J H Su
Affiliation: University of California
- Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brainJ H Su
Institute for Brain Aging and Dementia, University of California, Irvine, 92697 4540, USA
Brain Res 774:193-9. 1997..These data suggest the hypothesis that the neurons with DNA damage in the absence of tangle formation may degenerate by tangle-independent mechanisms and that oxidative damage may contribute to such mechanisms in AD...
- Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neuritesJ H Su
Institute for Brain Aging and Dementia, University of California Irvine, 92717 4550, USA
Acta Neuropathol 96:463-71. 1998..These data suggest that dystrophic neurites can develop retrogradely from focal plaque damage to induce somatic and dendritic degeneration and potentially contribute to neurofibrillary tangle formation...
- Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathologyJ H Su
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
Brain Res 898:350-7. 2001..These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain...
- Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's diseaseT T Rohn
Institute for Brain Aging and Dementia, University of California at Irvine, 92697-4540, USA
Am J Pathol 158:189-98. 2001..84). Taken together, these results provide evidence for the activation of apoptotic mechanisms in neurons in the AD brain and suggest that there is an association between NFT formation and the activation of apoptotic pathways in AD...
- Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusionJ A Martin
Alzheimer s Disease Research Center, University of California at Irvine, Irvine, CA 92697 4540, USA
Neurobiol Aging 22:195-207. 2001..55, p < 0.05). Furthermore, areas of significant astrogliosis corresponded to areas of SPECT hypoperfusion, suggesting that astrocytes may be affected by or perhaps have a causal role in the disturbances of cerebral perfusion in FTD...
- Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathologyJ H Su
Institute for Brain Aging and Dementia, University of California, Irvine 92697 4540, USA
J Neuropathol Exp Neurol 56:86-93. 1997..These findings suggest that Bax may contribute to neuronal cell death in AD. Furthermore, DNA damage and the upregulation of Bax appear to precede tangle formation or may represent an alternative pathway of cell death in AD...
- Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndromeE Head
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
J Neuropathol Exp Neurol 62:917-26. 2003..Thus, compensatory growth responses may occur in DS prior to extensive AD pathology and may be one mechanism underlying observations in PET studies of hypermetabolism in the entorhinal cortex of individuals with DS...
- Arsenite-induced nitric oxide generation is cell cycle-dependent and aberrant in NBS cellsS S Yuan
Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 807, Republic of China
Toxicol In Vitro 17:139-43. 2003..In summary, our study showed, for the first time, that arsenite-induced NO generation is cell-cycle- and NBS1-dependent...
- Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinomaY T Yeh
Department of Medical Research and Department of Obstetrics and Gynecology, E Da Hospital, Kaohsiung, Taiwan, ROC
Oncol Rep 17:35-9. 2007..In summary, our results indicated that an altered p-JAK1 expression might be involved in the development of breast infiltrating ductal carcinoma in an ERalpha-related manner...