Fayyaz S Sutterwala

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint The tiny conductor: immune regulation via commensal organisms
    SUZANNE L CASSEL
    Division of Allergy and Immunology, University of Iowa, Iowa City, IA 52242, USA
    Cell Host Microbe 3:340-1. 2008
  2. pmc NLRC4/IPAF: a CARD carrying member of the NLR family
    Fayyaz S Sutterwala
    Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA 52241, USA
    Clin Immunol 130:2-6. 2009
  3. pmc Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation
    Tyler K Ulland
    Inflammation Program, University of Iowa, Iowa City, Iowa, USA
    Infect Immun 81:201-8. 2013
  4. pmc Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans
    Sophie Joly
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 189:4713-7. 2012
  5. pmc Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice
    SUZANNE L CASSEL
    Inflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242
    Proc Natl Acad Sci U S A 111:1072-7. 2014
  6. pmc Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    Shankar S Iyer
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunity 39:311-23. 2013
  7. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
  8. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
  9. pmc Immune complexes inhibit IL-1 secretion and inflammasome activation
    John R Janczy
    Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242
    J Immunol 193:5190-8. 2014
  10. pmc Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo
    Ceren Ciraci
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 11:e0151252. 2016

Collaborators

Detail Information

Publications28

  1. doi request reprint The tiny conductor: immune regulation via commensal organisms
    SUZANNE L CASSEL
    Division of Allergy and Immunology, University of Iowa, Iowa City, IA 52242, USA
    Cell Host Microbe 3:340-1. 2008
    ..In a recent study in Nature, Mazmanian et al. (2008) reveal the ability of specific moieties on the surface of Bacteroides fragilis to direct the host's immune response...
  2. pmc NLRC4/IPAF: a CARD carrying member of the NLR family
    Fayyaz S Sutterwala
    Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA 52241, USA
    Clin Immunol 130:2-6. 2009
    ..This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation...
  3. pmc Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation
    Tyler K Ulland
    Inflammation Program, University of Iowa, Iowa City, Iowa, USA
    Infect Immun 81:201-8. 2013
    ..These findings further illustrate that F. tularensis LVS possesses numerous genes that influence its ability to activate the inflammasome, which is a key host strategy to control infection with this pathogen in vivo...
  4. pmc Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans
    Sophie Joly
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 189:4713-7. 2012
    ..albicans. However, Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection...
  5. pmc Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice
    SUZANNE L CASSEL
    Inflammation Program, Department of Internal Medicine, Graduate Program in Immunology, Department of Pediatrics, Department of Pathology, Department of Orthopedics, Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, and Department of Epidemiology, University of Iowa, Iowa City, IA 52242
    Proc Natl Acad Sci U S A 111:1072-7. 2014
    ..These data provide a rationale for directly targeting IL-1RI or IL-1β as a therapeutic strategy in CRMO. ..
  6. pmc Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    Shankar S Iyer
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunity 39:311-23. 2013
    ..Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of Nlrp3 to cardiolipin. ..
  7. pmc Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
    Shankar S Iyer
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:20388-93. 2009
    ..These findings suggest that the inhibition of Nlrp3 inflammasome activity can diminish the acute inflammation and damage associated with tissue injury...
  8. pmc Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    Sophie Joly
    Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 183:3578-81. 2009
    ..Nlrp3-deficient mice also demonstrated increased susceptibility to infection with C. albicans, which is consistent with a key role for Nlrp3 in innate immune responses to the pathogen C. albicans...
  9. pmc Immune complexes inhibit IL-1 secretion and inflammasome activation
    John R Janczy
    Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242
    J Immunol 193:5190-8. 2014
    ....
  10. pmc Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo
    Ceren Ciraci
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 11:e0151252. 2016
    ..Together these data represent a novel mechanism by which the generation of Th17 responses is regulated. ..
  11. doi request reprint Fungal pathogen recognition by the NLRP3 inflammasome
    Sophie Joly
    Inflammation Program, University of Iowa, Iowa City, IA, USA
    Virulence 1:276-80. 2010
    ..Here we will review these findings and discuss the role of the NLRP3 inflammasome in initiating an innate immune response to invasive C. albicans...
  12. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  13. pmc Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
    Tyler K Ulland
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nat Commun 7:13180. 2016
    ..These results demonstrate that C57BL/6J mice have a functional defect in NLRP12 and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites...
  14. pmc Mechanism of NLRP3 inflammasome activation
    Fayyaz S Sutterwala
    Inflammation Program, University of Iowa, Iowa City, Iowa Department of Internal Medicine, University of Iowa, Iowa City, Iowa Veterans Affairs Medical Center, Iowa City, Iowa
    Ann N Y Acad Sci 1319:82-95. 2014
    ..This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome. ..
  15. ncbi request reprint ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. Taken together, our data demonstrate that ASC and caspase-1 are critical for IFN-gamma-mediated control of A. phagocytophilum infection...
  16. pmc Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
    Tyler K Ulland
    Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2670-4. 2010
    ..This study demonstrates that mviN limits F. tularensis-induced absent in melanoma 2 inflammasome activation, which is critical for its virulence in vivo...
  17. pmc Sterile inflammatory responses mediated by the NLRP3 inflammasome
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Eur J Immunol 40:607-11. 2010
    ..Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses...
  18. pmc Obesity and cancer: inflammation bridges the two
    Ryan Kolb
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Curr Opin Pharmacol 29:77-89. 2016
    ..Since obesity is known to have global impact on inflammation, here we will summarize recent literature and discuss the potential of inflammation being the common causal mechanism to promote cancer promotion across cancer types. ..
  19. pmc Inflammasomes in cancer: a double-edged sword
    Ryan Kolb
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
    Protein Cell 5:12-20. 2014
    ....
  20. pmc Damage control: management of cellular stress by the NLRP3 inflammasome
    Stefanie Haasken
    Inflammation Program, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Eur J Immunol 43:2003-5. 2013
    ....
  21. pmc The NLRP3 inflammasome: a sensor of immune danger signals
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Semin Immunol 21:194-8. 2009
    ..One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review...
  22. doi request reprint Monocytes Take Their Own Path to IL-1β
    Eric I Elliott
    Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Immunity 44:713-5. 2016
    ..In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ..
  23. doi request reprint Atypical Inflammasomes
    Ann M Janowski
    Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Methods Mol Biol 1417:45-62. 2016
    ..The structure and function of these atypical inflammasomes will be highlighted here. ..
  24. pmc Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat
    Sailesh C Harwani
    From the Department of Internal Medicine S C H, J R, F S S, Z K B, M W C, F M A, Departments of Molecular Physiology and Biophysics M W C, F M A, and Veterans Affairs Medical Center F S S, Z K B, M W C, Iowa City and Department of Pathology D K M, Inflammation Program, Department of Internal Medicine F S S, Center for Immunology and Immune Mediated Diseases S C H, F S S, F M A, and Abboud Cardiovascular Research Center S C H, J R, M W C, F M A, University of Iowa Carver College of Medicine, Iowa City
    Circ Res 119:1101-1115. 2016
    ..Renal inflammation contributes to the pathophysiology of hypertension. CD161a+ immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in response to nicotinic cholinergic activation...
  25. pmc Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
    Ryan Kolb
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nat Commun 7:13007. 2016
    ....
  26. pmc Initiation and perpetuation of NLRP3 inflammasome activation and assembly
    Eric I Elliott
    Inflammation Program, University of Iowa, Iowa City, IA, USA Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA, USA Medical Scientist Training Program, University of Iowa, Iowa City, IA, USA
    Immunol Rev 265:35-52. 2015
    ..Here, we review the mechanisms and pathways regulating NLRP3 inflammasome activation, discuss emerging concepts in NLRP3 complex organization, and expose the knowledge gaps hindering a comprehensive understanding of NLRP3 activation. ..
  27. pmc Control of innate and adaptive immunity by the inflammasome
    Ceren Ciraci
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Microbes Infect 14:1263-70. 2012
    ..This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses...