Glenn C Telling

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc The mechanism of prion strain propagation
    Glenn C Telling
    Sanders Brown Center on Aging, Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Genome Biol 5:222. 2004
  2. pmc Nucleic acid-free mutation of prion strains
    Glenn C Telling
    Department of Microbiology, Immunology and Molecular Genetics, Sanders Brown Center on Aging, Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA
    Prion 4:252-5. 2010
  3. doi request reprint Transgenic mouse models and prion strains
    Glenn C Telling
    Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, KY 40506, USA
    Top Curr Chem 305:79-99. 2011
  4. pmc Prion strain mutation determined by prion protein conformational compatibility and primary structure
    Rachel C Angers
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Science 328:1154-8. 2010
  5. pmc B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease
    Candace K Mathiason
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 84:5097-107. 2010
  6. pmc Chronic wasting disease prions in elk antler velvet
    Rachel C Angers
    University of Kentucky Medical Center, Lexington, 40536, USA
    Emerg Infect Dis 15:696-703. 2009
  7. pmc Detection of protease-resistant cervid prion protein in water from a CWD-endemic area
    T A Nichols
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA
    Prion 3:171-83. 2009
  8. pmc Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer
    Nicholas J Haley
    Department of Microbiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 4:e7990. 2009
  9. pmc Characterization of conformation-dependent prion protein epitopes
    Hae Eun Kang
    Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 287:37219-32. 2012
  10. pmc Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease
    Brady Michel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center, Fort Collins, Colorado 80523, USA
    Int Immunol 25:697-702. 2013

Collaborators

Detail Information

Publications46

  1. pmc The mechanism of prion strain propagation
    Glenn C Telling
    Sanders Brown Center on Aging, Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Genome Biol 5:222. 2004
    ..Two recent studies of yeast prions have now formally demonstrated that multiple stable protein conformations are the basis of strain variation...
  2. pmc Nucleic acid-free mutation of prion strains
    Glenn C Telling
    Department of Microbiology, Immunology and Molecular Genetics, Sanders Brown Center on Aging, Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA
    Prion 4:252-5. 2010
    ..Here we review emerging evidence indicating how prion protein primary structures, in concert with PrP(Sc) conformational compatibility, determine prion strain mutation...
  3. doi request reprint Transgenic mouse models and prion strains
    Glenn C Telling
    Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, KY 40506, USA
    Top Curr Chem 305:79-99. 2011
    ....
  4. pmc Prion strain mutation determined by prion protein conformational compatibility and primary structure
    Rachel C Angers
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Science 328:1154-8. 2010
    ..The primary structures of deer and elk prion proteins differ at residue 226, which, in concert with PrPSc conformational compatibility, determines prion strain mutation in these cervids...
  5. pmc B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease
    Candace K Mathiason
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 84:5097-107. 2010
    ..Localization of CWD infectivity with leukocyte subpopulations may aid in enhancing the sensitivity of blood-based diagnostic assays for CWD and other TSEs...
  6. pmc Chronic wasting disease prions in elk antler velvet
    Rachel C Angers
    University of Kentucky Medical Center, Lexington, 40536, USA
    Emerg Infect Dis 15:696-703. 2009
    ....
  7. pmc Detection of protease-resistant cervid prion protein in water from a CWD-endemic area
    T A Nichols
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA
    Prion 3:171-83. 2009
    ..These data demonstrate detection of very low levels of PrP(CWD) in the environment by sPMCA and suggest persistence and accumulation of prions in the environment that may promote CWD transmission...
  8. pmc Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer
    Nicholas J Haley
    Department of Microbiology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS ONE 4:e7990. 2009
    ..This finding led us to examine further our initial cervid bioassay experiments using sPMCA...
  9. pmc Characterization of conformation-dependent prion protein epitopes
    Hae Eun Kang
    Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 287:37219-32. 2012
    ....
  10. pmc Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease
    Brady Michel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center, Fort Collins, Colorado 80523, USA
    Int Immunol 25:697-702. 2013
    ..The delayed kinetics in prion replication correlate with delayed disease kinetics in mice deficient in C3. Taken together, these data support a critical role of C3 in peripheral CWD prion pathogenesis...
  11. doi request reprint The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation
    Kristi M Green
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA
    J Gen Virol 89:598-608. 2008
    ....
  12. ncbi request reprint Detection of PrPCWD in feces from naturally exposed Rocky Mountain elk (Cervus elaphus nelsoni) using protein misfolding cyclic amplification
    Bruce Pulford
    Department of Microbiology, Immunology and Pathology, Prion Research Program, Colorado State University, 1619 Campus Delivery, Fort Collins, Colorado 80523, USA
    J Wildl Dis 48:425-34. 2012
    ..These data show for the first time PrP(CWD) in feces from naturally exposed free-ranging elk and demonstrate the potential of PMCA as a new, noninvasive CWD diagnostic tool to complement IHC...
  13. pmc Accelerated high fidelity prion amplification within and across prion species barriers
    Kristi M Green
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Pathog 4:e1000139. 2008
    ..Our studies demonstrate that combined transgenic mouse and PMCA approaches not only expedite intra- and inter-species prion transmission, but also provide a facile means of generating and characterizing novel prion strains...
  14. pmc Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease
    Brady Michel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Prion Research Center, Fort Collins, CO 80523, USA
    J Immunol 189:4520-7. 2012
    ..We further propose a potential role for CD21/35 in selecting prion quasi-species present in prion strains that may exhibit differential zoonotic potential compared with the parental strains...
  15. pmc Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease
    Nicholas J Haley
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    J Gen Virol 93:1141-50. 2012
    ....
  16. doi request reprint In vitro strain adaptation of CWD prions by serial protein misfolding cyclic amplification
    Crystal Meyerett
    Department of Microbiology, Immunology, and Pathology, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO 80523, USA
    Virology 382:267-76. 2008
    ..Thus sPMCA may represent a powerful tool to assess prion strain adaptation and species barriers in vitro...
  17. pmc Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission
    Nicholas J Haley
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 85:6309-18. 2011
    ..These findings offer unique insights into the transmission of CWD in particular and prion infection and trafficking overall...
  18. pmc Pathogenesis of chronic wasting disease in cervidized transgenic mice
    Davis M Seelig
    Colorado State University, Department of Microbiology, Immunology, and Pathology, 1619 Campus Delivery, Fort Collins, CO 80523, USA
    Am J Pathol 176:2785-97. 2010
    ..This work documents the multiroute susceptibility, pathogenesis, and lateral transmission of CWD infection in Tg[CerPrP] mice, affirming this model as a robust system to study this cervid transmissible spongiform encephalopathy...
  19. pmc Aerosol and nasal transmission of chronic wasting disease in cervidized mice
    Nathaniel D Denkers
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1619, USA
    J Gen Virol 91:1651-8. 2010
    ..These results demonstrate that CWD can be transmitted by aerosol (as well as nasal) exposure and suggest that exposure via the respiratory system merits consideration for prion disease transmission and biosafety...
  20. ncbi request reprint Prions in skeletal muscles of deer with chronic wasting disease
    Rachel C Angers
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Science 311:1117. 2006
    ....
  21. pmc Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay
    Nicholas J Haley
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
    PLoS ONE 4:e4848. 2009
    ..These findings help extend our understanding of CWD prion shedding and transmission and portend the detection of infectious prions in body fluids in other prion infections...
  22. pmc In vitro amplification of misfolded prion protein using lysate of cultured cells
    Charles E Mays
    Department of Microbiology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 6:e18047. 2011
    ....
  23. doi request reprint Trans-species amplification of PrP(CWD) and correlation with rigid loop 170N
    Timothy D Kurt
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA
    Virology 387:235-43. 2009
    ..Serial PMCA may offer insights into species barriers to transmission of CWD...
  24. ncbi request reprint GFP-tagged PrP supports compromised prion replication in transgenic mice
    Jifeng Bian
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA
    Biochem Biophys Res Commun 340:894-900. 2006
    ....
  25. pmc Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression
    Karah E Nazor
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1772:645-53. 2007
    ..Our results are consistent with a mechanism in which loss of normal PrP(C) function is an important pathological component of prion diseases...
  26. pmc Structural effects of PrP polymorphisms on intra- and interspecies prion transmission
    Rachel Angers
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40506
    Proc Natl Acad Sci U S A 111:11169-74. 2014
    ..These structure-function analyses are consistent with previous structural investigations and confirm a role for plasticity of this tertiary structural epitope in the control of PrP conversion and strain propagation. ..
  27. pmc Epigenetic dominance of prion conformers
    Eri Saijo
    Prion Research Center PRC and Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Pathog 9:e1003692. 2013
    ..This epigenetic mechanism thus expands the range of selectable conformations that can be adopted by PrP, and therefore the variety of options for strain propagation. ..
  28. pmc Chronic wasting disease prion trafficking via the autonomic nervous system
    Davis M Seelig
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
    Am J Pathol 179:1319-28. 2011
    ....
  29. doi request reprint Transgenic mouse models of prion diseases
    Glenn C Telling
    Department of Microbiology, Immunology and Molecular Genetics, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 459:249-63. 2008
    ..In this chapter, I review recent advances in our understanding of prion biology that derive from this powerful and informative approach...
  30. pmc Alteration of the chronic wasting disease species barrier by in vitro prion amplification
    Timothy D Kurt
    Department of Microbiology, Immunology and Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523 1619, USA
    J Virol 85:8528-37. 2011
    ..These results demonstrate that transspecies sPMCA of CWD prions can enhance the infectivity and adapt the host range of CWD prions and thereby may be useful to assess determinants of prion species barriers...
  31. pmc Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source
    Charles E Mays
    Sanders Brown Center on Aging, and Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Biochem Biophys Res Commun 388:306-10. 2009
    ..PMCA established here will contribute to optimizing conditions to enhance PrP(Sc) amplification by using concentrated PrP(C) source and expands the use of this methodology...
  32. pmc Efficient in vitro amplification of chronic wasting disease PrPRES
    Timothy D Kurt
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Virol 81:9605-8. 2007
    ..5 x 10(9)-fold amplification after six rounds. Highly efficient in vitro amplification of PrP(CWD) is a significant step toward detection of PrP(CWD) in the body fluids or excreta of CWD-susceptible species...
  33. pmc Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions
    Marcelo A Barria
    Mitchell Center for Alzheimer s Disease and Related Brain Disorders, Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Biol Chem 286:7490-5. 2011
    ..If our findings are corroborated by infectivity assays, they will imply that CWD prions have the potential to infect humans and that this ability progressively increases with CWD spreading...
  34. pmc Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice
    A Christy Wyckoff
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Prion Research Center at Colorado State University Fort Collins, CO, USA
    Front Microbiol 7:1885. 2016
    ..These results confirm clay components in soil as an important vector in CWD transmission at both environmental and organismal levels...
  35. pmc Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion
    Kristen A Davenport
    Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    J Virol 89:9524-31. 2015
    ..These results suggest that (i) at the level of protein-protein interactions, CWD adapts to a new species more readily than does BSE and (ii) the barrier preventing transmission of CWD to humans may be less robust than estimated...
  36. ncbi request reprint Infectious prions in the saliva and blood of deer with chronic wasting disease
    Candace K Mathiason
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biological Sciences CVMBS, Colorado State University CSU, Fort Collins, CO 80523, USA
    Science 314:133-6. 2006
    ..The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections...
  37. pmc Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice
    Karah E Nazor
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    EMBO J 24:2472-80. 2005
    ..Thus, while pathological mutant PrP possesses a subset of PrP(Sc) characteristics, we now show that the attribute of prion transmission suggested by previous studies is more accurately characterized as disease acceleration...
  38. pmc Unaltered prion protein expression in Alzheimer disease patients
    Eri Saijo
    Department of Microbiology, Immunology and Molecular Genetic, University of Kentucky Medical Center, Lexington, KY, USA
    Prion 5:109-16. 2011
    ..Our results indicate that, if PrP (C)  is involved in mediating the toxic effects of the oligomeric Aβ peptide, these effects occur independently of steady state levels of PrP or the codon 129 polymorphism...
  39. pmc Prion protein expression and functional importance in skeletal muscle
    Jeffrey D Smith
    Department of Physiology, University of Kentucky, Lexington, 40536, USA
    Antioxid Redox Signal 15:2465-75. 2011
    ..Skeletal muscle expresses prion protein (PrP) that buffers oxidant activity in neurons...
  40. pmc Minor oral lesions facilitate transmission of chronic wasting disease
    Nathaniel D Denkers
    Department of Microbiology, Immunology, and Pathology, Campus Delivery 1619, Colorado State University, Fort Collins, CO 80523 1619, USA
    J Virol 85:1396-9. 2011
    ..Results demonstrated that minor lingual abrasions substantially facilitate CWD transmission, revealing a cofactor that may be significant in cervids and perhaps other species...
  41. pmc Grass plants bind, retain, uptake, and transport infectious prions
    Sandra Pritzkow
    Mitchell Center for Alzheimer s Disease and Related Brain Disorders, Department of Neurology, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    Cell Rep 11:1168-75. 2015
    ..These findings demonstrate that plants can efficiently bind infectious prions and act as carriers of infectivity, suggesting a possible role of environmental prion contamination in the horizontal transmission of the disease. ..
  42. ncbi request reprint Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation
    Rajgopal Yadavalli
    Department of Microbiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 279:21948-56. 2004
    ..Our observations suggest that calpain-mediated endoproteolytic cleavage of PrP(Sc) may be an important event in prion propagation...
  43. pmc Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse
    Kathleen M Schoch
    Spinal Cord and Brain Injury Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurochem 125:909-20. 2013
    ..Augmenting calpastatin levels may be an effective method for calpain inhibition in traumatic brain injury and neurodegenerative disorders...
  44. pmc Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP
    Shawn R Browning
    Department of Microbiology, University of Kentucky, 800 Rose St, Lexington, KY 40536, USA
    J Virol 78:13345-50. 2004
    ..Transmission studies indicated that the same prion strain caused CWD in the analyzed mule deer and elk. These mice provide a new and reliable tool for detecting CWD prions...
  45. pmc Environmentally-relevant forms of the prion protein
    Samuel E Saunders
    Department of Civil Engineering, University of Nebraska Lincoln, Peter Kiewit Institute, Omaha, Nebraska, USA
    Environ Sci Technol 42:6573-9. 2008
    ..This indicates that the transgenic mouse-CWD model is a good surrogate for natural CWD prions, but that other rodent prion models might not accurately represent CWD prion fate in the environment...
  46. ncbi request reprint Special issue: prion-related disorders
    Glenn C Telling
    Biochim Biophys Acta 1772:597. 2007