Genomes and Genes
Teresa K Tarrant
Affiliation: University of North Carolina
- G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responsesTeresa K Tarrant
1 CB 7280, 3300 Manning Dr, Chapel Hill, NC 27599, USA
J Leukoc Biol 94:1243-51. 2013....
- Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis modelTeresa K Tarrant
Department of Medicine, University of North Carolina at Chapel Hill, CB 7280, 3300 Manning Drive, Chapel Hill, NC 27599, USA
Arthritis Rheum 64:1379-87. 2012..Because CX(3) CR1 is expressed on T cells and antigen-presenting cells, we also examined adaptive immune functions in this model...
- Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)Teresa K Tarrant
Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Clin Immunol 129:115-22. 2008..We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model...
- G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritisPatrick M Giguère
Department of Pharmacology, UNC School of Medicine, Chapel Hill, NC 27599 7365, USA
Mol Immunol 54:193-8. 2013..Our results suggest that GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM3 expression is protective in acute inflammatory arthritis...
- G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and MetastasisMatthew J Billard
Thurston Arthritis Research Center and the Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC 27599, United States of America
PLoS ONE 11:e0152856. 2016..These data demonstrate that GRK3 dysregulation may play an important part in TNBC metastasis. ..
- Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritisRishi R Rampersad
Department of Medicine, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 6:e25833. 2011....
- Targeting the molecular and cellular interactions of the bone marrow niche in immunologic diseaseJaime M Brozowski
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA
Curr Allergy Asthma Rep 14:402. 2014....
- Autoimmunity in immunodeficiencyKrista Todoric
Division of Allergy and Immunology, Dept of Pediatrics, University of North Carolina Hospitals, Chapel Hill, NC 27599, USA
Curr Allergy Asthma Rep 13:361-70. 2013..The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date. ..
- Cellular targeting in autoimmunityJennifer L Rogers
Division of Rheumatology, Allergy, and Immunology and the Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27517, USA
Curr Allergy Asthma Rep 12:495-510. 2012....
- Improved outcomes on subcutaneous IgG in patients with humoral immunodeficiency and co-morbid bowel diseaseShaili N Shah
University of North Carolina School of Medicine, 3300 Thurston Building, CB 7280, Chapel Hill, NC 27599 7280
Clin Case Rep Rev 1:151-152. 2015..Further characterization of the effects of co-morbid conditions on immunoglobulin replacement is critical to providing improved and informed patient care...
- Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus ErythematosusSunah Kang
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599
J Immunol 196:4030-9. 2016..Taken together, our findings reveal a previously unappreciated role for the cell surface accumulation of IgG-ICs in human and murine lupus. ..
- Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancerGina Song
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Nanomedicine 11:1797-807. 2015..These data emphasize that the interplay between PLD and chemokines may have an important role in optimizing PLD therapy...
- Second generation automated anti-CCP test better predicts the clinical diagnosis of rheumatoid arthritisMohamed Elrefaei
McLendon Clinical Laboratories, University of North Carolina Hospitals, Chapel Hill, NC, USA
J Clin Immunol 32:131-7. 2012..These two new anti-CCP antibody tests have the benefit of automation and may have better positive predictive value for the diagnosis of RA than our current manual ELISA...
- An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse modelsMaria A Graziewicz
Ercole Biotech, Inc, Research Triangle Park, North Carolina 27709, USA
Mol Ther 16:1316-22. 2008..This is the first report of upregulation of the endogenous, circulating TNF-alpha antagonist by oligonucleotide-induced splicing modulation...