Richard L Thompson

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0524, USA
    J Virol 75:6660-75. 2001
  2. pmc Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0524, USA
    J Virol 77:12319-30. 2003
  3. pmc The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections
    Richard L Thompson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Neurovirol 17:552-8. 2011
  4. pmc VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
    Nancy M Sawtell
    Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Neurovirol 17:546-51. 2011
  5. pmc Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0524, USA
    Future Med Chem 2:1099-105. 2010
  6. pmc De novo synthesis of VP16 coordinates the exit from HSV latency in vivo
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    PLoS Pathog 5:e1000352. 2009
  7. pmc Herpes simplex virus and the lexicon of latency and reactivation: a call for defining terms and building an integrated collective framework
    Nancy M Sawtell
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    F1000Res 5:. 2016
  8. pmc A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e92342. 2014
  9. doi request reprint Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo
    Nancy M Sawtell
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7017, Cincinnati, OH, 45229 3039, USA
    Methods Mol Biol 1144:129-47. 2014
  10. ncbi request reprint Determination, by inductively coupled plasma mass spectrometry, of changes in cellular metal content resulting from herpes simplex virus-1 (HSV-1) infection
    Katie DeNicola Cafferky
    Department of Chemistry, University of Cincinnati, Mail Location 0172, Cincinnati, OH 45221, USA
    Anal Bioanal Chem 387:2037-43. 2007

Collaborators

Detail Information

Publications10

  1. pmc Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0524, USA
    J Virol 75:6660-75. 2001
    ..Thus, one function of the LAT gene is to protect sensory neurons and enhance the establishment of latency in the PNS...
  2. pmc Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0524, USA
    J Virol 77:12319-30. 2003
    ..These last results strongly suggest that there is a posttranscriptional constraint on the expression of ICP0 protein during reactivation from latency and that this constraint is mediated by LAT...
  3. pmc The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections
    Richard L Thompson
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Neurovirol 17:552-8. 2011
    ..Here, we report that the latency associated transcript locus of HSV-1 is required for long-term maintenance of reactivation competent latent infections...
  4. pmc VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
    Nancy M Sawtell
    Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Neurovirol 17:546-51. 2011
    ....
  5. pmc Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0524, USA
    Future Med Chem 2:1099-105. 2010
    ..Blocking VP16 transactivation would reduce the spread of the virus in the population and, importantly, presumably reduce or prevent the pathological long term chronic inflammation in the nervous system...
  6. pmc De novo synthesis of VP16 coordinates the exit from HSV latency in vivo
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    PLoS Pathog 5:e1000352. 2009
    ..HSV reactivation from latency conforms to a model in which stochastic derepression of the VP16 promoter and expression of VP16 initiates entry into the lytic cycle...
  7. pmc Herpes simplex virus and the lexicon of latency and reactivation: a call for defining terms and building an integrated collective framework
    Nancy M Sawtell
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    F1000Res 5:. 2016
    ..We propose to open a dialogue among investigators for the purpose of updating and clearly defining terms used to describe these processes and to build a collective integrated framework to move our field forward. ..
  8. pmc A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice
    Richard L Thompson
    Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e92342. 2014
    ..To our knowledge this is the first report of a host genetic locus that modulates the severity of both herpetic disease in the nervous system and herpetic stromal keratitis...
  9. doi request reprint Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo
    Nancy M Sawtell
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7017, Cincinnati, OH, 45229 3039, USA
    Methods Mol Biol 1144:129-47. 2014
    ..Our strategy and protocols for generating, characterizing, and employing HSV viral promoter/reporter mutants in vivo are provided in this two-part chapter. ..
  10. ncbi request reprint Determination, by inductively coupled plasma mass spectrometry, of changes in cellular metal content resulting from herpes simplex virus-1 (HSV-1) infection
    Katie DeNicola Cafferky
    Department of Chemistry, University of Cincinnati, Mail Location 0172, Cincinnati, OH 45221, USA
    Anal Bioanal Chem 387:2037-43. 2007
    ..This work is the first step in the identification of metals pertinent to HSV-1 infection and lays the foundation for future studies concentrating on characterization of these metal-associated or containing molecules...