James M Wells
  • Richard J Morreale
  • Sandy Schwemberger
  • Lu Lu

Detail Information

Publications8

  1. pmc Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks
    Elisia D Tichy
    Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Stem Cells Dev 19:1699-711. 2010
    ..The data suggest that preferential use of HRR rather than NHEJ may lend ES cells an additional layer of genomic protection and that the limited levels of DNA Ligase IV may account for the low level of NHEJ activity...
  2. pmc The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati, College of Medicine, Cincinnati OH 45267, USA
    Stem Cell Res 9:124-34. 2012
    ..Finally, we show that only a small proportion of the abundant Rad51 protein population is activated under basal conditions in ES cells and recruited to DNA DSBs and/or stalled replication forks...
  3. pmc Mismatch and base excision repair proficiency in murine embryonic stem cells
    Elisia D Tichy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    DNA Repair (Amst) 10:445-51. 2011
    ..The data are consistent with the suggestion that ES cells have multiple mechanisms, including highly active MMR and BER that preserve genetic integrity and minimize the accumulation of mutations...
  4. pmc Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Exp Biol Med (Maywood) 236:987-96. 2011
    ..This review focuses on the mechanisms employed by murine ESCs, human ESCs and, where data are available, IPSCs to preserve genetic integrity...
  5. pmc The human DEK oncogene regulates DNA damage response signaling and repair
    Gina M Kavanaugh
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nucleic Acids Res 39:7465-76. 2011
    ..Taken together, the data demonstrate new molecular links between DEK and DNA damage response signaling pathways, and suggest that DEK contributes to DNA repair...
  6. pmc Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Stem Cell Res 10:428-41. 2013
    ..We coined the term charontosis after Charon, the ferryman of the dead in Greek mythology, to refer to the PCD signaling events induced by ETO in mESCs...
  7. pmc DNA repair in murine embryonic stem cells and differentiated cells
    Elisia D Tichy
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    Exp Cell Res 314:1929-36. 2008
    ..This minireview focuses on repair mechanisms ES cells may use to help preserve genomic integrity and compares available data regarding these mechanisms with those utilized by differentiated cells...
  8. doi request reprint Preservation of genomic integrity in mouse embryonic stem cells
    Peter J Stambrook
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio, 45267 0524, USA
    Adv Exp Med Biol 695:59-75. 2010
    ..When mouse ES cells are induced to differentiate, the predominant repair pathway switches from homology-mediated repair to nonhomologous end joining that is characteristic of somatic cells...