Genomes and Genes
Jay W Tichelaar
Affiliation: University of Cincinnati
- Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasiaJay W Tichelaar
University of Cincinnati, Cincinnati, OH 45267 0056, USA
Chest 125:153S. 2004
- Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsiesJay W Tichelaar
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
BMC Cancer 5:155. 2005..The acquisition of anti-apoptotic signals is critical for the survival of cancer cells but the pathways involved are incompletely characterized in developing intra-epithelial neoplasia (IEN)...
- Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expressionJay W Tichelaar
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Exp Lung Res 33:385-417. 2007..FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression...
- Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathologyMichael T Borchers
Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
Toxicol Sci 105:188-99. 2008..These data provide strong evidence that T-cell subpopulations in the lung are major determinants of pulmonary pathology and highlight the advantages of dissecting their effector functions in response to toxicant exposures...
- Gene expression changes during the development of acute lung injury: role of transforming growth factor betaScott C Wesselkamper
Department of Environmental Health, P O Box 670056, University of Cincinnati, Cincinnati, OH 45267 0056, USA
Am J Respir Crit Care Med 172:1399-411. 2005..Acute lung injury can occur from multiple causes, resulting in high mortality. The pathophysiology of nickel-induced acute lung injury in mice is remarkably complex, and the molecular mechanisms are uncertain...
- Fibroblast growth factor 18 influences proximal programming during lung morphogenesisJeffrey A Whitsett
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:22743-9. 2002..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis...
- Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like diseaseMichael T Borchers
Department of Environmental Health, Division of Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
J Clin Invest 119:636-49. 2009..These results demonstrate that aberrant, persistent NKG2D ligand expression in the pulmonary epithelium contributes to the development of COPD pathologies...
- SP-B deficiency causes respiratory failure in adult miceKristin R Melton
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function...
- Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosisWilliam D Hardie
Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004..Induction of pulmonary fibrosis by TGF-alpha was independent of inflammation or early activation of TGF-beta...
- CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposureMichael T Borchers
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
Exp Mol Pathol 83:301-10. 2007..In this study, we utilize a mouse model of COPD to examine the contributions of CD8(+) T cells in the persistent macrophage accumulation and airspace enlargement resulting from chronic irritant exposure...
- Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain miceMarshall W Anderson
Department of Molecular Oncogenesis, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
Carcinogenesis 29:1594-600. 2008..Our results suggest a potential role for green tea extracts in preventing the progression of large, aggressive lung adenocarcinomas...
- Conditional gene expression in the respiratory epithelium of the mouseAnne Karina T Perl
Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
Transgenic Res 11:21-9. 2002..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung...
- Over expression of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of Kerapr-rtTA/FGF7 bitransgenic miceMiyuki Hayashi
Department of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267 0527, USA
Mol Vis 11:201-7. 2005..In the present study, we used a binary inducible transgenic mouse model to examine the role of FGF7 on corneal epithelium proliferation...
- Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lungUrpo Lappalainen
Goteborg University, Department of Pediatrics, The Queen Silvia Children s Hospital, 41685 Goteborg, Sweden
Am J Respir Cell Mol Biol 32:311-8. 2005..Chronic production of IL-1beta in respiratory epithelial cells of adult mice causes lung inflammation, enlargement of distal airspaces, mucus metaplasia, and airway fibrosis in the adult mouse...