Changfeng Tai

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Role of spinal GABAA receptors in pudendal inhibition of nociceptive and nonnociceptive bladder reflexes in cats
    Zhiying Xiao
    Dept of Urology, Univ of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213
    Am J Physiol Renal Physiol 306:F781-9. 2014
  2. pmc Inhibition of bladder overactivity by duloxetine in combination with foot stimulation or WAY-100635 treatment in cats
    Zeyad Schwen
    Dept of Urology, Univ of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213
    Am J Physiol Renal Physiol 305:F1663-8. 2013
  3. pmc Involvement of opioid receptors in inhibition of bladder overactivity induced by foot stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 188:1012-6. 2012
  4. pmc Inhibition of micturition reflex by activation of somatic afferents in posterior femoral cutaneous nerve
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA 15213, USA
    J Physiol 590:4945-55. 2012
  5. doi request reprint Bladder inhibition by intermittent pudendal nerve stimulation in cat using transdermal amplitude-modulated signal (TAMS)
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 31:1181-4. 2012
  6. pmc Differential role of opioid receptors in tibial nerve inhibition of nociceptive and nonnociceptive bladder reflexes in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 302:F1090-7. 2012
  7. doi request reprint Inhibition of bladder overactivity by stimulation of feline pudendal nerve using transdermal amplitude-modulated signal (TAMS)
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BJU Int 109:782-7. 2012
  8. pmc Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 300:F385-92. 2011
  9. pmc Suppression of bladder overactivity by activation of somatic afferent nerves in the foot
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
    BJU Int 107:303-9. 2011
  10. pmc Brain switch for reflex micturition control detected by FMRI in rats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA 15213, USA
    J Neurophysiol 102:2719-30. 2009

Research Grants

Collaborators

Detail Information

Publications72

  1. pmc Role of spinal GABAA receptors in pudendal inhibition of nociceptive and nonnociceptive bladder reflexes in cats
    Zhiying Xiao
    Dept of Urology, Univ of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213
    Am J Physiol Renal Physiol 306:F781-9. 2014
    ..These results indicate that spinal GABAA receptors have different roles in controlling nociceptive and nonnociceptive reflex bladder activities and in PNS inhibition of these activities. ..
  2. pmc Inhibition of bladder overactivity by duloxetine in combination with foot stimulation or WAY-100635 treatment in cats
    Zeyad Schwen
    Dept of Urology, Univ of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213
    Am J Physiol Renal Physiol 305:F1663-8. 2013
    ..Duloxetine combined with WAY-100635, however, synergistically enhanced bladder inhibition, indicating a potential novel treatment for overactive bladder if duloxetine is combined with a 5-HT1A receptor antagonist drug. ..
  3. pmc Involvement of opioid receptors in inhibition of bladder overactivity induced by foot stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 188:1012-6. 2012
    ..We examined the role of opioid receptors in the inhibition of bladder overactivity induced by electrical stimulation of the foot...
  4. pmc Inhibition of micturition reflex by activation of somatic afferents in posterior femoral cutaneous nerve
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA 15213, USA
    J Physiol 590:4945-55. 2012
    ....
  5. doi request reprint Bladder inhibition by intermittent pudendal nerve stimulation in cat using transdermal amplitude-modulated signal (TAMS)
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 31:1181-4. 2012
    ..Intermittent stimulation consumes less electrical power than continuous stimulation, requiring a smaller battery and reducing the size of the stimulator for neuromodulation therapy...
  6. pmc Differential role of opioid receptors in tibial nerve inhibition of nociceptive and nonnociceptive bladder reflexes in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 302:F1090-7. 2012
    ....
  7. doi request reprint Inhibition of bladder overactivity by stimulation of feline pudendal nerve using transdermal amplitude-modulated signal (TAMS)
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BJU Int 109:782-7. 2012
    ..To develop a non-invasive neuromodulation method targeting the pudendal nerve...
  8. pmc Prolonged poststimulation inhibition of bladder activity induced by tibial nerve stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 300:F385-92. 2011
    ..These results in cats support the clinical observation that tibial nerve neuromodulation induces a long-lasting poststimulation inhibitory effect that is useful in treating overactive bladder symptoms...
  9. pmc Suppression of bladder overactivity by activation of somatic afferent nerves in the foot
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
    BJU Int 107:303-9. 2011
    ..To investigate the possibility of suppressing bladder overactivity by electrical activation of somatic afferent nerves in the foot...
  10. pmc Brain switch for reflex micturition control detected by FMRI in rats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA 15213, USA
    J Neurophysiol 102:2719-30. 2009
    ..Understanding brain control of reflex micturition is important for elucidating the mechanisms underlying neurogenic bladder dysfunctions including frequency, urgency, and incontinence...
  11. pmc Plasticity of urinary bladder reflexes evoked by stimulation of pudendal afferent nerves after chronic spinal cord injury in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Neurol 228:109-17. 2011
    ..However our data combined with published electrophysiological data strongly indicates that the spinal circuitry for both the excitatory and inhibitory PudA-to-Bladder reflexes undergoes a marked reorganization after SCI...
  12. pmc Mechanism of conduction block in amphibian myelinated axon induced by biphasic electrical current at ultra-high frequency
    Changfeng Tai
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA 15213, USA
    J Comput Neurosci 31:615-23. 2011
    ..The results from this simulation study are useful to guide future animal experiments to reveal the different mechanisms underlying nerve conduction block induced by high-frequency biphasic electrical current...
  13. pmc Analysis of nerve conduction block induced by direct current
    Changfeng Tai
    Department of Urology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Comput Neurosci 27:201-10. 2009
    ....
  14. pmc Irritation induced bladder overactivity is suppressed by tibial nerve stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Urol 186:326-30. 2011
    ..We investigated the effects of tibial nerve stimulation on bladder overactivity induced by acetic acid irritation...
  15. pmc Relationship between temperature and stimulation frequency in conduction block of amphibian myelinated axon
    Changfeng Tai
    Department of Urology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Comput Neurosci 26:331-8. 2009
    ..This study indicates that temperature might be one of the factors that cause the frequency discrepancy as reported in previous animal studies...
  16. pmc Influence of temperature on pudendal nerve block induced by high frequency biphasic electrical current
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 180:1173-8. 2008
    ..We determined the influence of temperature on the minimal stimulation frequency required to block pudendal nerve conduction...
  17. pmc Hindlimb movement in the cat induced by amplitude-modulated stimulation using extra-spinal electrodes
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Neural Eng 5:111-24. 2008
    ..The methods and the stimulation strategy developed in this study might be utilized to restore locomotor function after spinal cord injury...
  18. pmc Inhibitory and excitatory perigenital-to-bladder spinal reflexes in the cat
    Changfeng Tai
    Department of Urology, University, of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 294:F591-602. 2008
    ..The ability to either inhibit or excite the bladder by noninvasive methods could significantly transform the current clinical management of bladder function after SCI...
  19. pmc Voiding reflex in chronic spinal cord injured cats induced by stimulating and blocking pudendal nerves
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Neurourol Urodyn 26:879-86. 2007
    ..To induce efficient voiding in chronic spinal cord injured (SCI) cats...
  20. ncbi request reprint Bladder inhibition or voiding induced by pudendal nerve stimulation in chronic spinal cord injured cats
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Neurourol Urodyn 26:570-7. 2007
    ..To investigate pudendal-to-bladder spinal reflexes in chronic spinal cord injured (SCI) cats induced by electrical stimulation of the pudendal nerve...
  21. ncbi request reprint Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 172:2069-72. 2004
    ....
  22. pmc Spinal reflex control of micturition after spinal cord injury
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Restor Neurol Neurosci 24:69-78. 2006
    ....
  23. ncbi request reprint Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Exp Neurol 199:427-37. 2006
    ..Drugs that activate 5-HT1A receptors might be useful in treating detrusor overactivity after spinal cord injury...
  24. ncbi request reprint Response of external urethral sphincter to high frequency biphasic electrical stimulation of pudendal nerve
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 174:782-6. 2005
    ....
  25. pmc Simulation analysis of conduction block in unmyelinated axons induced by high-frequency biphasic electrical currents
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    IEEE Trans Biomed Eng 52:1323-32. 2005
    ....
  26. ncbi request reprint Pudendal-to-bladder reflex in chronic spinal-cord-injured cats
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Exp Neurol 197:225-34. 2006
    ..This study indicated the possibility of developing a neuroprosthetic device based on pudendal nerve electrical stimulation to restore micturition function after spinal cord injury...
  27. ncbi request reprint Simulation of nerve block by high-frequency sinusoidal electrical current based on the Hodgkin-Huxley model
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    IEEE Trans Neural Syst Rehabil Eng 13:415-22. 2005
    ....
  28. pmc Effect of methysergide on pudendal inhibition of micturition reflex in cats
    Yosuke Matsuta
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 247:250-8. 2013
    ..Understanding neurotransmitter mechanisms underlying pudendal neuromodulation is important for the development of new treatments for bladder disorders...
  29. pmc Conduction block of mammalian myelinated nerve by local cooling to 15-30°C after a brief heating
    Zhaocun Zhang
    Department of Urology, Qilu Hospital, Shandong University, Jinan, People s Republic of China Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania and
    J Neurophysiol 115:1436-45. 2016
    ..The effect of heating on cold block is of considerable interest because it raises many basic scientific questions that may help reveal the mechanisms underlying cold or heat block of axonal conduction...
  30. doi request reprint Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats
    Jathin Bandari
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuromodulation 20:81-87. 2017
    ..To determine the role of opioid, β-adrenergic, and metabotropic glutamate 5 receptors in sacral neuromodulation of bladder overactivity...
  31. pmc Effects of duloxetine and WAY100635 on pudendal inhibition of bladder overactivity in cats
    Jeremy Reese
    Department of Urology J R, Z X, Z S, Y M, B S, J W, C T and Department of Pharmacology and Chemical Biology J R R, W C D G, C T, University of Pittsburgh, Pittsburgh, Pennsylvania and Department of Urology, The Second Hospital, Shandong University, Jinan, People s Republic of China Z X
    J Pharmacol Exp Ther 349:402-7. 2014
    ....
  32. pmc Combination of foot stimulation and tramadol treatment reverses irritation induced bladder overactivity in cats
    Abhijith D Mally
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 188:2426-32. 2012
    ..We determined whether transcutaneous electrical foot stimulation combined with a low dose of tramadol (Sigma-Aldrich®) could completely suppress bladder overactivity...
  33. pmc Bladder inhibition or excitation by electrical perianal stimulation in a cat model of chronic spinal cord injury
    Jicheng Wang
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BJU Int 103:530-6. 2009
    ..To test the hypothesis that perianal electrical stimulation (PES) in chronic spinal cord-injured (SCI) cats could induce frequency-dependent inhibitory or excitatory reflex bladder responses...
  34. pmc Inhibition of bladder overactivity by a combination of tibial neuromodulation and tramadol treatment in cats
    Fan Zhang
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Renal Physiol 302:F1576-82. 2012
    ..The results suggest a novel treatment strategy for OAB by combining tibial neuromodulation with a low dose of tramadol, which is minimally invasive with a potentially high efficacy and fewer adverse effects...
  35. pmc Contribution of opioid and metabotropic glutamate receptor mechanisms to inhibition of bladder overactivity by tibial nerve stimulation
    Yosuke Matsuta
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Regul Integr Comp Physiol 305:R126-33. 2013
    ..Understanding neurotransmitter mechanisms underlying TNS inhibition of bladder overactivity is important for the development of new treatments for bladder disorders. ..
  36. pmc Post-stimulation inhibitory effect on reflex bladder activity induced by activation of somatic afferent nerves in the foot
    Guoqing Chen
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 187:338-43. 2012
    ..We determined whether transcutaneous electrical stimulation of somatic afferent nerves in the foot of cats would induce a post-stimulation increase in bladder capacity...
  37. pmc Influence of naloxone on inhibitory pudendal-to-bladder reflex in cats
    Mang L Chen
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 224:282-91. 2010
    ..Understanding the neurotransmitter mechanisms involved in the inhibitory pudendal-to-bladder reflex could promote the development of new treatments for bladder overactivity and incontinence...
  38. pmc Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats
    Jeffrey A Larson
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Physiol 589:5833-43. 2011
    ..These results indicate that glutamic acid has a transmitter function in bladder and somato-bladder reflex mechanisms and raise the possibility that mGluR5 may be a target for pharmacological treatment of lower urinary tract disorders...
  39. ncbi request reprint Bladder and urethral sphincter responses evoked by microstimulation of S2 sacral spinal cord in spinal cord intact and chronic spinal cord injured cats
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Neurol 190:171-83. 2004
    ....
  40. pmc The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current
    Hailong Liu
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    IEEE Trans Biomed Eng 56:137-46. 2009
    ..This simulation study reveals that in mammalian myelinated axons, the slow potassium current probably plays a critical role in the nerve conduction block induced by high-frequency biphasic electrical current...
  41. doi request reprint Neural pathways involved in sacral neuromodulation of reflex bladder activity in cats
    Fan Zhang
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 304:F710-7. 2013
    ....
  42. doi request reprint Neuromodulation of bladder activity by stimulation of feline pudendal nerve using a transdermal amplitude modulated signal (TAMS)
    Bing Shen
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurourol Urodyn 30:1686-94. 2011
    ..To develop a non-invasive neuromodulation method to regulate bladder activity...
  43. pmc Influence of frequency and temperature on the mechanisms of nerve conduction block induced by high-frequency biphasic electrical current
    Jicheng Wang
    Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Comput Neurosci 24:195-206. 2008
    ....
  44. pmc Mechanism of nerve conduction block induced by high-frequency biphasic electrical currents
    Xu Zhang
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    IEEE Trans Biomed Eng 53:2445-54. 2006
    ....
  45. doi request reprint Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats
    Utsav Bansal
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Neurourol Urodyn . 2016
    ..To determine the spinal segmental afferent contributions to tibial and pudendal inhibition of bladder overactivity...
  46. pmc Involvement of 5-HT3 receptors in pudendal inhibition of bladder overactivity in cats
    Zeyad Schwen
    Dept of Urology, Univ of Pittsburgh, 700 Kaufmann Bldg, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 305:F663-71. 2013
    ..This study revealed that activation of 5-HT3 receptors has a role in PNS inhibition of bladder overactivity. It also indicated that 5-HT3 receptor antagonists might be useful for the treatment of overactive bladder symptoms. ..
  47. pmc Role of opioid and metabotropic glutamate 5 receptors in pudendal inhibition of bladder overactivity in cats
    Abhijith D Mally
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Urol 189:1574-9. 2013
    ..We determined the role of opioid and metabotropic glutamate 5 receptors in the pudendal inhibition of bladder overactivity...
  48. doi request reprint Sacral neuromodulation of nociceptive bladder overactivity in cats
    Zhaocun Zhang
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Neurourol Urodyn . 2016
    ....
  49. pmc Sympathetic β-adrenergic mechanism in pudendal inhibition of nociceptive and non-nociceptive reflex bladder activity
    Brian T Kadow
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Renal Physiol 311:F78-84. 2016
    ..In addition to this peripheral mechanism, a central nervous system mechanism involving metabotropic glutamate 5 receptors also has a role in PNS inhibition. ..
  50. pmc Role of glycine in nociceptive and non-nociceptive bladder reflexes and pudendal afferent inhibition of these reflexes in cats
    Marc J Rogers
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Neurourol Urodyn 35:798-804. 2016
    ..This study examined the role of glycinergic transmission in nociceptive and non-nociceptive bladder reflexes and in inhibition of these reflexes by pudendal nerve stimulation (PNS)...
  51. pmc Modulation of axonal excitability by high-frequency biphasic electrical current
    Hailong Liu
    Department of Urology and Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261 USA
    IEEE Trans Biomed Eng 56:2167-76. 2009
    ..Understanding how HFB electrical current modulates the axonal excitability will further elucidate the possible mechanisms underlying the nerve conduction block induced by HFB electrical current...
  52. pmc Contribution of GABAA, Glycine, and Opioid Receptors to Sacral Neuromodulation of Bladder Overactivity in Cats
    Xuewen Jiang
    Department of Urology, Qilu Hospital, Shandong University, Jinan, P R China X J, Z Z Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania X J, T W F, J B, U B, Z Z, B S, J W, C T and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania J R R, W C D G, C T
    J Pharmacol Exp Ther 359:436-441. 2016
    ..The poststimulation inhibition unmasked by blocking spinal GABAA receptors was mediated by an opioid mechanism...
  53. pmc Pudendal but not tibial nerve stimulation inhibits bladder contractions induced by stimulation of pontine micturition center in cats
    Timothy D Lyon
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 310:R366-74. 2016
    ..Understanding the site of action involved in bladder neuromodulation is important for developing new therapies for bladder disorders...
  54. pmc Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats
    Jeremy N Reese
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Renal Physiol 308:F832-8. 2015
    ..This study shows that spinal mGluR5 plays an important role in the nociceptive C-fiber afferent-mediated spinal bladder reflex and in pudendal inhibition of this spinal reflex. ..
  55. pmc Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats
    Marc J Rogers
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 308:R42-9. 2015
    ..05) reduced the amplitude of the reflex bladder contractions. This study indicates an important role of β₁/β₂-adrenergic receptors in pudendal inhibition and spinal reflex bladder activity...
  56. doi request reprint Electrical stimulation of somatic afferent nerves in the foot increases bladder capacity in healthy human subjects
    Mang L Chen
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Urol 191:1009-13. 2014
    ..We determined whether electrical stimulation of somatic afferent nerves in the foot could delay bladder filling sensations and increase bladder capacity in healthy humans without overactive bladder...
  57. ncbi request reprint Multi-joint movement of the cat hindlimb evoked by microstimulation of the lumbosacral spinal cord
    Changfeng Tai
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Neurol 183:620-7. 2003
    ..This study indicates that functional hindlimb movements can be elicited by activating a small number of sites in lumbosacral spinal cord...
  58. pmc Post-stimulation block of frog sciatic nerve by high-frequency (kHz) biphasic stimulation
    Guangning Yang
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, Pittsburgh, PA, 15213, USA
    Med Biol Eng Comput . 2016
    ..Post-stimulation block can be induced by high-frequency biphasic stimulation, which is important for future investigations of the blocking mechanisms and for optimizing the stimulation parameters or protocols in clinical applications...
  59. pmc Combination of foot stimulation and tolterodine treatment eliminates bladder overactivity in cats
    Zeyad Schwen
    Department of Urology, University of Pittsburgh, PA
    Neurourol Urodyn 33:1266-71. 2014
    ..To determine whether transcutaneous foot stimulation combined with a lower dose tolterodine would inhibit bladder overactivity more effectively than either treatment alone...
  60. pmc Somatic modulation of spinal reflex bladder activity mediated by nociceptive bladder afferent nerve fibers in cats
    Zhiying Xiao
    Department of Urology, The Second Hospital, Shandong University, Jinan, China Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania and
    Am J Physiol Renal Physiol 307:F673-9. 2014
    ..Understanding the sites of action for PNS or TNS inhibition is important for the clinical application of pudendal or tibial neuromodulation to treat bladder dysfunctions. ..
  61. ncbi request reprint Bladder Adelta afferent nerve activity in normal cats and cats with feline interstitial cystitis
    James R Roppolo
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 173:1011-5. 2005
    ..In the current study we compared the effect of bladder distention and intravesical infusion of KCl solution on Adelta bladder afferent nerve activity in normal and FIC cats...
  62. pmc Role of the brain stem in tibial inhibition of the micturition reflex in cats
    Matthew C Ferroni
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Renal Physiol 309:F242-50. 2015
    ....
  63. pmc Effect of non-symmetric waveform on conduction block induced by high-frequency (kHz) biphasic stimulation in unmyelinated axon
    Shouguo Zhao
    Department of Urology, University of Pittsburgh, 700 Kaufmann Building, 15213, Pittsburgh, PA, USA
    J Comput Neurosci 37:377-86. 2014
    ....
  64. pmc Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats
    Zhaocun Zhang
    Department of Urology, Qilu Hospital, Shandong University, Jinan, P R China Z Z Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania Z Z, R C S, M C F, B K, T D L, B S, Z X, J W, A K, C T Department of Urology, The Second Hospital, Shandong University, Jinan, P R China Z X and the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania J R R, W C D, C T
    J Pharmacol Exp Ther 355:228-34. 2015
    ..These results indicate a major role of µ and κ ORs in TNS inhibition, whereas δ ORs play a minor role. Meanwhile, κ and δ ORs also have an excitatory role in irritation-induced bladder overactivity. ..
  65. pmc Pudendal nerve stimulation and block by a wireless-controlled implantable stimulator in cats
    Guangning Yang
    Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA Department of Biomedical Engineering, Beijing Jiaotong University, China
    Neuromodulation 17:490-6; discussion 496. 2014
    ..The study aims to determine the functionality of a wireless-controlled implantable stimulator designed for stimulation and block of the pudendal nerve...
  66. ncbi request reprint Therapeutic receptor targets for lower urinary tract dysfunction
    Naoki Yoshimura
    Department of Urology, University of Pittsburgh School of Medicine, Suite 700 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:437-48. 2008
    ....
  67. ncbi request reprint Simulation analysis of nerve block by high frequency biphasic electrical current based on frankenhaeuser-huxley model
    Xu Zhang
    Capital University of Medical Sciences, Beijing 100054, P R China Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA E mail
    Conf Proc IEEE Eng Med Biol Soc 4:4247-50. 2005
    ....
  68. ncbi request reprint Simulation analysis of conduction block in myelinated axons induced by high-frequency biphasic rectangular pulses
    Xu Zhang
    Department of Biomedical Engineering, Capital University of Medical Sciences, Beijing 100069, China
    IEEE Trans Biomed Eng 53:1433-6. 2006
    ..This simulation study can guide future animal experiments as well as optimize stimulation waveforms for electrical nerve block in clinical applications...
  69. ncbi request reprint Localization of P2X and P2Y receptors in dorsal root ganglia of the cat
    Huai Zhen Ruan
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    J Histochem Cytochem 53:1273-82. 2005
    ..A further difference was the low expression of P2Y(1) receptors in cat DRG neurons compared with more than 80% of the neurons in rat. Many small-diameter neurons were NF200-positive in cat, again differing from rat and mouse...
  70. ncbi request reprint Expression of P2X and P2Y receptors in the intramural parasympathetic ganglia of the cat urinary bladder
    Huai Zhen Ruan
    Autonomic Neuroscience Centre, Royal Free and Univ College Medical School, Rowland Hill St, London NW3 2PF, UK
    Am J Physiol Renal Physiol 290:F1143-52. 2006
    ..These novel histochemical properties of cholinergic neurons in the cat bladder suggest that the parasympathetic pathways to the cat bladder may be modulated by complex purinergic synaptic mechanisms...
  71. ncbi request reprint Release of GABA from sensory neurons transduced with a GAD67-expressing vector occurs by non-vesicular mechanisms
    Jun Liu
    Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Room 1914 TC, Ann Arbor, MI 48109 0316, USA
    Brain Res 1073:297-304. 2006
    ..We conclude that QHGAD67-mediated GABA release from dorsal root ganglion neurons is non-vesicular, independent of electrical depolarization, and that this efflux is mediated through reversal of the GABA transporter...

Research Grants2

  1. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  2. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..