Genomes and Genes
R A Terkeltaub
Affiliation: University of California
- Update on gout: new therapeutic strategies and optionsRobert Terkeltaub
Rheumatology Section, Veterans Affairs Medical Center, University of California, San Diego, 3350 La Jolla Village Drive, CA 92161, USA
Nat Rev Rheumatol 6:30-8. 2010..Collectively, novel approaches will hopefully lead to improved management of hyperuricemia and gout, and also to improvements in patient-centered outcomes, even for those who have previously failed to respond to treatment...
- Invited review: the mitochondrion in osteoarthritisRobert Terkeltaub
Veterans Affairs San Diego Health Care System, University of California, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Mitochondrion 1:301-19. 2002..The weight of evidence reviewed herein strongly supports chondrocyte mitochondrial impairment as a mediator of the establishment and progression of OA...
- Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasiaK Jagadeesha Dammanahalli
San Diego VA Healthcare System and Department of Medicine, University of California San Diego, San Diego, California, United States of America
PLoS ONE 7:e39106. 2012..Vanin-1 is a novel potential therapeutic target for neointimal hyperplasia following revascularization...
- Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitorsRobert A Terkeltaub
VA San Diego Medical Center, San Diego, CA 92161, USA
Arthritis Rheum 63:2226-37. 2011..The objective was to develop colchicine-dosing algorithms with improved safety...
- High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine studyRobert A Terkeltaub
VAMC San Diego, and University of California, San Diego, CA 92161, USA
Arthritis Rheum 62:1060-8. 2010....
- Gout. Novel therapies for treatment of gout and hyperuricemiaRobert Terkeltaub
Rheumatology Section, San Diego Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Arthritis Res Ther 11:236. 2009....
- The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot studyR Terkeltaub
VAMC Rheumatology, 111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Ann Rheum Dis 68:1613-7. 2009..Recent studies suggest that blockade of the NLRP3 (cryopyrin) inflammasome interleukin 1beta (IL1beta) pathway may offer a new treatment strategy for gout...
- Colchicine update: 2008Robert A Terkeltaub
VA Medical Center, San Diego, CA 92161, USA
Semin Arthritis Rheum 38:411-9. 2009..To review recent advances in the understanding of molecular mechanisms of drug disposition and cellular mechanisms of action and targets of colchicine, and disease applications and guidelines for oral colchicine use...
- Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytesDenise L Cecil
Veterans Affairs Medical Center, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Arthritis Rheum 52:144-54. 2005..This study was undertaken to test the hypothesis that IL-8 promotes chondrocyte hypertrophy by modulating chondrocyte PiT-1 expression and sodium-dependent Pi uptake, and to assess differential roles in this activity...
- Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeuticsRobert Terkeltaub
San Diego VAMC Rheumatology Section, and University of California San Diego, La Jolla, California, USA
Arthritis Res Ther 8:S4. 2006..For this reason, our discussion focuses on the development of the novel xanthine oxidase inhibitor febuxostat and modified recombinant uricase preparations...
- Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcificationRobert Terkeltaub
University of California School of Medicine, VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA, USA
Purinergic Signal 2:371-7. 2006..This review pays particular attention to the role of NPP1-catalyzed PP(i) generation in the pathogenesis of certain disorders associated with pathologic calcification...
- Inorganic pyrophosphate generation and disposition in pathophysiologyR A Terkeltaub
Veterans Affairs Medical Center and School of Medicine, University of California, San Diego, California 92161, USA
Am J Physiol Cell Physiol 281:C1-C11. 2001....
- Chemokines and atherosclerosisR Terkeltaub
Department of Medicine, VA Medical Centre, University of California, San Diego, USA
Curr Opin Lipidol 9:397-405. 1998..We also discuss new studies that reveal how CD40 ligand and certain other stimuli can promote chemokine expression in atherosclerosis...
- A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient miceW A Boisvert
The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 101:353-63. 1998..Thus, the capacity of leukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROalpha, mediated the intimal accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice...
- Interleukin-8 and its receptor CXCR2 in atherosclerosisW A Boisvert
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunol Res 21:129-37. 2000..Although the mechanism still needs to be worked out, it appears that CXCR2 expression on lesion Mphi is essential for these cells to be retained in the lesion...
- Noninvasive evaluation of adult onset myopathy from carnitine palmitoyl transferase II deficiency using proton magnetic resonance spectroscopyJ S Videen
Veterans Affairs Medical Center and the Department of Medicine, University of California San Diego 92161, USA
J Rheumatol 26:1757-63. 1999..We describe a proton magnetic resonance spectroscopy (MRS) technique, using a standard clinical magnetic resonance imaging scanner, to diagnose and help monitor the response to therapy in adult CPT II deficiency...
- High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defectsR S Goomer
Department of Orthopedics, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, California, 92093 0630, USA
Osteoarthritis Cartilage 9:248-56. 2001..Transfection of these cells with a gene that induces chondrocytic phenotype may form an ideal method to affect tissue engineering of articular cartilage...
- Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OAJ L Huebner
Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC 27710, USA
Osteoarthritis Cartilage 17:1056-64. 2009..Moreover, glucosamine, which is currently under investigation as an OA therapy, binds and inhibits TG2. Here, we examined TG2 as a potential marker of cartilage hypertrophy in the spontaneous guinea pig model of OA...
- Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excessK Johnson
Veterans Affairs Medical Center, UCSD, La Jolla, CA 92161, USA
Osteoarthritis Cartilage 12:321-35. 2004..Therefore, we assessed if dysregulated wild-type ANK expression could contribute to pathogenesis of idiopathic degenerative arthropathy through elevated ecPP(i)...
- Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expressionD W Burton
San Diego Veterans Administration Healthcare System, San Diego, CA 92161, USA
Osteoarthritis Cartilage 13:395-404. 2005..Hence, we examined chondrocyte CaR-mediated calcium-sensing in OA pathogenesis...
- Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritisH Mitsuyama
University of California, San Diego, Department of Orthopaedic Surgery, CA 92093 0630, USA
Osteoarthritis Cartilage 15:559-65. 2007..The purpose of this study was to examine the relationship between cartilage calcification and aging in an unselected donor population of diverse age using highly sensitive calcification imaging...
- Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequenceA Gujral
The Department of Medicine, University of California, and the Veterans Affairs Medical Center, San Diego 92161, USA
Cancer Res 61:2282-8. 2001..This novel pathway could mediate the effects of PTHrP on the progression of prostate cancer...
- Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytesK Johnson
Department of Veterans Affairs Medical Center, University of California, San Diego 92161, USA
Arthritis Rheum 42:1986-97. 1999..This study compared the roles of the transforming growth factor beta (TGFbeta)-inducible plasma cell membrane glycoprotein-1 (PC-1) and the closely related B10 NTPPPH activities in chondrocyte PPi metabolism...
- Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcificationK Johnson
VA Medical Center, San Diego, California 92161, USA
Arthritis Rheum 44:1071-81. 2001..Increased expression of PC-1 is both a marker and a potential pathogenic factor for knee meniscal cartilage matrix calcification...
- Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-betaR Huang
San Diego Veterans Affairs Medical Center, CA 92161
J Clin Invest 94:560-7. 1994..The identification of PC-1 as an NTPPPH expressed in cells derived from bone and cartilage may prove useful in furthering the understanding of the role of NTPPPH i n physiologic and pathologic mineralization...
- Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIaK Johnson
Department of Medicine, Rheumatology Allergy-Immunology Division, Veterans Affairs Medical Center, University of California at San Diego, USA
Am J Pathol 159:149-63. 2001..Because TGase activity promoted apatite deposition, our findings potentially implicate inflammation in the pathogenesis of cartilage matrix calcification...
- Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissuesL J Deftos
Dept of Medicine, San Diego VA Medical Center, University of California, La Jolla 92093 0822, USA
Endocrine 15:217-24. 2001..These results support the importance of these processing enzymes in their hypothesized roles in prohormone processing...
- Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophyKristen A Johnson
Veterans Affairs Medical Center, University of California San Diego, La Jolla, California 92161, USA
J Biol Chem 278:18824-32. 2003..TG2 is a potential site for intervention in pathologic calcification promoted by IL-1 beta and ATRA...
- External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcificationKristen A Johnson
Veterans Affairs Medical Center, University of California, San Diego, La Jolla, California 92161, USA
J Biol Chem 280:15004-12. 2005....
- Gout: on the brink of novel therapeutic options for an ancient diseaseJeffry D Bieber
Veterans Affairs Medical Center and University of California San Diego, San Diego, California 92161, USA
Arthritis Rheum 50:2400-14. 2004
- Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitisNicole Tramontini
Pfizer Global Research and Development, Ann Arbor, Michigan, USA
Arthritis Rheum 50:2633-9. 2004..Hence, we studied rabbits deficient in the MAC component C6 to determine if MAC mediated urate crystal-induced arthritis...
- Recent developments in diet and goutSusan J Lee
Center for Innovative Therapy, University of San Diego, La Jolla, California 92037, USA
Curr Opin Rheumatol 18:193-8. 2006..This review focuses on recent developments and their implications for clinical practice, including how we advise patients on appropriate diets and alcoholic beverage consumption...
- New developments in clinically relevant mechanisms and treatment of hyperuricemiaSusan J Lee
University of California, San Diego, Division of Rheumatology, Allergy, and Immunology, Center for Innovative Therapy, 9320 Campus Point Dr Suite 225, La Jolla, CA 92037 0943, USA
Curr Rheumatol Rep 8:224-30. 2006..These agents should provide novel options for patients with chronic, refractory gout and hyperuricemia, particularly in association with allopurinol hypersensitivity and renal insufficiency...
- Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cellsKristen A Johnson
Veterans Affairs Medical Center, University of California at San Diego, La Jolla, USA
Circ Res 102:529-37. 2008..Our results suggest that TG2 release in injured arteries is critical for programming chondro-osseous SMC differentiation and calcification in response to increased P(i) and bone morphogenetic protein-2...
- What does cartilage calcification tell us about osteoarthritis?Robert A Terkeltaub
J Rheumatol 29:411-5. 2002
- Clinical practice. GoutRobert A Terkeltaub
Rheumatology Section, Department of Medicine, San Diego Veterans Affairs Medical Center and the University of California San Diego School of Medicine, San Diego, CA 92161, USA
N Engl J Med 349:1647-55. 2003
- Questions & answers. What's the difference between gout and pseudogout?Robert A Terkeltaub
Rheumatology Section, University of California, San Diego, USA
Health News 9:16. 2003
- IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptorIngrid U Schraufstatter
Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
J Immunol 171:6714-22. 2003..These results indicate that IL-8-induced transactivation of the EGFR is mediated by the CXCR2 and involves cathepsin B, and that this pathway is important for the migratory and tumorigenic effects of IL-8...
- Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphateYun Zhang
Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
Arthritis Rheum 52:1110-7. 2005..This study investigated the potential for ANKH sequence variants to promote sporadic chondrocalcinosis...
- Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank miceKristen A Johnson
Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
Am J Pathol 172:440-53. 2008....
- Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progressionWilliam A Boisvert
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
Am J Pathol 168:1385-95. 2006....
- PTHRP 1 to 173 IN CHONDROCYTESRobert Terkeltaub; Fiscal Year: 2005..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
- ANK and Joint Ankylosis in SpondylitisRobert Terkeltaub; Fiscal Year: 2008..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
- Chondrocyte S100/Calgranulins and RAGE in OsteoarthritisRobert Terkeltaub; Fiscal Year: 2009..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..