MICHAEL ALBERT THOMAS

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Two-dimensional MR spectroscopy of healthy and cancerous prostates in vivo
    M Albert Thomas
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    MAGMA 21:443-58. 2008
  2. pmc Regional brain gray and white matter changes in perinatally HIV-infected adolescents
    Manoj K Sarma
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neuroimage Clin 4:29-34. 2014
  3. pmc 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities
    Rajakumar Nagarajan
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    Int J Hepatol 2012:179365. 2012
  4. pmc Correlation of Gleason scores with diffusion-weighted imaging findings of prostate cancer
    Rajakumar Nagarajan
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    Adv Urol 2012:374805. 2012
  5. doi request reprint Investigation of breast cancer using two-dimensional MRS
    M Albert Thomas
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    NMR Biomed 22:77-91. 2009
  6. ncbi request reprint Localized two-dimensional shift correlated MR spectroscopy of human brain
    M A Thomas
    Department of Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Magn Reson Med 46:58-67. 2001
  7. ncbi request reprint Localized two-dimensional 1H magnetic resonance exchange spectroscopy: a preliminary evaluation in human muscle
    M Albert Thomas
    Department of Radiological Sciences, Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Magn Reson Med 53:495-502. 2005
  8. ncbi request reprint Two-dimensional MR spectroscopic characterization of breast cancer in vivo
    M Albert Thomas
    Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Technol Cancer Res Treat 4:99-106. 2005
  9. ncbi request reprint Volume-localized two-dimensional correlated magnetic resonance spectroscopy of human breast cancer
    M A Thomas
    Department of Radiological Sciences, University of California, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 14:181-6. 2001
  10. ncbi request reprint Evaluation of two-dimensional L-COSY and JPRESS using a 3 T MRI scanner: from phantoms to human brain in vivo
    M Albert Thomas
    Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA
    NMR Biomed 16:245-51. 2003

Research Grants

Collaborators

Detail Information

Publications26

  1. doi request reprint Two-dimensional MR spectroscopy of healthy and cancerous prostates in vivo
    M Albert Thomas
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    MAGMA 21:443-58. 2008
    ..A major goal of this article is to summarize the current status of evaluating prostate metabolites non-invasively using spatially resolved two-dimensional (2D) MR Spectroscopy (MRS)...
  2. pmc Regional brain gray and white matter changes in perinatally HIV-infected adolescents
    Manoj K Sarma
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neuroimage Clin 4:29-34. 2014
    ....
  3. pmc 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities
    Rajakumar Nagarajan
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    Int J Hepatol 2012:179365. 2012
    ..Hence, glutathione and myo-inositol should be considered along with other metabolites as important markers of inflammation...
  4. pmc Correlation of Gleason scores with diffusion-weighted imaging findings of prostate cancer
    Rajakumar Nagarajan
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    Adv Urol 2012:374805. 2012
    ..05) between the three different scores with a trend of decreasing ADC values with increasing Gleason scores by one-way ANOVA method. This study shows that the DWI-derived ADC values may help differentiate aggressive from low-grade PCa...
  5. doi request reprint Investigation of breast cancer using two-dimensional MRS
    M Albert Thomas
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1721, USA
    NMR Biomed 22:77-91. 2009
    ..In addition, characterization of invasive ductal carcinomas and healthy fatty/glandular breast tissues non-invasively using the classification and regression tree (CART) analysis of two-dimensional MRS data is reviewed...
  6. ncbi request reprint Localized two-dimensional shift correlated MR spectroscopy of human brain
    M A Thomas
    Department of Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Magn Reson Med 46:58-67. 2001
    ..Localized COSY (L-COSY) spectra of cerebral prefrontal and occipital gray/white matter regions in 15 healthy controls are presented. Magn Reson Med 46:58-67, 2001...
  7. ncbi request reprint Localized two-dimensional 1H magnetic resonance exchange spectroscopy: a preliminary evaluation in human muscle
    M Albert Thomas
    Department of Radiological Sciences, Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Magn Reson Med 53:495-502. 2005
    ..Our preliminary results demonstrate that the intermolecular and intramolecular chemical exchange mechanisms can be monitored noninvasively in human calf muscle using 2D L-EXSY...
  8. ncbi request reprint Two-dimensional MR spectroscopic characterization of breast cancer in vivo
    M Albert Thomas
    Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095 1721, USA
    Technol Cancer Res Treat 4:99-106. 2005
    ..This is a first report on the statistical classification of 2D L-COSY in human breast carcinomas in vivo...
  9. ncbi request reprint Volume-localized two-dimensional correlated magnetic resonance spectroscopy of human breast cancer
    M A Thomas
    Department of Radiological Sciences, University of California, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 14:181-6. 2001
    ..Being in agreement with the conventional 1D magnetic resonance spectroscopy (MRS) results, elevated water to lipids ratios were found in breast cancers and choline was observed only in a few cancer patients...
  10. ncbi request reprint Evaluation of two-dimensional L-COSY and JPRESS using a 3 T MRI scanner: from phantoms to human brain in vivo
    M Albert Thomas
    Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA
    NMR Biomed 16:245-51. 2003
    ..Due to increased sampling rate, severe loss of metabolite signals due to T2 during t1 was a major drawback of 2D JPRESS in vivo...
  11. ncbi request reprint Reproducibility of localized 2D correlated MR spectroscopy
    Nader Binesh
    Department of Radiological Sciences, UCLA School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1721, USA
    Magn Reson Med 48:942-8. 2002
    ..The intraclass correlation coefficients were greater than 0.4 (P < 0.05) for the major metabolites, indicating that the 2D peak volumes were stable enough within individuals to detect reliable differences between normal subjects...
  12. ncbi request reprint Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    Mark A Frye
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
    Neuropsychopharmacology 32:2490-9. 2007
    ..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response...
  13. ncbi request reprint Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute and Hospital, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 29:2251-7. 2004
    ....
  14. ncbi request reprint Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents
    Pablo Davanzo
    Department of Psychiatry and Behavioral Sciences, UCLA School of Medicine, CA 90024, USA
    Am J Psychiatry 160:1442-52. 2003
    ....
  15. ncbi request reprint Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Psychiatry Res 154:259-65. 2007
    ..Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder...
  16. ncbi request reprint Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy
    Olusola Ajilore
    Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 32:1224-31. 2007
    ..These findings have broad implications and suggest that alterations in glutamate and glutamine levels in subcortical regions along with white matter changes in myo-inositol provide important neurobiological substrates of mood disorders...
  17. ncbi request reprint Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study
    Nader Binesh
    Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 20:1039-45. 2004
    ..To evaluate a two-dimensional localized chemical shift correlated spectroscopy (L-COSY) sequence in elderly patients with major depression...
  18. ncbi request reprint Magnetization transfer imaging and magnetic resonance spectroscopy of normal-appearing white matter in late-life major depression
    Nathaniel Wyckoff
    Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Magn Reson Imaging 18:537-43. 2003
    ....
  19. ncbi request reprint 2D JPRESS of human prostates using an endorectal receiver coil
    Kenneth Yue
    Department of Radiological Sciences, School of Medicine, University of California, Los Angeles, California, USA
    Magn Reson Med 47:1059-64. 2002
    ..The preliminary results suggest that the endorectal 2D JPRESS could be successfully implemented for the diagnostic examination of human prostates. ...
  20. doi request reprint Correlation of endorectal 2D JPRESS findings with pathological Gleason scores in prostate cancer patients
    Rajakumar Nagarajan
    Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    NMR Biomed 23:257-61. 2010
    ..Our pilot study suggests that 2D JPRESS can be reliably evaluated in a clinical setting using an endorectal coil. In addition to the citrate ratio, the spermine ratio also correlates with pathology based Gleason score...
  21. pmc Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy
    Aparna Singhal
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 30:1034-41. 2009
    ..To evaluate T(2)-relaxation changes in patients with minimal hepatic encephalopathy (MHE) using T(2) relaxometry and to correlate T(2) values with brain metabolites evaluated using 2D magnetic resonance spectroscopy (MRS)...
  22. ncbi request reprint Adding another spectral dimension to 1H magnetic resonance spectroscopy of hepatic encephalopathy
    Nader Binesh
    Department of Radiological Science, David Geffen School of Medicine at University of California, Los Angeles, California 90024 1721, USA
    J Magn Reson Imaging 21:398-405. 2005
    ....
  23. doi request reprint Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivo
    Aparna Singhal
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 32:35-43. 2010
    ....
  24. doi request reprint Voxel-based diffusion tensor magnetic resonance imaging evaluation of low-grade hepatic encephalopathy
    Rajesh Kumar
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1721, USA
    J Magn Reson Imaging 27:1061-8. 2008
    ..To quantify the changes in brain water diffusivity in hepatic encephalopathy (HE) associated with cirrhosis using diffusion tensor imaging (DTI) and to correlate with neuropsychological (NP) scores...
  25. ncbi request reprint Hepatic encephalopathy: a neurochemical, neuroanatomical, and neuropsychological study
    Nader Binesh
    Department of Radiological Sciences, University of California, Los Angeles, California 90095, USA
    J Appl Clin Med Phys 7:86-96. 2006
    ..It also indicates that the hyperintensity observed in globus pallidus could be used as complementary to the NP test scores in evaluating the mental health of HE patients...
  26. ncbi request reprint Emerging technologies in uroradiologic imaging
    Nicolette K Janzen
    Department of Urology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Urol Oncol 21:317-26. 2003
    ..We provide an overview of these four emerging imaging modalities and their potential applications and limitations in the diagnosis and management of urologic malignancy...

Research Grants2

  1. HEPATIC ENCEPHALOPATHY--NEUROPSYCHOLOGY & NEUROCHEMISTRY
    Michael Thomas; Fiscal Year: 2001
    ..This enhanced understanding of pathophysiology will improve our ability to diagnose and treat this condition, resulting in improved patient outcomes. ..
  2. Two-dimensional MR Spectroscopic Characterization of HE
    Michael Thomas; Fiscal Year: 2006
    ..Minimal spectral overlap leading to less ambiguous assignment and better quantitation of glutamate/glutamine, GABA, myo-inositol, threonine, glucose, taurine and glutathione, will be a major outcome of this work. ..