P I Tarr
Affiliation: University of Washington
- Escherichia coli O157:H7P I Tarr
Division of Gastroenterology, Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
Gastroenterol Clin North Am 30:735-51. 2001..The physician needs to notify immediately the appropriate public health authorities of the diagnosis and to ensure that the isolate is recovered by the microbiologist and forwarded for molecular linkage analyses...
- Escherichia coli O157:H7 in retail ground beef in Seattle: results of a one-year prospective studyP I Tarr
Children s Hospital and Regional Medical Center and the Department of Pediatrics, University of Washington School of Medicine, Seattle 98105, USA
J Food Prot 62:133-9. 1999..coli O157:H7 at a concentration below 1 CFU/g of meat. These data demonstrate that retail ground beef in Seattle is neither frequently nor heavily contaminated with E. coli O157:H7...
- Iha: a novel Escherichia coli O157:H7 adherence-conferring molecule encoded on a recently acquired chromosomal island of conserved structureP I Tarr
Division of Gastroenterology, Children s Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, Washington, USA
Infect Immun 68:1400-7. 2000..We conclude that Iha is a novel bacterial adherence-conferring protein and is contained within an E. coli chromosomal island of conserved structure. Pathogenic E. coli O157:H7 has only recently acquired this island...
- Acquisition of the rfb-gnd cluster in evolution of Escherichia coli O55 and O157P I Tarr
Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
J Bacteriol 182:6183-91. 2000..We conclude that rfb and gnd cotransferred into E. coli O55 and O157 in widely separated lineages and that recombination was responsible for recent antigenic shifts in the emergence of pathogenic E. coli O55 and O157...
- Characteristics of antibiotic-resistant Escherichia coli O157:H7 in Washington State, 1984-1991H H Kim
Department of Pediatrics, School of Public Health and Community Medicine, University of Washington, Seattle
J Infect Dis 170:1606-9. 1994..coli O157:H7 could be useful as a rapid epidemiologic marker and as a way to select this pathogen from suspected vehicles of transmission, but this resistance could also complicate therapeutic trials with sulfa-containing antibiotics...
- Role of the Escherichia coli O157:H7 O side chain in adherence and analysis of an rfb locusS S Bilge
Department of Pediatrics, University of Washington School of Medicine, Seattle, USA
Infect Immun 64:4795-801. 1996..coli rfb genes occurred independently in E. coli O157:H7 and unrelated O157 strains, and that the O side chain of E. coli O157:H7 lipopolysaccharide interferes with the adherence of E. coli O157:H7 to epithelial cells...
- Thrombogenic alleles, Escherichia coli O157:H7 infections, and hemolytic uremic syndromeJ T Sprouse
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Blood Coagul Fibrinolysis 12:283-8. 2001..Serum PAI-1 levels did not correlate with the PAI-1 genotype. We conclude that the alleles studied are not major risk factors for the acquisition of E. coli O157:H7 infection, or of E. coli O157:H7-related HUS...
- Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infectionManohar John
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
Infect Immun 73:2665-79. 2005..Also, such proteins may be exploited as markers of O157 infection in stool specimens...
- Using antibiotics in suspected haemolytic-uraemic syndrome: antibiotics should not be used in Escherichia coli O157:H7 infectionStephanie Dundas
BMJ 330:1209; author reply 1209. 2005
- Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansionJulie A Ake
Department of Medicine, Madigan Army Medical Center, Tacoma, Washington, USA
Pediatrics 115:e673-80. 2005....
- Enterohaemorrhagic Escherichia coli in human medicineHelge Karch
Institute for Hygiene, and National Consulting Laboratory on Haemolytic Uraemic Syndrome, University Hospital Munster, Robert Koch Str 41, D 48149 Munster, Germany
Int J Med Microbiol 295:405-18. 2005..This review will focus on the microbiology, epidemiology, and pathophysiology of EHEC-associated diseases, and illustrate future challenges and opportunities for their control...
- Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndromeAnne lie Ståhl
Department of Pediatrics, Clinical Sciences Lund, the Institute of Laboratory Medicine, Section for Microbiology, Immunology and Glycobiology, Lund University, 22185 Lund, Sweden
Blood 108:167-76. 2006..These data suggest that O157LPS on platelets might contribute to platelet consumption in HUS...
- Proteomics-based expression library screening (PELS): a novel method for rapidly defining microbial immunoproteomesIndira T Kudva
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Cell Proteomics 5:1514-9. 2006..In this report, we demonstrate "proof-of-principle" by identifying 207 proteins of the Escherichia coli O157:H7 immunome in bovine reservoirs in only 3 weeks...
- Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infectionsRebecca A Rashid
Department of Microbiology, University of Washington, 1959 N E Pacific St, Mail Stop 357242, Seattle, WA 98195, USA
Infect Immun 74:4142-8. 2006..Our results support the hypothesis that some virulence-associated genes of O157:H7 are differentially expressed in a host-specific manner...
- Expression of the Escherichia coli IrgA homolog adhesin is regulated by the ferric uptake regulation proteinRebecca A Rashid
Department of Microbiology, University of Washington, 1959 NE Pacific St Mailstop 357242, Seattle, WA 98195, USA
Microb Pathog 41:207-17. 2006..We identified strain-dependent differences in iha expression and determined that single nucleotide polymorphisms upstream of the iha promoter, in particular position -85, contribute to differences in expression levels...
- Greater diversity of Shiga toxin-encoding bacteriophage insertion sites among Escherichia coli O157:H7 isolates from cattle than in those from humansThomas E Besser
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
Appl Environ Microbiol 73:671-9. 2007..coli O157:H7 genotypes...
- Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: an evolutionary and functional analysisNurmohammad Shaikh
Washington University School of Medicine, St Louis, MO 63110, USA
FEMS Microbiol Lett 273:58-63. 2007..coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen...
- Explaining unexplained diarrhea and associating risks and infectionsDonna M Denno
Department of Health Services, University of Washington School of Medicine, Seattle, WA, USA
Anim Health Res Rev 8:69-80. 2007..By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses...
- Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndromePhillip I Tarr
Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
Lancet 365:1073-86. 2005..The vascular injury leading to HUS is likely to be well under way by the time infected patients seek medical attention for diarrhoea. The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria...
- Phenotypic and molecular analysis of tellurite resistance among enterohemorrhagic Escherichia coli O157:H7 and sorbitol-fermenting O157:NM clinical isolatesMartina Bielaszewska
Institut fur Hygiene, Universitatsklinikum Munster, Robert Koch Str 41, 48149 Munster, Germany
J Clin Microbiol 43:452-4. 2005..5%) of 86 sorbitol-fermenting (SF) EHEC O157:NM strains had Te MICs of </=4 microg/ml, did not grow on Te-containing media, and lacked ter genes. Optimal detection of SF EHEC O157:NM strains requires Te-independent strategies...
- Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndromeWayne L Chandler
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98105, USA
N Engl J Med 346:23-32. 2002..The hemolytic-uremic syndrome is a thrombotic complication of Escherichia coli O157:H7 infection. It is not known whether the coagulation abnormalities precede, and potentially cause, this disorder...
- ABO and P1 blood group antigen expression and stx genotype and outcome of childhood Escherichia coli O157:H7 infectionsSrdjan Jelacic
Division of Gastroenterology, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
J Infect Dis 185:214-9. 2002..In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS...
- Rebuttal to: von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndromeHan Mou Tsai
Thromb Haemost 87:548-9; author's reply 549-50. 2002
- Escherichia coli O157:H7 infections: discordance between filterable fecal shiga toxin and disease outcomeNancy A Cornick
Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa, USA
J Infect Dis 186:57-63. 2002..These data suggest that therapeutic and diagnostic strategies directed toward binding or identifying intraintestinal fecal Stx may have limited success...
- Molecular characterization of a serotype O121:H19 clone, a distinct Shiga toxin-producing clone of pathogenic Escherichia coliCheryl L Tarr
Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA
Infect Immun 70:6853-9. 2002..On the basis of sequencing analysis with 13 housekeeping genes, the O121:H19 clone did not fall into any of the four classical EHEC and enteropathogenic E. coli groups but instead was closely related to two eae-negative STEC strains...
- Platelet-activating factor and Escherichia coliO157:H7 infectionsJodi M Smith
Division of Nephrology, Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington, USA
Pediatr Nephrol 17:1047-52. 2002..Thus, elevated plasma PAF levels occur in E. coliO157:H7-infected children, even without HUS, but diminish when HUS develops. The PAF-AH ( G994T) allele does not contribute to the risk of developing HUS...
- Risk of hemolytic uremic syndrome from antibiotic treatment of Escherichia coli O157:H7 colitisPhillip I Tarr
JAMA 288:3111-2; author reply 3112. 2002
- Cardiac ischemia during hemolytic uremic syndromeMeena Thayu
Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
Pediatr Nephrol 18:286-9. 2003..It is possible that myocardial ischemia and secondary arrhythmias account for some sudden deaths that occur during acute HUS...
- Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implicationsNurmohammad Shaikh
Children s Hospital and the University of Washington, Seattle, Washington, USA
J Bacteriol 185:3596-605. 2003....
- Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profilesJill K Jelacic
University of Washington School of Medicine, Seattle, Washington, USA
J Infect Dis 188:719-29. 2003..033). Non-O157:H7 STEC are more heterogeneous and cause bloody diarrhea less frequently than do E. coli O157:H7. Bloody diarrhea cannot be attributed simply to the stx genotype of the infecting organism...
- Shiga toxin antigen detection should not replace sorbitol MacConkey agar screening of stool specimensEileen J Klein
J Clin Microbiol 42:4416; author reply 4416-7. 2004
- Isolation of patients acutely infected with Escherichia coli O157:H7: low-tech, highly effective prevention of hemolytic uremic syndromeChristina K Ahn
Clin Infect Dis 46:1197-9. 2008