JOSHUA THURMAN

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc All Things Complement
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado and
    Clin J Am Soc Nephrol . 2016
  2. doi request reprint Never make assumptions: the complicated role of complement in urinary tract infections
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA Electronic address
    Kidney Int 90:469-71. 2016
  3. pmc Targeting the complement cascade: novel treatments coming down the pike
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA Electronic address
    Kidney Int 90:746-52. 2016
  4. pmc Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO and Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, CO Electronic address
    Adv Chronic Kidney Dis 20:488-99. 2013
  5. pmc Detection of complement activation using monoclonal antibodies against C3d
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 123:2218-30. 2013
  6. doi request reprint Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis
    Joshua M Thurman
    Division of Nephrology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Kidney Int 82:945-7. 2012
  7. pmc IgM contributes to glomerular injury in FSGS
    Derek Strassheim
    Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Am Soc Nephrol 24:393-406. 2013
  8. ncbi request reprint Noninvasive detection of complement activation through radiologic imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Adv Exp Med Biol 735:271-82. 2013
  9. ncbi request reprint Noninvasive detection of complement activation through radiologic imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, 80045, USA
    Adv Exp Med Biol 734:271-82. 2013
  10. pmc Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Physiol Renal Physiol 302:F1529-36. 2012

Collaborators

Detail Information

Publications12

  1. pmc All Things Complement
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado and
    Clin J Am Soc Nephrol . 2016
    ..The use of these drugs in patients with kidney disease will expand our understanding of the benefits and limitations of C inhibition...
  2. doi request reprint Never make assumptions: the complicated role of complement in urinary tract infections
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA Electronic address
    Kidney Int 90:469-71. 2016
    ..These data indicate that complement inhibition may have some unexpected benefits. These results also demonstrate, however, that the complement cascade probably has physiologic functions that have yet to be discovered. ..
  3. pmc Targeting the complement cascade: novel treatments coming down the pike
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA Electronic address
    Kidney Int 90:746-52. 2016
    ..In spite of these challenges, new therapeutic options for targeting the complement system will likely become available in the near future and may prove useful for treating patients with kidney disease. ..
  4. pmc Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO and Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, CO Electronic address
    Adv Chronic Kidney Dis 20:488-99. 2013
    ..This review describes the clinical need for new methods of monitoring kidney inflammation and recent advances in the development of nanosized contrast agents for the detection of inflammatory markers of kidney disease. ..
  5. pmc Detection of complement activation using monoclonal antibodies against C3d
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 123:2218-30. 2013
    ..Our results demonstrate that imaging methods that use these antibodies may provide a sensitive means of detecting and monitoring complement activation-associated tissue inflammation...
  6. doi request reprint Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis
    Joshua M Thurman
    Division of Nephrology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Kidney Int 82:945-7. 2012
    ..These results suggest that factor H may be critical for limiting injury in a wide range of autoimmune and inflammatory renal diseases...
  7. pmc IgM contributes to glomerular injury in FSGS
    Derek Strassheim
    Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Am Soc Nephrol 24:393-406. 2013
    ..Strategies that reduce IgM natural antibody or that prevent complement activation may slow the progression of glomerulosclerosis...
  8. ncbi request reprint Noninvasive detection of complement activation through radiologic imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Adv Exp Med Biol 735:271-82. 2013
    ..These results may open up new avenues to develop tools for the monitoring of disease progression in complement-dependent diseases...
  9. ncbi request reprint Noninvasive detection of complement activation through radiologic imaging
    Joshua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, 80045, USA
    Adv Exp Med Biol 734:271-82. 2013
    ..These results may open up new avenues to develop tools for the monitoring of disease progression in complement-dependent diseases...
  10. pmc Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis
    Joshua M Thurman
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Physiol Renal Physiol 302:F1529-36. 2012
    ..Thus, although the glomerulus is resistant to antibody-initiated, alternative pathway-mediated injury, inhibition of this complement pathway may be beneficial in chronic immune complex-mediated diseases...
  11. pmc Therapeutic regulation of complement in patients with renal disease - where is the promise?
    Johua M Thurman
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Nephrol 77:413-23. 2012
    ..Herein we review the rationale for using complement inhibitors in patients with renal disease and discuss several drugs and approaches that are currently under development...
  12. pmc Dynamic control of the complement system by modulated expression of regulatory proteins
    Joshua M Thurman
    Division of Nephrology and Hypertension, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Lab Invest 91:4-11. 2011
    ..A full understanding of the mechanisms by which the complement system is modulated at the local level can have important implications for how we diagnose and treat a wide range of inflammatory diseases...