J David Sweatt

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
    Iva B Zovkic
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL, USA
    Front Psychiatry 4:60. 2013
  2. pmc The emerging field of neuroepigenetics
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA Electronic address
    Neuron 80:624-32. 2013
  3. pmc Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Exp Mol Med 45:e21. 2013
  4. pmc DNA methylation regulates neuronal glutamatergic synaptic scaling
    Jarrod P Meadows
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Sci Signal 8:ra61. 2015
  5. pmc Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1
    Frankie D Heyward
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Neurosci 36:1324-35. 2016
  6. pmc Histone H2A.Z subunit exchange controls consolidation of recent and remote memory
    Iva B Zovkic
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 515:582-6. 2014
  7. pmc Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity
    Mikael C Guzman-Karlsson
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Neuropharmacology 80:3-17. 2014
  8. doi request reprint Pitt-Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo
    Vladimir Grubisic
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama
    Autism Res 8:629-33. 2015
  9. pmc DNA methylation and its implications and accessibility for neuropsychiatric therapeutics
    Jeremy J Day
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 email
    Annu Rev Pharmacol Toxicol 55:591-611. 2015
  10. doi request reprint The role of the Gadd45 family in the nervous system: a focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics
    Faraz A Sultan
    Department of Neurobiology, University of Alabama at Birmingham, Shelby 1010, 1825 University Blvd, Birmingham, AL, 35294, USA
    Adv Exp Med Biol 793:81-119. 2013

Collaborators

  • John J Hablitz
  • Vladimir Parpura
  • Jing Wang
  • Guo li Ming
  • Hongjun Song
  • Jeremy J Day
  • Jarrod P Meadows
  • Mikael C Guzman-Karlsson
  • Iva B Zovkic
  • GARRETT A KAAS
  • Frankie D Heyward
  • Andrew J Kennedy
  • Cristin F Gavin
  • Vladimir Grubisic
  • Jerome Moulden
  • Faraz A Sultan
  • John Lewis
  • Mark A Coleman
  • Garrett Kaas
  • Daniel Gilliam
  • Richard Trieu
  • Scott Phillips
  • Jessica L Posey
  • Cassie Holleman
  • Brynna S Paulukaitis
  • Deepa M Etikala
  • Absar Tahir
  • Esther Song
  • Daniel Childs
  • Daniel L Ross
  • Raj V Vachhani
  • Jennifer R King
  • Dawn E Eason
  • Mercy Kibe
  • Chun Zhong

Detail Information

Publications12

  1. pmc Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
    Iva B Zovkic
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL, USA
    Front Psychiatry 4:60. 2013
    ....
  2. pmc The emerging field of neuroepigenetics
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA Electronic address
    Neuron 80:624-32. 2013
    ..In this brief commentary, I will attempt to address and delineate some of the open questions and areas of opportunity that discoveries in epigenetics are providing to the discipline of neuroscience. ..
  3. pmc Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription
    J David Sweatt
    Department of Neurobiology and Evelyn F McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Exp Mol Med 45:e21. 2013
    ....
  4. pmc DNA methylation regulates neuronal glutamatergic synaptic scaling
    Jarrod P Meadows
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Sci Signal 8:ra61. 2015
    ..Furthermore, covalent DNA modifications may contribute to synaptic plasticity events that underlie the formation and stabilization of memories. ..
  5. pmc Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1
    Frankie D Heyward
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Neurosci 36:1324-35. 2016
    ..Thus, our findings suggest that the memory-impairing effects of diet-induced obesity may potentially be mediated by neuroepigenetic dysregulation of SIRT1 within the hippocampus...
  6. pmc Histone H2A.Z subunit exchange controls consolidation of recent and remote memory
    Iva B Zovkic
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 515:582-6. 2014
    ..Overall, our data introduce histone variant exchange as a novel mechanism contributing to the molecular basis of cognitive function and implicate H2A.Z as a potential therapeutic target for memory disorders. ..
  7. pmc Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity
    Mikael C Guzman-Karlsson
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Neuropharmacology 80:3-17. 2014
    ..In doing so, we aim to expand upon the idea that epigenetic mechanisms are critical regulators of both Hebbian and non-Hebbian forms of plasticity that ultimately drive learning and memory...
  8. doi request reprint Pitt-Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo
    Vladimir Grubisic
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama
    Autism Res 8:629-33. 2015
    ..This is the first evidence of specific gut related problems in the PTHS mice. Our study also validates the TCF4 functional knockout mice as an animal model to study PTHS-associated GI disturbances...
  9. pmc DNA methylation and its implications and accessibility for neuropsychiatric therapeutics
    Jeremy J Day
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 email
    Annu Rev Pharmacol Toxicol 55:591-611. 2015
    ..Lastly, we speculate upon potential categories of CNS cognitive disorders that might be amenable to methylomic targeting. ..
  10. doi request reprint The role of the Gadd45 family in the nervous system: a focus on neurodevelopment, neuronal injury, and cognitive neuroepigenetics
    Faraz A Sultan
    Department of Neurobiology, University of Alabama at Birmingham, Shelby 1010, 1825 University Blvd, Birmingham, AL, 35294, USA
    Adv Exp Med Biol 793:81-119. 2013
    ..In this review, we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes. ..
  11. pmc TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation
    GARRETT A KAAS
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 79:1086-93. 2013
    ..In summary, we show that neuronal Tet1 regulates DNA methylation levels and that its expression, independent of its catalytic activity, regulates the expression of CNS activity-dependent genes and memory formation...
  12. pmc DNA methylation regulates associative reward learning
    Jeremy J Day
    1 Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA 2 Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Neurosci 16:1445-52. 2013
    ..These results provide the first evidence that that activity-dependent methylation and demethylation of DNA is an essential substrate for the behavioral and neuronal plasticity driven by reward-related experiences. ..