J A Sweeney

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Inhibitory control of attention declines more than working memory during normal aging
    J A Sweeney
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurobiol Aging 22:39-47. 2001
  2. ncbi request reprint Stimulus-response incompatibility activates cortex proximate to three eye fields
    E P Merriam
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 13:794-800. 2001
  3. ncbi request reprint Cortical networks subserving pursuit and saccadic eye movements in humans: an FMRI study
    R A Berman
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Hum Brain Mapp 8:209-25. 1999
  4. ncbi request reprint Maturation of widely distributed brain function subserves cognitive development
    B Luna
    Neurobehavioral Studies Program, MR Research Center, Pittsburgh, Pennsylvania, USA
    Neuroimage 13:786-93. 2001
  5. pmc Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders
    M W Mosconi
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychol Med 39:1559-66. 2009
  6. ncbi request reprint Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study
    B Luna
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, PA, USA
    Cereb Cortex 8:40-7. 1998
  7. ncbi request reprint Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
  8. ncbi request reprint Delay to first antipsychotic medication in schizophrenia: impact on symptomatology and clinical course of illness
    G L Haas
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    J Psychiatr Res 32:151-9. 1998
  9. pmc Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Psychiatry Neurosci 22:29-38. 1997
  10. ncbi request reprint Research and treatment strategies in first-episode psychoses. The Pittsburgh experience
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Br J Psychiatry Suppl 172:60-5. 1998

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Inhibitory control of attention declines more than working memory during normal aging
    J A Sweeney
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurobiol Aging 22:39-47. 2001
    ..These findings indicate changes in frontostriatal systems during normal aging that adversely affect volitional inhibitory processes but spare encoding and retrieval components of spatial working memory...
  2. ncbi request reprint Stimulus-response incompatibility activates cortex proximate to three eye fields
    E P Merriam
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 13:794-800. 2001
    ..These areas may contribute to the suppression of prepotent responses and in holding novel visuomotor associations in working memory...
  3. ncbi request reprint Cortical networks subserving pursuit and saccadic eye movements in humans: an FMRI study
    R A Berman
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260, USA
    Hum Brain Mapp 8:209-25. 1999
    ....
  4. ncbi request reprint Maturation of widely distributed brain function subserves cognitive development
    B Luna
    Neurobehavioral Studies Program, MR Research Center, Pittsburgh, Pennsylvania, USA
    Neuroimage 13:786-93. 2001
    ....
  5. pmc Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders
    M W Mosconi
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychol Med 39:1559-66. 2009
    ..These deficits may underlie patterns of repetitive behaviors associated with the disorder...
  6. ncbi request reprint Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study
    B Luna
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, PA, USA
    Cereb Cortex 8:40-7. 1998
    ..These differences may have functional implications for the roles these areas play in visuomotor processes...
  7. ncbi request reprint Thalamic volumes in patients with first-episode schizophrenia
    A R Gilbert
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:618-24. 2001
    ..Future analysis of individual thalamic nuclei may reveal important, specific relationships between thalamic abnormalities and schizophrenia...
  8. ncbi request reprint Delay to first antipsychotic medication in schizophrenia: impact on symptomatology and clinical course of illness
    G L Haas
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    J Psychiatr Res 32:151-9. 1998
    ..These findings indicate the importance of early detection of illness and early initiation of antipsychotic treatment for the first psychotic symptoms of schizophrenia...
  9. pmc Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits
    D R Rosenberg
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Psychiatry Neurosci 22:29-38. 1997
    ..A basic disturbance of neurobehavioral inhibition in OCD may underlie the repetitive behavior that characterizes the illness and be related to abnormalities in orbital prefrontal ventral striatal circuits...
  10. ncbi request reprint Research and treatment strategies in first-episode psychoses. The Pittsburgh experience
    M S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Br J Psychiatry Suppl 172:60-5. 1998
    ..Prospective studies of this population can clarify the impact of illness course and treatment on neurobiology...
  11. ncbi request reprint Decreased caudate volume in neuroleptic-naive psychotic patients
    M S Keshavan
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 155:774-8. 1998
    ..Previous studies, mostly involving neuroleptic-treated patients, have suggested enlarged basal ganglia size in schizophrenia. The authors sought to examine basal ganglia volume in neuroleptic-naive psychotic patients...
  12. ncbi request reprint Studies of brain and cognitive maturation through childhood and adolescence: a strategy for testing neurodevelopmental hypotheses
    B Luna
    Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    Schizophr Bull 27:443-55. 2001
    ....
  13. ncbi request reprint Magnetic resonance imaging of children without sedation: preparation with simulation
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 36:853-9. 1997
    ....
  14. ncbi request reprint Neocortical system abnormalities in autism: an fMRI study of spatial working memory
    B Luna
    Department of Psychiatry, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Neurology 59:834-40. 2002
    ..To test the hypothesis that deficits in spatial working memory in autism are due to abnormalities in prefrontal circuitry...
  15. pmc Rare inherited A2BP1 deletion in a proband with autism and developmental hemiparesis
    L K Davis
    Department of Psychiatry, University of Illinois, Chicago, Illinois 60637, USA
    Am J Med Genet A 158:1654-61. 2012
    ..This study provides further support for the possible role of rare copy number variants in A2BP1 in the development of autism and associated motor asymmetries...
  16. ncbi request reprint Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:831-8. 1997
    ....
  17. ncbi request reprint Suicidal behavior in patients with schizophrenia and other psychotic disorders
    E D Radomsky
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1590-5. 1999
    ..However, little research has been conducted to determine whether the risk for suicidal behavior is elevated among patients with psychosis in general...
  18. pmc Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes
    J M Stevenson
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Transl Psychiatry 6:e739. 2016
    ..These associations indicate a role for gene variants related to glutamate signaling and antipsychotic response with more broad association patterns indicating the potential importance of genes involved in neuronal development. ..
  19. pmc Theory of mind and social inference in children and adolescents with bipolar disorder
    L S Schenkel
    Center for Cognitive Medicine and the Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Psychol Med 38:791-800. 2008
    ..To date, there have been no investigations of ToM in pediatric bipolar disorder (PBD). The aim of the current study was to investigate this ability in PBD patients and healthy controls...
  20. pmc Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia
    M S Keshavan
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 72:757-60. 2002
    ..Areas of primary and association cortices have been topographically mapped in the CC...
  21. pmc Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments
    Matcheri Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201, St Antoine Blvd, Detroit, MI 48201, USA
    Schizophr Res 103:114-20. 2008
    ..We examined the prevalence and correlates of psychopathology in an ongoing study of offspring genetically at risk for schizophrenia...
  22. ncbi request reprint Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Biol Psychiatry 62:818-21. 2007
    ....
  23. ncbi request reprint When does the brain inform the eyes whether and where to move? An EEG study in humans
    Brett A Clementz
    Department of Psychology and Neuroscience, Bio Imaging Research Center, University of Georgia, Athens, GA 30602, USA
    Cereb Cortex 17:2634-43. 2007
    ..These data highlight how a distributed neural architecture supports the evaluation of stimuli and response choices...
  24. ncbi request reprint Affective neural circuitry during facial emotion processing in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 62:158-67. 2007
    ..Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder...
  25. ncbi request reprint Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Arch Gen Psychiatry 63:1189-97. 2006
    ..The oculomotor delayed response task is a translational spatial working memory paradigm used to characterize the neurophysiologic and neurochemical aspects of working memory in the primate brain...
  26. ncbi request reprint Spatial working memory deficits in autism
    Shelly D Steele
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60612 7327, USA
    J Autism Dev Disord 37:605-12. 2007
    ..Overall, these results demonstrate reduced spatial working memory abilities in autism, and extend previous findings by demonstrating that these deficits are significant when tasks impose heavier demands on working memory...
  27. ncbi request reprint Brain basis of developmental change in visuospatial working memory
    K Suzanne Scherf
    University of Pittsburgh, PA 15213, USA
    J Cogn Neurosci 18:1045-58. 2006
    ..These results suggest that the maturation of adult-level cognition involves a combination of increasing localization within necessary regions and their integration with performance-enhancing regions...
  28. ncbi request reprint Biological risk factors in pediatric bipolar disorder
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
    Biol Psychiatry 60:936-41. 2006
    ..The current study attempted to determine whether neurodevelopmental and acquired brain abnormalities are more common in pediatric bipolar disorder (PBD)...
  29. ncbi request reprint Cognitive processes in the development of TOL performance
    Miya R Asato
    Laboratory of Neurocognitive Development, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychologia 44:2259-69. 2006
    ....
  30. ncbi request reprint Impact of neurocognitive function on academic difficulties in pediatric bipolar disorder: A clinical translation
    Mani N Pavuluri
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
    Biol Psychiatry 60:951-6. 2006
    ..Investigation of the degree to which neuropsychological deficits might contribute to those academic problems is needed to aid in the recognition and intervention for school achievement difficulties in PBD...
  31. ncbi request reprint Maturation of executive function in autism
    Beatriz Luna
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 61:474-81. 2007
    ..Executive dysfunction has been reported at different ages in autism. It is not clear however, when this impairment emerges or how its expression is affected by development...
  32. ncbi request reprint Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task
    Sarah K Keedy
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Psychiatry Res 146:199-211. 2006
    ....
  33. pmc Effects of second-generation antipsychotic medication on smooth pursuit performance in antipsychotic-naive schizophrenia
    Rebekka Lencer
    Department of Psychiatry, University of Lubeck, Lubeck, Germany
    Arch Gen Psychiatry 65:1146-54. 2008
    ..Although pursuit eye tracking deficits have been widely reported in schizophrenia, the integrity of discrete components of pursuit responses and the effect of second-generation antipsychotic medication on them are not well established...
  34. pmc Sex difference in cognitive response to antipsychotic treatment in first episode schizophrenia
    Leah H Rubin
    Department of Psychiatry and Psychology, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:290-7. 2008
    ..Future studies of the neurocognitive effects of antipsychotic treatment may need to take potential sex differences in cognitive response into account...
  35. pmc An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine at the University of Illinois at Chicago UIC, Chicago, IL 60612, USA
    Psychiatry Res 162:244-55. 2008
    ..This pattern of functional alteration in affective and cognitive circuitry may contribute to the reduced capacity for affect regulation and behavioral self-control in pediatric bipolar disorder...
  36. pmc Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Int Neuropsychol Soc 14:209-21. 2008
    ....
  37. pmc Neurocognitive allied phenotypes for schizophrenia and bipolar disorder
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Bull 34:743-59. 2008
    ..However, very few studies have evaluated neurocognitive dimensions in bipolar probands or their unaffected relatives, and much work in this area is needed...
  38. pmc Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 63:776-83. 2008
    ..This suggests that dysregulation of automatic attentional processes may contribute to disturbances in prefrontally mediated control of voluntary behavior...
  39. pmc Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, Chicago, IL 60612, USA
    Schizophr Bull 34:494-506. 2008
    ..These findings warrant further investigation regarding the utility of neurophysiological biomarkers for assessing cognitive outcomes of antipsychotic treatment in clinical trials and in early-phase drug development...
  40. pmc Atypical involvement of frontostriatal systems during sensorimotor control in autism
    Yukari Takarae
    Department of Psychiatry MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 156:117-27. 2007
    ..These findings document that neurodevelopmental disturbances in autism affect widely distributed brain systems beyond those mediating language and social cognition...
  41. ncbi request reprint White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study
    Marilyn F Kraus
    Department of Psychiatry, University of Illinois at Chicago Medical Center, Chicago, IL, USA
    Brain 130:2508-19. 2007
    ..The more severe injuries impact both. DTI provides an objective means for determining the relationship of cognitive deficits to TBI, even in cases where the injury was sustained years prior to the evaluation...
  42. ncbi request reprint Oculomotor function in chronic traumatic brain injury
    Marilyn F Kraus
    Center for Cognitive Medicine and Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Cogn Behav Neurol 20:170-8. 2007
    ..To characterize oculomotor function using visually guided saccade and antisaccade (AS) tasks in chronic traumatic brain injury (TBI) and assess the relationship to neuropsychologic testing...
  43. pmc What aspects of emotional functioning are impaired in schizophrenia?
    Ellen S Herbener
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street M C 913, Chicago, IL 60612, USA
    Schizophr Res 98:239-46. 2008
    ....
  44. ncbi request reprint Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 164:1061-71. 2007
    ..The authors sought to compare the effects of olanzapine, quetiapine, and risperidone on neurocognitive function in patients with early psychosis...
  45. pmc fMRI studies of eye movement control: investigating the interaction of cognitive and sensorimotor brain systems
    John A Sweeney
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 S Wood Street MC 913, Chicago, IL 60612 7327, USA
    Neuroimage 36:T54-60. 2007
    ....
  46. ncbi request reprint Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients
    Mani N Pavuluri
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 South Wood St M C 913, Chicago, IL 60612, USA
    Am J Psychiatry 163:286-93. 2006
    ....
  47. ncbi request reprint Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia?
    Vaibhav A Diwadkar
    Depatment of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:230-8. 2006
    ..We propose that schizotypy may define a hyper vulnerable sub-sample among individuals genetically predisposed to schizophrenia and that future studies that attempt to assess risk may benefit from such a convergent approach...
  48. ncbi request reprint Psychotic symptoms in pediatric bipolar disorder
    Mani N Pavuluri
    Center for Cognitive Medicine, University of Illinois at Chicago, USA
    J Affect Disord 80:19-28. 2004
    ..There is under-recognition or misdiagnosis of pediatric bipolar disorder with psychotic features. It is of major public health importance to recognize psychosis in bipolar disorder...
  49. ncbi request reprint Neuropsychological dysfunction in antipsychotic-naive first-episode unipolar psychotic depression
    S Kristian Hill
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Psychiatry 161:996-1003. 2004
    ....
  50. ncbi request reprint Impairment of verbal memory and learning in antipsychotic-naïve patients with first-episode schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:127-36. 2004
    ..The goal of this study was to characterize the nature of verbal memory impairments in antipsychotic-naïve schizophrenic patients early in the course of illness...
  51. ncbi request reprint Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    ..CC maturational changes appeared synchronous across sub-regions suggesting parallel maturation of diverse brain regions during childhood and adolescence...
  52. ncbi request reprint Combining brains: a survey of methods for statistical pooling of information
    Nicole A Lazar
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 16:538-50. 2002
    ..Given a combination of brain images, the researcher needs to interpret the result and decide on areas of activation; the question of thresholding is critical here and is also explored...
  53. ncbi request reprint Psychosis proneness and ADHD in young relatives of schizophrenia patients
    Matcheri S Keshavan
    Department of Psychiatry, UPMC Health System Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room 984, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Schizophr Res 59:85-92. 2003
    ..Longitudinal studies can clarify whether an "ADHD subgroup" within HR subjects predict an increased risk for future emergence of schizophrenia...
  54. ncbi request reprint A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Room 984, University of Pittsburgh School of Medicine, 3811 0 Hara Street, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:1143-9. 2002
    ..These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders...
  55. ncbi request reprint Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  56. ncbi request reprint Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses
    Matcheri S Keshavan
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Schizophr Bull 29:757-69. 2003
    ..The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia...
  57. ncbi request reprint Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
    Vaibhav A Diwadkar
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 67:277-82. 2004
    ....
  58. ncbi request reprint Insight and prefrontal cortex in first-episode Schizophrenia
    Mujeeb U Shad
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 22:1315-20. 2004
    ....
  59. ncbi request reprint The emergence of collaborative brain function: FMRI studies of the development of response inhibition
    Beatriz Luna
    Laboratory of Neurocognitive Development, University of Pittsburgh Medical Center, 3501 Forbes Avenue, 743, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:296-309. 2004
    ..We also propose a model for brain-behavior maturation that allows for the qualitative changes in cognitive processes that occur during adolescence...
  60. ncbi request reprint Maturation of cognitive processes from late childhood to adulthood
    Beatriz Luna
    Laboratory of Neurocognitive Development, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Child Dev 75:1357-72. 2004
    ..How brain maturation specific to adolescence may support cognitive maturation is discussed...
  61. ncbi request reprint Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia
    Daniel Schuepbach
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Res 53:249-61. 2002
    ..Reduction in positive symptoms was not associated with change in cognitive abilities. These findings suggest a linkage between early, treatment-induced improvements in negative symptoms and reductions in distinct cognitive deficits...
  62. ncbi request reprint Oculomotor studies of cerebellar function in autism
    Caralynn V Nowinski
    Department of Psychiatry, MC 913, University of Illinois at Chicago, 912 S Wood St, Suite 235, Chicago, IL 60612 7327, USA
    Psychiatry Res 137:11-9. 2005
    ..The atypical metrics of intrusive saccades that were observed may be attributable to faulty functional connectivity in cortico-cerebellar networks...
  63. ncbi request reprint Premorbid indicators and risk for schizophrenia: a selective review and update
    Matcheri S Keshavan
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 4201 St Antoine, Suite 9B, Detroit, MI 48201, USA
    Schizophr Res 79:45-57. 2005
    ..Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology...
  64. ncbi request reprint Effects of antipsychotic treatment on emotion perception deficits in first-episode schizophrenia
    Ellen S Herbener
    Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, 912 S Wood St, Chicago, IL 60612, USA
    Am J Psychiatry 162:1746-8. 2005
    ..The authors evaluated emotion perception in acutely ill patients experiencing a first episode of schizophrenia. They also investigated the effects of antipsychotic medication on emotion perception...
  65. ncbi request reprint Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followup
    Daniel Schuepbach
    Psychiatric University Hospital Zurich, PO Box 68, CH 8029 Zurich, Switzerland
    Schizophr Bull 30:837-48. 2004
    ..These findings suggest an important relationship between treatment efficacy of antipsychotic medication and the longer term course of cognitive deficits in schizophrenia...
  66. ncbi request reprint Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems
    Lucia S Simo
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois, Chicago, IL 60611, USA
    Cereb Cortex 15:1982-91. 2005
    ..Anticipatory behavior induced by the PRED task required less sensory-related processing activity and was subserved by a distributed cortico-subcortical memory system including prefronto-striatal circuitry...
  67. ncbi request reprint Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia
    James L Reilly
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biol Psychiatry 57:145-54. 2005
    ..Previous studies have reported intact visually guided saccades in schizophrenia, but these are limited by potential acute and long-term pharmacological treatment effects, small sample sizes, and a failure to follow patients over time...
  68. ncbi request reprint Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis
    Richard D Sanders
    Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 16:480-7. 2004
    ..Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared...
  69. ncbi request reprint Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses
    Matcheri S Keshavan
    Department of Psychiatry, Western Psychiatric Institute and Clinic and University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Am J Psychiatry 160:1298-304. 2003
    ..This study examined the neuroanatomical correlates and diagnostic specificity of abnormal findings on the neurological examination in first-episode schizophrenia and other psychotic disorders...
  70. ncbi request reprint Pursuit and saccadic eye movement subregions in human frontal eye field: a high-resolution fMRI investigation
    Caterina Rosano
    Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Cereb Cortex 12:107-15. 2002
    ..These findings localize distinct pursuit and saccadic subregions of FEF in humans and demonstrate a high degree of homology in the organization of these FEF subregions in the human and the macaque monkey...
  71. ncbi request reprint Mechanisms underlying spatial representation revealed through studies of hemispatial neglect
    Marlene Behrmann
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Cogn Neurosci 14:272-90. 2002
    ..The findings dovetail well with results from existing neurophysiological studies and shed further light on the spatial representations mediated by the human parietal cortex...
  72. ncbi request reprint Commentary: eye movement research with clinical populations
    John A Sweeney
    Center for Cognitive Medicine, Departments of Psychiatry, Neurology and Psychology, University of Illinois at Chicago, MC 913, 912 S Wood St, Neuropsychiatric Institute, Chicago, IL 60612, USA
    Prog Brain Res 140:507-22. 2002
    ....
  73. ncbi request reprint Frequency and metrics of square-wave jerks: influences of task-demand characteristics
    Dennis M Shaffer
    Social and Behavioral Sciences Program, Arizona State University West, Phoenix, Arizona, USA
    Invest Ophthalmol Vis Sci 44:1082-7. 2003
    ..Square-wave jerks (SWJs) during visual fixation and pursuit tracking of targets of varying speed and predictability were investigated in the present study...
  74. ncbi request reprint Abnormal brain lateralization in high-functioning autism
    Paul R Escalante-Mead
    University of Illinois at Chicago, Chicago, IL 60612, USA
    J Autism Dev Disord 33:539-43. 2003
    ..The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism...
  75. ncbi request reprint Facial emotion processing in acutely ill and euthymic patients with pediatric bipolar disorder
    Lindsay S Schenkel
    Department of Psychiatry, University of Illinois at Chicago, USA
    J Am Acad Child Adolesc Psychiatry 46:1070-9. 2007
    ..However, the extent to which these deficits represent state- and trait-related factors is unclear. We investigated facial affect processing in acutely ill and clinically stabilized children with PBD and matched healthy subjects...
  76. ncbi request reprint Eye movements in neurodevelopmental disorders
    John A Sweeney
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612 7327, USA
    Curr Opin Neurol 17:37-42. 2004
    ..It thus provides a promising methodology for characterizing and documenting maturational abnormalities in brain systems associated with neurodevelopmental disorders...
  77. ncbi request reprint Longitudinal studies of antisaccades in antipsychotic-naive first-episode schizophrenia
    Margret S H Harris
    Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Psychol Med 36:485-94. 2006
    ..Some data suggest that treatment with antipsychotic medications may ameliorate these deficits...
  78. pmc Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: a single-voxel 1H spectroscopy study
    Jeffrey A Stanley
    Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States
    Schizophr Res 93:23-32. 2007
    ....
  79. ncbi request reprint Estimation and classification of fMRI hemodynamic response patterns
    Robert D Gibbons
    Center for Health Statistics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroimage 22:804-14. 2004
    ..The procedure is demonstrated on real data from an event-related design experiment of visually guided saccades and shown to be an effective alternative to existing methods...
  80. ncbi request reprint Pursuit eye movement deficits in autism
    Yukari Takarae
    University of Illinois at Chicago, Chicago, Illinois and 2 University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Brain 127:2584-94. 2004
    ....
  81. ncbi request reprint Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study
    Ragy R Girgis
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Schizophr Res 82:89-94. 2006
    ..No areas of change were found in controls. The results of this exploratory investigation support the possibility that risperidone has short-term effects on brain parenchyma in individuals with first-episode psychosis...
  82. ncbi request reprint Failure of positive but not negative emotional valence to enhance memory in schizophrenia
    Ellen S Herbener
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Abnorm Psychol 116:43-55. 2007
    ....