Affiliation: University of Kentucky
- Effects of long-term pioglitazone treatment on peripheral and central markers of agingEric M Blalock
Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky, United States of America
PLoS ONE 5:e10405. 2010..Because aging is a common risk factor for both AD and T2DM, we investigated whether the TZD, pioglitazone could alter brain aging under non-pathological conditions...
- Hippocampal calcium dysregulation at the nexus of diabetes and brain agingOlivier Thibault
Department of Molecular and Biomedical Pharmacology, MS 313, 800 Rose Street, University of Kentucky Medical Center, Lexington, KY 40536, United States Electronic address
Eur J Pharmacol 719:34-43. 2013..Thus, while additional testing is needed, the results to date are consistent with the view that strategies that enhance insulin signaling can counteract the effect of aging on Ca(2+) dysregulation. ..
- Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's diseaseOlivier Thibault
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
Biochim Biophys Acta 1822:546-9. 2012..The results suggest that mechanisms for Ca(2+) dysregulation can differ substantially between animal models of normal aging and models of pathological aging...
- Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticityO Thibault
Department of Molecular and Biomedical Pharmacology, MS 307 University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
J Neurosci 21:9744-56. 2001..Together, the results elucidate novel processes that may contribute to impaired cognitive function in aging...
- Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slicesK C Chen
Department of Pharmacology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
Proc Natl Acad Sci U S A 97:4357-62. 2000..Thus, these studies support the possibility that the level of alpha(1D) gene expression regulates the density of functional L-VSCCs...
- FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?J C Gant
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 800 Rose St, UKMC Lexington, KY 40536, United States
Eur J Pharmacol 739:74-82. 2014..These results suggest the novel hypothesis that declining FKBP function is a key factor in aging-related Ca(2+) dysregulation in the brain and point to potential new therapeutic targets for counteracting unhealthy brain aging. ..
- Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate releaseC M Norris
Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305, UKMC, Lexington, KY 40536 0298, USA
J Neurophysiol 96:2488-500. 2006....
- Mechanisms and use of antidiabetic agents in brain aging and Alzheimer's diseaseOlivier Thibault; Fiscal Year: 2008..Furthermore, these studies will contribute to future drug discovery efforts to generate new TZD-derived or similar drugs for the treatment of AD. [unreadable] [unreadable] [unreadable]..